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The map label for this gene is mdh [H]

Identifier: 116694777

GI number: 116694777

Start: 940282

End: 941373

Strand: Direct

Name: mdh [H]

Synonym: H16_B0831

Alternate gene names: 116694777

Gene position: 940282-941373 (Clockwise)

Preceding gene: 116694775

Following gene: 116694778

Centisome position: 32.28

GC content: 67.49

Gene sequence:

>1092_bases
ATGAACCATGCCTACCACAACCCCGTGTCGATCCATTGCGGGGCTGGCAGCCTTGACCGGCTCCCGGCCCTGCTGCACGG
CCGGCGCGTCGTCGTCGTGACCTTTCCCGAAGCGCGTGCGCTGGGACTGGTGGCGCGGCTTGAAGCCCTGCTGGGCGCAG
ACCTTGCCGGGCTGATCGAAGACGTGCAGCCGAACCCGGATGTCGCCCAGTTGTCCGGCCTGTACAACCGCTTCTGGGAA
GACGCCGACGCCTGCGACGCCATCGTTGCGGTCGGTGGCGGCAGCGCGATCGATACCGCCAAGGCGTTGATGGTAGGGAC
CAGGTCGGGCCGGTTCGATTCGCTGATCAGCCTGCTGGCGACCGGCAAGGCGTTCACGCCGGCGCAGGTCAAGCCGCTGA
TCGCGGTGCCGACGACTGCCGGCACCGGCAGCGAAGTGACGCCCTGGGCCACCATCTGGGACGCCGCGAACCAGAAGAAG
TACTCGCTTCACCTGCAGGCAACCTGGCCCGAAGCGGCCATCGTGGATGCGGAGCTGATGATGTCGGTGCCGCGGGACAC
CACGATCTCCACCGGGCTCGATGCCCTGTCCCACGCGCTGGAATCGATCTGGAACGTCAACGCCAACCCGGTTTCCGACA
CCTTCGCGATTTCGGCGGTGGAGGACATCTTCGACACCTTGCCGGAACTGGTGCGCAACCTGGACGACATTGGCCTGCGT
GAGCGCATGGCGCTGGCCGCCCTCAAGGCCGGACTGGCGTTCTCCAATACCAAGACGGCACTTGCGCACTCCATCTCCTA
CGAAATGACGCTGCGCCATGGCCTGCCGCACGGCATCGCGTGCTCGTTCACGCTGCCGATGGTGCTTGAAAAGGCGTGGG
CACGCCGGCCCGACCGCGACCGCACGCTGCAGCGGCTGTTCGGGCCGGTGCTGGGCGACGGGCAGCAGCGGCTGCGCGCC
TTCCTGCAGGACCTGGGCGTGAAGACCGAGTTTGCCGACTACGGCGTCTCCGACGACGAGGCCGGCGCCATGATCGCGCG
TGCGCTGGACGGCGCCCGGGGCAAGAACTTCATCGGCGCTGTGCCGGCCTAG

Upstream 100 bases:

>100_bases
GCGATTGGACCGGGGGTTTGGCGTCTCCCAAACTTCAGCCACCAGGAAACGCGGCTCAAGCCGCCGCCCAGGCTACCCAG
AAAAGAAGTGAGGAGACCCC

Downstream 100 bases:

>100_bases
TAGCACGACCCCCGGCCGACGGGTGCAGCCGGCCAACACGAGCCCGCAATACGGGCCGACAATACAAGAGGAGACAAAAA
TGGAAACTGCCGATCGCATC

Product: alcohol dehydrogenase, class IV

Products: NA

Alternate protein names: MEDH [H]

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MNHAYHNPVSIHCGAGSLDRLPALLHGRRVVVVTFPEARALGLVARLEALLGADLAGLIEDVQPNPDVAQLSGLYNRFWE
DADACDAIVAVGGGSAIDTAKALMVGTRSGRFDSLISLLATGKAFTPAQVKPLIAVPTTAGTGSEVTPWATIWDAANQKK
YSLHLQATWPEAAIVDAELMMSVPRDTTISTGLDALSHALESIWNVNANPVSDTFAISAVEDIFDTLPELVRNLDDIGLR
ERMALAALKAGLAFSNTKTALAHSISYEMTLRHGLPHGIACSFTLPMVLEKAWARRPDRDRTLQRLFGPVLGDGQQRLRA
FLQDLGVKTEFADYGVSDDEAGAMIARALDGARGKNFIGAVPA

Sequences:

>Translated_363_residues
MNHAYHNPVSIHCGAGSLDRLPALLHGRRVVVVTFPEARALGLVARLEALLGADLAGLIEDVQPNPDVAQLSGLYNRFWE
DADACDAIVAVGGGSAIDTAKALMVGTRSGRFDSLISLLATGKAFTPAQVKPLIAVPTTAGTGSEVTPWATIWDAANQKK
YSLHLQATWPEAAIVDAELMMSVPRDTTISTGLDALSHALESIWNVNANPVSDTFAISAVEDIFDTLPELVRNLDDIGLR
ERMALAALKAGLAFSNTKTALAHSISYEMTLRHGLPHGIACSFTLPMVLEKAWARRPDRDRTLQRLFGPVLGDGQQRLRA
FLQDLGVKTEFADYGVSDDEAGAMIARALDGARGKNFIGAVPA
>Mature_363_residues
MNHAYHNPVSIHCGAGSLDRLPALLHGRRVVVVTFPEARALGLVARLEALLGADLAGLIEDVQPNPDVAQLSGLYNRFWE
DADACDAIVAVGGGSAIDTAKALMVGTRSGRFDSLISLLATGKAFTPAQVKPLIAVPTTAGTGSEVTPWATIWDAANQKK
YSLHLQATWPEAAIVDAELMMSVPRDTTISTGLDALSHALESIWNVNANPVSDTFAISAVEDIFDTLPELVRNLDDIGLR
ERMALAALKAGLAFSNTKTALAHSISYEMTLRHGLPHGIACSFTLPMVLEKAWARRPDRDRTLQRLFGPVLGDGQQRLRA
FLQDLGVKTEFADYGVSDDEAGAMIARALDGARGKNFIGAVPA

Specific function: May Act On The Acetaldehyde Produced From The Degradation Of Ethanolamine. [C]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Integral Membrane Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=317, Percent_Identity=32.807570977918, Blast_Score=99, Evalue=7e-21,
Organism=Escherichia coli, GI87082107, Length=271, Percent_Identity=35.4243542435424, Blast_Score=144, Evalue=7e-36,
Organism=Escherichia coli, GI48994951, Length=263, Percent_Identity=31.9391634980989, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1789163, Length=334, Percent_Identity=30.2395209580838, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI1787493, Length=232, Percent_Identity=34.051724137931, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1789386, Length=362, Percent_Identity=24.3093922651934, Blast_Score=75, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17537053, Length=299, Percent_Identity=29.7658862876254, Blast_Score=104, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6321181, Length=347, Percent_Identity=29.6829971181556, Blast_Score=135, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24657991, Length=312, Percent_Identity=29.1666666666667, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.244 [H]

Molecular weight: Translated: 38770; Mature: 38770

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00913 ADH_IRON_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHAYHNPVSIHCGAGSLDRLPALLHGRRVVVVTFPEARALGLVARLEALLGADLAGLIE
CCCCCCCCEEEEECCCCHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHCCHHHHHHH
DVQPNPDVAQLSGLYNRFWEDADACDAIVAVGGGSAIDTAKALMVGTRSGRFDSLISLLA
HCCCCCCHHHHHHHHHHHHCCCCHHCEEEEECCCCHHHHHHHHHEECCCCCHHHHHHHHH
TGKAFTPAQVKPLIAVPTTAGTGSEVTPWATIWDAANQKKYSLHLQATWPEAAIVDAELM
CCCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHCCCCCEEEEEEEEECCCHHHHHHHHH
MSVPRDTTISTGLDALSHALESIWNVNANPVSDTFAISAVEDIFDTLPELVRNLDDIGLR
HHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHH
ERMALAALKAGLAFSNTKTALAHSISYEMTLRHGLPHGIACSFTLPMVLEKAWARRPDRD
HHHHHHHHHHCCCCCCCHHHHHHHHHHEEHHHCCCCCCEEHHHHHHHHHHHHHHCCCCHH
RTLQRLFGPVLGDGQQRLRAFLQDLGVKTEFADYGVSDDEAGAMIARALDGARGKNFIGA
HHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHHHCCCCCCCCCCC
VPA
CCC
>Mature Secondary Structure
MNHAYHNPVSIHCGAGSLDRLPALLHGRRVVVVTFPEARALGLVARLEALLGADLAGLIE
CCCCCCCCEEEEECCCCHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHCCHHHHHHH
DVQPNPDVAQLSGLYNRFWEDADACDAIVAVGGGSAIDTAKALMVGTRSGRFDSLISLLA
HCCCCCCHHHHHHHHHHHHCCCCHHCEEEEECCCCHHHHHHHHHEECCCCCHHHHHHHHH
TGKAFTPAQVKPLIAVPTTAGTGSEVTPWATIWDAANQKKYSLHLQATWPEAAIVDAELM
CCCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHCCCCCEEEEEEEEECCCHHHHHHHHH
MSVPRDTTISTGLDALSHALESIWNVNANPVSDTFAISAVEDIFDTLPELVRNLDDIGLR
HHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHH
ERMALAALKAGLAFSNTKTALAHSISYEMTLRHGLPHGIACSFTLPMVLEKAWARRPDRD
HHHHHHHHHHCCCCCCCHHHHHHHHHHEEHHHCCCCCCEEHHHHHHHHHHHHHHCCCCHH
RTLQRLFGPVLGDGQQRLRAFLQDLGVKTEFADYGVSDDEAGAMIARALDGARGKNFIGA
HHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHHHCCCCCCCCCCC
VPA
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1644761; 1995642 [H]