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The map label for this gene is mmgC [H]

Identifier: 116694611

GI number: 116694611

Start: 734160

End: 735326

Strand: Direct

Name: mmgC [H]

Synonym: H16_B0660

Alternate gene names: 116694611

Gene position: 734160-735326 (Clockwise)

Preceding gene: 116694610

Following gene: 116694612

Centisome position: 25.21

GC content: 70.18

Gene sequence:

>1167_bases
ATGCAGCTTGAATACACCGACGCCCAGCGCGCCTTCCGCGCCGAGGTGCGCGACTGGATGGCCGCGCACGTGCCGCGCAC
GCCGCTGGCGAGCTTCGATACCGAAGCGGGCTTCGCCCAGCACCGCGCGTGGGAGGCCACGCTCAACCAGGGCCGCTGGA
GCATGGTCACGTGGCCGGCCGAGCTGGGCGGGCGCGGCTGCGACCTGATCGAGTGGCTGATCTTCGAGGAGGAGTACTGG
CGTGCCGGCGCGCCGATGCGCGTCAACCAGAACGGCATCTTCCTGCTCGGGCCCACGCTGATGGAATTCGGCACCGAGGC
GCAGAAGGCGCGCTTCCTGCCGCGCATGGCCTCGGGCGAGCATGTCTGGGCGCAGGGCTGGTCCGAGCCGAGCGCAGGCT
CGGACATGGCCGCGATCCGCTGCAGCGCGATCCGGCAGGGCGATGACTATGTGATCAACGGCCAGAAGATCTGGTCGACG
CGGGCGGTGTGGGCGGACTGGCTGTTCGGCCTGTTCCGCACCGACCCGGCCTCGACCCGACACCATGGCCTGACCTTCAT
CCTGATGCCGCTGGACACGCCCGGCATCATCGTGCGCCCGATCCGCCAGCTCAACGGCCAGACCGGCTTTGCCGAGATCT
TCTTCGACGACGTGCGCGTGCCGGTGGAAAACCGCCTGGCCGCAGAAGGCGCCGGCTGGCAGGTGGCCATGGCCACCGCC
GGCTTCGAACGCGGCCTGATGCTGCGCTCGCCGGCGCGCTTCCAGGAAACCGCGCGCGCGCTGGTCAGGCTGTACCAGGC
CAACCGCGAGGCGGCGGACCGCGACCCGTCGCTGCGCGAGGCGGTGCTGCGCGCCTGGATGGACGCCGAGGCCTACACGC
TGTCCACCTACGCCACCGCGAGCCGCCTGGTGCGCGGCGGCCATATCGGCGCGGAGTCGAGCACGAACAAGGTGTTCTGG
TCCGAGCTGGACATCCATATGCACGATACCGCGCTGGCCATCCTGGGGCAGTCCGCAGAGGTCGCGCCCGACGGCCAGCC
GCCGGGTTCGCTCGGCCACTGGCTGGATGGCTTCCTGTTCTCGCAGGCCGGGCCGATCTATGCCGGCACCAACGAGATCC
AGCGCAATATCGTCGCCGAGCGCCTGCTCGGCATGCCGCGCGCATGA

Upstream 100 bases:

>100_bases
CAGGGCTTCACGCTGCAGGCCTACATGAGCGCCGATTCCGGCGAGGCGCGCGCCGCCTTTGTCGAAGGCCGCGAAGCCCG
CTTTGCGCAGGGAGAGCGCG

Downstream 100 bases:

>100_bases
CGGCACCCGGGGAAAACACCATGGATTTCGCATTGACCGAAGAGCAGGAGCAGTTTGCCGAGGCGATCCGGCGCTTCCTG
ATGACCGAGATGACGCCCGA

Product: Acyl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MQLEYTDAQRAFRAEVRDWMAAHVPRTPLASFDTEAGFAQHRAWEATLNQGRWSMVTWPAELGGRGCDLIEWLIFEEEYW
RAGAPMRVNQNGIFLLGPTLMEFGTEAQKARFLPRMASGEHVWAQGWSEPSAGSDMAAIRCSAIRQGDDYVINGQKIWST
RAVWADWLFGLFRTDPASTRHHGLTFILMPLDTPGIIVRPIRQLNGQTGFAEIFFDDVRVPVENRLAAEGAGWQVAMATA
GFERGLMLRSPARFQETARALVRLYQANREAADRDPSLREAVLRAWMDAEAYTLSTYATASRLVRGGHIGAESSTNKVFW
SELDIHMHDTALAILGQSAEVAPDGQPPGSLGHWLDGFLFSQAGPIYAGTNEIQRNIVAERLLGMPRA

Sequences:

>Translated_388_residues
MQLEYTDAQRAFRAEVRDWMAAHVPRTPLASFDTEAGFAQHRAWEATLNQGRWSMVTWPAELGGRGCDLIEWLIFEEEYW
RAGAPMRVNQNGIFLLGPTLMEFGTEAQKARFLPRMASGEHVWAQGWSEPSAGSDMAAIRCSAIRQGDDYVINGQKIWST
RAVWADWLFGLFRTDPASTRHHGLTFILMPLDTPGIIVRPIRQLNGQTGFAEIFFDDVRVPVENRLAAEGAGWQVAMATA
GFERGLMLRSPARFQETARALVRLYQANREAADRDPSLREAVLRAWMDAEAYTLSTYATASRLVRGGHIGAESSTNKVFW
SELDIHMHDTALAILGQSAEVAPDGQPPGSLGHWLDGFLFSQAGPIYAGTNEIQRNIVAERLLGMPRA
>Mature_388_residues
MQLEYTDAQRAFRAEVRDWMAAHVPRTPLASFDTEAGFAQHRAWEATLNQGRWSMVTWPAELGGRGCDLIEWLIFEEEYW
RAGAPMRVNQNGIFLLGPTLMEFGTEAQKARFLPRMASGEHVWAQGWSEPSAGSDMAAIRCSAIRQGDDYVINGQKIWST
RAVWADWLFGLFRTDPASTRHHGLTFILMPLDTPGIIVRPIRQLNGQTGFAEIFFDDVRVPVENRLAAEGAGWQVAMATA
GFERGLMLRSPARFQETARALVRLYQANREAADRDPSLREAVLRAWMDAEAYTLSTYATASRLVRGGHIGAESSTNKVFW
SELDIHMHDTALAILGQSAEVAPDGQPPGSLGHWLDGFLFSQAGPIYAGTNEIQRNIVAERLLGMPRA

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI187960098, Length=400, Percent_Identity=28.75, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI4557231, Length=246, Percent_Identity=33.3333333333333, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI226958412, Length=252, Percent_Identity=29.3650793650794, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI4557233, Length=335, Percent_Identity=28.955223880597, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI4501859, Length=393, Percent_Identity=26.7175572519084, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI226958414, Length=220, Percent_Identity=30.4545454545455, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI76496475, Length=343, Percent_Identity=31.1953352769679, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI4557235, Length=343, Percent_Identity=31.1953352769679, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI4501857, Length=386, Percent_Identity=24.8704663212435, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI21361497, Length=306, Percent_Identity=30.3921568627451, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI48976061, Length=212, Percent_Identity=32.5471698113208, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI211971008, Length=212, Percent_Identity=32.5471698113208, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI38505218, Length=152, Percent_Identity=35.5263157894737, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI7656849, Length=138, Percent_Identity=32.6086956521739, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1786223, Length=344, Percent_Identity=23.8372093023256, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI87081958, Length=260, Percent_Identity=23.4615384615385, Blast_Score=73, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17570075, Length=397, Percent_Identity=29.9748110831234, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17538396, Length=386, Percent_Identity=27.720207253886, Blast_Score=117, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI17534899, Length=244, Percent_Identity=31.1475409836066, Blast_Score=104, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17551932, Length=194, Percent_Identity=33.5051546391753, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17505929, Length=221, Percent_Identity=30.7692307692308, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17569725, Length=398, Percent_Identity=27.8894472361809, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17508101, Length=347, Percent_Identity=25.0720461095101, Blast_Score=88, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71985184, Length=164, Percent_Identity=34.7560975609756, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71985192, Length=164, Percent_Identity=34.7560975609756, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17506239, Length=336, Percent_Identity=26.7857142857143, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71990804, Length=187, Percent_Identity=28.8770053475936, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17562446, Length=183, Percent_Identity=30.6010928961749, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI32563615, Length=186, Percent_Identity=30.1075268817204, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17533517, Length=147, Percent_Identity=30.6122448979592, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI21356377, Length=353, Percent_Identity=28.6118980169972, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI21355753, Length=366, Percent_Identity=27.8688524590164, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24646207, Length=346, Percent_Identity=28.0346820809249, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24660351, Length=208, Percent_Identity=37.0192307692308, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI281363737, Length=353, Percent_Identity=27.7620396600567, Blast_Score=101, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24666513, Length=276, Percent_Identity=28.6231884057971, Blast_Score=99, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 43249; Mature: 43249

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLEYTDAQRAFRAEVRDWMAAHVPRTPLASFDTEAGFAQHRAWEATLNQGRWSMVTWPA
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECH
ELGGRGCDLIEWLIFEEEYWRAGAPMRVNQNGIFLLGPTLMEFGTEAQKARFLPRMASGE
HHCCCCCHHHHHHHHHHHHHCCCCCEEECCCCEEEECHHHHHHCCHHHHHHHCCCCCCCC
HVWAQGWSEPSAGSDMAAIRCSAIRQGDDYVINGQKIWSTRAVWADWLFGLFRTDPASTR
EEEECCCCCCCCCCCHHHHHHHHHCCCCCEEECCCEEEHHHHHHHHHHHHHHCCCCCCCC
HHGLTFILMPLDTPGIIVRPIRQLNGQTGFAEIFFDDVRVPVENRLAAEGAGWQVAMATA
CCCEEEEEEECCCCCHHHHHHHHHCCCCCEEEEEHHCCCCCHHHHHCCCCCCCEEEEECC
GFERGLMLRSPARFQETARALVRLYQANREAADRDPSLREAVLRAWMDAEAYTLSTYATA
CCCCCEEECCCHHHHHHHHHHHHHHHHCCHHCCCCCHHHHHHHHHHHCCCCEEEHHHHHH
SRLVRGGHIGAESSTNKVFWSELDIHMHDTALAILGQSAEVAPDGQPPGSLGHWLDGFLF
HHHHHCCCCCCCCCCCEEEEEEEEEEECHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHH
SQAGPIYAGTNEIQRNIVAERLLGMPRA
HCCCCCEECHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MQLEYTDAQRAFRAEVRDWMAAHVPRTPLASFDTEAGFAQHRAWEATLNQGRWSMVTWPA
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECH
ELGGRGCDLIEWLIFEEEYWRAGAPMRVNQNGIFLLGPTLMEFGTEAQKARFLPRMASGE
HHCCCCCHHHHHHHHHHHHHCCCCCEEECCCCEEEECHHHHHHCCHHHHHHHCCCCCCCC
HVWAQGWSEPSAGSDMAAIRCSAIRQGDDYVINGQKIWSTRAVWADWLFGLFRTDPASTR
EEEECCCCCCCCCCCHHHHHHHHHCCCCCEEECCCEEEHHHHHHHHHHHHHHCCCCCCCC
HHGLTFILMPLDTPGIIVRPIRQLNGQTGFAEIFFDDVRVPVENRLAAEGAGWQVAMATA
CCCEEEEEEECCCCCHHHHHHHHHCCCCCEEEEEHHCCCCCHHHHHCCCCCCCEEEEECC
GFERGLMLRSPARFQETARALVRLYQANREAADRDPSLREAVLRAWMDAEAYTLSTYATA
CCCCCEEECCCHHHHHHHHHHHHHHHHCCHHCCCCCHHHHHHHHHHHCCCCEEEHHHHHH
SRLVRGGHIGAESSTNKVFWSELDIHMHDTALAILGQSAEVAPDGQPPGSLGHWLDGFLF
HHHHHCCCCCCCCCCCEEEEEEEEEEECHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHH
SQAGPIYAGTNEIQRNIVAERLLGMPRA
HCCCCCEECHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]