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The map label for this gene is nhaA

Identifier: 116694391

GI number: 116694391

Start: 496908

End: 498314

Strand: Direct

Name: nhaA

Synonym: H16_B0439

Alternate gene names: 116694391

Gene position: 496908-498314 (Clockwise)

Preceding gene: 116694390

Following gene: 116694398

Centisome position: 17.06

GC content: 61.48

Gene sequence:

>1407_bases
GTGGACCGACTCCCGCCCCCACCGCCCCCACCACGGCAACCATTGCCGCGTGCTCAAGTTTTAGCCGAGAAGGCATTCTC
GGCGCTCGAACATTTTCTTCATATCGAGGCCGTCAGCGGCATTGTCCTGCTCGCCGCCGCCGGGATCGCGCTACTTTGGG
CGAATTCCCCCGCTTCCCACAGCTACCACGCCCTATGGCATACCCCGCTCTCATTCGGGATAGGTAGCCATCTGGTATCG
CAATCCCTGCATTTCTGGATCAACGACGCCCTGATGACCATCTTCTTTCTCGTCGTTGGGATGGAAATCCGGCGCGAAAT
CCATGAGGGAGCGCTGGCGAACGTGCGCCTTTCGGCCCTGCCAATGGCTGCGGCGCTTGGTGGCGTGATCGTCCCCGCGT
TGATCTACCTCGCGATAAACACAGAGATGCCCCAGCGCCAGGGTTGGGCGGTGCCAACCGCTACTGACATCGCGTTCGCC
GTCGGGGTGCTCGCGTTACTCGGCAAATCCATACCCGGCAACGTTCGAGTGTTCCTGCTCGCGCTGGCGATCATCGACGA
CATTGTCGCGGTCCTGATTATCGCAGTGGCCTTCTCGGGCGGGTTGGACTATGGGGGGTTTCTTGTTGCAGGTACAGGTA
TTCTAATGGTCCTGGGGCTGCAATGGATCGGCGTCGGAACCGCCTATGCTTACGTCGTACCGGGGGCCATTCTGTGGCTG
GGAATGCTGAAGACCGGTGCCCACCCGACGCTCGCTGGCGTCGTGCTTGGCATGATGACGCCGGTACTGCCCGGTCGCAC
GCGAGAACGGCCTTTGGATGTGGCCATGCGTGCGCTCCTTGATCTGCGCGCTCGCGCGACCGCTCGGACACCTAAACCAG
AACACATCGCGGCACCGCTTAAGCAACTGCGTCACGCCCAGCGGGAGCTACTACCGCCCGTGATCCGTGTACAGATGGCG
CTTCACCCTTGGGTCGCCTACCTTGTCATGCCGCTCTTTGCCTTGGCAAATGCCGGAGTGAGCATTGATGGCGTCGATCT
CACTAGCGGCGGATCGCTAGGCGCGATGTTTGGTGTTGTCCTTGCACTGGTCGTAGGCAAACCTCTCGGCATCGTGTCGG
TCAGCTGGCTGGCCGTACGCCTGGGCTGGTGCCAGTTGCCGCCCGACGTGACCTGGCGCGGCGTATGCCTGGTTGGACTA
CTGGCCGGCATCGGCTTCACGATGTCGATATTCATCGCCACGCTTGCGTTCGAGGATGTCAACCTACTTGGGGCTGCCAA
GCTTGGCGTGCTCTTGGCATCGGCGATAGCTGCCACCATAGGGCTGACCTGGGGTTTCATTTATGCCAGGGGCCGAAGAC
CGAGCATGGAACGAGCCGACGAATCTACTGCGGCGGCGTCCGACTGA

Upstream 100 bases:

>100_bases
GGCAGCTCATGTACAATCGCCGATAGGGTGTCTACGCTGCACGTCGCAGTGAGACAGGTTAATGCGTTGGTCGGGCCGCC
AACGCAAATGCTCTATGACT

Downstream 100 bases:

>100_bases
AGGGGCTACGCGTGCATCGGCGTGGGAAGTTGCTACAGAATCGAGGCTAGCCATACCGCGATGATCGCCTCTAAACTCAA
TGTCACCACCAGCACCAGCT

Product: Na+/H+ antiporter 1

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MDRLPPPPPPPRQPLPRAQVLAEKAFSALEHFLHIEAVSGIVLLAAAGIALLWANSPASHSYHALWHTPLSFGIGSHLVS
QSLHFWINDALMTIFFLVVGMEIRREIHEGALANVRLSALPMAAALGGVIVPALIYLAINTEMPQRQGWAVPTATDIAFA
VGVLALLGKSIPGNVRVFLLALAIIDDIVAVLIIAVAFSGGLDYGGFLVAGTGILMVLGLQWIGVGTAYAYVVPGAILWL
GMLKTGAHPTLAGVVLGMMTPVLPGRTRERPLDVAMRALLDLRARATARTPKPEHIAAPLKQLRHAQRELLPPVIRVQMA
LHPWVAYLVMPLFALANAGVSIDGVDLTSGGSLGAMFGVVLALVVGKPLGIVSVSWLAVRLGWCQLPPDVTWRGVCLVGL
LAGIGFTMSIFIATLAFEDVNLLGAAKLGVLLASAIAATIGLTWGFIYARGRRPSMERADESTAAASD

Sequences:

>Translated_468_residues
MDRLPPPPPPPRQPLPRAQVLAEKAFSALEHFLHIEAVSGIVLLAAAGIALLWANSPASHSYHALWHTPLSFGIGSHLVS
QSLHFWINDALMTIFFLVVGMEIRREIHEGALANVRLSALPMAAALGGVIVPALIYLAINTEMPQRQGWAVPTATDIAFA
VGVLALLGKSIPGNVRVFLLALAIIDDIVAVLIIAVAFSGGLDYGGFLVAGTGILMVLGLQWIGVGTAYAYVVPGAILWL
GMLKTGAHPTLAGVVLGMMTPVLPGRTRERPLDVAMRALLDLRARATARTPKPEHIAAPLKQLRHAQRELLPPVIRVQMA
LHPWVAYLVMPLFALANAGVSIDGVDLTSGGSLGAMFGVVLALVVGKPLGIVSVSWLAVRLGWCQLPPDVTWRGVCLVGL
LAGIGFTMSIFIATLAFEDVNLLGAAKLGVLLASAIAATIGLTWGFIYARGRRPSMERADESTAAASD
>Mature_468_residues
MDRLPPPPPPPRQPLPRAQVLAEKAFSALEHFLHIEAVSGIVLLAAAGIALLWANSPASHSYHALWHTPLSFGIGSHLVS
QSLHFWINDALMTIFFLVVGMEIRREIHEGALANVRLSALPMAAALGGVIVPALIYLAINTEMPQRQGWAVPTATDIAFA
VGVLALLGKSIPGNVRVFLLALAIIDDIVAVLIIAVAFSGGLDYGGFLVAGTGILMVLGLQWIGVGTAYAYVVPGAILWL
GMLKTGAHPTLAGVVLGMMTPVLPGRTRERPLDVAMRALLDLRARATARTPKPEHIAAPLKQLRHAQRELLPPVIRVQMA
LHPWVAYLVMPLFALANAGVSIDGVDLTSGGSLGAMFGVVLALVVGKPLGIVSVSWLAVRLGWCQLPPDVTWRGVCLVGL
LAGIGFTMSIFIATLAFEDVNLLGAAKLGVLLASAIAATIGLTWGFIYARGRRPSMERADESTAAASD

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family

Homologues:

Organism=Escherichia coli, GI1786201, Length=420, Percent_Identity=43.0952380952381, Blast_Score=287, Evalue=9e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NHAA_CUPNH (Q0K437)

Other databases:

- EMBL:   AM260480
- RefSeq:   YP_728602.1
- ProteinModelPortal:   Q0K437
- SMR:   Q0K437
- STRING:   Q0K437
- GeneID:   4456341
- GenomeReviews:   AM260480_GR
- KEGG:   reh:H16_B0439
- eggNOG:   COG3004
- HOGENOM:   HBG665619
- PhylomeDB:   Q0K437
- ProtClustDB:   CLSK909502
- BioCyc:   REUT381666:H16_B0439-MONOMER
- HAMAP:   MF_01844
- InterPro:   IPR023171
- InterPro:   IPR004670
- TIGRFAMs:   TIGR00773

Pfam domain/function: PF06965 Na_H_antiport_1

EC number: NA

Molecular weight: Translated: 49452; Mature: 49452

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x108124e4)-; HASH(0x189cc3f8)-; HASH(0x1883b394)-; HASH(0x189cab14)-; HASH(0x189c9de8)-; HASH(0x189cc578)-; HASH(0x185b8dc4)-; HASH(0x18379f94)-; HASH(0x189c773c)-; HASH(0x189cd190)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRLPPPPPPPRQPLPRAQVLAEKAFSALEHFLHIEAVSGIVLLAAAGIALLWANSPASH
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCC
SYHALWHTPLSFGIGSHLVSQSLHFWINDALMTIFFLVVGMEIRREIHEGALANVRLSAL
CCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHH
PMAAALGGVIVPALIYLAINTEMPQRQGWAVPTATDIAFAVGVLALLGKSIPGNVRVFLL
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHH
ALAIIDDIVAVLIIAVAFSGGLDYGGFLVAGTGILMVLGLQWIGVGTAYAYVVPGAILWL
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GMLKTGAHPTLAGVVLGMMTPVLPGRTRERPLDVAMRALLDLRARATARTPKPEHIAAPL
HHHHCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
KQLRHAQRELLPPVIRVQMALHPWVAYLVMPLFALANAGVSIDGVDLTSGGSLGAMFGVV
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCEEECCCCCHHHHHHHH
LALVVGKPLGIVSVSWLAVRLGWCQLPPDVTWRGVCLVGLLAGIGFTMSIFIATLAFEDV
HHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLLGAAKLGVLLASAIAATIGLTWGFIYARGRRPSMERADESTAAASD
HHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHCCCCCCCCCH
>Mature Secondary Structure
MDRLPPPPPPPRQPLPRAQVLAEKAFSALEHFLHIEAVSGIVLLAAAGIALLWANSPASH
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCC
SYHALWHTPLSFGIGSHLVSQSLHFWINDALMTIFFLVVGMEIRREIHEGALANVRLSAL
CCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHH
PMAAALGGVIVPALIYLAINTEMPQRQGWAVPTATDIAFAVGVLALLGKSIPGNVRVFLL
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHH
ALAIIDDIVAVLIIAVAFSGGLDYGGFLVAGTGILMVLGLQWIGVGTAYAYVVPGAILWL
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GMLKTGAHPTLAGVVLGMMTPVLPGRTRERPLDVAMRALLDLRARATARTPKPEHIAAPL
HHHHCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
KQLRHAQRELLPPVIRVQMALHPWVAYLVMPLFALANAGVSIDGVDLTSGGSLGAMFGVV
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCEEECCCCCHHHHHHHH
LALVVGKPLGIVSVSWLAVRLGWCQLPPDVTWRGVCLVGLLAGIGFTMSIFIATLAFEDV
HHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLLGAAKLGVLLASAIAATIGLTWGFIYARGRRPSMERADESTAAASD
HHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA