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The map label for this gene is metK

Identifier: 113478041

GI number: 113478041

Start: 7167561

End: 7168823

Strand: Reverse

Name: metK

Synonym: Tery_4661

Alternate gene names: 113478041

Gene position: 7168823-7167561 (Counterclockwise)

Preceding gene: 113478042

Following gene: 113478036

Centisome position: 92.5

GC content: 39.11

Gene sequence:

>1263_bases
TTGTCTAGTCGTTACTTATTCACTTCTGAGTCTGTTACAGAAGGACATCCAGATAAAATTTGCGACCAAATTTCAGACAC
AATTATAGATGCTATACTAGCCCAAGATCCTCAAAGTCGTGTAGCTGCTGAAGTAGTAGTGAACACAGGGTTAGTACTAA
TTACTGGTGAAATTACAACCAAGGCCCAAGTAAATTATATAGAATTGGCCAGAAAAAAAATTGCTGACATTGGCTATGTC
CATGCCGAAAATGGTTTTTCTGCTGATAGTTGTTCCGTTTTAGTAGCTCTTGATGAGCAATCAGCAGATATTGCTCAAGG
AGTAGACAAAGCTCAAGAAACTCGTGAACTCTTAAGTGAAGAAGAACTTGATGCAGTGGGAGCAGGAGACCAGGGCTTAA
TGTTTGGTTTTGCTTGTAATGAAACTCCTGAATTAATGCCTTTACCTATAAGTTTAGCACATCGAGTTTGCCGGCAACTA
ACTGCGGTGAGAAAAACAGGTCAACTTCCCTATTTAAGGCCAGATGGCAAAAGTCAAGTCACTATTACTTATGAAGATGG
CCGTCCTGTTGGTATCGATACAATCTTAATTTCTACCCAACATACTGCTAAAATTGGGGAAATCACAGAATTATCAGATA
TTCAAGCTAAGATTAAAGAAGACCTCTGGAAGTATGTTGTTGAGCCAATATTTAAAGACGCAGAGATTAAACCTAATTCA
CAAACTCGTTTTCTTGTCAACCCCACTGGTAAATTTGTTATTGGCGGTCCACAGGGAGATTGTGGTCTGACAGGACGTAA
AATCATAATAGATACTTATGGTGGTTATTCCCGTCATGGAGGCGGTGCTTTTTCAGGAAAAGATCCCACTAAGGTAGACC
GCTCAGCAGCTTATGCTTGTCGCTATATAGCTAAAAATATTGTTGCAGCAGATCTAGCAGAAAAGTGTGAGGTTCAAATT
AGTTATGCGATTGGTGTAGCAAAACCTGTTAGTATGATGATTGAAACTTTTGGTACTTCTAAGGTTGATGAAGATAAGTT
ATTAGAAGTAGTGAAAGAAAACTTTGAACTCCGTCCAGCAGGAATTATTCAGAATTTTAACCTTCGGAACTTGCCTGGAG
AAAGAGGAGGTCGTTTTTATCAAGATGTTGCTGCTTATGGTCACTTGGGACGTACCGATCTAGATTTACCTTGGGAGCAA
ACAGATAAAGTGGAGTTATTAAAGCAAGCATTTAGTCCACAGTTATTAGCTACAGCTTCATAA

Upstream 100 bases:

>100_bases
ACAGTAGAAAAAAGTAGTTATTCTGGATAAATATTATCCCTAAGTTAAAGTTTATTACCTGTTCGGCTAATTCGTGGAAA
AATATAAGGAGGAATTACTA

Downstream 100 bases:

>100_bases
GTCTCTATAGACTTTTGATTACCAAATAATATTTAATTTGGAGCAACCAAGAGAACTCAGTTTCTTTTGGTTGTTAATTT
ATTTCTGTTCGTACTTATAT

Product: S-adenosylmethionine synthetase

Products: NA

Alternate protein names: AdoMet synthase; MAT; Methionine adenosyltransferase

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MSSRYLFTSESVTEGHPDKICDQISDTIIDAILAQDPQSRVAAEVVVNTGLVLITGEITTKAQVNYIELARKKIADIGYV
HAENGFSADSCSVLVALDEQSADIAQGVDKAQETRELLSEEELDAVGAGDQGLMFGFACNETPELMPLPISLAHRVCRQL
TAVRKTGQLPYLRPDGKSQVTITYEDGRPVGIDTILISTQHTAKIGEITELSDIQAKIKEDLWKYVVEPIFKDAEIKPNS
QTRFLVNPTGKFVIGGPQGDCGLTGRKIIIDTYGGYSRHGGGAFSGKDPTKVDRSAAYACRYIAKNIVAADLAEKCEVQI
SYAIGVAKPVSMMIETFGTSKVDEDKLLEVVKENFELRPAGIIQNFNLRNLPGERGGRFYQDVAAYGHLGRTDLDLPWEQ
TDKVELLKQAFSPQLLATAS

Sequences:

>Translated_420_residues
MSSRYLFTSESVTEGHPDKICDQISDTIIDAILAQDPQSRVAAEVVVNTGLVLITGEITTKAQVNYIELARKKIADIGYV
HAENGFSADSCSVLVALDEQSADIAQGVDKAQETRELLSEEELDAVGAGDQGLMFGFACNETPELMPLPISLAHRVCRQL
TAVRKTGQLPYLRPDGKSQVTITYEDGRPVGIDTILISTQHTAKIGEITELSDIQAKIKEDLWKYVVEPIFKDAEIKPNS
QTRFLVNPTGKFVIGGPQGDCGLTGRKIIIDTYGGYSRHGGGAFSGKDPTKVDRSAAYACRYIAKNIVAADLAEKCEVQI
SYAIGVAKPVSMMIETFGTSKVDEDKLLEVVKENFELRPAGIIQNFNLRNLPGERGGRFYQDVAAYGHLGRTDLDLPWEQ
TDKVELLKQAFSPQLLATAS
>Mature_419_residues
SSRYLFTSESVTEGHPDKICDQISDTIIDAILAQDPQSRVAAEVVVNTGLVLITGEITTKAQVNYIELARKKIADIGYVH
AENGFSADSCSVLVALDEQSADIAQGVDKAQETRELLSEEELDAVGAGDQGLMFGFACNETPELMPLPISLAHRVCRQLT
AVRKTGQLPYLRPDGKSQVTITYEDGRPVGIDTILISTQHTAKIGEITELSDIQAKIKEDLWKYVVEPIFKDAEIKPNSQ
TRFLVNPTGKFVIGGPQGDCGLTGRKIIIDTYGGYSRHGGGAFSGKDPTKVDRSAAYACRYIAKNIVAADLAEKCEVQIS
YAIGVAKPVSMMIETFGTSKVDEDKLLEVVKENFELRPAGIIQNFNLRNLPGERGGRFYQDVAAYGHLGRTDLDLPWEQT
DKVELLKQAFSPQLLATAS

Specific function: Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the e

COG id: COG0192

COG function: function code H; S-adenosylmethionine synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AdoMet synthase family

Homologues:

Organism=Homo sapiens, GI5174529, Length=405, Percent_Identity=50.1234567901235, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI4557737, Length=404, Percent_Identity=50.7425742574257, Blast_Score=362, Evalue=1e-100,
Organism=Escherichia coli, GI1789311, Length=408, Percent_Identity=55.8823529411765, Blast_Score=465, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI25145633, Length=410, Percent_Identity=49.2682926829268, Blast_Score=374, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17538498, Length=407, Percent_Identity=49.3857493857494, Blast_Score=374, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17538494, Length=414, Percent_Identity=49.2753623188406, Blast_Score=373, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17551082, Length=423, Percent_Identity=46.3356973995272, Blast_Score=364, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI32565905, Length=414, Percent_Identity=44.6859903381643, Blast_Score=317, Evalue=8e-87,
Organism=Caenorhabditis elegans, GI32565911, Length=360, Percent_Identity=46.9444444444444, Blast_Score=302, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI25145635, Length=362, Percent_Identity=46.9613259668508, Blast_Score=302, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI32565903, Length=340, Percent_Identity=47.0588235294118, Blast_Score=278, Evalue=5e-75,
Organism=Caenorhabditis elegans, GI32565909, Length=83, Percent_Identity=56.6265060240964, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI32565907, Length=39, Percent_Identity=71.7948717948718, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320710, Length=409, Percent_Identity=47.921760391198, Blast_Score=369, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6323209, Length=404, Percent_Identity=47.5247524752475, Blast_Score=364, Evalue=1e-101,
Organism=Drosophila melanogaster, GI45552159, Length=406, Percent_Identity=46.7980295566502, Blast_Score=339, Evalue=2e-93,
Organism=Drosophila melanogaster, GI24580529, Length=406, Percent_Identity=46.7980295566502, Blast_Score=339, Evalue=2e-93,
Organism=Drosophila melanogaster, GI24580537, Length=406, Percent_Identity=46.7980295566502, Blast_Score=339, Evalue=2e-93,
Organism=Drosophila melanogaster, GI24580533, Length=406, Percent_Identity=46.7980295566502, Blast_Score=339, Evalue=2e-93,
Organism=Drosophila melanogaster, GI24580535, Length=406, Percent_Identity=46.7980295566502, Blast_Score=339, Evalue=2e-93,
Organism=Drosophila melanogaster, GI24580531, Length=406, Percent_Identity=46.7980295566502, Blast_Score=339, Evalue=2e-93,
Organism=Drosophila melanogaster, GI24580527, Length=406, Percent_Identity=46.3054187192118, Blast_Score=334, Evalue=6e-92,
Organism=Drosophila melanogaster, GI24580525, Length=406, Percent_Identity=46.3054187192118, Blast_Score=334, Evalue=6e-92,
Organism=Drosophila melanogaster, GI24580541, Length=393, Percent_Identity=45.0381679389313, Blast_Score=311, Evalue=7e-85,
Organism=Drosophila melanogaster, GI24580539, Length=127, Percent_Identity=51.1811023622047, Blast_Score=126, Evalue=2e-29,

Paralogues:

None

Copy number: 7,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): METK_TRIEI (Q10VU5)

Other databases:

- EMBL:   CP000393
- RefSeq:   YP_724102.1
- ProteinModelPortal:   Q10VU5
- SMR:   Q10VU5
- STRING:   Q10VU5
- GeneID:   4246315
- GenomeReviews:   CP000393_GR
- KEGG:   ter:Tery_4661
- NMPDR:   fig|203124.1.peg.4394
- eggNOG:   COG0192
- HOGENOM:   HBG443662
- OMA:   IYYAHRL
- PhylomeDB:   Q10VU5
- ProtClustDB:   PRK05250
- BioCyc:   TERY203124:TERY_4661-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00086
- InterPro:   IPR022631
- InterPro:   IPR022630
- InterPro:   IPR022629
- InterPro:   IPR022628
- InterPro:   IPR002133
- InterPro:   IPR022636
- PANTHER:   PTHR11964
- PIRSF:   PIRSF000497
- TIGRFAMs:   TIGR01034

Pfam domain/function: PF02773 S-AdoMet_synt_C; PF02772 S-AdoMet_synt_M; PF00438 S-AdoMet_synt_N; SSF55973 S-AdoMet_synt

EC number: =2.5.1.6

Molecular weight: Translated: 45818; Mature: 45687

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00376 ADOMET_SYNTHASE_1; PS00377 ADOMET_SYNTHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSRYLFTSESVTEGHPDKICDQISDTIIDAILAQDPQSRVAAEVVVNTGLVLITGEITT
CCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCEEEEEECCCC
KAQVNYIELARKKIADIGYVHAENGFSADSCSVLVALDEQSADIAQGVDKAQETRELLSE
CCCCHHHHHHHHHHHHHCEEECCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHH
EELDAVGAGDQGLMFGFACNETPELMPLPISLAHRVCRQLTAVRKTGQLPYLRPDGKSQV
HHHHHCCCCCCCEEEEEECCCCCCCEECCHHHHHHHHHHHHHHHHCCCCCEECCCCCCEE
TITYEDGRPVGIDTILISTQHTAKIGEITELSDIQAKIKEDLWKYVVEPIFKDAEIKPNS
EEEECCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
QTRFLVNPTGKFVIGGPQGDCGLTGRKIIIDTYGGYSRHGGGAFSGKDPTKVDRSAAYAC
CEEEEECCCCCEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHH
RYIAKNIVAADLAEKCEVQISYAIGVAKPVSMMIETFGTSKVDEDKLLEVVKENFELRPA
HHHHHHHHHHHHHHHCEEEEEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCC
GIIQNFNLRNLPGERGGRFYQDVAAYGHLGRTDLDLPWEQTDKVELLKQAFSPQLLATAS
HHEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEECC
>Mature Secondary Structure 
SSRYLFTSESVTEGHPDKICDQISDTIIDAILAQDPQSRVAAEVVVNTGLVLITGEITT
CCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCEEEEEECCCC
KAQVNYIELARKKIADIGYVHAENGFSADSCSVLVALDEQSADIAQGVDKAQETRELLSE
CCCCHHHHHHHHHHHHHCEEECCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHH
EELDAVGAGDQGLMFGFACNETPELMPLPISLAHRVCRQLTAVRKTGQLPYLRPDGKSQV
HHHHHCCCCCCCEEEEEECCCCCCCEECCHHHHHHHHHHHHHHHHCCCCCEECCCCCCEE
TITYEDGRPVGIDTILISTQHTAKIGEITELSDIQAKIKEDLWKYVVEPIFKDAEIKPNS
EEEECCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
QTRFLVNPTGKFVIGGPQGDCGLTGRKIIIDTYGGYSRHGGGAFSGKDPTKVDRSAAYAC
CEEEEECCCCCEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHH
RYIAKNIVAADLAEKCEVQISYAIGVAKPVSMMIETFGTSKVDEDKLLEVVKENFELRPA
HHHHHHHHHHHHHHHCEEEEEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCC
GIIQNFNLRNLPGERGGRFYQDVAAYGHLGRTDLDLPWEQTDKVELLKQAFSPQLLATAS
HHEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA