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The map label for this gene is purC

Identifier: 113478036

GI number: 113478036

Start: 7159519

End: 7160247

Strand: Reverse

Name: purC

Synonym: Tery_4655

Alternate gene names: 113478036

Gene position: 7160247-7159519 (Counterclockwise)

Preceding gene: 113478041

Following gene: 113478035

Centisome position: 92.39

GC content: 36.08

Gene sequence:

>729_bases
ATGTCATCTCATCAAAAACTTTACGAAGGTAAAGCTAAAATTCTCTATACTACTGACGATCCAGAAATATTGCTAACTTA
TTTTAAAGATGATGCTACAGCATTTAATGCTCAAAAAAAAGGCACAATAACAGGGAAAGGTAAGATTAACTGTACTATTT
CCAGTCATATATTTAAACTATTAGAAACTAATGAGATACCTACTCATTTTATTGATTGTCCCGCATCAGATAAAATGCGA
GTCCGAAGGGTGAAAATTCTACCAATAGAAGTCATTGTGAGAAATATTGCTGCTGGTAGTCTTTGCAGACAAACTCTCTT
AACAGAAGGAACTATCTTGAAATTTCCCTTAGTAGAATATTGTTACAAAAATGATACTCTACAAGACCCACTTCTGACAC
GCGATCGCCTCTTAATACTAGAATTAGCTACCCCAGAACAATTAGAGCAAATACGAACTTTTGCGGTGAAAATTAATGAT
ATTCTGATAAATTTCTTTAACCAGTGCCAAATTACTCTTGTGGACTTCAAAATCGAATTTGGCCTAGATAAGCATGAGAA
TCTAATTCTAGCGGATGAAATAAGTCCAGATAGCTGCCGACTTTGGGACCAATATCAAACCGACCCAAACCAGCGAGTTA
TGGACAAAGACCGATTTCGTCGGGATCTTGGTAAAGTAGAAACTGGGTATCAACAAGTCCTAGAAAGGATTTTAGCTCAT
CAAGGTTGA

Upstream 100 bases:

>100_bases
CTAAAATCTCTGTCAAAATATTGACATTAAATTCATAATATGATAGCTTCATACTAATTTTTTATCACTACTCTATTTTT
ATTCTTTAGTCAAAAATTTT

Downstream 100 bases:

>100_bases
GAGAACCCTCAACAGTGTACAATTCTACATAAAAACTGGGTCTGAAGCATTGCCCTTTTAGGGTAACTTTTTAGTTGATT
CTGTTTGAATAAATATGTCA

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase

Number of amino acids: Translated: 242; Mature: 241

Protein sequence:

>242_residues
MSSHQKLYEGKAKILYTTDDPEILLTYFKDDATAFNAQKKGTITGKGKINCTISSHIFKLLETNEIPTHFIDCPASDKMR
VRRVKILPIEVIVRNIAAGSLCRQTLLTEGTILKFPLVEYCYKNDTLQDPLLTRDRLLILELATPEQLEQIRTFAVKIND
ILINFFNQCQITLVDFKIEFGLDKHENLILADEISPDSCRLWDQYQTDPNQRVMDKDRFRRDLGKVETGYQQVLERILAH
QG

Sequences:

>Translated_242_residues
MSSHQKLYEGKAKILYTTDDPEILLTYFKDDATAFNAQKKGTITGKGKINCTISSHIFKLLETNEIPTHFIDCPASDKMR
VRRVKILPIEVIVRNIAAGSLCRQTLLTEGTILKFPLVEYCYKNDTLQDPLLTRDRLLILELATPEQLEQIRTFAVKIND
ILINFFNQCQITLVDFKIEFGLDKHENLILADEISPDSCRLWDQYQTDPNQRVMDKDRFRRDLGKVETGYQQVLERILAH
QG
>Mature_241_residues
SSHQKLYEGKAKILYTTDDPEILLTYFKDDATAFNAQKKGTITGKGKINCTISSHIFKLLETNEIPTHFIDCPASDKMRV
RRVKILPIEVIVRNIAAGSLCRQTLLTEGTILKFPLVEYCYKNDTLQDPLLTRDRLLILELATPEQLEQIRTFAVKINDI
LINFFNQCQITLVDFKIEFGLDKHENLILADEISPDSCRLWDQYQTDPNQRVMDKDRFRRDLGKVETGYQQVLERILAHQ
G

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Homo sapiens, GI119220557, Length=246, Percent_Identity=33.739837398374, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI5453539, Length=246, Percent_Identity=33.739837398374, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI119220559, Length=253, Percent_Identity=33.201581027668, Blast_Score=98, Evalue=8e-21,
Organism=Escherichia coli, GI1788820, Length=237, Percent_Identity=35.0210970464135, Blast_Score=155, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17531275, Length=239, Percent_Identity=30.1255230125523, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24583917, Length=247, Percent_Identity=28.3400809716599, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI18860083, Length=228, Percent_Identity=27.6315789473684, Blast_Score=89, Evalue=3e-18,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR7_TRIEI (Q10VV0)

Other databases:

- EMBL:   CP000393
- RefSeq:   YP_724097.1
- ProteinModelPortal:   Q10VV0
- STRING:   Q10VV0
- GeneID:   4246309
- GenomeReviews:   CP000393_GR
- KEGG:   ter:Tery_4655
- NMPDR:   fig|203124.1.peg.4389
- eggNOG:   COG0152
- HOGENOM:   HBG306070
- OMA:   YKDDALG
- PhylomeDB:   Q10VV0
- ProtClustDB:   PRK09362
- BioCyc:   TERY203124:TERY_4655-MONOMER
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609
- TIGRFAMs:   TIGR00081

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 27936; Mature: 27804

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSHQKLYEGKAKILYTTDDPEILLTYFKDDATAFNAQKKGTITGKGKINCTISSHIFKL
CCCCHHHHCCCEEEEEECCCCEEEEEEECCCCCEECCCCCCEEECCCEEEEEEHHHHHHH
LETNEIPTHFIDCPASDKMRVRRVKILPIEVIVRNIAAGSLCRQTLLTEGTILKFPLVEY
HHCCCCCCEEEECCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHH
CYKNDTLQDPLLTRDRLLILELATPEQLEQIRTFAVKINDILINFFNQCQITLVDFKIEF
HHCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEEE
GLDKHENLILADEISPDSCRLWDQYQTDPNQRVMDKDRFRRDLGKVETGYQQVLERILAH
CCCCCCCEEEEECCCCCCCEECHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
QG
CC
>Mature Secondary Structure 
SSHQKLYEGKAKILYTTDDPEILLTYFKDDATAFNAQKKGTITGKGKINCTISSHIFKL
CCCHHHHCCCEEEEEECCCCEEEEEEECCCCCEECCCCCCEEECCCEEEEEEHHHHHHH
LETNEIPTHFIDCPASDKMRVRRVKILPIEVIVRNIAAGSLCRQTLLTEGTILKFPLVEY
HHCCCCCCEEEECCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHH
CYKNDTLQDPLLTRDRLLILELATPEQLEQIRTFAVKINDILINFFNQCQITLVDFKIEF
HHCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEEE
GLDKHENLILADEISPDSCRLWDQYQTDPNQRVMDKDRFRRDLGKVETGYQQVLERILAH
CCCCCCCEEEEECCCCCCCEECHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
QG
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA