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The map label for this gene is ilvC

Identifier: 113477739

GI number: 113477739

Start: 6682448

End: 6683443

Strand: Reverse

Name: ilvC

Synonym: Tery_4335

Alternate gene names: 113477739

Gene position: 6683443-6682448 (Counterclockwise)

Preceding gene: 113477740

Following gene: 113477737

Centisome position: 86.24

GC content: 42.87

Gene sequence:

>996_bases
ATGGCCAGAATGTACTATGACTCTGATGCTAACCTGGACATCTTAAATGACAAAACGATCGCTATCATTGGATATGGTTC
TCAAGGTCATGCTCACGCCCTTAATCTCAAAGATAGTGGCTCAAAGGTAATTGTAGGCCTCTATTCAGGTAGTAAATCTG
CTACCAAAGCCAAAGACGCAGGTCTAGATGTTTACCCAGTAGATGAAGCTGCGGAAAAAGCAGACCTAATCATGATTCTA
TTACCAGACGAAGTGCAGAAAACCGTCTATAAAAATCAAATTGAACCCCATCTCAAAGAAGGAAAAATTTTAGCTTTTGC
CCACGGTTTCAATATTCACTTTGGCCAAATTATTCCCCCAGAAAATGTGGATGTAGTAATGGTAGCACCAAAAGGCCCTG
GACATTTAGTCAGGCGTACTTATGAACAAGGAGAAGGAGTCCCCTGTCTATTTGCCATTTTCCAAGATGCTTCTGGTCAA
GGACGCGATCGCGCTATGGCTTATGCTAAAGGTATTGGTGGTACTCGCGCTGGTATCCTAGAAACTACCTTCCGGGAAGA
AACTGAAACAGACCTCTTTGGTGAACAAGTTGTTCTCTGTGGTGGCCTCAGTGCATTAATTAAAGCTGGATTTGAAACCT
TAGTAAAAGCTGGATATCAACCAGAACTAGCATACTTTGAGTGTCTCCATGAAGTTAAACTTATAGTCGATCTAGTTGTC
GAAGGTGGTCTAGCTAATATGCGTGACAGTATCTCCAATACTGCTGAGTTTGGCGACTACACTCGCGGGCCTCGCATCGT
TACAGATGAAACTCGCGCTCAGATGCAGAAAATTTTAAGTGAAATTCAATCTGGTCAGTTTGCCAGGGAATTTGTCATGG
AAAACCAAACCGGTAAACCTGTATTTACTGCCATGCGCCGCCAAGAAGCAGAACACTCTATTGAAGAAGTTGGGAAAGAC
TTACGCGCTATGTTTAGCTGGTTAAAGAAACGCTAA

Upstream 100 bases:

>100_bases
AGTCTTGGCTATATTGTCGATATTTAAATGCTTAAAGTTATATTTGATATGATAAAAATCTCTCATATATGATAACAGTT
GCTAATAGGAGAAAAAAATA

Downstream 100 bases:

>100_bases
AAATTTTCTAGGAAAAGGGAAGAGGTAATTCCAGTCATTAGTTATCAGTACCTCTTACTTCCAACTGGAAACTTGAGATC
TAACTTTCTGGTCAAGATAC

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MARMYYDSDANLDILNDKTIAIIGYGSQGHAHALNLKDSGSKVIVGLYSGSKSATKAKDAGLDVYPVDEAAEKADLIMIL
LPDEVQKTVYKNQIEPHLKEGKILAFAHGFNIHFGQIIPPENVDVVMVAPKGPGHLVRRTYEQGEGVPCLFAIFQDASGQ
GRDRAMAYAKGIGGTRAGILETTFREETETDLFGEQVVLCGGLSALIKAGFETLVKAGYQPELAYFECLHEVKLIVDLVV
EGGLANMRDSISNTAEFGDYTRGPRIVTDETRAQMQKILSEIQSGQFAREFVMENQTGKPVFTAMRRQEAEHSIEEVGKD
LRAMFSWLKKR

Sequences:

>Translated_331_residues
MARMYYDSDANLDILNDKTIAIIGYGSQGHAHALNLKDSGSKVIVGLYSGSKSATKAKDAGLDVYPVDEAAEKADLIMIL
LPDEVQKTVYKNQIEPHLKEGKILAFAHGFNIHFGQIIPPENVDVVMVAPKGPGHLVRRTYEQGEGVPCLFAIFQDASGQ
GRDRAMAYAKGIGGTRAGILETTFREETETDLFGEQVVLCGGLSALIKAGFETLVKAGYQPELAYFECLHEVKLIVDLVV
EGGLANMRDSISNTAEFGDYTRGPRIVTDETRAQMQKILSEIQSGQFAREFVMENQTGKPVFTAMRRQEAEHSIEEVGKD
LRAMFSWLKKR
>Mature_330_residues
ARMYYDSDANLDILNDKTIAIIGYGSQGHAHALNLKDSGSKVIVGLYSGSKSATKAKDAGLDVYPVDEAAEKADLIMILL
PDEVQKTVYKNQIEPHLKEGKILAFAHGFNIHFGQIIPPENVDVVMVAPKGPGHLVRRTYEQGEGVPCLFAIFQDASGQG
RDRAMAYAKGIGGTRAGILETTFREETETDLFGEQVVLCGGLSALIKAGFETLVKAGYQPELAYFECLHEVKLIVDLVVE
GGLANMRDSISNTAEFGDYTRGPRIVTDETRAQMQKILSEIQSGQFAREFVMENQTGKPVFTAMRRQEAEHSIEEVGKDL
RAMFSWLKKR

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=285, Percent_Identity=37.1929824561403, Blast_Score=148, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6323387, Length=325, Percent_Identity=30.7692307692308, Blast_Score=142, Evalue=8e-35,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_TRIEI (Q10WP7)

Other databases:

- EMBL:   CP000393
- RefSeq:   YP_723800.1
- ProteinModelPortal:   Q10WP7
- SMR:   Q10WP7
- STRING:   Q10WP7
- GeneID:   4245987
- GenomeReviews:   CP000393_GR
- KEGG:   ter:Tery_4335
- NMPDR:   fig|203124.1.peg.3099
- eggNOG:   COG0059
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- PhylomeDB:   Q10WP7
- ProtClustDB:   PRK05479
- BioCyc:   TERY203124:TERY_4335-MONOMER
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 36437; Mature: 36306

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: NA

Important sites: ACT_SITE 108-108

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARMYYDSDANLDILNDKTIAIIGYGSQGHAHALNLKDSGSKVIVGLYSGSKSATKAKDA
CCEEEECCCCCEEEECCCEEEEEEECCCCCEEEEEECCCCCEEEEEEECCCCCCCCHHHC
GLDVYPVDEAAEKADLIMILLPDEVQKTVYKNQIEPHLKEGKILAFAHGFNIHFGQIIPP
CCEEEECCHHHCCCCEEEEEECHHHHHHHHHHCCCCCCCCCCEEEEEECCCEEECCCCCC
ENVDVVMVAPKGPGHLVRRTYEQGEGVPCLFAIFQDASGQGRDRAMAYAKGIGGTRAGIL
CCCCEEEECCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCHHH
ETTFREETETDLFGEQVVLCGGLSALIKAGFETLVKAGYQPELAYFECLHEVKLIVDLVV
HHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
EGGLANMRDSISNTAEFGDYTRGPRIVTDETRAQMQKILSEIQSGQFAREFVMENQTGKP
CCCHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCH
VFTAMRRQEAEHSIEEVGKDLRAMFSWLKKR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ARMYYDSDANLDILNDKTIAIIGYGSQGHAHALNLKDSGSKVIVGLYSGSKSATKAKDA
CEEEECCCCCEEEECCCEEEEEEECCCCCEEEEEECCCCCEEEEEEECCCCCCCCHHHC
GLDVYPVDEAAEKADLIMILLPDEVQKTVYKNQIEPHLKEGKILAFAHGFNIHFGQIIPP
CCEEEECCHHHCCCCEEEEEECHHHHHHHHHHCCCCCCCCCCEEEEEECCCEEECCCCCC
ENVDVVMVAPKGPGHLVRRTYEQGEGVPCLFAIFQDASGQGRDRAMAYAKGIGGTRAGIL
CCCCEEEECCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCHHH
ETTFREETETDLFGEQVVLCGGLSALIKAGFETLVKAGYQPELAYFECLHEVKLIVDLVV
HHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
EGGLANMRDSISNTAEFGDYTRGPRIVTDETRAQMQKILSEIQSGQFAREFVMENQTGKP
CCCHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCH
VFTAMRRQEAEHSIEEVGKDLRAMFSWLKKR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA