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The map label for this gene is srrA [H]

Identifier: 113477636

GI number: 113477636

Start: 6514681

End: 6515646

Strand: Reverse

Name: srrA [H]

Synonym: Tery_4223

Alternate gene names: 113477636

Gene position: 6515646-6514681 (Counterclockwise)

Preceding gene: 113477642

Following gene: 113477633

Centisome position: 84.07

GC content: 34.47

Gene sequence:

>966_bases
ATGGCCTTAATTTTAATTACAGATGATACGGCATTTGCCCGTCGGATGGTCAAAAAAGCTATCAAAGAAGATGACCATAA
AATTATAGAAGCTAGTAATGGTCAAGAATGCTTGGAAATGGTTGCCACTAATTCTCCTGATTGTATTCTTCTAGATTTGT
TAATGCCAGAGCTTGATGGTTTTGGGGTACTAAAAGAACTTCAAAAGAAAGGCTCTAAAATTCCTGTTATTGTATTATCA
GCAGATATTCAAGATACTACCCGAACTCAATGTGAAGAGTTAGGAGCATTTATGATCTTACAAAAACCCCCAAAACCTCT
TGAAATTATAAAAGCAATTTCTGAAGCACTCAAAGCAGTGGAAAATAAAGTGGTAAATCTGACAGACAAGCAACTAGATA
TTTTAACTGAGTTAATTAATATCGGTATTGGCCAAGGGGCGAAAATGCTAAACGAAATGATAGAATCTCAAATTAATCTA
CAAGTACCTTTCTTAAAGTTATTAGCAAAGGTTGAAGTACAAGAGGTATTGAGGCAACGTTTAGGTTACGATAAATTATC
TTCGATACAATTAGATTTTAAGGGGTATTTTGCTGGTTCGGCAAAGTTGGTTTTTCCCAGAGAAAGTGCAGCTAATCTAG
TTGCTGTCCTCACTGGAAAAAACCTAGAAAATGCGGATTTGGATATTGTCCAAATTGGGACATTAACTGAAGTAGGGAAT
ATTGTCATTAATGGTGTGATGGGGTCTTTAGGAAATAAGTTATATAAACAAATTTACTATGATGTTCCTTGTTATGCTGA
GGAAGATATTGCACAGCTATTACCAATGGAGGAACCCAATAATTCTGTCCTTTTAGCTCAGGCAAAATTTGATATTGAAG
ATTTACAAATTACAGGGGATATTATTTTGTTCTTTAAAGTAGGTTCTTTTGATGGTTTACTCAGTGTCATTGAAGATTTA
GATTAG

Upstream 100 bases:

>100_bases
CCAACTTAAACTTGATCAGGTGTATAAATCCACTACATTAATTCTGAAGAACACGATGAGGTATAATCCAAGCTTAGTAA
TAAGTGGTGAATCAAAATTT

Downstream 100 bases:

>100_bases
GTGTAGGTTCGGTTTTTGGAACCAGAGTATAATAGTTTGAAAATCTTTTGAGTCTAATTATATGTAAAATACAAGGCTTT
TACTTCCATATTTTTTGATT

Product: response regulator receiver protein

Products: NA

Alternate protein names: Staphylococcal respiratory response protein A [H]

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MALILITDDTAFARRMVKKAIKEDDHKIIEASNGQECLEMVATNSPDCILLDLLMPELDGFGVLKELQKKGSKIPVIVLS
ADIQDTTRTQCEELGAFMILQKPPKPLEIIKAISEALKAVENKVVNLTDKQLDILTELINIGIGQGAKMLNEMIESQINL
QVPFLKLLAKVEVQEVLRQRLGYDKLSSIQLDFKGYFAGSAKLVFPRESAANLVAVLTGKNLENADLDIVQIGTLTEVGN
IVINGVMGSLGNKLYKQIYYDVPCYAEEDIAQLLPMEEPNNSVLLAQAKFDIEDLQITGDIILFFKVGSFDGLLSVIEDL
D

Sequences:

>Translated_321_residues
MALILITDDTAFARRMVKKAIKEDDHKIIEASNGQECLEMVATNSPDCILLDLLMPELDGFGVLKELQKKGSKIPVIVLS
ADIQDTTRTQCEELGAFMILQKPPKPLEIIKAISEALKAVENKVVNLTDKQLDILTELINIGIGQGAKMLNEMIESQINL
QVPFLKLLAKVEVQEVLRQRLGYDKLSSIQLDFKGYFAGSAKLVFPRESAANLVAVLTGKNLENADLDIVQIGTLTEVGN
IVINGVMGSLGNKLYKQIYYDVPCYAEEDIAQLLPMEEPNNSVLLAQAKFDIEDLQITGDIILFFKVGSFDGLLSVIEDL
D
>Mature_320_residues
ALILITDDTAFARRMVKKAIKEDDHKIIEASNGQECLEMVATNSPDCILLDLLMPELDGFGVLKELQKKGSKIPVIVLSA
DIQDTTRTQCEELGAFMILQKPPKPLEIIKAISEALKAVENKVVNLTDKQLDILTELINIGIGQGAKMLNEMIESQINLQ
VPFLKLLAKVEVQEVLRQRLGYDKLSSIQLDFKGYFAGSAKLVFPRESAANLVAVLTGKNLENADLDIVQIGTLTEVGNI
VINGVMGSLGNKLYKQIYYDVPCYAEEDIAQLLPMEEPNNSVLLAQAKFDIEDLQITGDIILFFKVGSFDGLLSVIEDLD

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. SrrA binds to the agr, spa and tst promoters and represses their transcript

COG id: COG0784

COG function: function code T; FOG: CheY-like receiver

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=100, Percent_Identity=36, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1786911, Length=147, Percent_Identity=30.6122448979592, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1790299, Length=143, Percent_Identity=27.2727272727273, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 35410; Mature: 35279

Theoretical pI: Translated: 4.32; Mature: 4.32

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALILITDDTAFARRMVKKAIKEDDHKIIEASNGQECLEMVATNSPDCILLDLLMPELDG
CEEEEEECCHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHCCCCCEEEEEEHHCCCCC
FGVLKELQKKGSKIPVIVLSADIQDTTRTQCEELGAFMILQKPPKPLEIIKAISEALKAV
CHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHH
ENKVVNLTDKQLDILTELINIGIGQGAKMLNEMIESQINLQVPFLKLLAKVEVQEVLRQR
HHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
LGYDKLSSIQLDFKGYFAGSAKLVFPRESAANLVAVLTGKNLENADLDIVQIGTLTEVGN
CCCCCCCCEEEEEEEEECCCEEEEECCCCCCCEEEEEECCCCCCCCCCEEEECCHHHHHH
IVINGVMGSLGNKLYKQIYYDVPCYAEEDIAQLLPMEEPNNSVLLAQAKFDIEDLQITGD
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCEEEEEECCCHHHEEEECC
IILFFKVGSFDGLLSVIEDLD
EEEEEEECCHHHHHHHHHHCC
>Mature Secondary Structure 
ALILITDDTAFARRMVKKAIKEDDHKIIEASNGQECLEMVATNSPDCILLDLLMPELDG
EEEEEECCHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHCCCCCEEEEEEHHCCCCC
FGVLKELQKKGSKIPVIVLSADIQDTTRTQCEELGAFMILQKPPKPLEIIKAISEALKAV
CHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHH
ENKVVNLTDKQLDILTELINIGIGQGAKMLNEMIESQINLQVPFLKLLAKVEVQEVLRQR
HHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
LGYDKLSSIQLDFKGYFAGSAKLVFPRESAANLVAVLTGKNLENADLDIVQIGTLTEVGN
CCCCCCCCEEEEEEEEECCCEEEEECCCCCCCEEEEEECCCCCCCCCCEEEECCHHHHHH
IVINGVMGSLGNKLYKQIYYDVPCYAEEDIAQLLPMEEPNNSVLLAQAKFDIEDLQITGD
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCEEEEEECCCHHHEEEECC
IILFFKVGSFDGLLSVIEDLD
EEEEEEECCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA