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The map label for this gene is birA [H]

Identifier: 113476866

GI number: 113476866

Start: 5142563

End: 5143429

Strand: Reverse

Name: birA [H]

Synonym: Tery_3352

Alternate gene names: 113476866

Gene position: 5143429-5142563 (Counterclockwise)

Preceding gene: 113476869

Following gene: 113476865

Centisome position: 66.37

GC content: 38.41

Gene sequence:

>867_bases
TTGTTAGAATTTAATCAACAAAAATTTATCAACTCCCTATCAAATATTCAGGGAACGAAATTATCCCACAGCTCGAGTCC
TTTAACCCCCAATCATTTGCACATTTTTTCTAGCCTTCCCTCAACAAATCAAACCCTCTGGCAACTAATTGACTCAGGAG
CATCATCAGGAACTATGGTCATAGCTGCCCAACAAACAGCAGGGCGAGGACAATGGGGTAGAAACTGGATATCAAGTATT
GGCGGACTATATATGTCAGTAGCTTTCTGTAAGGGTTGCGGATGGACGAGTATGCCCAAAATATTGATATCTCATATCCC
ACAACTAACCTTATGTACAGCTTGGGGTATAGCCTCAAGTTTGCAGAATTATGGTGTACCAGTTAAAATTAAGTGGCCTA
ACGACTTAATTCTAGAAAATCGAAAATTAGGTGGTATCCTTACAGAAACGAGGGTCAAGAAAGAAAAAGTTCCTTGGGCA
GTAATTGGTATTGGGATTAACTGGGCAAATTCTGAGATAGGAGATACAGGGATTAACCTGCAAAGTTATTATAGAAACGA
GTCTCAACCAGGAATATCTTCTCTAGAAATGTTAGCGGCAATAGTTTTTCATGCATTAGAGTCTGCCATTAGACAACTTT
TAGACTCAGGAATAGAAAATATTTTACCTGCCTATAATCAACTATTAATAAATATGGGGAAGCAGGTATTGGTGGAAGAT
CGTCTTGGGGAGGTTGTAGGAGTGACAAAGAGTGGGGAGTTAAAAGTAAAAATTAATTCTGGTTCAGCTACTGCAAAAAC
TCAGTCTCAAATATTACCTTCAGAAATATATCTAAAACCAGGTACAATCAGTCTGGGTTATGGTTAA

Upstream 100 bases:

>100_bases
GTGCTTATAAAAATGAATTAGCTATGAGAAGAAAAGTTTAGTTTAGCCAAATCAATCAAAACCATAATACATAAATATAG
AATTATCTAAAGAAAAAAAA

Downstream 100 bases:

>100_bases
TGGGTGAATAGACTTAAAGTGCAAAGAGGAGAAAGTGGTAAGGGAGAAAAAAATAATTGTCATTGCTTAAATTTTGTGCT
GGCTTGATAGAGAGCTAAAT

Product: biotin--acetyl-CoA-carboxylase ligase

Products: NA

Alternate protein names: Biotin operon repressor; Biotin--[acetyl-CoA-carboxylase] synthetase; Biotin--protein ligase [H]

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MLEFNQQKFINSLSNIQGTKLSHSSSPLTPNHLHIFSSLPSTNQTLWQLIDSGASSGTMVIAAQQTAGRGQWGRNWISSI
GGLYMSVAFCKGCGWTSMPKILISHIPQLTLCTAWGIASSLQNYGVPVKIKWPNDLILENRKLGGILTETRVKKEKVPWA
VIGIGINWANSEIGDTGINLQSYYRNESQPGISSLEMLAAIVFHALESAIRQLLDSGIENILPAYNQLLINMGKQVLVED
RLGEVVGVTKSGELKVKINSGSATAKTQSQILPSEIYLKPGTISLGYG

Sequences:

>Translated_288_residues
MLEFNQQKFINSLSNIQGTKLSHSSSPLTPNHLHIFSSLPSTNQTLWQLIDSGASSGTMVIAAQQTAGRGQWGRNWISSI
GGLYMSVAFCKGCGWTSMPKILISHIPQLTLCTAWGIASSLQNYGVPVKIKWPNDLILENRKLGGILTETRVKKEKVPWA
VIGIGINWANSEIGDTGINLQSYYRNESQPGISSLEMLAAIVFHALESAIRQLLDSGIENILPAYNQLLINMGKQVLVED
RLGEVVGVTKSGELKVKINSGSATAKTQSQILPSEIYLKPGTISLGYG
>Mature_288_residues
MLEFNQQKFINSLSNIQGTKLSHSSSPLTPNHLHIFSSLPSTNQTLWQLIDSGASSGTMVIAAQQTAGRGQWGRNWISSI
GGLYMSVAFCKGCGWTSMPKILISHIPQLTLCTAWGIASSLQNYGVPVKIKWPNDLILENRKLGGILTETRVKKEKVPWA
VIGIGINWANSEIGDTGINLQSYYRNESQPGISSLEMLAAIVFHALESAIRQLLDSGIENILPAYNQLLINMGKQVLVED
RLGEVVGVTKSGELKVKINSGSATAKTQSQILPSEIYLKPGTISLGYG

Specific function: BirA acts both as a biotin-operon repressor and as the enzyme that synthesizes the corepressor, acetyl-CoA:carbon-dioxide ligase. This protein also activates biotin to form biotinyl-5'- adenylate and transfers the biotin moiety to biotin-accepting protein

COG id: COG0340

COG function: function code H; Biotin-(acetyl-CoA carboxylase) ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biotin--protein ligase family [H]

Homologues:

Organism=Homo sapiens, GI46255045, Length=243, Percent_Identity=25.9259259259259, Blast_Score=73, Evalue=2e-13,
Organism=Escherichia coli, GI1790408, Length=228, Percent_Identity=31.140350877193, Blast_Score=79, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24644246, Length=220, Percent_Identity=28.1818181818182, Blast_Score=71, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: =6.3.4.15 [H]

Molecular weight: Translated: 31279; Mature: 31279

Theoretical pI: Translated: 9.33; Mature: 9.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEFNQQKFINSLSNIQGTKLSHSSSPLTPNHLHIFSSLPSTNQTLWQLIDSGASSGTMV
CCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCEEE
IAAQQTAGRGQWGRNWISSIGGLYMSVAFCKGCGWTSMPKILISHIPQLTLCTAWGIASS
EEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHH
LQNYGVPVKIKWPNDLILENRKLGGILTETRVKKEKVPWAVIGIGINWANSEIGDTGINL
HHHCCCEEEEECCCCCEECCCCCCCCHHHHHHHHHCCCEEEEEEEEEECCCCCCCCCCCH
QSYYRNESQPGISSLEMLAAIVFHALESAIRQLLDSGIENILPAYNQLLINMGKQVLVED
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
RLGEVVGVTKSGELKVKINSGSATAKTQSQILPSEIYLKPGTISLGYG
HHHHEEECCCCCEEEEEECCCCCCHHHHHHCCCHHEEECCCEEECCCC
>Mature Secondary Structure
MLEFNQQKFINSLSNIQGTKLSHSSSPLTPNHLHIFSSLPSTNQTLWQLIDSGASSGTMV
CCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCEEE
IAAQQTAGRGQWGRNWISSIGGLYMSVAFCKGCGWTSMPKILISHIPQLTLCTAWGIASS
EEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHH
LQNYGVPVKIKWPNDLILENRKLGGILTETRVKKEKVPWAVIGIGINWANSEIGDTGINL
HHHCCCEEEEECCCCCEECCCCCCCCHHHHHHHHHCCCEEEEEEEEEECCCCCCCCCCCH
QSYYRNESQPGISSLEMLAAIVFHALESAIRQLLDSGIENILPAYNQLLINMGKQVLVED
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
RLGEVVGVTKSGELKVKINSGSATAKTQSQILPSEIYLKPGTISLGYG
HHHHEEECCCCCEEEEEECCCCCCHHHHHHCCCHHEEECCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7730294 [H]