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The map label for this gene is hemY [H]

Identifier: 113475859

GI number: 113475859

Start: 3457034

End: 3458482

Strand: Direct

Name: hemY [H]

Synonym: Tery_2218

Alternate gene names: 113475859

Gene position: 3457034-3458482 (Clockwise)

Preceding gene: 113475858

Following gene: 113475863

Centisome position: 44.61

GC content: 40.99

Gene sequence:

>1449_bases
ATGACTGAAATATTAGATGTCTTAGTCGTGGGTGCAGGTATCAGTGGCTTGAGTTTAGCCCATAAACTGACAAAATTAAG
TAATAATTCACCCTTGAAAATTTTAGTTGCTGAGAGCCAAAACCGAGTCGGGGGTAATATCACGACAGTTTCTCAAGGAG
AATTTCTTTGGGAAGAAGGTCCTAATAGTTTTTCTCCCACCCCTGAGCTTTTAAAGTTGGCTGTAGATGTTGGCCTCAAA
GAGGATTTGATTTTTGCAGACCGTAAGTTACCTCGTTATGTTTATTGGAATGGTCAATTACTACCAGTACCAATGAGCCC
AAAGGCAATGTTACAGTCTCAACTACTGAGTAATACTGGAAAGTTACGCGCTTTAGTTGGTGCTTTGGGTTTTGTTCCAC
CTGTTGTTGGTATGGATCTATCTCAGGAAGGGGGAGAAGAAACTGTATCCCAATTTTTCCAAAGACATCTTGGTAAAGAG
GTAATGGAACGATTAGTTGAACCTTTTGTTTCTGGTGTTTACGCTGGAGACCCTAGTCAACTTAGTGCTACTGCTGCTTT
TTCTAAAGTGGCTCGAATGGCTGACCTTGGTGGTGGACTTTTGGCTGGTGCTGTTTTGTCTGCTCAAAGAAACCCTAAGT
CAAAGGCTGCTGCTAATTCTAATATTCCTAAAACTAAACCTGGAGAGTTGGGTTCTTTCCGACGTGGTTTGGAGGTATTG
CCAAAAGCGATCGCTACTTATTTAGGACAAGCAGTCAAGCTCAATTGGTCTCTCGTGGGTCTTCGTCCGACAGAAAAACA
GACTTATATAGCAGAATTTTCGACTCCCAATGGTTCTCAGCAAATAGAAACTCGTACCATTGCCCTCTCCAGCCCTGCTT
ATGCCTGTGCTAAATTATTTAGACCTTTACTTCCTGAAATTGCTGGTACTCTTGATGAATTCTATTATCCTACTGTTGCC
TGTGTAGTTTTGGCATATCCTGTTTCTTCTATCAAGGCCAAGATAGATGGCTTTGGTAATTTGATTCCTAGAGGTCAAGG
CATTCGGACTCTTGGTACTATTTGGTCTTCTGCTTTATTTTCTGGTAGAACACCTCTTGGATGGCAAATTTTTACTAATT
ATATTGGTGGTGCAACAGACCCAGAAATTTCTCACTTAGATAGTGAAGCCATCGTTGCACAAGTTCATCAAGACCTTTGT
CAAACTCTATTAAACCAGAATCCTGAAAAACCAAAAGTTCTGGCAGTACATATATGGTCTCGTGCTATTCCTCAGTATAA
TTTAGGTTATAGTTCTAGGCTGGCTCAGATTAATCATGGCTTAAAATCTTGGCCTGGAGTATATCTATGTAGTAATTATA
TTGGTGGTGTGGCTCTGGGAGATTGTGTTCGTCGTAGTATAGAAGTAGCGACTGATATTTATTCGGGTATGGGGTTTGGG
GAGCTTTAA

Upstream 100 bases:

>100_bases
ACGGACTAAATTTGAAGGTTTGGGAATCTCAATCCCGCCCTGGGGACTATTATATAAACAACATCGTGAAAAATAGTATG
CTAAATATATTTAAGAACAA

Downstream 100 bases:

>100_bases
CACCCCCCTTGTTTAAGGCTGGGGATAAATCGACTCCCGAAGAGATAAAATAGACAGCTCAATTTTGTTTATTTTGTCAT
CTTTACAAAGGAGATTTGTA

Product: protoporphyrinogen oxidase

Products: NA

Alternate protein names: PPO [H]

Number of amino acids: Translated: 482; Mature: 481

Protein sequence:

>482_residues
MTEILDVLVVGAGISGLSLAHKLTKLSNNSPLKILVAESQNRVGGNITTVSQGEFLWEEGPNSFSPTPELLKLAVDVGLK
EDLIFADRKLPRYVYWNGQLLPVPMSPKAMLQSQLLSNTGKLRALVGALGFVPPVVGMDLSQEGGEETVSQFFQRHLGKE
VMERLVEPFVSGVYAGDPSQLSATAAFSKVARMADLGGGLLAGAVLSAQRNPKSKAAANSNIPKTKPGELGSFRRGLEVL
PKAIATYLGQAVKLNWSLVGLRPTEKQTYIAEFSTPNGSQQIETRTIALSSPAYACAKLFRPLLPEIAGTLDEFYYPTVA
CVVLAYPVSSIKAKIDGFGNLIPRGQGIRTLGTIWSSALFSGRTPLGWQIFTNYIGGATDPEISHLDSEAIVAQVHQDLC
QTLLNQNPEKPKVLAVHIWSRAIPQYNLGYSSRLAQINHGLKSWPGVYLCSNYIGGVALGDCVRRSIEVATDIYSGMGFG
EL

Sequences:

>Translated_482_residues
MTEILDVLVVGAGISGLSLAHKLTKLSNNSPLKILVAESQNRVGGNITTVSQGEFLWEEGPNSFSPTPELLKLAVDVGLK
EDLIFADRKLPRYVYWNGQLLPVPMSPKAMLQSQLLSNTGKLRALVGALGFVPPVVGMDLSQEGGEETVSQFFQRHLGKE
VMERLVEPFVSGVYAGDPSQLSATAAFSKVARMADLGGGLLAGAVLSAQRNPKSKAAANSNIPKTKPGELGSFRRGLEVL
PKAIATYLGQAVKLNWSLVGLRPTEKQTYIAEFSTPNGSQQIETRTIALSSPAYACAKLFRPLLPEIAGTLDEFYYPTVA
CVVLAYPVSSIKAKIDGFGNLIPRGQGIRTLGTIWSSALFSGRTPLGWQIFTNYIGGATDPEISHLDSEAIVAQVHQDLC
QTLLNQNPEKPKVLAVHIWSRAIPQYNLGYSSRLAQINHGLKSWPGVYLCSNYIGGVALGDCVRRSIEVATDIYSGMGFG
EL
>Mature_481_residues
TEILDVLVVGAGISGLSLAHKLTKLSNNSPLKILVAESQNRVGGNITTVSQGEFLWEEGPNSFSPTPELLKLAVDVGLKE
DLIFADRKLPRYVYWNGQLLPVPMSPKAMLQSQLLSNTGKLRALVGALGFVPPVVGMDLSQEGGEETVSQFFQRHLGKEV
MERLVEPFVSGVYAGDPSQLSATAAFSKVARMADLGGGLLAGAVLSAQRNPKSKAAANSNIPKTKPGELGSFRRGLEVLP
KAIATYLGQAVKLNWSLVGLRPTEKQTYIAEFSTPNGSQQIETRTIALSSPAYACAKLFRPLLPEIAGTLDEFYYPTVAC
VVLAYPVSSIKAKIDGFGNLIPRGQGIRTLGTIWSSALFSGRTPLGWQIFTNYIGGATDPEISHLDSEAIVAQVHQDLCQ
TLLNQNPEKPKVLAVHIWSRAIPQYNLGYSSRLAQINHGLKSWPGVYLCSNYIGGVALGDCVRRSIEVATDIYSGMGFGE
L

Specific function: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. May have an essential extracellular function during development, possibly as a pheromone [H]

COG id: COG1232

COG function: function code H; Protoporphyrinogen oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protoporphyrinogen oxidase family [H]

Homologues:

Organism=Homo sapiens, GI170650615, Length=491, Percent_Identity=26.6802443991853, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI4506001, Length=491, Percent_Identity=26.6802443991853, Blast_Score=104, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24649745, Length=487, Percent_Identity=25.4620123203285, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002937
- InterPro:   IPR016040
- InterPro:   IPR004572 [H]

Pfam domain/function: PF01593 Amino_oxidase [H]

EC number: =1.3.3.4 [H]

Molecular weight: Translated: 51885; Mature: 51754

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEILDVLVVGAGISGLSLAHKLTKLSNNSPLKILVAESQNRVGGNITTVSQGEFLWEEG
CHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEECCCCCHHCCC
PNSFSPTPELLKLAVDVGLKEDLIFADRKLPRYVYWNGQLLPVPMSPKAMLQSQLLSNTG
CCCCCCCHHHHHHHHHCCCCHHHHHHCCCCCEEEEECCEEEECCCCHHHHHHHHHHHCCH
KLRALVGALGFVPPVVGMDLSQEGGEETVSQFFQRHLGKEVMERLVEPFVSGVYAGDPSQ
HHHHHHHHHHHHCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
LSATAAFSKVARMADLGGGLLAGAVLSAQRNPKSKAAANSNIPKTKPGELGSFRRGLEVL
HHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHH
PKAIATYLGQAVKLNWSLVGLRPTEKQTYIAEFSTPNGSQQIETRTIALSSPAYACAKLF
HHHHHHHCCCEEEEEEEEEECCCCCCCEEEEEECCCCCCCEEEEEEEEECCHHHHHHHHH
RPLLPEIAGTLDEFYYPTVACVVLAYPVSSIKAKIDGFGNLIPRGQGIRTLGTIWSSALF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
SGRTPLGWQIFTNYIGGATDPEISHLDSEAIVAQVHQDLCQTLLNQNPEKPKVLAVHIWS
CCCCCCCHHHHHHHCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHH
RAIPQYNLGYSSRLAQINHGLKSWPGVYLCSNYIGGVALGDCVRRSIEVATDIYSGMGFG
HCCCCCCCCHHHHHHHHHCCHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
EL
CC
>Mature Secondary Structure 
TEILDVLVVGAGISGLSLAHKLTKLSNNSPLKILVAESQNRVGGNITTVSQGEFLWEEG
HHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEECCCCCHHCCC
PNSFSPTPELLKLAVDVGLKEDLIFADRKLPRYVYWNGQLLPVPMSPKAMLQSQLLSNTG
CCCCCCCHHHHHHHHHCCCCHHHHHHCCCCCEEEEECCEEEECCCCHHHHHHHHHHHCCH
KLRALVGALGFVPPVVGMDLSQEGGEETVSQFFQRHLGKEVMERLVEPFVSGVYAGDPSQ
HHHHHHHHHHHHCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
LSATAAFSKVARMADLGGGLLAGAVLSAQRNPKSKAAANSNIPKTKPGELGSFRRGLEVL
HHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHH
PKAIATYLGQAVKLNWSLVGLRPTEKQTYIAEFSTPNGSQQIETRTIALSSPAYACAKLF
HHHHHHHCCCEEEEEEEEEECCCCCCCEEEEEECCCCCCCEEEEEEEEECCHHHHHHHHH
RPLLPEIAGTLDEFYYPTVACVVLAYPVSSIKAKIDGFGNLIPRGQGIRTLGTIWSSALF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
SGRTPLGWQIFTNYIGGATDPEISHLDSEAIVAQVHQDLCQTLLNQNPEKPKVLAVHIWS
CCCCCCCHHHHHHHCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHH
RAIPQYNLGYSSRLAQINHGLKSWPGVYLCSNYIGGVALGDCVRRSIEVATDIYSGMGFG
HCCCCCCCCHHHHHHHHHCCHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
EL
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1372277; 8621504 [H]