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The map label for this gene is dut

Identifier: 113475736

GI number: 113475736

Start: 3251479

End: 3251907

Strand: Direct

Name: dut

Synonym: Tery_2083

Alternate gene names: 113475736

Gene position: 3251479-3251907 (Clockwise)

Preceding gene: 113475735

Following gene: 113475737

Centisome position: 41.95

GC content: 32.63

Gene sequence:

>429_bases
ATGAAACTGAAAATCAAAAAGTTAGATGAATTAGCAATTATTCCTTTTTATGCTCATAAAGGAGATGCTGGATTAGATTT
ATTTTCTATTGATGAGTCAACAATTAATCCAGGGGAAAGTAAACTGATTCATACAGGTATTTCCATAGAATTACCATCAG
GAACAGAAGCACAAATTCGCCCGCGAAGTGGATTAGCATTAAAACATCAAATTACTGTTTTAAATACCCCCGGAACTATC
GACGAAACTTACCGAGGAGAAATAGGAATAATTCTGATAAATCATGGCAAAAATTCTTTTCAAGTAACAAAAAGAATGAA
AATAGCCCAAATGGTAATAACGTCAGTTTTATCTGTTAAGGTAGAAGAAGTCAATCAATTAAGTACAACTCAAAGAGACA
TTAATGGATTTGGTTCAACAGGAACATGA

Upstream 100 bases:

>100_bases
AACTGATAAATGATAACTAAAATCACACATTTTTCAACGATAATCTAAAATCAACGAAACTCCCTATTCTCAATAAACTC
CCTATTCCTTATTACCTATT

Downstream 100 bases:

>100_bases
GAGAACAAATATATCAAAGACCAAGCTGGGATGAATACTTTTTAATGATTGCCAAATTAGCTGCTACTCGCTCAACTTGT
TTAGCTTTTCCAGTAGGAGC

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase

Number of amino acids: Translated: 142; Mature: 142

Protein sequence:

>142_residues
MKLKIKKLDELAIIPFYAHKGDAGLDLFSIDESTINPGESKLIHTGISIELPSGTEAQIRPRSGLALKHQITVLNTPGTI
DETYRGEIGIILINHGKNSFQVTKRMKIAQMVITSVLSVKVEEVNQLSTTQRDINGFGSTGT

Sequences:

>Translated_142_residues
MKLKIKKLDELAIIPFYAHKGDAGLDLFSIDESTINPGESKLIHTGISIELPSGTEAQIRPRSGLALKHQITVLNTPGTI
DETYRGEIGIILINHGKNSFQVTKRMKIAQMVITSVLSVKVEEVNQLSTTQRDINGFGSTGT
>Mature_142_residues
MKLKIKKLDELAIIPFYAHKGDAGLDLFSIDESTINPGESKLIHTGISIELPSGTEAQIRPRSGLALKHQITVLNTPGTI
DETYRGEIGIILINHGKNSFQVTKRMKIAQMVITSVLSVKVEEVNQLSTTQRDINGFGSTGT

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family

Homologues:

Organism=Homo sapiens, GI70906444, Length=141, Percent_Identity=43.9716312056738, Blast_Score=119, Evalue=6e-28,
Organism=Homo sapiens, GI4503423, Length=141, Percent_Identity=43.9716312056738, Blast_Score=119, Evalue=7e-28,
Organism=Homo sapiens, GI70906441, Length=141, Percent_Identity=43.9716312056738, Blast_Score=119, Evalue=7e-28,
Organism=Escherichia coli, GI1790071, Length=148, Percent_Identity=36.4864864864865, Blast_Score=86, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI71988561, Length=140, Percent_Identity=41.4285714285714, Blast_Score=103, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6319729, Length=140, Percent_Identity=32.8571428571429, Blast_Score=82, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24583610, Length=139, Percent_Identity=34.5323741007194, Blast_Score=90, Evalue=4e-19,
Organism=Drosophila melanogaster, GI19921126, Length=139, Percent_Identity=34.5323741007194, Blast_Score=90, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DUT_TRIEI (Q113K0)

Other databases:

- EMBL:   CP000393
- RefSeq:   YP_721797.1
- ProteinModelPortal:   Q113K0
- SMR:   Q113K0
- STRING:   Q113K0
- GeneID:   4245731
- GenomeReviews:   CP000393_GR
- KEGG:   ter:Tery_2083
- NMPDR:   fig|203124.1.peg.2187
- eggNOG:   COG0756
- HOGENOM:   HBG436079
- OMA:   GTIDEGY
- PhylomeDB:   Q113K0
- BioCyc:   TERY203124:TERY_2083-MONOMER
- HAMAP:   MF_00116
- InterPro:   IPR008180
- InterPro:   IPR008181
- TIGRFAMs:   TIGR00576

Pfam domain/function: PF00692 dUTPase

EC number: =3.6.1.23

Molecular weight: Translated: 15500; Mature: 15500

Theoretical pI: Translated: 8.98; Mature: 8.98

Prosite motif: NA

Important sites: BINDING 75-75

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLKIKKLDELAIIPFYAHKGDAGLDLFSIDESTINPGESKLIHTGISIELPSGTEAQIR
CCEECCCCCCEEEEEEEECCCCCCCEEEECCCCCCCCCCCEEEEECEEEECCCCCCCEEE
PRSGLALKHQITVLNTPGTIDETYRGEIGIILINHGKNSFQVTKRMKIAQMVITSVLSVK
CCCCCEEEEEEEEEECCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
VEEVNQLSTTQRDINGFGSTGT
HHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKLKIKKLDELAIIPFYAHKGDAGLDLFSIDESTINPGESKLIHTGISIELPSGTEAQIR
CCEECCCCCCEEEEEEEECCCCCCCEEEECCCCCCCCCCCEEEEECEEEECCCCCCCEEE
PRSGLALKHQITVLNTPGTIDETYRGEIGIILINHGKNSFQVTKRMKIAQMVITSVLSVK
CCCCCEEEEEEEEEECCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
VEEVNQLSTTQRDINGFGSTGT
HHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA