Click here to switch to the map view.

The map label for this gene is ctaB

Identifier: 113475452

GI number: 113475452

Start: 2718049

End: 2719035

Strand: Direct

Name: ctaB

Synonym: Tery_1781

Alternate gene names: 113475452

Gene position: 2718049-2719035 (Clockwise)

Preceding gene: 113475451

Following gene: 113475453

Centisome position: 35.07

GC content: 39.41

Gene sequence:

>987_bases
ATGCAACAAGTTATTTCTCATAGTCTACCACGGCGCCATAACAATATCCTACAGGTATTTAAAAGCTATTATCAACTTAC
AAAACCCCGCATTATTTTGCTGCTATTAATTACAACTGCAGCGGGAATGTGGTTGGGAGCAAAAGGAGAAGTATCTCTCT
TTCTTTTGTTCGTTACATTAACAGGTGGTGCATTAGCTTCTGGTGCAGCTAATGCTATTAACTGTATCTACGACAGCGAT
ATTGACTATATTATGGAGCGTACTCGCTGGCGTCCTATTCCATCTGGGAGAGTTAAACCTCGTGATGCTCTGATTTTTGC
GTTGACTCTGGCAGCAACATCATTTACTTTACTCACAGTTTTTGCTAATTTACTAGCTGCACTGTTGGCCATGTCGGGAA
TAGTTTTTTATGTTGGTGTTTACACTCACTGGTTAAAACGTCACAGTGTTCAAAATATTGTAATTGGTGGTGCTGCTGGT
GCTATTCCTCCGTTAGTGGGTTGGGCCGCAGTCACAGGGGAATTGAGTTGGGCTGCTTGGTTATTATTTGCAATTATTGT
GGTCTGGACTCCTCCTCATTTTTGGGCATTAGCAATTTATATTCGTGATGAATATCAGGAAGTTGGGGTGCCTATGTTAC
CTGTAATTGAGGGAAATGAGGAAACAGCTAGACAGATTTGGGTTTATACTCTAATTTTAATTCCTATGACGCTATTGCTG
GTTTATCCGTTGCATGTGAGTGGAGCCATTTATGCAGTATTAGCGACTTACCTTGGTGTAATTTTTATTAAGAAAGCTTG
GCAGTTGTTGAAAGATCCTTCGAATAAAGATGTAGCACGATCGCTGTTTAAGTATTCTATCTACTATATGATGTTATTGT
GTTTGGTAATGGTCATTGATAGTTTGCCTTTTACTCATGGAATTACTACTGCTTTAGCAGATAGTTGGCAAACTTTTATT
GGTGGAGCGATCGCAATTTTATTTTAG

Upstream 100 bases:

>100_bases
CCAAAATGGACTGGCACTAAGATCCGTTTCTATATAGCTTATAAACTTTAGATGATGGAAATTATAACCAGTTTCAATAG
AAAATTAACAAATAAAATCC

Downstream 100 bases:

>100_bases
GAGCTATATCAAAATAAGTTGTATAAATTTCATTTGAGATGAATTGTGAAATTTAGCTTCTATCAAAAAACTGTTTGAGT
TATTTTTACCAAAAAATTGG

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MQQVISHSLPRRHNNILQVFKSYYQLTKPRIILLLLITTAAGMWLGAKGEVSLFLLFVTLTGGALASGAANAINCIYDSD
IDYIMERTRWRPIPSGRVKPRDALIFALTLAATSFTLLTVFANLLAALLAMSGIVFYVGVYTHWLKRHSVQNIVIGGAAG
AIPPLVGWAAVTGELSWAAWLLFAIIVVWTPPHFWALAIYIRDEYQEVGVPMLPVIEGNEETARQIWVYTLILIPMTLLL
VYPLHVSGAIYAVLATYLGVIFIKKAWQLLKDPSNKDVARSLFKYSIYYMMLLCLVMVIDSLPFTHGITTALADSWQTFI
GGAIAILF

Sequences:

>Translated_328_residues
MQQVISHSLPRRHNNILQVFKSYYQLTKPRIILLLLITTAAGMWLGAKGEVSLFLLFVTLTGGALASGAANAINCIYDSD
IDYIMERTRWRPIPSGRVKPRDALIFALTLAATSFTLLTVFANLLAALLAMSGIVFYVGVYTHWLKRHSVQNIVIGGAAG
AIPPLVGWAAVTGELSWAAWLLFAIIVVWTPPHFWALAIYIRDEYQEVGVPMLPVIEGNEETARQIWVYTLILIPMTLLL
VYPLHVSGAIYAVLATYLGVIFIKKAWQLLKDPSNKDVARSLFKYSIYYMMLLCLVMVIDSLPFTHGITTALADSWQTFI
GGAIAILF
>Mature_328_residues
MQQVISHSLPRRHNNILQVFKSYYQLTKPRIILLLLITTAAGMWLGAKGEVSLFLLFVTLTGGALASGAANAINCIYDSD
IDYIMERTRWRPIPSGRVKPRDALIFALTLAATSFTLLTVFANLLAALLAMSGIVFYVGVYTHWLKRHSVQNIVIGGAAG
AIPPLVGWAAVTGELSWAAWLLFAIIVVWTPPHFWALAIYIRDEYQEVGVPMLPVIEGNEETARQIWVYTLILIPMTLLL
VYPLHVSGAIYAVLATYLGVIFIKKAWQLLKDPSNKDVARSLFKYSIYYMMLLCLVMVIDSLPFTHGITTALADSWQTFI
GGAIAILF

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=191, Percent_Identity=38.7434554973822, Blast_Score=117, Evalue=2e-26,
Organism=Escherichia coli, GI1786631, Length=300, Percent_Identity=37, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI1790473, Length=209, Percent_Identity=26.3157894736842, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71998235, Length=266, Percent_Identity=31.9548872180451, Blast_Score=100, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6325085, Length=229, Percent_Identity=32.7510917030568, Blast_Score=110, Evalue=4e-25,
Organism=Drosophila melanogaster, GI19921064, Length=284, Percent_Identity=29.2253521126761, Blast_Score=109, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX_TRIEI (Q114N4)

Other databases:

- EMBL:   CP000393
- RefSeq:   YP_721513.1
- STRING:   Q114N4
- GeneID:   4242246
- GenomeReviews:   CP000393_GR
- KEGG:   ter:Tery_1781
- NMPDR:   fig|203124.1.peg.444
- eggNOG:   COG0109
- HOGENOM:   HBG656003
- OMA:   SYYQLTK
- PhylomeDB:   Q114N4
- ProtClustDB:   PRK04375
- BioCyc:   TERY203124:TERY_1781-MONOMER
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 36434; Mature: 36434

Theoretical pI: Translated: 9.31; Mature: 9.31

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x17196254)-; HASH(0x173f8d38)-; HASH(0x17767d74)-; HASH(0x1791c9c4)-; HASH(0x166aa41c)-; HASH(0x170d4dec)-; HASH(0x1768b3c4)-; HASH(0x17b68ef4)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQVISHSLPRRHNNILQVFKSYYQLTKPRIILLLLITTAAGMWLGAKGEVSLFLLFVTL
CCCHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEECCCCCHHHHHHHHHH
TGGALASGAANAINCIYDSDIDYIMERTRWRPIPSGRVKPRDALIFALTLAATSFTLLTV
CCCHHHCCCCHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
FANLLAALLAMSGIVFYVGVYTHWLKRHSVQNIVIGGAAGAIPPLVGWAAVTGELSWAAW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCCHHHHHH
LLFAIIVVWTPPHFWALAIYIRDEYQEVGVPMLPVIEGNEETARQIWVYTLILIPMTLLL
HHHHHHHHCCCCHHHEEEEEEEHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHH
VYPLHVSGAIYAVLATYLGVIFIKKAWQLLKDPSNKDVARSLFKYSIYYMMLLCLVMVID
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SLPFTHGITTALADSWQTFIGGAIAILF
CCCCHHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure
MQQVISHSLPRRHNNILQVFKSYYQLTKPRIILLLLITTAAGMWLGAKGEVSLFLLFVTL
CCCHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEECCCCCHHHHHHHHHH
TGGALASGAANAINCIYDSDIDYIMERTRWRPIPSGRVKPRDALIFALTLAATSFTLLTV
CCCHHHCCCCHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
FANLLAALLAMSGIVFYVGVYTHWLKRHSVQNIVIGGAAGAIPPLVGWAAVTGELSWAAW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCCHHHHHH
LLFAIIVVWTPPHFWALAIYIRDEYQEVGVPMLPVIEGNEETARQIWVYTLILIPMTLLL
HHHHHHHHCCCCHHHEEEEEEEHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHH
VYPLHVSGAIYAVLATYLGVIFIKKAWQLLKDPSNKDVARSLFKYSIYYMMLLCLVMVID
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SLPFTHGITTALADSWQTFIGGAIAILF
CCCCHHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA