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The map label for this gene is cobD [H]

Identifier: 113475302

GI number: 113475302

Start: 2465278

End: 2466384

Strand: Direct

Name: cobD [H]

Synonym: Tery_1611

Alternate gene names: 113475302

Gene position: 2465278-2466384 (Clockwise)

Preceding gene: 113475301

Following gene: 113475303

Centisome position: 31.81

GC content: 40.2

Gene sequence:

>1107_bases
TTGCCGAAAGAAACGGTAAATAATTATTATCCAGCTTTGAGTAAACCATTACACGGAGGAAACTTAGCTTGGGCGGCCAC
AGTAGCAGGTTGCCCGATGTCTGCTATTGTTGATTTCTCGGCTAGTATTAATCCTCTGGGGCTACCTGATTCTGCTATCC
AAGCTATTCAAACTAATATCAGCAAACTTGGAGCTTATCCAGACCCTAATTATCAGGAATTAAAAAAGGCTCTTAGTTTG
GCTCATCCTCCTCTGACTTCAGAGTGGATATTGCCTGGCAATGGTGCAGCCGAATTATTAACTTGGGCGGCCCTAGATTT
ATCAAAGCTGGAAGCTGTTTATTTACTAACTCCCGCTTTTGGTGACTATAGACGCGCTTTAAAAACTTTTACAGCTAATG
TAATTGAATGTCCCCTAAAAGTTGGGGAATCGAAATTAACTGAATTACAAGAATTACAGATAGAAATTGACACAGATAAA
GGACTACTGCTCAATAACCCTCATAATCCTACGGGATTATTGATGGAAGTGGAAACAATAGTCCCTTTTTTAGAAAAGTT
TGGTTTAGTAGTGGTAGATGAAGCATTTATGGACTTTTTACCACCACCCCAAGCTCAAAGCTTGGTGCCACTGGTAACTA
AATTTCATAATTTGGTTATTTTACGCTCTCTGACTAAATTTTACAGTTTACCTGGATTAAGGCTAGGTTATGCAATTTCT
CATCCTGAACGCCTTCGGAAATGGCAAAAGTGGCGAGATCCTTGGCCTGTAAATACTTTAGCTATAGCTGCTGCCCAAGC
AGTTCTAGAAGACCAAGTTTTTCAACAGCAAACTTGGGATTGGTTAGCAGATGCTCGTCCTCAACTGTTCCAAGGTTTGG
CAGAGTTACCTGGTTTACAGCCATGTCCTGGTGCAGCTAACTTTTTATTAGTCCACTCGGAAAAGTCTGTTGATTGGCTA
CAGACAACATTACTGAAAAAGCATAGAATTTTAATTAGAGATGGGTCCAGTTTTCCAGAATTGGGCGATCGCTATTTTCG
AGTTGCTGTTCGTACCCAAGAAGATAATCAAAAGTTAGTTGATGCTTTGGGACAAATTTTGAAGTAA

Upstream 100 bases:

>100_bases
AAAGCCAGAGAGGGCCGTAATCCCAAAACAGGTGACAAAATGGAAATACCTGAAACTACAGTGCCTGCTTTTTCTGCGGG
CAAATCTTTCAAAGAGTTAG

Downstream 100 bases:

>100_bases
TTGAAATAAGTTTTAGGTAAGTAGGTAGGTATAAAGAAATCTGACAAATAAAAAAAATCGGAAAAAGAACTTAGAAGTAA
CTTTTTAAATGATTCTCACC

Product: threonine-phosphate decarboxylase

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 368; Mature: 367

Protein sequence:

>368_residues
MPKETVNNYYPALSKPLHGGNLAWAATVAGCPMSAIVDFSASINPLGLPDSAIQAIQTNISKLGAYPDPNYQELKKALSL
AHPPLTSEWILPGNGAAELLTWAALDLSKLEAVYLLTPAFGDYRRALKTFTANVIECPLKVGESKLTELQELQIEIDTDK
GLLLNNPHNPTGLLMEVETIVPFLEKFGLVVVDEAFMDFLPPPQAQSLVPLVTKFHNLVILRSLTKFYSLPGLRLGYAIS
HPERLRKWQKWRDPWPVNTLAIAAAQAVLEDQVFQQQTWDWLADARPQLFQGLAELPGLQPCPGAANFLLVHSEKSVDWL
QTTLLKKHRILIRDGSSFPELGDRYFRVAVRTQEDNQKLVDALGQILK

Sequences:

>Translated_368_residues
MPKETVNNYYPALSKPLHGGNLAWAATVAGCPMSAIVDFSASINPLGLPDSAIQAIQTNISKLGAYPDPNYQELKKALSL
AHPPLTSEWILPGNGAAELLTWAALDLSKLEAVYLLTPAFGDYRRALKTFTANVIECPLKVGESKLTELQELQIEIDTDK
GLLLNNPHNPTGLLMEVETIVPFLEKFGLVVVDEAFMDFLPPPQAQSLVPLVTKFHNLVILRSLTKFYSLPGLRLGYAIS
HPERLRKWQKWRDPWPVNTLAIAAAQAVLEDQVFQQQTWDWLADARPQLFQGLAELPGLQPCPGAANFLLVHSEKSVDWL
QTTLLKKHRILIRDGSSFPELGDRYFRVAVRTQEDNQKLVDALGQILK
>Mature_367_residues
PKETVNNYYPALSKPLHGGNLAWAATVAGCPMSAIVDFSASINPLGLPDSAIQAIQTNISKLGAYPDPNYQELKKALSLA
HPPLTSEWILPGNGAAELLTWAALDLSKLEAVYLLTPAFGDYRRALKTFTANVIECPLKVGESKLTELQELQIEIDTDKG
LLLNNPHNPTGLLMEVETIVPFLEKFGLVVVDEAFMDFLPPPQAQSLVPLVTKFHNLVILRSLTKFYSLPGLRLGYAISH
PERLRKWQKWRDPWPVNTLAIAAAQAVLEDQVFQQQTWDWLADARPQLFQGLAELPGLQPCPGAANFLLVHSEKSVDWLQ
TTLLKKHRILIRDGSSFPELGDRYFRVAVRTQEDNQKLVDALGQILK

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=286, Percent_Identity=29.020979020979, Blast_Score=89, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6322075, Length=342, Percent_Identity=27.4853801169591, Blast_Score=97, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 40915; Mature: 40783

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKETVNNYYPALSKPLHGGNLAWAATVAGCPMSAIVDFSASINPLGLPDSAIQAIQTNI
CCCCHHHHHCHHHCCCCCCCCEEEEHHHCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHH
SKLGAYPDPNYQELKKALSLAHPPLTSEWILPGNGAAELLTWAALDLSKLEAVYLLTPAF
HHHCCCCCCCHHHHHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHHHHHCCEEEEECCCH
GDYRRALKTFTANVIECPLKVGESKLTELQELQIEIDTDKGLLLNNPHNPTGLLMEVETI
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHEEEEECCCCEEECCCCCCCCCEEEHHHH
VPFLEKFGLVVVDEAFMDFLPPPQAQSLVPLVTKFHNLVILRSLTKFYSLPGLRLGYAIS
HHHHHHCCEEEEEHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEC
HPERLRKWQKWRDPWPVNTLAIAAAQAVLEDQVFQQQTWDWLADARPQLFQGLAELPGLQ
CHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCC
PCPGAANFLLVHSEKSVDWLQTTLLKKHRILIRDGSSFPELGDRYFRVAVRTQEDNQKLV
CCCCCCCEEEEECCCCHHHHHHHHHHHCEEEEECCCCCCHHCCCEEEEEEECCCCHHHHH
DALGQILK
HHHHHHCC
>Mature Secondary Structure 
PKETVNNYYPALSKPLHGGNLAWAATVAGCPMSAIVDFSASINPLGLPDSAIQAIQTNI
CCCHHHHHCHHHCCCCCCCCEEEEHHHCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHH
SKLGAYPDPNYQELKKALSLAHPPLTSEWILPGNGAAELLTWAALDLSKLEAVYLLTPAF
HHHCCCCCCCHHHHHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHHHHHCCEEEEECCCH
GDYRRALKTFTANVIECPLKVGESKLTELQELQIEIDTDKGLLLNNPHNPTGLLMEVETI
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHEEEEECCCCEEECCCCCCCCCEEEHHHH
VPFLEKFGLVVVDEAFMDFLPPPQAQSLVPLVTKFHNLVILRSLTKFYSLPGLRLGYAIS
HHHHHHCCEEEEEHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEC
HPERLRKWQKWRDPWPVNTLAIAAAQAVLEDQVFQQQTWDWLADARPQLFQGLAELPGLQ
CHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCC
PCPGAANFLLVHSEKSVDWLQTTLLKKHRILIRDGSSFPELGDRYFRVAVRTQEDNQKLV
CCCCCCCEEEEECCCCHHHHHHHHHHHCEEEEECCCCCCHHCCCEEEEEEECCCCHHHHH
DALGQILK
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]