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The map label for this gene is merA [H]

Identifier: 113475303

GI number: 113475303

Start: 2466637

End: 2468106

Strand: Direct

Name: merA [H]

Synonym: Tery_1612

Alternate gene names: 113475303

Gene position: 2466637-2468106 (Clockwise)

Preceding gene: 113475302

Following gene: 113475304

Centisome position: 31.83

GC content: 33.4

Gene sequence:

>1470_bases
ATGCTGGATTACGATGTAGTAATTGTAGGTGGAACAATAACAGGTATTTATGCAGCTATCACTGCAACAAAACTTCAAGG
TCGTGTTGCTCTTATACAACCTCCTCCTACGGAAATAAATACAGTTACTTCCCCAATTTTTAGTAATACTCAAGGATTTA
ATCACAACAAAATTATCAGTAAAATAGCAAATTTTGTCGAACAAATACACCACAAAAAACAGTTTGGTATTTATGAGGGA
ACTGATGATTCTGGAGAAGTTTGGGTAAAGTTTCAAGAAGCTAAAAAGTATGCTGATTATGTAGTGAATAATCAATTAGC
TAAATATGAACCAGAAGTTTTAGCAACTTTAGGAATAGACGTGATTTTTGGTGAGGGAAAGTTTGTCGATCGCCCAAAAC
TTGCTTTTGTTGTTAAAGGAAGACATCTACGCTCACGCAAATATTTATTAGCTACTCCATCTCAGCCTATAATACCAGCA
ATTCCTGGATTAATAAGTACTGGATTTATTACTCCCGAAGAAATTCAAGAACTATCAAAGGTTCCCGAAACTTTAGCTGT
TATTGGTGGGGACCCCAGCGGAATAGAAATAGCACAAAGTTTTTCTCGCTTAGGAACTCAAGTAACTATAGTAGTCAAAA
ATTCTCATATTTTAGGTAAAGAAGATTCAGAAGCAGCATTTTTAGTTCAAGCTCAGTTAGAAGCTGAAGGTATTAGAATA
TTAACTCAAACAGAAGTATCTCAAGTGAGAAAAATTAAGAATAAAAAATGGATTTTAGCAAGAAATGAAGCTATAGAGGT
AGATGAAATTATCTTGGCAGCAGGTAATAAAGCAAATCTGCAAACTTTAAATTTAGAAGCAGTAGGAGTCAAGTTTAATG
GTCATAAATTGTTATTAAATAAAAAGCTACAAACTAGCAATTATCGAATTTATGGTTGTGGAGATTTAATGGGTGGATAT
TCATTTCGCCATGTTGCTAATTATGAAGCTAGAGTAGCAATAAAAAATATTCTCTATTTACCTATTTTTTCAGTTAATTA
TAGTGGTATTCCTTGGGCAATATTTTCAGATCCACAATTAGCAAGAGTTGGTTTAACTGAGCAACAAGCTAGACGACGTT
ATGGAGAAAATGTATTTGTTCATCGGCAATATCTCAAACATCAAGATTGGGCACAAATTTTAAATAAAACAACAGGATAT
TGTAAAATAGTAGGTCATAGTAATGGTAAAATTTTAGGTGTTTCAGTGGTAGGAAATCAAGCAAGTGAGATAATTCATGT
GATGGCATTAGCTATTCGTGAAGGAATAACAATAGAAGCGATCGCTGACTTACCTCATATTTGGCCAACAGCATCAGAGA
TTAATGGTCAAACAGCAACAGTATGGTTAAGGCAAAAACGAGAGAATAATAAAATAGTTAAAGATTGTTTGTTAAATTTA
TTTCATTGGCGACGTTCCTTGATAGAATAG

Upstream 100 bases:

>100_bases
AGGTTTTGAGTATTAGGTTAGTACCTAGGGATGCTTTGAGATTTTTAAGTTCAAAAATAGCTTAAAACTCAATAGGGACA
AAGAAAAAAAATTATAGATT

Downstream 100 bases:

>100_bases
TTAGCTCAGGAGTTAGGAGTTAAGGTATTAAAGTGTAAGATTTAAATAGGGTAAATATCACAGGAATGATAGGATAAATA
ATATTGAAACTCTAATTTTT

Product: pyridine nucleotide-disulfide oxidoreductase dimerisation subunit

Products: NA

Alternate protein names: Hg(II) reductase [H]

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MLDYDVVIVGGTITGIYAAITATKLQGRVALIQPPPTEINTVTSPIFSNTQGFNHNKIISKIANFVEQIHHKKQFGIYEG
TDDSGEVWVKFQEAKKYADYVVNNQLAKYEPEVLATLGIDVIFGEGKFVDRPKLAFVVKGRHLRSRKYLLATPSQPIIPA
IPGLISTGFITPEEIQELSKVPETLAVIGGDPSGIEIAQSFSRLGTQVTIVVKNSHILGKEDSEAAFLVQAQLEAEGIRI
LTQTEVSQVRKIKNKKWILARNEAIEVDEIILAAGNKANLQTLNLEAVGVKFNGHKLLLNKKLQTSNYRIYGCGDLMGGY
SFRHVANYEARVAIKNILYLPIFSVNYSGIPWAIFSDPQLARVGLTEQQARRRYGENVFVHRQYLKHQDWAQILNKTTGY
CKIVGHSNGKILGVSVVGNQASEIIHVMALAIREGITIEAIADLPHIWPTASEINGQTATVWLRQKRENNKIVKDCLLNL
FHWRRSLIE

Sequences:

>Translated_489_residues
MLDYDVVIVGGTITGIYAAITATKLQGRVALIQPPPTEINTVTSPIFSNTQGFNHNKIISKIANFVEQIHHKKQFGIYEG
TDDSGEVWVKFQEAKKYADYVVNNQLAKYEPEVLATLGIDVIFGEGKFVDRPKLAFVVKGRHLRSRKYLLATPSQPIIPA
IPGLISTGFITPEEIQELSKVPETLAVIGGDPSGIEIAQSFSRLGTQVTIVVKNSHILGKEDSEAAFLVQAQLEAEGIRI
LTQTEVSQVRKIKNKKWILARNEAIEVDEIILAAGNKANLQTLNLEAVGVKFNGHKLLLNKKLQTSNYRIYGCGDLMGGY
SFRHVANYEARVAIKNILYLPIFSVNYSGIPWAIFSDPQLARVGLTEQQARRRYGENVFVHRQYLKHQDWAQILNKTTGY
CKIVGHSNGKILGVSVVGNQASEIIHVMALAIREGITIEAIADLPHIWPTASEINGQTATVWLRQKRENNKIVKDCLLNL
FHWRRSLIE
>Mature_489_residues
MLDYDVVIVGGTITGIYAAITATKLQGRVALIQPPPTEINTVTSPIFSNTQGFNHNKIISKIANFVEQIHHKKQFGIYEG
TDDSGEVWVKFQEAKKYADYVVNNQLAKYEPEVLATLGIDVIFGEGKFVDRPKLAFVVKGRHLRSRKYLLATPSQPIIPA
IPGLISTGFITPEEIQELSKVPETLAVIGGDPSGIEIAQSFSRLGTQVTIVVKNSHILGKEDSEAAFLVQAQLEAEGIRI
LTQTEVSQVRKIKNKKWILARNEAIEVDEIILAAGNKANLQTLNLEAVGVKFNGHKLLLNKKLQTSNYRIYGCGDLMGGY
SFRHVANYEARVAIKNILYLPIFSVNYSGIPWAIFSDPQLARVGLTEQQARRRYGENVFVHRQYLKHQDWAQILNKTTGY
CKIVGHSNGKILGVSVVGNQASEIIHVMALAIREGITIEAIADLPHIWPTASEINGQTATVWLRQKRENNKIVKDCLLNL
FHWRRSLIE

Specific function: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0) [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=470, Percent_Identity=25.7446808510638, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI91199540, Length=329, Percent_Identity=27.355623100304, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI33519430, Length=327, Percent_Identity=25.0764525993884, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI33519428, Length=327, Percent_Identity=25.0764525993884, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI33519426, Length=327, Percent_Identity=25.0764525993884, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI148277065, Length=327, Percent_Identity=25.0764525993884, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI148277071, Length=327, Percent_Identity=25.0764525993884, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI22035672, Length=347, Percent_Identity=25.0720461095101, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI291045266, Length=349, Percent_Identity=25.214899713467, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI87081717, Length=469, Percent_Identity=25.7995735607676, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI1789915, Length=353, Percent_Identity=30.5949008498584, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI87082354, Length=463, Percent_Identity=25.0539956803456, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1786307, Length=477, Percent_Identity=23.0607966457023, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17557007, Length=473, Percent_Identity=25.1585623678647, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI32565766, Length=478, Percent_Identity=24.4769874476987, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI71983429, Length=334, Percent_Identity=26.0479041916168, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71983419, Length=334, Percent_Identity=26.0479041916168, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71982272, Length=352, Percent_Identity=23.0113636363636, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6325166, Length=422, Percent_Identity=26.5402843601896, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6321091, Length=489, Percent_Identity=25.7668711656442, Blast_Score=110, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6325240, Length=333, Percent_Identity=24.3243243243243, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24640549, Length=473, Percent_Identity=25.7928118393235, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24640553, Length=473, Percent_Identity=25.7928118393235, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24640551, Length=473, Percent_Identity=25.7928118393235, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI17737741, Length=475, Percent_Identity=24.8421052631579, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI21358499, Length=328, Percent_Identity=28.3536585365854, Blast_Score=108, Evalue=6e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000815
- InterPro:   IPR021179
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00403 HMA; PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.16.1.1 [H]

Molecular weight: Translated: 54498; Mature: 54498

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDYDVVIVGGTITGIYAAITATKLQGRVALIQPPPTEINTVTSPIFSNTQGFNHNKIIS
CCCEEEEEECCCHHHHHHHHHHEEECCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHH
KIANFVEQIHHKKQFGIYEGTDDSGEVWVKFQEAKKYADYVVNNQLAKYEPEVLATLGID
HHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHHHHHHHHCCCHHHCCCCEEEEECEE
VIFGEGKFVDRPKLAFVVKGRHLRSRKYLLATPSQPIIPAIPGLISTGFITPEEIQELSK
EEECCCCCCCCCCEEEEEECCEECCCEEEEECCCCCCCHHCCHHHHCCCCCHHHHHHHHC
VPETLAVIGGDPSGIEIAQSFSRLGTQVTIVVKNSHILGKEDSEAAFLVQAQLEAEGIRI
CCCEEEEECCCCCCHHHHHHHHHCCCEEEEEEECCEEECCCCCCEEEEEEEEECCCCEEE
LTQTEVSQVRKIKNKKWILARNEAIEVDEIILAAGNKANLQTLNLEAVGVKFNGHKLLLN
EEHHHHHHHHHHCCCEEEEEECCCCCEEEEEEECCCCCCEEEEEEEEEEEEECCCEEEEE
KKLQTSNYRIYGCGDLMGGYSFRHVANYEARVAIKNILYLPIFSVNYSGIPWAIFSDPQL
CCCCCCCEEEEECHHCCCCCCEEEECCCHHHEEEEHEEEEEEEEECCCCCCEEEECCCCE
ARVGLTEQQARRRYGENVFVHRQYLKHQDWAQILNKTTGYCKIVGHSNGKILGVSVVGNQ
EECCCCHHHHHHHHCCCEEEEHHHHCCCHHHHHHHCCCCEEEEEECCCCCEEEEEEECCC
ASEIIHVMALAIREGITIEAIADLPHIWPTASEINGQTATVWLRQKRENNKIVKDCLLNL
HHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHCCCCEEEEEEEECCCCCHHHHHHHHHH
FHWRRSLIE
HHHHHHHCC
>Mature Secondary Structure
MLDYDVVIVGGTITGIYAAITATKLQGRVALIQPPPTEINTVTSPIFSNTQGFNHNKIIS
CCCEEEEEECCCHHHHHHHHHHEEECCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHH
KIANFVEQIHHKKQFGIYEGTDDSGEVWVKFQEAKKYADYVVNNQLAKYEPEVLATLGID
HHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHHHHHHHHCCCHHHCCCCEEEEECEE
VIFGEGKFVDRPKLAFVVKGRHLRSRKYLLATPSQPIIPAIPGLISTGFITPEEIQELSK
EEECCCCCCCCCCEEEEEECCEECCCEEEEECCCCCCCHHCCHHHHCCCCCHHHHHHHHC
VPETLAVIGGDPSGIEIAQSFSRLGTQVTIVVKNSHILGKEDSEAAFLVQAQLEAEGIRI
CCCEEEEECCCCCCHHHHHHHHHCCCEEEEEEECCEEECCCCCCEEEEEEEEECCCCEEE
LTQTEVSQVRKIKNKKWILARNEAIEVDEIILAAGNKANLQTLNLEAVGVKFNGHKLLLN
EEHHHHHHHHHHCCCEEEEEECCCCCEEEEEEECCCCCCEEEEEEEEEEEEECCCEEEEE
KKLQTSNYRIYGCGDLMGGYSFRHVANYEARVAIKNILYLPIFSVNYSGIPWAIFSDPQL
CCCCCCCEEEEECHHCCCCCCEEEECCCHHHEEEEHEEEEEEEEECCCCCCEEEECCCCE
ARVGLTEQQARRRYGENVFVHRQYLKHQDWAQILNKTTGYCKIVGHSNGKILGVSVVGNQ
EECCCCHHHHHHHHCCCEEEEHHHHCCCHHHHHHHCCCCEEEEEECCCCCEEEEEEECCC
ASEIIHVMALAIREGITIEAIADLPHIWPTASEINGQTATVWLRQKRENNKIVKDCLLNL
HHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHCCCCEEEEEEEECCCCCHHHHHHHHHH
FHWRRSLIE
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3037534 [H]