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The map label for this gene is tmk

Identifier: 113475256

GI number: 113475256

Start: 2389695

End: 2390372

Strand: Direct

Name: tmk

Synonym: Tery_1564

Alternate gene names: 113475256

Gene position: 2389695-2390372 (Clockwise)

Preceding gene: 113475254

Following gene: 113475257

Centisome position: 30.83

GC content: 33.63

Gene sequence:

>678_bases
ATGATAGGCAAATTTATAGTTTTTGAAGGTGTAGAAGGAGGGGGTAAAACCACTCAAATTGAACTTTTACAAGATTGGTT
ATTAGAAACAGGAGAGTCGAGGCAAATTTTGCCAAAGTCTATAGATTTAGATTTAGAAGTAGTTATCACCCGAGAACCGG
GAGGAACAAAACTAGGTAAAGCTTTACGAGAATTACTTTTAAGTCCAGATGTATTGGCAGAAAAAATTCAAGAAACATCT
GAGTTACTATTATATGCTGCAGATAGAGCGCAACATATAGAAGCTTTGATTAAACCTTGTTTGGAAAGAGGGACAATAGT
TCTGTGCGATCGCTTCATTGACTCAACTATTGCTTATCAAGGATACGGTCGTGGTTTAGATGTTGAATTAATTAAACAAC
TGAATTATATTGCTACAGGTGGTTTAAAAAGTGATTTAACTTTTTGGTTAGATATTGATGTAGAAATTGGTTTAGCTAGA
GCTAAAAGTAGGGGAAATTTTGACAGAATGGAACAAGCAAATATTGAATTTCATCGGCGGGTACAACAAGGGTATCAAGA
GTTAGCTAAAAACAATTCTTTAATAGTACGAATAGATGCTAACTTGACTAGAGAAAAAGTACAACAGCAAATTCAAGCAA
TTATTATGCAAAAATTAGTAGAATGGAAGTATATTTGA

Upstream 100 bases:

>100_bases
ACAGCAATAGTCAATATAGCAGTATAGTAAGCCATAAAAAACTCCAATCAGAGAAAAAACACTTAAAATTAAATATAATT
AATTAATTAGAACTTACATA

Downstream 100 bases:

>100_bases
TTAAAAGATAGTTTTTTTGTCATTATTATGGAGTATAAATATACAGATGATTTCGCGAAAATTATGTGGTGCGGGAAGTT
GTCTGAGTGAGCTTACCTTA

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MIGKFIVFEGVEGGGKTTQIELLQDWLLETGESRQILPKSIDLDLEVVITREPGGTKLGKALRELLLSPDVLAEKIQETS
ELLLYAADRAQHIEALIKPCLERGTIVLCDRFIDSTIAYQGYGRGLDVELIKQLNYIATGGLKSDLTFWLDIDVEIGLAR
AKSRGNFDRMEQANIEFHRRVQQGYQELAKNNSLIVRIDANLTREKVQQQIQAIIMQKLVEWKYI

Sequences:

>Translated_225_residues
MIGKFIVFEGVEGGGKTTQIELLQDWLLETGESRQILPKSIDLDLEVVITREPGGTKLGKALRELLLSPDVLAEKIQETS
ELLLYAADRAQHIEALIKPCLERGTIVLCDRFIDSTIAYQGYGRGLDVELIKQLNYIATGGLKSDLTFWLDIDVEIGLAR
AKSRGNFDRMEQANIEFHRRVQQGYQELAKNNSLIVRIDANLTREKVQQQIQAIIMQKLVEWKYI
>Mature_225_residues
MIGKFIVFEGVEGGGKTTQIELLQDWLLETGESRQILPKSIDLDLEVVITREPGGTKLGKALRELLLSPDVLAEKIQETS
ELLLYAADRAQHIEALIKPCLERGTIVLCDRFIDSTIAYQGYGRGLDVELIKQLNYIATGGLKSDLTFWLDIDVEIGLAR
AKSRGNFDRMEQANIEFHRRVQQGYQELAKNNSLIVRIDANLTREKVQQQIQAIIMQKLVEWKYI

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=218, Percent_Identity=40.3669724770642, Blast_Score=143, Evalue=7e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_TRIEI (Q115I0)

Other databases:

- EMBL:   CP000393
- RefSeq:   YP_721317.1
- ProteinModelPortal:   Q115I0
- SMR:   Q115I0
- STRING:   Q115I0
- GeneID:   4242122
- GenomeReviews:   CP000393_GR
- KEGG:   ter:Tery_1564
- NMPDR:   fig|203124.1.peg.5661
- eggNOG:   COG0125
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- PhylomeDB:   Q115I0
- ProtClustDB:   CLSK896248
- BioCyc:   TERY203124:TERY_1564-MONOMER
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 25514; Mature: 25514

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGKFIVFEGVEGGGKTTQIELLQDWLLETGESRQILPKSIDLDLEVVITREPGGTKLGK
CCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHH
ALRELLLSPDVLAEKIQETSELLLYAADRAQHIEALIKPCLERGTIVLCDRFIDSTIAYQ
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHC
GYGRGLDVELIKQLNYIATGGLKSDLTFWLDIDVEIGLARAKSRGNFDRMEQANIEFHRR
CCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEEEEEEEHHHHCCCCCHHHHHHHCHHHHHH
VQQGYQELAKNNSLIVRIDANLTREKVQQQIQAIIMQKLVEWKYI
HHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIGKFIVFEGVEGGGKTTQIELLQDWLLETGESRQILPKSIDLDLEVVITREPGGTKLGK
CCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHH
ALRELLLSPDVLAEKIQETSELLLYAADRAQHIEALIKPCLERGTIVLCDRFIDSTIAYQ
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHC
GYGRGLDVELIKQLNYIATGGLKSDLTFWLDIDVEIGLARAKSRGNFDRMEQANIEFHRR
CCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEEEEEEEHHHHCCCCCHHHHHHHCHHHHHH
VQQGYQELAKNNSLIVRIDANLTREKVQQQIQAIIMQKLVEWKYI
HHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA