Click here to switch to the map view.

The map label for this gene is folP [H]

Identifier: 113475100

GI number: 113475100

Start: 2115235

End: 2116080

Strand: Direct

Name: folP [H]

Synonym: Tery_1381

Alternate gene names: 113475100

Gene position: 2115235-2116080 (Clockwise)

Preceding gene: 113475099

Following gene: 113475101

Centisome position: 27.29

GC content: 33.33

Gene sequence:

>846_bases
ATGCAGAGTTTAACTGAAAGTTTTATTTGGGGAAAACGTACCTACATAATGGGTATTTTGAATGTTACACCAGATAGTTT
TAGCGATGGTGGTGATTTTAATACACCAGAAACAGCTTTAATGCAGGCAAAAAAAATGGTGAAGGCGGGTGCTGATATGA
TTGATATTGGTGGTCAATCAACTAGACCAGGGTCTGAAGTTGTTTCCATAGATGAGGAACTTAATCGTGTTTTAGCAATA
ATTAAGTTGTTAAGAAGCAATAAAAATATTGGTGCTGAAATTATAATTTCTGTTGATACTACTAGGGCGATAGTTGCAGA
AAAATCTGTTGAAGCTGGTGCTAATTTAATTAATGATATTTCTGCTGGAACATATGATGATGAAATGTTTTCTGTGGTAG
CTGCTCTGAAAGTTCCGATTATCTTAATGCACATCCGTGGTACACCAAAAACTATGCAAAAATTGACAGACTATCAAGAT
TTAATTGGGGAAATTTATCAGTTTTTAGAGAGCAGAATTAAGATTGCTTTTAAAGCAGGAATTAAAAGAGAGAAAATTAT
TATTGACCCTGGTATTGGTTTTGCTAAAAATTACGAACAAAATTTAGAAATTATCCGCAATTTATCAAGATTTAAAAGTT
TAAATTGTCCCATTTTAGTGGGATTATCTCGTAAAAGTTTTATTGGTCAAATTTTAAATCAACCTAATGCTAAACAAAGG
GTTTGGGGAACTGCTGCTGGTTGTGTGGCAGCGATCGCTCAATACGTAGATATTTTACGGGTTCACGATGTTAAAGAAAT
GTCTGAAGTTTGTCGAGTTGCTGATATTATTTTTAGGAATAAATAA

Upstream 100 bases:

>100_bases
TATTACTTACTATAGGATATTTCTTTAAAAAAAACAACTAGTCTCCCACTGATGGGCAAGCTTTTAAAGCAAATTTTTTG
GTAAACAGGGAATAGAAAAA

Downstream 100 bases:

>100_bases
TTATCAAATCTTGGCACGACCATCTTCGGTGAAACAACCATAACTCACTTTTAACGAAATCCTCTAAAACTAAGCGGTCG
ATACTGACAACCAATAACTG

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MQSLTESFIWGKRTYIMGILNVTPDSFSDGGDFNTPETALMQAKKMVKAGADMIDIGGQSTRPGSEVVSIDEELNRVLAI
IKLLRSNKNIGAEIIISVDTTRAIVAEKSVEAGANLINDISAGTYDDEMFSVVAALKVPIILMHIRGTPKTMQKLTDYQD
LIGEIYQFLESRIKIAFKAGIKREKIIIDPGIGFAKNYEQNLEIIRNLSRFKSLNCPILVGLSRKSFIGQILNQPNAKQR
VWGTAAGCVAAIAQYVDILRVHDVKEMSEVCRVADIIFRNK

Sequences:

>Translated_281_residues
MQSLTESFIWGKRTYIMGILNVTPDSFSDGGDFNTPETALMQAKKMVKAGADMIDIGGQSTRPGSEVVSIDEELNRVLAI
IKLLRSNKNIGAEIIISVDTTRAIVAEKSVEAGANLINDISAGTYDDEMFSVVAALKVPIILMHIRGTPKTMQKLTDYQD
LIGEIYQFLESRIKIAFKAGIKREKIIIDPGIGFAKNYEQNLEIIRNLSRFKSLNCPILVGLSRKSFIGQILNQPNAKQR
VWGTAAGCVAAIAQYVDILRVHDVKEMSEVCRVADIIFRNK
>Mature_281_residues
MQSLTESFIWGKRTYIMGILNVTPDSFSDGGDFNTPETALMQAKKMVKAGADMIDIGGQSTRPGSEVVSIDEELNRVLAI
IKLLRSNKNIGAEIIISVDTTRAIVAEKSVEAGANLINDISAGTYDDEMFSVVAALKVPIILMHIRGTPKTMQKLTDYQD
LIGEIYQFLESRIKIAFKAGIKREKIIIDPGIGFAKNYEQNLEIIRNLSRFKSLNCPILVGLSRKSFIGQILNQPNAKQR
VWGTAAGCVAAIAQYVDILRVHDVKEMSEVCRVADIIFRNK

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=269, Percent_Identity=42.3791821561338, Blast_Score=221, Evalue=5e-59,
Organism=Saccharomyces cerevisiae, GI6324073, Length=318, Percent_Identity=36.7924528301887, Blast_Score=185, Evalue=7e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 31082; Mature: 31082

Theoretical pI: Translated: 8.77; Mature: 8.77

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSLTESFIWGKRTYIMGILNVTPDSFSDGGDFNTPETALMQAKKMVKAGADMIDIGGQS
CCHHHHHHHCCCHHHEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCCC
TRPGSEVVSIDEELNRVLAIIKLLRSNKNIGAEIIISVDTTRAIVAEKSVEAGANLINDI
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHC
SAGTYDDEMFSVVAALKVPIILMHIRGTPKTMQKLTDYQDLIGEIYQFLESRIKIAFKAG
CCCCCHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
IKREKIIIDPGIGFAKNYEQNLEIIRNLSRFKSLNCPILVGLSRKSFIGQILNQPNAKQR
CCCCEEEECCCCCCHHCHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHCCCCHHHH
VWGTAAGCVAAIAQYVDILRVHDVKEMSEVCRVADIIFRNK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQSLTESFIWGKRTYIMGILNVTPDSFSDGGDFNTPETALMQAKKMVKAGADMIDIGGQS
CCHHHHHHHCCCHHHEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCCC
TRPGSEVVSIDEELNRVLAIIKLLRSNKNIGAEIIISVDTTRAIVAEKSVEAGANLINDI
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHC
SAGTYDDEMFSVVAALKVPIILMHIRGTPKTMQKLTDYQDLIGEIYQFLESRIKIAFKAG
CCCCCHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
IKREKIIIDPGIGFAKNYEQNLEIIRNLSRFKSLNCPILVGLSRKSFIGQILNQPNAKQR
CCCCEEEECCCCCCHHCHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHCCCCHHHH
VWGTAAGCVAAIAQYVDILRVHDVKEMSEVCRVADIIFRNK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]