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The map label for this gene is tpiA

Identifier: 113475099

GI number: 113475099

Start: 2113589

End: 2114314

Strand: Direct

Name: tpiA

Synonym: Tery_1380

Alternate gene names: 113475099

Gene position: 2113589-2114314 (Clockwise)

Preceding gene: 113475098

Following gene: 113475100

Centisome position: 27.27

GC content: 38.84

Gene sequence:

>726_bases
GTGAGAAAAACTATAATTGCTGGTAATTGGAAAATGTACAAGACCCAACTAGAAGCTAAAGAGTTTCTCGAGGGTTTGAT
GTCTCAACTAACAAAAACCCCCGAAGAACGTGAAGTAGTTCTCTGCACTCCCTTCACGGCACTAGATTTTATGTCAAAAA
TTTTGCATGGGAGTCTGATCAGGTTAGGTGCGCAAAATGTTCACTGGGAAGATGAAGGAGCATATACAGGAGAAATTTCT
GGCTTAATGCTGAAAGATGTGGGAGTTAGTTATGTAATTGTGGGTCACAGTGAGCGCCGTCAATATTTTGGCGAAACTGA
TGAAACGGTGAATATGCGCTTAAAAGCTGCTCAGAAGCACGGTTTAACCCCTATTCTCTGTGTGGGAGAAACTAAACAAC
AAAGAGATTCAGGTGAGACAGAATCACATATATTTTCTCAGTTGGCCAATGATTTAGTTGATGTCGATCAAGAAAATCTA
GTAATTGCTTATGAACCAATATGGGCCATTGGTACTGGTGATACCTGTGAAGCTAAAGAAGCTAACCGAGTTATTGGTTT
AATTCGTGGTAAGTTAAATAATTCTAATGTCACTATTCAATATGGCGGTTCTGTTAAACCTAATAATGTTGATGATATTA
TGGCACAAGAAGAAATTGATGGTGCTTTAGTTGGGGGTGCAAGTTTGAATCCCGAGAGTTTTAGTCGTTTGGTTAACTAT
CAATAA

Upstream 100 bases:

>100_bases
AAAAGTAAAACAATTACTTTTTTCAGTCTAGAAAAAAGTTCCATAAAGTTTTAGAATGAAGTTTTGTAGATAGTAAAGTT
TGAGGTATTAAGAATCAACA

Downstream 100 bases:

>100_bases
CTTCAATTTTTTCTTGTTCCCGGGAACTTGGAATTGGGAATCGGTGAAGACATGAGAGATATATTGGTCACTTATTTTTC
TTTTCAAGAAAATAGGTGAA

Product: triosephosphate isomerase

Products: NA

Alternate protein names: TIM; Triose-phosphate isomerase

Number of amino acids: Translated: 241; Mature: 241

Protein sequence:

>241_residues
MRKTIIAGNWKMYKTQLEAKEFLEGLMSQLTKTPEEREVVLCTPFTALDFMSKILHGSLIRLGAQNVHWEDEGAYTGEIS
GLMLKDVGVSYVIVGHSERRQYFGETDETVNMRLKAAQKHGLTPILCVGETKQQRDSGETESHIFSQLANDLVDVDQENL
VIAYEPIWAIGTGDTCEAKEANRVIGLIRGKLNNSNVTIQYGGSVKPNNVDDIMAQEEIDGALVGGASLNPESFSRLVNY
Q

Sequences:

>Translated_241_residues
MRKTIIAGNWKMYKTQLEAKEFLEGLMSQLTKTPEEREVVLCTPFTALDFMSKILHGSLIRLGAQNVHWEDEGAYTGEIS
GLMLKDVGVSYVIVGHSERRQYFGETDETVNMRLKAAQKHGLTPILCVGETKQQRDSGETESHIFSQLANDLVDVDQENL
VIAYEPIWAIGTGDTCEAKEANRVIGLIRGKLNNSNVTIQYGGSVKPNNVDDIMAQEEIDGALVGGASLNPESFSRLVNY
Q
>Mature_241_residues
MRKTIIAGNWKMYKTQLEAKEFLEGLMSQLTKTPEEREVVLCTPFTALDFMSKILHGSLIRLGAQNVHWEDEGAYTGEIS
GLMLKDVGVSYVIVGHSERRQYFGETDETVNMRLKAAQKHGLTPILCVGETKQQRDSGETESHIFSQLANDLVDVDQENL
VIAYEPIWAIGTGDTCEAKEANRVIGLIRGKLNNSNVTIQYGGSVKPNNVDDIMAQEEIDGALVGGASLNPESFSRLVNY
Q

Specific function: Plays an important role in several metabolic pathways. [C]

COG id: COG0149

COG function: function code G; Triosephosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the triosephosphate isomerase family

Homologues:

Organism=Homo sapiens, GI226529917, Length=249, Percent_Identity=40.1606425702811, Blast_Score=165, Evalue=4e-41,
Organism=Homo sapiens, GI4507645, Length=251, Percent_Identity=39.8406374501992, Blast_Score=165, Evalue=4e-41,
Organism=Escherichia coli, GI1790353, Length=250, Percent_Identity=40.4, Blast_Score=182, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17536593, Length=250, Percent_Identity=38.8, Blast_Score=157, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6320255, Length=246, Percent_Identity=39.0243902439024, Blast_Score=162, Evalue=6e-41,
Organism=Drosophila melanogaster, GI28572008, Length=246, Percent_Identity=39.4308943089431, Blast_Score=163, Evalue=9e-41,
Organism=Drosophila melanogaster, GI28572006, Length=246, Percent_Identity=39.4308943089431, Blast_Score=163, Evalue=9e-41,
Organism=Drosophila melanogaster, GI28572004, Length=246, Percent_Identity=39.4308943089431, Blast_Score=162, Evalue=1e-40,

Paralogues:

None

Copy number: 1120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): TPIS_TRIEI (Q115Y7)

Other databases:

- EMBL:   CP000393
- RefSeq:   YP_721160.1
- ProteinModelPortal:   Q115Y7
- SMR:   Q115Y7
- STRING:   Q115Y7
- GeneID:   4245480
- GenomeReviews:   CP000393_GR
- KEGG:   ter:Tery_1380
- NMPDR:   fig|203124.1.peg.4949
- eggNOG:   COG0149
- HOGENOM:   HBG708281
- OMA:   DIRSVQT
- ProtClustDB:   PRK00042
- BioCyc:   TERY203124:TERY_1380-MONOMER
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00147_B
- InterPro:   IPR013785
- InterPro:   IPR022896
- InterPro:   IPR000652
- InterPro:   IPR020861
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR21139
- TIGRFAMs:   TIGR00419

Pfam domain/function: PF00121 TIM; SSF51351 Triophos_ismrse

EC number: =5.3.1.1

Molecular weight: Translated: 26711; Mature: 26711

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00171 TIM_1; PS51440 TIM_2

Important sites: ACT_SITE 96-96 ACT_SITE 165-165 BINDING 9-9 BINDING 11-11

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKTIIAGNWKMYKTQLEAKEFLEGLMSQLTKTPEEREVVLCTPFTALDFMSKILHGSLI
CCCEEEECCCEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHH
RLGAQNVHWEDEGAYTGEISGLMLKDVGVSYVIVGHSERRQYFGETDETVNMRLKAAQKH
HHCCCCCCCCCCCCEECCCCCEEEECCCEEEEEEECHHHHHHCCCCCCHHHHEEEEHHHC
GLTPILCVGETKQQRDSGETESHIFSQLANDLVDVDQENLVIAYEPIWAIGTGDTCEAKE
CCCEEEEECCCHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCEEEECCCCCCCCHH
ANRVIGLIRGKLNNSNVTIQYGGSVKPNNVDDIMAQEEIDGALVGGASLNPESFSRLVNY
HHHEEEEEECCCCCCEEEEEECCCCCCCCHHHHHHHHHCCCEEECCCCCCHHHHHHHHCC
Q
C
>Mature Secondary Structure
MRKTIIAGNWKMYKTQLEAKEFLEGLMSQLTKTPEEREVVLCTPFTALDFMSKILHGSLI
CCCEEEECCCEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHH
RLGAQNVHWEDEGAYTGEISGLMLKDVGVSYVIVGHSERRQYFGETDETVNMRLKAAQKH
HHCCCCCCCCCCCCEECCCCCEEEECCCEEEEEEECHHHHHHCCCCCCHHHHEEEEHHHC
GLTPILCVGETKQQRDSGETESHIFSQLANDLVDVDQENLVIAYEPIWAIGTGDTCEAKE
CCCEEEEECCCHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCEEEECCCCCCCCHH
ANRVIGLIRGKLNNSNVTIQYGGSVKPNNVDDIMAQEEIDGALVGGASLNPESFSRLVNY
HHHEEEEEECCCCCCEEEEEECCCCCCCCHHHHHHHHHCCCEEECCCCCCHHHHHHHHCC
Q
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA