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The map label for this gene is phrA [H]

Identifier: 113474888

GI number: 113474888

Start: 1751417

End: 1752841

Strand: Direct

Name: phrA [H]

Synonym: Tery_1113

Alternate gene names: 113474888

Gene position: 1751417-1752841 (Clockwise)

Preceding gene: 113474887

Following gene: 113474891

Centisome position: 22.6

GC content: 36.0

Gene sequence:

>1425_bases
ATGTCTAACTTAATCCTATTTTGGCATCGGCGTGATTTACGAATTTCAGATAATGTCGGACTGACACAAGCATCTCAAGA
AGGTCAAACCGTAGTAGGTATATTTTGTCTTGATGAAAATATTCTTAAACGAGACGATATTGCTTCTGCAAGAGTTACTT
ATATGATTGGTTGTTTACAGCATCTACAAAAACGCTATAAACAAATAGGAAGTCAACTTTTAATAATGTCCGGAAAACCT
ATAGAAGCTATACCAAAATTAGCAACTTTTTTGGAGGCTAAAGCTGTATATTGGAACCTGGATGTTGAACCTTATAGTAG
GAAACGCGATCGCCAAGTGAAAGAAAACTTAGAAGCTGCAAATATTCAAGTAAAAACTTTTTGGGAGCAACTTCTTCATT
CCCCAGAAGAAATATTTACTTCCACAAAAAAACCCTACTCTGTCTACACTCCTTTCTGGAAAAATTGGCAGGGGAAAAAA
AAATCTAACCCGCTAAATACTCCCGTACTCAAAGGTTTAACTGAAGATCAGCTTCAATACACAAAAAAAATTGGAGTAAT
TGACTTGCCTACTGCTAAACAATTAGGATTTAATTGGGACAATAAACTAATTCTTGAACCAGGAGAAACAGCAGCATTAG
AAAAACTAGAAAAATTTTCTAATGGGGCGATATCTTCATATCAAGAACAACGAAACTTCCCCAGTCTTGATGGAACATCT
CAACTAAGTGTCGCTCTAAAATTTGGTACTATTGGTATTCGTACTGTTTGGGCAAAAACTCAAGAATTAATTGAAAATTG
CTATAGTAGTGAAGTATTTGAAAATATAGAAACCTGGCAAAAAGAAATAGCATGGCGGGAATTTTATCAATATGTTATGT
ACCATTATCCCGAATTAGAAACAGGTCCCTACCGAGAACATTGGAAAAATTTTCCTTGGAAAAATAATAAAGCACATTTT
CAAGCTTGGTGCGAAGGAAATACGGGTTATCCTATTGTTGATGCTGCTATGCGTCAGTTAAATGAAACAGGTTGGATGCA
CAACCGTTGCCGGATGATAGTTGCCAGTTTTTTAACCAAAGATTTAATTATTAACTGGCAGTGGGGCGAAAAATATTTTA
TGCAGAATTTAATAGATGGAGACCTTTGTGCTAATAATGGTGGTTGGCAATGGAGTGCTTCCAGTGGAATGGACCCAAAA
CCCTTGAGAATATTTAATCCTGTATCTCAGACACAAAAATATGACCCAGAAGGGGAATATATTCGACAGTGGGTTTGTGA
ATTGCGGAGTGTAGATACTCAATATTTAGTTACGGGTAAAATTCCAGCGGAAGAAAGAGAGGCTATAGGTTATCCTCTAC
CTATTGTTGACCATAAAAAACAACAACAACTATTCAAGGATCTTTACCGAGAACAGAAAAATTGA

Upstream 100 bases:

>100_bases
TACTTGATCATTACCATGTAAAATTATCAAAATGAAAATGATAAATAACTGATAACTACTCTAAACTTAGTTATTAAAGC
TAACACTAAACTCAAATAAA

Downstream 100 bases:

>100_bases
TTTTTTAGATTAGAAGGTTGAAGTTAATATAAACTCAAATTAATTATAACACAAAAACGTCAAGCTTGTAACAACTCATA
GTCCCATTATAAGTATAAAA

Product: deoxyribodipyrimidine photo-lyase type I

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 474; Mature: 473

Protein sequence:

>474_residues
MSNLILFWHRRDLRISDNVGLTQASQEGQTVVGIFCLDENILKRDDIASARVTYMIGCLQHLQKRYKQIGSQLLIMSGKP
IEAIPKLATFLEAKAVYWNLDVEPYSRKRDRQVKENLEAANIQVKTFWEQLLHSPEEIFTSTKKPYSVYTPFWKNWQGKK
KSNPLNTPVLKGLTEDQLQYTKKIGVIDLPTAKQLGFNWDNKLILEPGETAALEKLEKFSNGAISSYQEQRNFPSLDGTS
QLSVALKFGTIGIRTVWAKTQELIENCYSSEVFENIETWQKEIAWREFYQYVMYHYPELETGPYREHWKNFPWKNNKAHF
QAWCEGNTGYPIVDAAMRQLNETGWMHNRCRMIVASFLTKDLIINWQWGEKYFMQNLIDGDLCANNGGWQWSASSGMDPK
PLRIFNPVSQTQKYDPEGEYIRQWVCELRSVDTQYLVTGKIPAEEREAIGYPLPIVDHKKQQQLFKDLYREQKN

Sequences:

>Translated_474_residues
MSNLILFWHRRDLRISDNVGLTQASQEGQTVVGIFCLDENILKRDDIASARVTYMIGCLQHLQKRYKQIGSQLLIMSGKP
IEAIPKLATFLEAKAVYWNLDVEPYSRKRDRQVKENLEAANIQVKTFWEQLLHSPEEIFTSTKKPYSVYTPFWKNWQGKK
KSNPLNTPVLKGLTEDQLQYTKKIGVIDLPTAKQLGFNWDNKLILEPGETAALEKLEKFSNGAISSYQEQRNFPSLDGTS
QLSVALKFGTIGIRTVWAKTQELIENCYSSEVFENIETWQKEIAWREFYQYVMYHYPELETGPYREHWKNFPWKNNKAHF
QAWCEGNTGYPIVDAAMRQLNETGWMHNRCRMIVASFLTKDLIINWQWGEKYFMQNLIDGDLCANNGGWQWSASSGMDPK
PLRIFNPVSQTQKYDPEGEYIRQWVCELRSVDTQYLVTGKIPAEEREAIGYPLPIVDHKKQQQLFKDLYREQKN
>Mature_473_residues
SNLILFWHRRDLRISDNVGLTQASQEGQTVVGIFCLDENILKRDDIASARVTYMIGCLQHLQKRYKQIGSQLLIMSGKPI
EAIPKLATFLEAKAVYWNLDVEPYSRKRDRQVKENLEAANIQVKTFWEQLLHSPEEIFTSTKKPYSVYTPFWKNWQGKKK
SNPLNTPVLKGLTEDQLQYTKKIGVIDLPTAKQLGFNWDNKLILEPGETAALEKLEKFSNGAISSYQEQRNFPSLDGTSQ
LSVALKFGTIGIRTVWAKTQELIENCYSSEVFENIETWQKEIAWREFYQYVMYHYPELETGPYREHWKNFPWKNNKAHFQ
AWCEGNTGYPIVDAAMRQLNETGWMHNRCRMIVASFLTKDLIINWQWGEKYFMQNLIDGDLCANNGGWQWSASSGMDPKP
LRIFNPVSQTQKYDPEGEYIRQWVCELRSVDTQYLVTGKIPAEEREAIGYPLPIVDHKKQQQLFKDLYREQKN

Specific function: Involved in repair of UV radiation-induced DNA damage. Exhibits specific, light-dependent repair activity for a cyclobutyl pyrimidine dimer by catalyzing the light-dependent monomerization (300-600 nm) of the dimers (in cis-syn configuration), which are f

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Homo sapiens, GI4758072, Length=483, Percent_Identity=26.9151138716356, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI188536100, Length=480, Percent_Identity=25.4166666666667, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI188536103, Length=432, Percent_Identity=25.462962962963, Blast_Score=149, Evalue=5e-36,
Organism=Escherichia coli, GI1786926, Length=468, Percent_Identity=34.8290598290598, Blast_Score=268, Evalue=4e-73,
Organism=Saccharomyces cerevisiae, GI6324962, Length=516, Percent_Identity=30.6201550387597, Blast_Score=229, Evalue=5e-61,
Organism=Drosophila melanogaster, GI17137248, Length=445, Percent_Identity=30.7865168539326, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24585455, Length=445, Percent_Identity=30.7865168539326, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24648152, Length=494, Percent_Identity=24.6963562753036, Blast_Score=141, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002081
- InterPro:   IPR018394
- InterPro:   IPR006050
- InterPro:   IPR019947
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 55328; Mature: 55196

Theoretical pI: Translated: 8.03; Mature: 8.03

Prosite motif: PS00394 DNA_PHOTOLYASES_1_1 ; PS00691 DNA_PHOTOLYASES_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNLILFWHRRDLRISDNVGLTQASQEGQTVVGIFCLDENILKRDDIASARVTYMIGCLQ
CCCEEEEEECCCCEECCCCCCCCCCCCCCEEEEEEEECCCHHHHCCHHHHHHHHHHHHHH
HLQKRYKQIGSQLLIMSGKPIEAIPKLATFLEAKAVYWNLDVEPYSRKRDRQVKENLEAA
HHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHCHHHH
NIQVKTFWEQLLHSPEEIFTSTKKPYSVYTPFWKNWQGKKKSNPLNTPVLKGLTEDQLQY
CCHHHHHHHHHHCCHHHHHHCCCCCCEECCCHHCCCCCCCCCCCCCCHHHCCCCHHHHHH
TKKIGVIDLPTAKQLGFNWDNKLILEPGETAALEKLEKFSNGAISSYQEQRNFPSLDGTS
HHHCCCEECCCHHHHCCCCCCEEEECCCCHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCC
QLSVALKFGTIGIRTVWAKTQELIENCYSSEVFENIETWQKEIAWREFYQYVMYHYPELE
CEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TGPYREHWKNFPWKNNKAHFQAWCEGNTGYPIVDAAMRQLNETGWMHNRCRMIVASFLTK
CCCCHHHHCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
DLIINWQWGEKYFMQNLIDGDLCANNGGWQWSASSGMDPKPLRIFNPVSQTQKYDPEGEY
HHEEEEECCHHHHHHHCCCCCEECCCCCEEECCCCCCCCCCCEEECCHHHHCCCCCCHHH
IRQWVCELRSVDTQYLVTGKIPAEEREAIGYPLPIVDHKKQQQLFKDLYREQKN
HHHHHHHHHCCCCEEEEECCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SNLILFWHRRDLRISDNVGLTQASQEGQTVVGIFCLDENILKRDDIASARVTYMIGCLQ
CCEEEEEECCCCEECCCCCCCCCCCCCCEEEEEEEECCCHHHHCCHHHHHHHHHHHHHH
HLQKRYKQIGSQLLIMSGKPIEAIPKLATFLEAKAVYWNLDVEPYSRKRDRQVKENLEAA
HHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHCHHHH
NIQVKTFWEQLLHSPEEIFTSTKKPYSVYTPFWKNWQGKKKSNPLNTPVLKGLTEDQLQY
CCHHHHHHHHHHCCHHHHHHCCCCCCEECCCHHCCCCCCCCCCCCCCHHHCCCCHHHHHH
TKKIGVIDLPTAKQLGFNWDNKLILEPGETAALEKLEKFSNGAISSYQEQRNFPSLDGTS
HHHCCCEECCCHHHHCCCCCCEEEECCCCHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCC
QLSVALKFGTIGIRTVWAKTQELIENCYSSEVFENIETWQKEIAWREFYQYVMYHYPELE
CEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TGPYREHWKNFPWKNNKAHFQAWCEGNTGYPIVDAAMRQLNETGWMHNRCRMIVASFLTK
CCCCHHHHCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
DLIINWQWGEKYFMQNLIDGDLCANNGGWQWSASSGMDPKPLRIFNPVSQTQKYDPEGEY
HHEEEEECCHHHHHHHCCCCCEECCCCCEEECCCCCCCCCCCEEECCHHHHCCCCCCHHH
IRQWVCELRSVDTQYLVTGKIPAEEREAIGYPLPIVDHKKQQQLFKDLYREQKN
HHHHHHHHHCCCCEEEEECCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11254140; 8905231; 10896222; 10871367 [H]