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The map label for this gene is folE [H]

Identifier: 113474764

GI number: 113474764

Start: 1525249

End: 1525980

Strand: Direct

Name: folE [H]

Synonym: Tery_0969

Alternate gene names: 113474764

Gene position: 1525249-1525980 (Clockwise)

Preceding gene: 113474763

Following gene: 113474765

Centisome position: 19.68

GC content: 39.07

Gene sequence:

>732_bases
ATGACTCAATCTTCTTCCAACCGTTCCAATTCTAAGAACACACTCAACATGAATGGAGTTAAAACTTCTGATGCAAATAT
GACGAGTCAAATTTCCTATAGACCTGAGCGTATCTCCTCATCCAATGGTCAATCAATTAAGCAAAAGCTTTCTACTGAAG
ACAGCAATGAGAGAATGAAGGAGGCAGTGCGGACAATCTTACTCTCAGTAGAAGAAAATCCTGAACGAGAAGGATTACTC
AATACTCCCAAGCGGTTTGCAGAAGCAATGCAGTTTCTGACTAGTGGCTACAGTCAATCCCTCGAAGAAATTGTGAATGG
TGCGATTTTTGACGAAGGTCATAATGAAATGGTTCTAGTTAGAGATATCAATTTTTTTAGTCTTTGTGAACATCATATGT
TACCCTTCATGGGAAAAGCTCATATCGCTTACATTCCTAATCAAAAAGTAGTAGGACTCAGTAAGCTAGCTAGAGTTGTC
GACATGTACTCTCGTAGATTGCAAGTCCAGGAGCGACTAAATCGTCAAATTGCTGAGGCAATTCAAACAATTTTGGAACC
AAAGGGCGTAGCAGTTGTAATTGAGGCTACTCATATATCTATGGTAATGCGAGGGGTTCAAAAACCTGGTTCTTGGACTG
TTACTAGTGCCATGGTTGGTCTTTTTAAAGAAGATCAGAAAACAAGAGAAGAATATCTAAACTTAATTCGCCATCAACCT
ACCTTCTTTTAA

Upstream 100 bases:

>100_bases
TTAGTATTAATAAACAAAAAATTATAATCTAAGCTAAAAAATCTAGCATAAGTTAGGTCAAAATACAATTTGCTTTTTTT
AAATTTGATCCCAATCTATT

Downstream 100 bases:

>100_bases
CTGCCCCGAGAAGTCCTGCGCTCTTTTGAAGGAGAGCGTCGGGATAAAAGTCGGGCGTTATGTGCGTTTTTGATCTTAAT
TTTTATGATGGCTATTAACG

Product: GTP cyclohydrolase

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 243; Mature: 242

Protein sequence:

>243_residues
MTQSSSNRSNSKNTLNMNGVKTSDANMTSQISYRPERISSSNGQSIKQKLSTEDSNERMKEAVRTILLSVEENPEREGLL
NTPKRFAEAMQFLTSGYSQSLEEIVNGAIFDEGHNEMVLVRDINFFSLCEHHMLPFMGKAHIAYIPNQKVVGLSKLARVV
DMYSRRLQVQERLNRQIAEAIQTILEPKGVAVVIEATHISMVMRGVQKPGSWTVTSAMVGLFKEDQKTREEYLNLIRHQP
TFF

Sequences:

>Translated_243_residues
MTQSSSNRSNSKNTLNMNGVKTSDANMTSQISYRPERISSSNGQSIKQKLSTEDSNERMKEAVRTILLSVEENPEREGLL
NTPKRFAEAMQFLTSGYSQSLEEIVNGAIFDEGHNEMVLVRDINFFSLCEHHMLPFMGKAHIAYIPNQKVVGLSKLARVV
DMYSRRLQVQERLNRQIAEAIQTILEPKGVAVVIEATHISMVMRGVQKPGSWTVTSAMVGLFKEDQKTREEYLNLIRHQP
TFF
>Mature_242_residues
TQSSSNRSNSKNTLNMNGVKTSDANMTSQISYRPERISSSNGQSIKQKLSTEDSNERMKEAVRTILLSVEENPEREGLLN
TPKRFAEAMQFLTSGYSQSLEEIVNGAIFDEGHNEMVLVRDINFFSLCEHHMLPFMGKAHIAYIPNQKVVGLSKLARVVD
MYSRRLQVQERLNRQIAEAIQTILEPKGVAVVIEATHISMVMRGVQKPGSWTVTSAMVGLFKEDQKTREEYLNLIRHQPT
FF

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=209, Percent_Identity=57.4162679425837, Blast_Score=251, Evalue=4e-67,
Organism=Homo sapiens, GI4503949, Length=209, Percent_Identity=57.4162679425837, Blast_Score=251, Evalue=4e-67,
Organism=Homo sapiens, GI66932970, Length=178, Percent_Identity=52.247191011236, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI66932972, Length=169, Percent_Identity=54.4378698224852, Blast_Score=195, Evalue=3e-50,
Organism=Escherichia coli, GI1788476, Length=125, Percent_Identity=48.8, Blast_Score=119, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17560486, Length=187, Percent_Identity=59.3582887700535, Blast_Score=242, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6321706, Length=181, Percent_Identity=57.4585635359116, Blast_Score=227, Evalue=1e-60,
Organism=Drosophila melanogaster, GI24656782, Length=178, Percent_Identity=58.4269662921348, Blast_Score=223, Evalue=8e-59,
Organism=Drosophila melanogaster, GI24656791, Length=178, Percent_Identity=58.4269662921348, Blast_Score=223, Evalue=9e-59,
Organism=Drosophila melanogaster, GI24656796, Length=178, Percent_Identity=58.4269662921348, Blast_Score=223, Evalue=1e-58,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 27555; Mature: 27424

Theoretical pI: Translated: 8.98; Mature: 8.98

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1 ; PS00860 GTP_CYCLOHYDROL_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQSSSNRSNSKNTLNMNGVKTSDANMTSQISYRPERISSSNGQSIKQKLSTEDSNERMK
CCCCCCCCCCCCCEEEECCCCCCCCCCHHHHCCCHHHHCCCCCHHHHHHHCCCCHHHHHH
EAVRTILLSVEENPEREGLLNTPKRFAEAMQFLTSGYSQSLEEIVNGAIFDEGHNEMVLV
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCEEEE
RDINFFSLCEHHMLPFMGKAHIAYIPNQKVVGLSKLARVVDMYSRRLQVQERLNRQIAEA
ECCCHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IQTILEPKGVAVVIEATHISMVMRGVQKPGSWTVTSAMVGLFKEDQKTREEYLNLIRHQP
HHHHHCCCCCEEEEEHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TFF
CCC
>Mature Secondary Structure 
TQSSSNRSNSKNTLNMNGVKTSDANMTSQISYRPERISSSNGQSIKQKLSTEDSNERMK
CCCCCCCCCCCCEEEECCCCCCCCCCHHHHCCCHHHHCCCCCHHHHHHHCCCCHHHHHH
EAVRTILLSVEENPEREGLLNTPKRFAEAMQFLTSGYSQSLEEIVNGAIFDEGHNEMVLV
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCEEEE
RDINFFSLCEHHMLPFMGKAHIAYIPNQKVVGLSKLARVVDMYSRRLQVQERLNRQIAEA
ECCCHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IQTILEPKGVAVVIEATHISMVMRGVQKPGSWTVTSAMVGLFKEDQKTREEYLNLIRHQP
HHHHHCCCCCEEEEEHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TFF
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA