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The map label for this gene is hisS [H]

Identifier: 113474598

GI number: 113474598

Start: 1217233

End: 1218636

Strand: Direct

Name: hisS [H]

Synonym: Tery_0758

Alternate gene names: 113474598

Gene position: 1217233-1218636 (Clockwise)

Preceding gene: 113474597

Following gene: 113474599

Centisome position: 15.71

GC content: 35.11

Gene sequence:

>1404_bases
ATGGCAAAAGCAGATAAAATTAATTATAGTTGTCCGAGTGGTTTTCCCGAATTTCTACCTGGTGAAAAACGATTGGAAAG
TTATTTAATGGATACAATTCGTCAGGTGTTTGAACGCTACGGATTTACACCTATTGAAACTCCAGCAGTAGAACGTTTAG
AAGTACTACAAGCTAAAGGAAATCAAGGGGATAATATTGTTTATGGTTTATCTCCAATTTTACCTCCAAATCGTCAGGCA
GAAAAAGACCAAGCAGGAGATAGTGGTTCAGAAGAAAGGGGGTTAAAATTTGACCAAACTGTTCCTTTAGCTGCTTATAT
TGCTCGGCATTTAAATGCTTTAAATTTTCCTTTTGCTCGTTATCAAATGGATGTGGTTTTTCGAGGTGAGCGGGCAAAAG
ATGGTCGTTTTCGACAGTTCAGACAATGCGATATTGATGTTGTAGGTAGAGGAAAATTAAGTTTATTATATGATGCACAA
ATTCCAGCTATTATTGCTGAAATATTTGAAGCTATTAAAATTGGAGATTTTCTAATAAGGATTAATAATCGTAAGGTTTT
GACTGGTTTTTTTGCATCTGTGGGTGTGTTAGTAGAGAATATTGTTTCCTGTATTCGGATTGTTGATACTGTGGAAAAAG
TGGGAGAAGTCAAGGTAAAAAAAGCTTTGAAAGAAATTGGTTTATCTGAAGATCAAGTAGAAAAAGTTTGGGATTTTACT
AATATTAAGGGTACCGTTGATGATGTTTTAGATAAGTTGAAAAGTATGACAAAAACTGTGGAAAATTCTGAGGTTTTAAG
TCAGGGAATTTATGAGTTAGAAACAGTAATTTCTGGGGTCAGAAATTTGGGAGTTTCAGACCAACGTTTTTGTATTGATC
TATCAATAGCTAGGGGATTAGATTATTATACAGGTACAGTTTATGAAACGACTTTAATAGGGCATGAAGCTTTAGGAAGT
ATTTGTTCTGGGGGTAGATATGAAGAATTAGTTGGAACGTTTATTGGGGAAAAAATGCCTGGGGTTGGTATTTCTATTGG
TTTAACTAGATTAATGAGTCGTTTATTAAAGGCGGGTATTCTGGAATCTTTTGCTCCTACTCCAGCAACAGTTATGGTTG
TGAATATGCAGGAAAGTTTGATGGCTACTTATTTGGATGTTTCCCAAAAATTGCGTCGTAGTGGGATGAATGTTATAACA
AGTTTTGATGGTCGTGGAGTTGGAAAACAATTACAACAAGCTGATAAGCAGAAAATTCCTTTTTGCATTATTATTGGCTC
TGAGGAAGCAGCAGCTAATATGTGTAGTTTAAAAGATTTAAGAACTGGAGAACAAATGAAAGTGCCTATAGGGAGTTTAG
CAGATGTATTAAAACAAAGACTGAGTAATATCATCTCTGGTTGA

Upstream 100 bases:

>100_bases
CCTAATAACTCTAGCTCTTAATTCCTATGACCAGGGGACGACTTTATGCAAAATCCCTACTTACTCTCTGCTCTAAAGAA
AAAAATATCTGAGGTTAAAA

Downstream 100 bases:

>100_bases
ATATTTATAATTAAGTTTTGTAGTAGGGCTTTAGCTTTATTTTTCTTAGGGCTAAGACTCTACTATAAACAATTTTTTTT
TGACCACTTACTATTTGGGA

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS [H]

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MAKADKINYSCPSGFPEFLPGEKRLESYLMDTIRQVFERYGFTPIETPAVERLEVLQAKGNQGDNIVYGLSPILPPNRQA
EKDQAGDSGSEERGLKFDQTVPLAAYIARHLNALNFPFARYQMDVVFRGERAKDGRFRQFRQCDIDVVGRGKLSLLYDAQ
IPAIIAEIFEAIKIGDFLIRINNRKVLTGFFASVGVLVENIVSCIRIVDTVEKVGEVKVKKALKEIGLSEDQVEKVWDFT
NIKGTVDDVLDKLKSMTKTVENSEVLSQGIYELETVISGVRNLGVSDQRFCIDLSIARGLDYYTGTVYETTLIGHEALGS
ICSGGRYEELVGTFIGEKMPGVGISIGLTRLMSRLLKAGILESFAPTPATVMVVNMQESLMATYLDVSQKLRRSGMNVIT
SFDGRGVGKQLQQADKQKIPFCIIIGSEEAAANMCSLKDLRTGEQMKVPIGSLADVLKQRLSNIISG

Sequences:

>Translated_467_residues
MAKADKINYSCPSGFPEFLPGEKRLESYLMDTIRQVFERYGFTPIETPAVERLEVLQAKGNQGDNIVYGLSPILPPNRQA
EKDQAGDSGSEERGLKFDQTVPLAAYIARHLNALNFPFARYQMDVVFRGERAKDGRFRQFRQCDIDVVGRGKLSLLYDAQ
IPAIIAEIFEAIKIGDFLIRINNRKVLTGFFASVGVLVENIVSCIRIVDTVEKVGEVKVKKALKEIGLSEDQVEKVWDFT
NIKGTVDDVLDKLKSMTKTVENSEVLSQGIYELETVISGVRNLGVSDQRFCIDLSIARGLDYYTGTVYETTLIGHEALGS
ICSGGRYEELVGTFIGEKMPGVGISIGLTRLMSRLLKAGILESFAPTPATVMVVNMQESLMATYLDVSQKLRRSGMNVIT
SFDGRGVGKQLQQADKQKIPFCIIIGSEEAAANMCSLKDLRTGEQMKVPIGSLADVLKQRLSNIISG
>Mature_466_residues
AKADKINYSCPSGFPEFLPGEKRLESYLMDTIRQVFERYGFTPIETPAVERLEVLQAKGNQGDNIVYGLSPILPPNRQAE
KDQAGDSGSEERGLKFDQTVPLAAYIARHLNALNFPFARYQMDVVFRGERAKDGRFRQFRQCDIDVVGRGKLSLLYDAQI
PAIIAEIFEAIKIGDFLIRINNRKVLTGFFASVGVLVENIVSCIRIVDTVEKVGEVKVKKALKEIGLSEDQVEKVWDFTN
IKGTVDDVLDKLKSMTKTVENSEVLSQGIYELETVISGVRNLGVSDQRFCIDLSIARGLDYYTGTVYETTLIGHEALGSI
CSGGRYEELVGTFIGEKMPGVGISIGLTRLMSRLLKAGILESFAPTPATVMVVNMQESLMATYLDVSQKLRRSGMNVITS
FDGRGVGKQLQQADKQKIPFCIIIGSEEAAANMCSLKDLRTGEQMKVPIGSLADVLKQRLSNIISG

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI6996014, Length=467, Percent_Identity=31.4775160599572, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI15029520, Length=482, Percent_Identity=28.6307053941909, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI65287717, Length=429, Percent_Identity=22.8438228438228, Blast_Score=94, Evalue=4e-19,
Organism=Escherichia coli, GI1788861, Length=479, Percent_Identity=24.8434237995825, Blast_Score=112, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI71993693, Length=478, Percent_Identity=27.6150627615063, Blast_Score=171, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI71993686, Length=478, Percent_Identity=27.6150627615063, Blast_Score=171, Evalue=7e-43,
Organism=Saccharomyces cerevisiae, GI6325290, Length=504, Percent_Identity=27.3809523809524, Blast_Score=161, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24643061, Length=491, Percent_Identity=30.142566191446, Blast_Score=198, Evalue=6e-51,
Organism=Drosophila melanogaster, GI24643059, Length=510, Percent_Identity=29.2156862745098, Blast_Score=192, Evalue=5e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.21 [H]

Molecular weight: Translated: 51580; Mature: 51449

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKADKINYSCPSGFPEFLPGEKRLESYLMDTIRQVFERYGFTPIETPAVERLEVLQAKG
CCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCC
NQGDNIVYGLSPILPPNRQAEKDQAGDSGSEERGLKFDQTVPLAAYIARHLNALNFPFAR
CCCCEEEEECCCCCCCCCCCCHHCCCCCCCHHCCCCCCCCCCHHHHHHHHHHHCCCCHHH
YQMDVVFRGERAKDGRFRQFRQCDIDVVGRGKLSLLYDAQIPAIIAEIFEAIKIGDFLIR
EEEEEEEECCCCCCCHHHHHHHCCCEEECCCCEEEEECCHHHHHHHHHHHHHHHCCEEEE
INNRKVLTGFFASVGVLVENIVSCIRIVDTVEKVGEVKVKKALKEIGLSEDQVEKVWDFT
ECCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHC
NIKGTVDDVLDKLKSMTKTVENSEVLSQGIYELETVISGVRNLGVSDQRFCIDLSIARGL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHCC
DYYTGTVYETTLIGHEALGSICSGGRYEELVGTFIGEKMPGVGISIGLTRLMSRLLKAGI
CHHCCCEEHHHHHCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
LESFAPTPATVMVVNMQESLMATYLDVSQKLRRSGMNVITSFDGRGVGKQLQQADKQKIP
HHHCCCCCCEEEEEECHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHCCC
FCIIIGSEEAAANMCSLKDLRTGEQMKVPIGSLADVLKQRLSNIISG
EEEEECCCHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AKADKINYSCPSGFPEFLPGEKRLESYLMDTIRQVFERYGFTPIETPAVERLEVLQAKG
CCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCC
NQGDNIVYGLSPILPPNRQAEKDQAGDSGSEERGLKFDQTVPLAAYIARHLNALNFPFAR
CCCCEEEEECCCCCCCCCCCCHHCCCCCCCHHCCCCCCCCCCHHHHHHHHHHHCCCCHHH
YQMDVVFRGERAKDGRFRQFRQCDIDVVGRGKLSLLYDAQIPAIIAEIFEAIKIGDFLIR
EEEEEEEECCCCCCCHHHHHHHCCCEEECCCCEEEEECCHHHHHHHHHHHHHHHCCEEEE
INNRKVLTGFFASVGVLVENIVSCIRIVDTVEKVGEVKVKKALKEIGLSEDQVEKVWDFT
ECCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHC
NIKGTVDDVLDKLKSMTKTVENSEVLSQGIYELETVISGVRNLGVSDQRFCIDLSIARGL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHCC
DYYTGTVYETTLIGHEALGSICSGGRYEELVGTFIGEKMPGVGISIGLTRLMSRLLKAGI
CHHCCCEEHHHHHCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
LESFAPTPATVMVVNMQESLMATYLDVSQKLRRSGMNVITSFDGRGVGKQLQQADKQKIP
HHHCCCCCCEEEEEECHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHCCC
FCIIIGSEEAAANMCSLKDLRTGEQMKVPIGSLADVLKQRLSNIISG
EEEEECCCHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA