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The map label for this gene is lktA [H]

Identifier: 113474447

GI number: 113474447

Start: 949911

End: 952352

Strand: Direct

Name: lktA [H]

Synonym: Tery_0591

Alternate gene names: 113474447

Gene position: 949911-952352 (Clockwise)

Preceding gene: 113474445

Following gene: 113474449

Centisome position: 12.26

GC content: 42.59

Gene sequence:

>2442_bases
ATGCTGAATTTATCCAAAAATTGTTCGGTCGGTGAGGCTTCCTGCCTAGCTCCACCACCTCAAACTTTAGTGGCGATCGA
CTCCCGAGTTGATAACTCTCAAATATTACTTACAGGAGTTAAACCCGGAGTTAAAGCTGTAATTATAGATAGGGAGGAAG
ATGCTATTCCTCAAATTACTCTAGCTTTATCGAAATATCCCGCCCGTAATTTACAAATTGTTTGTCACGGCGAACCGGGT
ATTTTATATTTAGGCAAAACCCCTATTACTGCCCCTACTATGGAAGGATATTCCCATTTGTTAGCAGAGTGGGATGTAGA
GGATATTTTATTATATGCTTGTCAAGTGGCGGGTCTCTCCAACAATACCGTTAATTCTTTATTAGCTCGACTGCATCAAT
TAACAGGAGCAAATATTGCTGCCTCAACCCACCGGGTAGGAAGTCAACAGTTAGATGGCAGTTGGGAGTTAGATACTTTT
ATCGGTCAGGTTAATTCTGAGTTAGCTTTGTTACCAGAAGTGGTGGAAAGTTATCCGGGGGTATTAGCGACATTTGGTGA
ACCTACTACTTATCCTACAGGTGGACTTGAACCTATCTACTTAAAAACAGGAGACTTGAACAACGACAACATTCCTGATG
TTGTGACTGGCAATGGTGAGTCAGATAATGTCTCTATATTTTTAGGTAAAGGTAATGGTACTTTTGAAGTAGCTACCCGC
ATTCCAGCAGGAGATGGACCTACTGGCGTCAATATCGGTGACTTCAATAAAGATGGCTTTAATGATATTGTTGTTAGTAA
CTTTGATGAAGATACTGTATCAGTCTTTTTAGCTGATGGTATGGGTAGTTTTTTAACTCCTCAAACCTTTGCCGGAATAG
GCGCTCCTACTGAAATTCAAGTAGCAGACTTTAATAAAGATGGAAATCAAGATATAGTAGTTACAACCCAGTCTAGAGGA
AATAGCATCATTACGCTGCTAGGAAATGGGAATGGTGACTTTAATCAATTAACAACTCAGGCGACAGGTGCTTGGTTGTC
AGCTAAAGGGGATTTTAATCAGGATTCGATCCTAGACCTTGCCACTGTTCAAGCCATTGGTGGCGGTTTGACTTCTTATG
TTTCCATCTATTTAGGCAACGGTATTGGCGGTTTTTCTACTCCTGCTCAATATAATACAGGTGGAAATTCTGGTGATGTG
GAAGTAGGTAATTTTAATAACGATCGCTTCATTGACTTGGTTACCACTAACGAGGAGTCAGACAATATTTCTATCCTATT
AGGTAATGGAAATGGTACCTTTGAGAACCCTCTCTTACTTGATGCCAGCGATGCGCCAGATGGTGTGGCTGTAGCTGATC
TAAATAAAGATGGTTTTGATGATATTGCGGTAGCTCACAATAGCTCAAATAATGTTTTAGTGTTTTTAGGAAAAGGGAAA
GCTAAATTTGCTTCACCTATTGATCTTCCTACAGGAGGCGCTGACGCCAGAATTTTAAAGTTATCCGACCTTGATAGTGA
CAATGACTTGGATATTGTGGTGCCCAATAGAGACTCTTCCAATATCTCAGTGATACTAAATACATCCCTCATCGGTAACA
ACAAAAATAACACCCTCAAAGGAAATAACAAAGCCAACTTCATCAACGGTGTTGGTGGTAAAGATAACTTAAAAGGCAGT
GGTGGTAACGATACCATATTAGGAGGAGGCGGAAACGATCGCCTAGATGGCAACAGTGGCAATGACACCCTTACTGGTGA
AGCAGGGAACGATAGCCTCAACGGTGGCAGCGGTAACGACAAACTCAACGGTGGTGGAGGCAATGACATACTCAACGGTG
GTAGCGGAAGAGATAGACTTGATGGTAGTGGAGGCAACGATATACTTAATGGTGGCAGCAGCAATGACAAACTCAACGGT
GGTGGAGGCAATGACAAACTCAATGGTGGCAGCGGAAGGGATAGACTGATCGGCAATAATGGCAAGGACATCCTAACCGG
CGGCAGTGGTAACGATACCATATTAGGAGGCGGTGGAGACGATGAATTAATTGGGGGTAGTGGCAACGACCTACTAAATG
GTGGATCCGGTGACGACAAATTTATCTATAGTAGTCGCAAAGCTTTTAACAGAAAAACCTTCGGCAAAGACAGAATAGCT
AACTTTGCCCCAGGATCCGATAAAATTATCTTAGATAAAACAACATTCACAAGCTTAGATAGCACAGCCGGTGAAAGCTT
CAGCAATGACAGCGAATTTGAGATAGTCACCAACAACTCTGCAGCATCCAGCAGTAGCGCCGAAATTGTTTACGTTTCAT
CTACCGGCAACTTGTATTACAACCCCAACGGTAGCGACGCCGGTTTTGGTGGTGGCGGGCAGTTTGCTAAGTTGCTCGGC
AGACCCGCTCTAACAGATAGCGACTTTTTAATTGAAAATTAG

Upstream 100 bases:

>100_bases
CCTAAGACACAATAAATATGTTCTCCAGGTAATTTAACGTGTAAATCTTTTTGTCTACCTACTTATTAACAAATTGCCAA
CAAAATAGATAGGGGAAACT

Downstream 100 bases:

>100_bases
TTGTCCATACTAGAAATTCTAATAGTAGAAACTGGGGTCAAATGATAATTCTGTAGGGACGTTGCATGCAGCGTCCCTAA
TTTATGAAACGCTCCTACTG

Product: hypothetical protein

Products: NA

Alternate protein names: Lkt [H]

Number of amino acids: Translated: 813; Mature: 813

Protein sequence:

>813_residues
MLNLSKNCSVGEASCLAPPPQTLVAIDSRVDNSQILLTGVKPGVKAVIIDREEDAIPQITLALSKYPARNLQIVCHGEPG
ILYLGKTPITAPTMEGYSHLLAEWDVEDILLYACQVAGLSNNTVNSLLARLHQLTGANIAASTHRVGSQQLDGSWELDTF
IGQVNSELALLPEVVESYPGVLATFGEPTTYPTGGLEPIYLKTGDLNNDNIPDVVTGNGESDNVSIFLGKGNGTFEVATR
IPAGDGPTGVNIGDFNKDGFNDIVVSNFDEDTVSVFLADGMGSFLTPQTFAGIGAPTEIQVADFNKDGNQDIVVTTQSRG
NSIITLLGNGNGDFNQLTTQATGAWLSAKGDFNQDSILDLATVQAIGGGLTSYVSIYLGNGIGGFSTPAQYNTGGNSGDV
EVGNFNNDRFIDLVTTNEESDNISILLGNGNGTFENPLLLDASDAPDGVAVADLNKDGFDDIAVAHNSSNNVLVFLGKGK
AKFASPIDLPTGGADARILKLSDLDSDNDLDIVVPNRDSSNISVILNTSLIGNNKNNTLKGNNKANFINGVGGKDNLKGS
GGNDTILGGGGNDRLDGNSGNDTLTGEAGNDSLNGGSGNDKLNGGGGNDILNGGSGRDRLDGSGGNDILNGGSSNDKLNG
GGGNDKLNGGSGRDRLIGNNGKDILTGGSGNDTILGGGGDDELIGGSGNDLLNGGSGDDKFIYSSRKAFNRKTFGKDRIA
NFAPGSDKIILDKTTFTSLDSTAGESFSNDSEFEIVTNNSAASSSSAEIVYVSSTGNLYYNPNGSDAGFGGGGQFAKLLG
RPALTDSDFLIEN

Sequences:

>Translated_813_residues
MLNLSKNCSVGEASCLAPPPQTLVAIDSRVDNSQILLTGVKPGVKAVIIDREEDAIPQITLALSKYPARNLQIVCHGEPG
ILYLGKTPITAPTMEGYSHLLAEWDVEDILLYACQVAGLSNNTVNSLLARLHQLTGANIAASTHRVGSQQLDGSWELDTF
IGQVNSELALLPEVVESYPGVLATFGEPTTYPTGGLEPIYLKTGDLNNDNIPDVVTGNGESDNVSIFLGKGNGTFEVATR
IPAGDGPTGVNIGDFNKDGFNDIVVSNFDEDTVSVFLADGMGSFLTPQTFAGIGAPTEIQVADFNKDGNQDIVVTTQSRG
NSIITLLGNGNGDFNQLTTQATGAWLSAKGDFNQDSILDLATVQAIGGGLTSYVSIYLGNGIGGFSTPAQYNTGGNSGDV
EVGNFNNDRFIDLVTTNEESDNISILLGNGNGTFENPLLLDASDAPDGVAVADLNKDGFDDIAVAHNSSNNVLVFLGKGK
AKFASPIDLPTGGADARILKLSDLDSDNDLDIVVPNRDSSNISVILNTSLIGNNKNNTLKGNNKANFINGVGGKDNLKGS
GGNDTILGGGGNDRLDGNSGNDTLTGEAGNDSLNGGSGNDKLNGGGGNDILNGGSGRDRLDGSGGNDILNGGSSNDKLNG
GGGNDKLNGGSGRDRLIGNNGKDILTGGSGNDTILGGGGDDELIGGSGNDLLNGGSGDDKFIYSSRKAFNRKTFGKDRIA
NFAPGSDKIILDKTTFTSLDSTAGESFSNDSEFEIVTNNSAASSSSAEIVYVSSTGNLYYNPNGSDAGFGGGGQFAKLLG
RPALTDSDFLIEN
>Mature_813_residues
MLNLSKNCSVGEASCLAPPPQTLVAIDSRVDNSQILLTGVKPGVKAVIIDREEDAIPQITLALSKYPARNLQIVCHGEPG
ILYLGKTPITAPTMEGYSHLLAEWDVEDILLYACQVAGLSNNTVNSLLARLHQLTGANIAASTHRVGSQQLDGSWELDTF
IGQVNSELALLPEVVESYPGVLATFGEPTTYPTGGLEPIYLKTGDLNNDNIPDVVTGNGESDNVSIFLGKGNGTFEVATR
IPAGDGPTGVNIGDFNKDGFNDIVVSNFDEDTVSVFLADGMGSFLTPQTFAGIGAPTEIQVADFNKDGNQDIVVTTQSRG
NSIITLLGNGNGDFNQLTTQATGAWLSAKGDFNQDSILDLATVQAIGGGLTSYVSIYLGNGIGGFSTPAQYNTGGNSGDV
EVGNFNNDRFIDLVTTNEESDNISILLGNGNGTFENPLLLDASDAPDGVAVADLNKDGFDDIAVAHNSSNNVLVFLGKGK
AKFASPIDLPTGGADARILKLSDLDSDNDLDIVVPNRDSSNISVILNTSLIGNNKNNTLKGNNKANFINGVGGKDNLKGS
GGNDTILGGGGNDRLDGNSGNDTLTGEAGNDSLNGGSGNDKLNGGGGNDILNGGSGRDRLDGSGGNDILNGGSSNDKLNG
GGGNDKLNGGSGRDRLIGNNGKDILTGGSGNDTILGGGGDDELIGGSGNDLLNGGSGDDKFIYSSRKAFNRKTFGKDRIA
NFAPGSDKIILDKTTFTSLDSTAGESFSNDSEFEIVTNNSAASSSSAEIVYVSSTGNLYYNPNGSDAGFGGGGQFAKLLG
RPALTDSDFLIEN

Specific function: One of the virulence factors of A.actinomycetemcomitans might be a cytotoxin, possibly the membrane-bound hemolysin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein. Secreted (By similarity) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 7 hemolysin-type calcium-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018511
- InterPro:   IPR001343
- InterPro:   IPR018504
- InterPro:   IPR003995
- InterPro:   IPR011049 [H]

Pfam domain/function: PF00353 HemolysinCabind; PF02382 RTX [H]

EC number: NA

Molecular weight: Translated: 83904; Mature: 83904

Theoretical pI: Translated: 4.03; Mature: 4.03

Prosite motif: PS00330 HEMOLYSIN_CALCIUM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNLSKNCSVGEASCLAPPPQTLVAIDSRVDNSQILLTGVKPGVKAVIIDREEDAIPQIT
CCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEEECCCCEEEEEEECCCCCCCEEE
LALSKYPARNLQIVCHGEPGILYLGKTPITAPTMEGYSHLLAEWDVEDILLYACQVAGLS
EEEHHCCCCCEEEEEECCCCEEEECCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCC
NNTVNSLLARLHQLTGANIAASTHRVGSQQLDGSWELDTFIGQVNSELALLPEVVESYPG
CCHHHHHHHHHHHHCCCCEEECHHHCCCHHCCCCEEHHHHHHHCCCCHHHHHHHHHHCCC
VLATFGEPTTYPTGGLEPIYLKTGDLNNDNIPDVVTGNGESDNVSIFLGKGNGTFEVATR
EEEECCCCCCCCCCCCCEEEEEECCCCCCCCCCEEECCCCCCEEEEEEECCCCEEEEEEE
IPAGDGPTGVNIGDFNKDGFNDIVVSNFDEDTVSVFLADGMGSFLTPQTFAGIGAPTEIQ
CCCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEEECCCCCCCCCHHHHCCCCCCEEE
VADFNKDGNQDIVVTTQSRGNSIITLLGNGNGDFNQLTTQATGAWLSAKGDFNQDSILDL
EEECCCCCCCEEEEEECCCCCEEEEEEECCCCCHHHHHHHHCCCEEEECCCCCCCHHHHH
ATVQAIGGGLTSYVSIYLGNGIGGFSTPAQYNTGGNSGDVEVGNFNNDRFIDLVTTNEES
HHHHHHCCCHHHEEEEEECCCCCCCCCCCCCCCCCCCCCEEECCCCCCEEEEEEECCCCC
DNISILLGNGNGTFENPLLLDASDAPDGVAVADLNKDGFDDIAVAHNSSNNVLVFLGKGK
CCEEEEEECCCCCCCCCEEEECCCCCCCEEEEECCCCCCCCEEEEECCCCCEEEEEECCC
AKFASPIDLPTGGADARILKLSDLDSDNDLDIVVPNRDSSNISVILNTSLIGNNKNNTLK
CCCCCCCCCCCCCCCEEEEEEECCCCCCCEEEEECCCCCCCEEEEEEEEEECCCCCCCCC
GNNKANFINGVGGKDNLKGSGGNDTILGGGGNDRLDGNSGNDTLTGEAGNDSLNGGSGND
CCCCCCEEECCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEECCCCCCCCCCCCCCC
KLNGGGGNDILNGGSGRDRLDGSGGNDILNGGSSNDKLNGGGGNDKLNGGSGRDRLIGNN
CCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCC
GKDILTGGSGNDTILGGGGDDELIGGSGNDLLNGGSGDDKFIYSSRKAFNRKTFGKDRIA
CCEEEECCCCCCEEEECCCCCCEECCCCCCCCCCCCCCCCEEECCHHHHCCCCCCHHHHC
NFAPGSDKIILDKTTFTSLDSTAGESFSNDSEFEIVTNNSAASSSSAEIVYVSSTGNLYY
CCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCEEEEEECCCCEEE
NPNGSDAGFGGGGQFAKLLGRPALTDSDFLIEN
CCCCCCCCCCCCHHHHHHHCCCCCCCCCEEECC
>Mature Secondary Structure
MLNLSKNCSVGEASCLAPPPQTLVAIDSRVDNSQILLTGVKPGVKAVIIDREEDAIPQIT
CCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEEECCCCEEEEEEECCCCCCCEEE
LALSKYPARNLQIVCHGEPGILYLGKTPITAPTMEGYSHLLAEWDVEDILLYACQVAGLS
EEEHHCCCCCEEEEEECCCCEEEECCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCC
NNTVNSLLARLHQLTGANIAASTHRVGSQQLDGSWELDTFIGQVNSELALLPEVVESYPG
CCHHHHHHHHHHHHCCCCEEECHHHCCCHHCCCCEEHHHHHHHCCCCHHHHHHHHHHCCC
VLATFGEPTTYPTGGLEPIYLKTGDLNNDNIPDVVTGNGESDNVSIFLGKGNGTFEVATR
EEEECCCCCCCCCCCCCEEEEEECCCCCCCCCCEEECCCCCCEEEEEEECCCCEEEEEEE
IPAGDGPTGVNIGDFNKDGFNDIVVSNFDEDTVSVFLADGMGSFLTPQTFAGIGAPTEIQ
CCCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEEECCCCCCCCCHHHHCCCCCCEEE
VADFNKDGNQDIVVTTQSRGNSIITLLGNGNGDFNQLTTQATGAWLSAKGDFNQDSILDL
EEECCCCCCCEEEEEECCCCCEEEEEEECCCCCHHHHHHHHCCCEEEECCCCCCCHHHHH
ATVQAIGGGLTSYVSIYLGNGIGGFSTPAQYNTGGNSGDVEVGNFNNDRFIDLVTTNEES
HHHHHHCCCHHHEEEEEECCCCCCCCCCCCCCCCCCCCCEEECCCCCCEEEEEEECCCCC
DNISILLGNGNGTFENPLLLDASDAPDGVAVADLNKDGFDDIAVAHNSSNNVLVFLGKGK
CCEEEEEECCCCCCCCCEEEECCCCCCCEEEEECCCCCCCCEEEEECCCCCEEEEEECCC
AKFASPIDLPTGGADARILKLSDLDSDNDLDIVVPNRDSSNISVILNTSLIGNNKNNTLK
CCCCCCCCCCCCCCCEEEEEEECCCCCCCEEEEECCCCCCCEEEEEEEEEECCCCCCCCC
GNNKANFINGVGGKDNLKGSGGNDTILGGGGNDRLDGNSGNDTLTGEAGNDSLNGGSGND
CCCCCCEEECCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEECCCCCCCCCCCCCCC
KLNGGGGNDILNGGSGRDRLDGSGGNDILNGGSSNDKLNGGGGNDKLNGGSGRDRLIGNN
CCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCC
GKDILTGGSGNDTILGGGGDDELIGGSGNDLLNGGSGDDKFIYSSRKAFNRKTFGKDRIA
CCEEEECCCCCCEEEECCCCCCEECCCCCCCCCCCCCCCCEEECCHHHHCCCCCCHHHHC
NFAPGSDKIILDKTTFTSLDSTAGESFSNDSEFEIVTNNSAASSSSAEIVYVSSTGNLYY
CCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCEEEEEECCCCEEE
NPNGSDAGFGGGGQFAKLLGRPALTDSDFLIEN
CCCCCCCCCCCCHHHHHHHCCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2670940 [H]