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The map label for this gene is fabF [H]

Identifier: 113474322

GI number: 113474322

Start: 716384

End: 717634

Strand: Reverse

Name: fabF [H]

Synonym: Tery_0451

Alternate gene names: 113474322

Gene position: 717634-716384 (Counterclockwise)

Preceding gene: 113474323

Following gene: 113474321

Centisome position: 9.26

GC content: 41.41

Gene sequence:

>1251_bases
ATGACAAACAAAGAGCTTAAACGGGTAGTTGTCACAGGAATGGGTGCAATAACACCAATTGGCAACACTCTGTCTGAATA
TTGGGATGGTTTATTAAACGGTAAAAGTGGTGTAGACAAAATAACCCTATTTGATAGTTCTAAACACAAATGTTGTATTG
CGGCAGAGGTCAAAGGCTTTGACCCTCTTGAACATATGGATCGCAAACAGGCAAAACACATGGACCGCTTTACTCAGTTT
GCAGTTGCAGCCAGCAAACAGACAATTGCTGATGCAAAATTTGAAATCAACGATCTAAACGCAGAACAGGTGGGAGTAAT
TATTGGTACTGGGGTGGGTGGCATTAAAGTCTTAGAAGACCAGCAAGAAATATATTTAAATCGTGGCCCTAATAAGTGTA
GTCCTTTTATGATTCCGATGATGATTGCTAATATGGCCGCAGGTCTAACAGCAATTCATACTGGGGCTAAAGGACCAAAT
TCTTGTACTATGACTGCTTGTGCTTCTGGGTCAAATGCTATAGGAGATGCTTTCCGTTTGATCCAAAGAGGATATGCTCA
AGCAATGATTTGTGGTGGAACTGAATCTCCAGTAACACCTTTGGGATTAGCAGGATTTTCTTCTGTTAAGGCTTTGTCTA
CTCGTAATGATGACCCCACTTCTGCCAGTCGTCCTTTTGACCGCGATCGCGATGGCTTTGTCATGGGTGAAGGTGCAGGT
ATTCTAATCTTAGAAGAATTAGAATGTGCTCTTAGTAGGGGAGCAAGAATATATGCAGAGATGGTCGGTTATGGTATGAC
CTGTGATGCCTATCACATGACTTCCCCAGTACCTGATGGAGAGGGGGCAACTAGAGCTATCCAATTAGCAATGAAAGACG
CTGGCTTAACTCCTGCACAAATTAGTTATATAAATGCTCATGGTACCAGTACACGAGCAAACGATACAACAGAAACAAAA
GCCATCAAAAAGGTACTAGGAGAAAGTGCCTCTCAGGTAGCAATTAGTTCAACTAAGTCAATGACTGGCCATTTATTGGG
TGGCTCTGGAGGTATTGAAGCGATCGCTACAGTAATGGCGATCGCCAATGATAAAATCCCACCAACTATTAATTTGGATA
ATCCTGATCCAGAGTGTGACCTAGATTATGTCCCCAAAAAAAGTCGCTCTCAAATAATAGAAGTAGCTTTATCTAATTCA
TTTGGATTTGGAGGCCATAATGTGACTCTGGCATTTAAAAAATATCGATAA

Upstream 100 bases:

>100_bases
TCCAGTTCAAGAAGTATAACGCTATAAAACGTCTAAGCCCAAAGTTTCTGGGTTCTGGGTTCTACGTGTGGAATTTCTGA
AAACTAAAAATAAAAAAAAT

Downstream 100 bases:

>100_bases
ATACTAAAAGAAGGTTTATAGTTTGGAATCTAAAGCTAATAATCATACCTGAATATAACATTTAGCTCGTGATTAGGGAT
GCTGACGATCAAATCATCTT

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MTNKELKRVVVTGMGAITPIGNTLSEYWDGLLNGKSGVDKITLFDSSKHKCCIAAEVKGFDPLEHMDRKQAKHMDRFTQF
AVAASKQTIADAKFEINDLNAEQVGVIIGTGVGGIKVLEDQQEIYLNRGPNKCSPFMIPMMIANMAAGLTAIHTGAKGPN
SCTMTACASGSNAIGDAFRLIQRGYAQAMICGGTESPVTPLGLAGFSSVKALSTRNDDPTSASRPFDRDRDGFVMGEGAG
ILILEELECALSRGARIYAEMVGYGMTCDAYHMTSPVPDGEGATRAIQLAMKDAGLTPAQISYINAHGTSTRANDTTETK
AIKKVLGESASQVAISSTKSMTGHLLGGSGGIEAIATVMAIANDKIPPTINLDNPDPECDLDYVPKKSRSQIIEVALSNS
FGFGGHNVTLAFKKYR

Sequences:

>Translated_416_residues
MTNKELKRVVVTGMGAITPIGNTLSEYWDGLLNGKSGVDKITLFDSSKHKCCIAAEVKGFDPLEHMDRKQAKHMDRFTQF
AVAASKQTIADAKFEINDLNAEQVGVIIGTGVGGIKVLEDQQEIYLNRGPNKCSPFMIPMMIANMAAGLTAIHTGAKGPN
SCTMTACASGSNAIGDAFRLIQRGYAQAMICGGTESPVTPLGLAGFSSVKALSTRNDDPTSASRPFDRDRDGFVMGEGAG
ILILEELECALSRGARIYAEMVGYGMTCDAYHMTSPVPDGEGATRAIQLAMKDAGLTPAQISYINAHGTSTRANDTTETK
AIKKVLGESASQVAISSTKSMTGHLLGGSGGIEAIATVMAIANDKIPPTINLDNPDPECDLDYVPKKSRSQIIEVALSNS
FGFGGHNVTLAFKKYR
>Mature_415_residues
TNKELKRVVVTGMGAITPIGNTLSEYWDGLLNGKSGVDKITLFDSSKHKCCIAAEVKGFDPLEHMDRKQAKHMDRFTQFA
VAASKQTIADAKFEINDLNAEQVGVIIGTGVGGIKVLEDQQEIYLNRGPNKCSPFMIPMMIANMAAGLTAIHTGAKGPNS
CTMTACASGSNAIGDAFRLIQRGYAQAMICGGTESPVTPLGLAGFSSVKALSTRNDDPTSASRPFDRDRDGFVMGEGAGI
LILEELECALSRGARIYAEMVGYGMTCDAYHMTSPVPDGEGATRAIQLAMKDAGLTPAQISYINAHGTSTRANDTTETKA
IKKVLGESASQVAISSTKSMTGHLLGGSGGIEAIATVMAIANDKIPPTINLDNPDPECDLDYVPKKSRSQIIEVALSNSF
GFGGHNVTLAFKKYR

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=415, Percent_Identity=46.0240963855422, Blast_Score=354, Evalue=9e-98,
Organism=Homo sapiens, GI223972627, Length=145, Percent_Identity=53.1034482758621, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI41872631, Length=430, Percent_Identity=25.8139534883721, Blast_Score=117, Evalue=1e-26,
Organism=Escherichia coli, GI1787337, Length=410, Percent_Identity=50.4878048780488, Blast_Score=399, Evalue=1e-112,
Organism=Escherichia coli, GI1788663, Length=415, Percent_Identity=36.6265060240964, Blast_Score=226, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI71983541, Length=417, Percent_Identity=35.9712230215827, Blast_Score=264, Evalue=6e-71,
Organism=Caenorhabditis elegans, GI71983535, Length=264, Percent_Identity=40.530303030303, Blast_Score=205, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI212642053, Length=357, Percent_Identity=25.4901960784314, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17550940, Length=425, Percent_Identity=23.0588235294118, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320904, Length=446, Percent_Identity=36.9955156950673, Blast_Score=273, Evalue=3e-74,
Organism=Drosophila melanogaster, GI24644341, Length=423, Percent_Identity=43.7352245862884, Blast_Score=343, Evalue=1e-94,
Organism=Drosophila melanogaster, GI221330659, Length=430, Percent_Identity=24.1860465116279, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI19920632, Length=430, Percent_Identity=24.1860465116279, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24581345, Length=429, Percent_Identity=23.7762237762238, Blast_Score=89, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44085; Mature: 43954

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNKELKRVVVTGMGAITPIGNTLSEYWDGLLNGKSGVDKITLFDSSKHKCCIAAEVKGF
CCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCCEEEEEECCCC
DPLEHMDRKQAKHMDRFTQFAVAASKQTIADAKFEINDLNAEQVGVIIGTGVGGIKVLED
CHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCEEEEECCCCCCEEEEEECCCCCEEEECC
QQEIYLNRGPNKCSPFMIPMMIANMAAGLTAIHTGAKGPNSCTMTACASGSNAIGDAFRL
CHHHEEECCCCCCCCCHHHHHHHHHHHCHHEEECCCCCCCCEEEEEECCCCCHHHHHHHH
IQRGYAQAMICGGTESPVTPLGLAGFSSVKALSTRNDDPTSASRPFDRDRDGFVMGEGAG
HHHCCCCEEEECCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCC
ILILEELECALSRGARIYAEMVGYGMTCDAYHMTSPVPDGEGATRAIQLAMKDAGLTPAQ
EEEEHHHHHHHHCCHHHHHHHHCCCCCCCCEECCCCCCCCCCCHHHEEEEHHHCCCCCHH
ISYINAHGTSTRANDTTETKAIKKVLGESASQVAISSTKSMTGHLLGGSGGIEAIATVMA
EEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCEEECCCCCCCEEEECCCCCHHHHHHHHH
IANDKIPPTINLDNPDPECDLDYVPKKSRSQIIEVALSNSFGFGGHNVTLAFKKYR
HHCCCCCCEEECCCCCCCCCCCCCCCHHHHHEEEEEECCCCCCCCCEEEEEEEECC
>Mature Secondary Structure 
TNKELKRVVVTGMGAITPIGNTLSEYWDGLLNGKSGVDKITLFDSSKHKCCIAAEVKGF
CCHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCCEEEEEECCCC
DPLEHMDRKQAKHMDRFTQFAVAASKQTIADAKFEINDLNAEQVGVIIGTGVGGIKVLED
CHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCEEEEECCCCCCEEEEEECCCCCEEEECC
QQEIYLNRGPNKCSPFMIPMMIANMAAGLTAIHTGAKGPNSCTMTACASGSNAIGDAFRL
CHHHEEECCCCCCCCCHHHHHHHHHHHCHHEEECCCCCCCCEEEEEECCCCCHHHHHHHH
IQRGYAQAMICGGTESPVTPLGLAGFSSVKALSTRNDDPTSASRPFDRDRDGFVMGEGAG
HHHCCCCEEEECCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCC
ILILEELECALSRGARIYAEMVGYGMTCDAYHMTSPVPDGEGATRAIQLAMKDAGLTPAQ
EEEEHHHHHHHHCCHHHHHHHHCCCCCCCCEECCCCCCCCCCCHHHEEEEHHHCCCCCHH
ISYINAHGTSTRANDTTETKAIKKVLGESASQVAISSTKSMTGHLLGGSGGIEAIATVMA
EEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCEEECCCCCCCEEEECCCCCHHHHHHHHH
IANDKIPPTINLDNPDPECDLDYVPKKSRSQIIEVALSNSFGFGGHNVTLAFKKYR
HHCCCCCCEEECCCCCCCCCCCCCCCHHHHHEEEEEECCCCCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231; 11152607 [H]