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The map label for this gene is ndhD2 [H]

Identifier: 113474232

GI number: 113474232

Start: 540346

End: 541866

Strand: Reverse

Name: ndhD2 [H]

Synonym: Tery_0349

Alternate gene names: 113474232

Gene position: 541866-540346 (Counterclockwise)

Preceding gene: 113474234

Following gene: 113474231

Centisome position: 6.99

GC content: 37.41

Gene sequence:

>1521_bases
ATGCTCAATAGTCTCATCTTAGTACCACTAATTGGTGCTGGTATTATTGGTTTTTGGCCAAGTTACCTATCGCCAAAATT
GGCCCGCCAACTAGCTTTAATAGTGGCCATCATTAGTCTTTTATGGTCTTTGGTGTTACTTACCCAATTCAATACACAAG
ATCCAAATCAACAATTTGTTGTTATGGTTCCCTGGATAGATTCCCTAGGCCTAAACTACTCCTTAGGAATAGACGGTTTA
TCTCTACCATTAGTGGTATTAAACGGTATATTAACCACTATTGCCATATATGCTACAGATGAATCAATTAATAGACCTCG
TTTTTATTACTCCTTAATATTATTATTGGCCCTTAGTGTATTTGGAGCCTTTCTTGCTCAAGATTTACTACTGTTTTTCC
TGTTTTATGAACTCGAACTTATTCCTTTATACCTATTAATTGCAATTTGGGGAGGACTAAAACGGGGTTACGCATCCACT
AAATTTCTTATTTATACAGCAATTTCAGGAATCCTAATCTTAGTAGGCTTTCTTGGAGTAGTTTGGTTAAGTGGTTCGTC
AAATTTTGCTTATGACCAAGCAGTTGTCCATACTCTACCTTTAGGAACTCAACTATTATTATTAGGAGCAATAGTTGTCG
GGTTTGGAATTAAAATTCCCCTAGTTCCCTTTCATACATGGTTGCCAGATGCCCATGTTGAAGCCTCTACACCAGTTTCT
GTACTCTTAGCAGGAGTACTATTAAAATTAGGAACTTATGGTTTGCTAAGATTTGGATTAAATATGTTTCCTGAAGCTTG
GGCAGATGTTTCTCCCTGGTTAGCAGTGTGGGCTGTAGTAAGTGTAATTTACGGTTCACTTAATGCGATCGCTCAAAAAG
ACATGAAAAAAATGGTGGCTTATAGTTCAGTTGGTCACATGGGTTACATTTTGTTAGCTAGTGCAGCAGCAACTCCCCTC
AGTATCTTGGGCACAGTTTTTCAAATGATTAGCCACGGTCTAATTTCAGGCCTACTATTTTTATTAGTGGGAATAGTCTA
CAAAAAAGCTGGTACAAGGGATATAGATTTATTGCGAGGTCTATTAAACCCAGAACAAGGTTTACCAATGGTTGGCAGTC
TCATGATTTTAGGAGTAATGGCAAGTGCTGGTATTCCAGGAATGGTTGGATTTATTTCTGAATTTTTAGTATTTAGAGGC
AGTTTTAATGCTTTTAGAATTCCAACTCTATTGTGTATGATTGGAACAGGATTAACATCAGCCTATTTCTTGCTTTTAAT
TAACCGAGTATTTTTTGGTAGGTTATCTGAAACAGTAATCAATCTGCCTCCAGTAAAATGGTCTGATAGAATACCAGCAA
TTGTTTTAGCAGTTATGATCGTTGTTCTAGGAATACAGCCTAATTGGGTGGTGCGTTGGACTGAAACTGAAGCAAATAGT
ATGAGCACTAGTAAAACTACAGTCTCACAGGTAGTTAACAAATCTGCGATCGCTACCCCATCTCCATTTCAAGGAAGTTA
A

Upstream 100 bases:

>100_bases
CTTATAATCTGCTTTTAGACACAAAGAATACTATTATATTGTAATAAGTTATTTGTAGTTAATCAATTTGTATCTTGACG
TTAAAGGAAAATATAAATAA

Downstream 100 bases:

>100_bases
AAGTCATGCATTAAGATTTTACAGTTTCAACACTAAGAAAAATTTTGCTCAGAATTCTTAGTAAGTAGGTCTACTTAATT
ATTAGTACAATAGCAAGAAA

Product: NAD(P)H-quinone oxidoreductase subunit D4

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase I, chain 4 2; NDH-1, chain 4 2 [H]

Number of amino acids: Translated: 506; Mature: 506

Protein sequence:

>506_residues
MLNSLILVPLIGAGIIGFWPSYLSPKLARQLALIVAIISLLWSLVLLTQFNTQDPNQQFVVMVPWIDSLGLNYSLGIDGL
SLPLVVLNGILTTIAIYATDESINRPRFYYSLILLLALSVFGAFLAQDLLLFFLFYELELIPLYLLIAIWGGLKRGYAST
KFLIYTAISGILILVGFLGVVWLSGSSNFAYDQAVVHTLPLGTQLLLLGAIVVGFGIKIPLVPFHTWLPDAHVEASTPVS
VLLAGVLLKLGTYGLLRFGLNMFPEAWADVSPWLAVWAVVSVIYGSLNAIAQKDMKKMVAYSSVGHMGYILLASAAATPL
SILGTVFQMISHGLISGLLFLLVGIVYKKAGTRDIDLLRGLLNPEQGLPMVGSLMILGVMASAGIPGMVGFISEFLVFRG
SFNAFRIPTLLCMIGTGLTSAYFLLLINRVFFGRLSETVINLPPVKWSDRIPAIVLAVMIVVLGIQPNWVVRWTETEANS
MSTSKTTVSQVVNKSAIATPSPFQGS

Sequences:

>Translated_506_residues
MLNSLILVPLIGAGIIGFWPSYLSPKLARQLALIVAIISLLWSLVLLTQFNTQDPNQQFVVMVPWIDSLGLNYSLGIDGL
SLPLVVLNGILTTIAIYATDESINRPRFYYSLILLLALSVFGAFLAQDLLLFFLFYELELIPLYLLIAIWGGLKRGYAST
KFLIYTAISGILILVGFLGVVWLSGSSNFAYDQAVVHTLPLGTQLLLLGAIVVGFGIKIPLVPFHTWLPDAHVEASTPVS
VLLAGVLLKLGTYGLLRFGLNMFPEAWADVSPWLAVWAVVSVIYGSLNAIAQKDMKKMVAYSSVGHMGYILLASAAATPL
SILGTVFQMISHGLISGLLFLLVGIVYKKAGTRDIDLLRGLLNPEQGLPMVGSLMILGVMASAGIPGMVGFISEFLVFRG
SFNAFRIPTLLCMIGTGLTSAYFLLLINRVFFGRLSETVINLPPVKWSDRIPAIVLAVMIVVLGIQPNWVVRWTETEANS
MSTSKTTVSQVVNKSAIATPSPFQGS
>Mature_506_residues
MLNSLILVPLIGAGIIGFWPSYLSPKLARQLALIVAIISLLWSLVLLTQFNTQDPNQQFVVMVPWIDSLGLNYSLGIDGL
SLPLVVLNGILTTIAIYATDESINRPRFYYSLILLLALSVFGAFLAQDLLLFFLFYELELIPLYLLIAIWGGLKRGYAST
KFLIYTAISGILILVGFLGVVWLSGSSNFAYDQAVVHTLPLGTQLLLLGAIVVGFGIKIPLVPFHTWLPDAHVEASTPVS
VLLAGVLLKLGTYGLLRFGLNMFPEAWADVSPWLAVWAVVSVIYGSLNAIAQKDMKKMVAYSSVGHMGYILLASAAATPL
SILGTVFQMISHGLISGLLFLLVGIVYKKAGTRDIDLLRGLLNPEQGLPMVGSLMILGVMASAGIPGMVGFISEFLVFRG
SFNAFRIPTLLCMIGTGLTSAYFLLLINRVFFGRLSETVINLPPVKWSDRIPAIVLAVMIVVLGIQPNWVVRWTETEANS
MSTSKTTVSQVVNKSAIATPSPFQGS

Specific function: NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton tran

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cellular thylakoid membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=350, Percent_Identity=32, Blast_Score=152, Evalue=8e-37,
Organism=Homo sapiens, GI251831117, Length=337, Percent_Identity=27.0029673590504, Blast_Score=79, Evalue=9e-15,
Organism=Escherichia coli, GI1788613, Length=452, Percent_Identity=38.4955752212389, Blast_Score=282, Evalue=3e-77,
Organism=Escherichia coli, GI1788829, Length=480, Percent_Identity=28.9583333333333, Blast_Score=118, Evalue=1e-27,
Organism=Escherichia coli, GI1788827, Length=303, Percent_Identity=30.03300330033, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1788831, Length=368, Percent_Identity=28.5326086956522, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI145693160, Length=414, Percent_Identity=28.2608695652174, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI2367154, Length=324, Percent_Identity=26.8518518518519, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1788614, Length=424, Percent_Identity=26.6509433962264, Blast_Score=76, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022997
- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: 1.6.5.3

Molecular weight: Translated: 54840; Mature: 54840

Theoretical pI: Translated: 9.25; Mature: 9.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNSLILVPLIGAGIIGFWPSYLSPKLARQLALIVAIISLLWSLVLLTQFNTQDPNQQFV
CCCCEEHHHHHHHHHHHHCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
VMVPWIDSLGLNYSLGIDGLSLPLVVLNGILTTIAIYATDESINRPRFYYSLILLLALSV
EEEECHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHH
FGAFLAQDLLLFFLFYELELIPLYLLIAIWGGLKRGYASTKFLIYTAISGILILVGFLGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
VWLSGSSNFAYDQAVVHTLPLGTQLLLLGAIVVGFGIKIPLVPFHTWLPDAHVEASTPVS
HEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCEEHHHCCCCCCCCCCCCHH
VLLAGVLLKLGTYGLLRFGLNMFPEAWADVSPWLAVWAVVSVIYGSLNAIAQKDMKKMVA
HHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YSSVGHMGYILLASAAATPLSILGTVFQMISHGLISGLLFLLVGIVYKKAGTRDIDLLRG
HHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
LLNPEQGLPMVGSLMILGVMASAGIPGMVGFISEFLVFRGSFNAFRIPTLLCMIGTGLTS
HCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHH
AYFLLLINRVFFGRLSETVINLPPVKWSDRIPAIVLAVMIVVLGIQPNWVVRWTETEANS
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCC
MSTSKTTVSQVVNKSAIATPSPFQGS
CCCHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MLNSLILVPLIGAGIIGFWPSYLSPKLARQLALIVAIISLLWSLVLLTQFNTQDPNQQFV
CCCCEEHHHHHHHHHHHHCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
VMVPWIDSLGLNYSLGIDGLSLPLVVLNGILTTIAIYATDESINRPRFYYSLILLLALSV
EEEECHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHH
FGAFLAQDLLLFFLFYELELIPLYLLIAIWGGLKRGYASTKFLIYTAISGILILVGFLGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
VWLSGSSNFAYDQAVVHTLPLGTQLLLLGAIVVGFGIKIPLVPFHTWLPDAHVEASTPVS
HEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCEEHHHCCCCCCCCCCCCHH
VLLAGVLLKLGTYGLLRFGLNMFPEAWADVSPWLAVWAVVSVIYGSLNAIAQKDMKKMVA
HHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YSSVGHMGYILLASAAATPLSILGTVFQMISHGLISGLLFLLVGIVYKKAGTRDIDLLRG
HHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
LLNPEQGLPMVGSLMILGVMASAGIPGMVGFISEFLVFRGSFNAFRIPTLLCMIGTGLTS
HCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHH
AYFLLLINRVFFGRLSETVINLPPVKWSDRIPAIVLAVMIVVLGIQPNWVVRWTETEANS
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCC
MSTSKTTVSQVVNKSAIATPSPFQGS
CCCHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12240834 [H]