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The map label for this gene is kbl [C]

Identifier: 113474234

GI number: 113474234

Start: 544282

End: 545463

Strand: Reverse

Name: kbl [C]

Synonym: Tery_0352

Alternate gene names: 113474234

Gene position: 545463-544282 (Counterclockwise)

Preceding gene: 113474238

Following gene: 113474232

Centisome position: 7.04

GC content: 33.16

Gene sequence:

>1182_bases
ATGCAAAATAACCCCTATAGTTGGATAGAGTCATCCCTATCAACAATACATAAAGCTAACTGGTATCGTTCGGTCAAAAC
TATTGAAAGTATTCCCGGTGCAATAATTAAATTAGAAGGAAAAAAACTAATAAATTTTGCCAGTAATGATTATCTAGGAT
TAGCAGGAGATGAACGTTTAATCGCAGCAGCTATACAAGCAACAAAAGAATTTGGTAGCGGTAGTACAGGCTCGCGTTTA
TTAACAGGTCATCGAGAAATACATCAGGAATTAGAACGAGAAATAGCCAAATTAAAACAAACAGAATCAGCATTAGTATT
TAGTTCAGGATATTTAGCAAATATTGGTGTAATCTCTTCGGTTGTCAGTCAACGTGACCTAATTTTATCAGATGAATATA
ATCATTCTAGCCTGAAAAATGGAGCTATTCTTAGTGGTGCCAAAATTATCGAATATAGCCACAATAATATTGAATATTTA
AAAAATAAATTAGAACAAAAACGAGAAAATTATCGCCGCAGTTTAATAATTACAGATAGTGTTTTTAGTATGGATGGTGA
TTTATGTAAATTGCCATTGTTATTAGATTTAGCAGAAAAATATAATAGTATGCTTTTAGTAGATGAAGCTCATGCAACAG
GAGTATTTGGAATTAATGGAGGAGGTTGTGTTGAACACTTTAACTGTACAGGAAAACAATTAATTCAAATTGGTACTTTG
AGTAAAGCATTAGGAAGTTTAGGCGGCTATGTTGCCGGGTCAAAAAATTTAATAGAATTTCTCAGAAATAGAACACCCAC
TTGGATATATACCACAGGTTTAACTCCTGCTGATACTGCAGCAGCTTTAACAGCTATAAAAATTATTAAAAAAGAGCCAG
AACGTCGTATGAAACTATGGCAGAATTTAGAGATTTTTATTAATTTACTAGAAACAGAAAGTCAATTGTTACACAAAGGT
AAGAAAACCTCTAATTATGAATCACCAATTATTTGTTTTCCCCTTAAAAATGCAGTCGAAGCATTGAAAGTTGGAGAAAA
GTTAAAACAGGAAGGAATATTTGCTCCTGCCATTCGCCCGCCTACTGTTAATACCAGTCGCATTCGTATTTCTCTAATGT
CTACCCATGAAACAAGTCATCTTCAGCAATTAATAGCTGCATTAATTAATTTGAGTCAGTGA

Upstream 100 bases:

>100_bases
CCTTAAAAATGTTAAGTGATAAATAATTTAATTTTTGGCCACTCCCTACTTTATTCTCTCTACTCCCTATTTCTTATTCC
ATATTTCCTATTCCTTAAAA

Downstream 100 bases:

>100_bases
TACCAATTCCAGAAAATAGCCCAAGGCCTTACTCAAAATTTTAGTTATTAAGTAATAAGTAAATAATAACGATATCTTTA
ATAATTATAGGCGAAAAGCG

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MQNNPYSWIESSLSTIHKANWYRSVKTIESIPGAIIKLEGKKLINFASNDYLGLAGDERLIAAAIQATKEFGSGSTGSRL
LTGHREIHQELEREIAKLKQTESALVFSSGYLANIGVISSVVSQRDLILSDEYNHSSLKNGAILSGAKIIEYSHNNIEYL
KNKLEQKRENYRRSLIITDSVFSMDGDLCKLPLLLDLAEKYNSMLLVDEAHATGVFGINGGGCVEHFNCTGKQLIQIGTL
SKALGSLGGYVAGSKNLIEFLRNRTPTWIYTTGLTPADTAAALTAIKIIKKEPERRMKLWQNLEIFINLLETESQLLHKG
KKTSNYESPIICFPLKNAVEALKVGEKLKQEGIFAPAIRPPTVNTSRIRISLMSTHETSHLQQLIAALINLSQ

Sequences:

>Translated_393_residues
MQNNPYSWIESSLSTIHKANWYRSVKTIESIPGAIIKLEGKKLINFASNDYLGLAGDERLIAAAIQATKEFGSGSTGSRL
LTGHREIHQELEREIAKLKQTESALVFSSGYLANIGVISSVVSQRDLILSDEYNHSSLKNGAILSGAKIIEYSHNNIEYL
KNKLEQKRENYRRSLIITDSVFSMDGDLCKLPLLLDLAEKYNSMLLVDEAHATGVFGINGGGCVEHFNCTGKQLIQIGTL
SKALGSLGGYVAGSKNLIEFLRNRTPTWIYTTGLTPADTAAALTAIKIIKKEPERRMKLWQNLEIFINLLETESQLLHKG
KKTSNYESPIICFPLKNAVEALKVGEKLKQEGIFAPAIRPPTVNTSRIRISLMSTHETSHLQQLIAALINLSQ
>Mature_393_residues
MQNNPYSWIESSLSTIHKANWYRSVKTIESIPGAIIKLEGKKLINFASNDYLGLAGDERLIAAAIQATKEFGSGSTGSRL
LTGHREIHQELEREIAKLKQTESALVFSSGYLANIGVISSVVSQRDLILSDEYNHSSLKNGAILSGAKIIEYSHNNIEYL
KNKLEQKRENYRRSLIITDSVFSMDGDLCKLPLLLDLAEKYNSMLLVDEAHATGVFGINGGGCVEHFNCTGKQLIQIGTL
SKALGSLGGYVAGSKNLIEFLRNRTPTWIYTTGLTPADTAAALTAIKIIKKEPERRMKLWQNLEIFINLLETESQLLHKG
KKTSNYESPIICFPLKNAVEALKVGEKLKQEGIFAPAIRPPTVNTSRIRISLMSTHETSHLQQLIAALINLSQ

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family

Homologues:

Organism=Homo sapiens, GI7657118, Length=390, Percent_Identity=31.025641025641, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI284448556, Length=416, Percent_Identity=29.0865384615385, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI4758668, Length=397, Percent_Identity=30.9823677581864, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI83977442, Length=354, Percent_Identity=30.5084745762712, Blast_Score=168, Evalue=6e-42,
Organism=Homo sapiens, GI83977440, Length=354, Percent_Identity=30.5084745762712, Blast_Score=168, Evalue=7e-42,
Organism=Homo sapiens, GI83977444, Length=381, Percent_Identity=29.9212598425197, Blast_Score=168, Evalue=7e-42,
Organism=Homo sapiens, GI119220554, Length=364, Percent_Identity=29.9450549450549, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI4502025, Length=356, Percent_Identity=30.3370786516854, Blast_Score=155, Evalue=6e-38,
Organism=Homo sapiens, GI40316939, Length=356, Percent_Identity=30.3370786516854, Blast_Score=155, Evalue=6e-38,
Organism=Homo sapiens, GI5454084, Length=265, Percent_Identity=30.188679245283, Blast_Score=125, Evalue=9e-29,
Organism=Escherichia coli, GI1790046, Length=398, Percent_Identity=33.1658291457286, Blast_Score=224, Evalue=5e-60,
Organism=Escherichia coli, GI1786993, Length=363, Percent_Identity=31.129476584022, Blast_Score=166, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI71994529, Length=397, Percent_Identity=33.7531486146096, Blast_Score=218, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI32566772, Length=397, Percent_Identity=28.2115869017632, Blast_Score=168, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI17560914, Length=414, Percent_Identity=27.7777777777778, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17560912, Length=414, Percent_Identity=27.7777777777778, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI71982617, Length=274, Percent_Identity=28.1021897810219, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71982625, Length=274, Percent_Identity=28.1021897810219, Blast_Score=135, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6320438, Length=418, Percent_Identity=31.3397129186603, Blast_Score=159, Evalue=6e-40,
Organism=Saccharomyces cerevisiae, GI6320267, Length=259, Percent_Identity=32.4324324324324, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6323954, Length=254, Percent_Identity=28.3464566929134, Blast_Score=119, Evalue=8e-28,
Organism=Drosophila melanogaster, GI24662918, Length=388, Percent_Identity=30.9278350515464, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI17137420, Length=354, Percent_Identity=31.0734463276836, Blast_Score=161, Evalue=8e-40,
Organism=Drosophila melanogaster, GI17136286, Length=319, Percent_Identity=30.7210031347962, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24653280, Length=339, Percent_Identity=27.4336283185841, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI24653276, Length=339, Percent_Identity=27.4336283185841, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI24653278, Length=339, Percent_Identity=27.4336283185841, Blast_Score=145, Evalue=5e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BIKB_TRIEI (Q119K2)

Other databases:

- EMBL:   CP000393
- RefSeq:   YP_720295.1
- ProteinModelPortal:   Q119K2
- SMR:   Q119K2
- STRING:   Q119K2
- GeneID:   4242528
- GenomeReviews:   CP000393_GR
- KEGG:   ter:Tery_0352
- NMPDR:   fig|203124.1.peg.2452
- eggNOG:   COG0156
- HOGENOM:   HBG649839
- OMA:   ANWYRSV
- PhylomeDB:   Q119K2
- ProtClustDB:   PRK05958
- BioCyc:   TERY203124:TERY_0352-MONOMER
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR00858

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.3.1.29; =2.3.1.47

Molecular weight: Translated: 43484; Mature: 43484

Theoretical pI: Translated: 9.17; Mature: 9.17

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: BINDING 23-23 BINDING 135-135 BINDING 183-183 BINDING 362-362

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNNPYSWIESSLSTIHKANWYRSVKTIESIPGAIIKLEGKKLINFASNDYLGLAGDERL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEECCCCEEECCCCHHH
IAAAIQATKEFGSGSTGSRLLTGHREIHQELEREIAKLKQTESALVFSSGYLANIGVISS
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHH
VVSQRDLILSDEYNHSSLKNGAILSGAKIIEYSHNNIEYLKNKLEQKRENYRRSLIITDS
HHHHCCEEEECCCCCCCCCCCCEECCCEEEEECCCCHHHHHHHHHHHHHHHHCEEEEEEH
VFSMDGDLCKLPLLLDLAEKYNSMLLVDEAHATGVFGINGGGCVEHFNCTGKQLIQIGTL
HHHCCCCHHHHHHHHHHHHHHCCEEEEEECCCCEEEECCCCCCEEECCCCHHHHHHHHHH
SKALGSLGGYVAGSKNLIEFLRNRTPTWIYTTGLTPADTAAALTAIKIIKKEPERRMKLW
HHHHHHHCCCCCCCHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHHH
QNLEIFINLLETESQLLHKGKKTSNYESPIICFPLKNAVEALKVGEKLKQEGIFAPAIRP
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCC
PTVNTSRIRISLMSTHETSHLQQLIAALINLSQ
CCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQNNPYSWIESSLSTIHKANWYRSVKTIESIPGAIIKLEGKKLINFASNDYLGLAGDERL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEECCCCEEECCCCHHH
IAAAIQATKEFGSGSTGSRLLTGHREIHQELEREIAKLKQTESALVFSSGYLANIGVISS
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHH
VVSQRDLILSDEYNHSSLKNGAILSGAKIIEYSHNNIEYLKNKLEQKRENYRRSLIITDS
HHHHCCEEEECCCCCCCCCCCCEECCCEEEEECCCCHHHHHHHHHHHHHHHHCEEEEEEH
VFSMDGDLCKLPLLLDLAEKYNSMLLVDEAHATGVFGINGGGCVEHFNCTGKQLIQIGTL
HHHCCCCHHHHHHHHHHHHHHCCEEEEEECCCCEEEECCCCCCEEECCCCHHHHHHHHHH
SKALGSLGGYVAGSKNLIEFLRNRTPTWIYTTGLTPADTAAALTAIKIIKKEPERRMKLW
HHHHHHHCCCCCCCHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHHH
QNLEIFINLLETESQLLHKGKKTSNYESPIICFPLKNAVEALKVGEKLKQEGIFAPAIRP
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCC
PTVNTSRIRISLMSTHETSHLQQLIAALINLSQ
CCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA