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The map label for this gene is pepA

Identifier: 113473990

GI number: 113473990

Start: 94683

End: 96173

Strand: Direct

Name: pepA

Synonym: Tery_0069

Alternate gene names: 113473990

Gene position: 94683-96173 (Clockwise)

Preceding gene: 113473989

Following gene: 113473992

Centisome position: 1.22

GC content: 39.77

Gene sequence:

>1491_bases
ATGGAAATTAAAGTAGGTAACATACCTCAGTTGAAATGGGCCGGAGATGCTCTAGCTATTGGTTTATTTGAAGATGCTAT
AAAATTAACTGAAGATGCTATAGAATTAACTGAGGAAATGGCCGAATTGGACGAAATGCTATCTGGTACTTTATCTGAAT
TAATTAAAGAAACAGAATTTAAAGGTAAAGCGAATAGCAGTGTCTCAACTCGTGTCGGTATAAAAACCTCTATTCGGAAA
ATTATTGTAGTTGGCCTAGGTAAATTAGAGAAGTTCAAATTAGATTCTCTGCGCCAAGCTGCAGCTACCTGTGGACGCTT
GGCAAAAAAGGAGAGATGTAAAACTTTAGGGATTAGCCTGCCAATGTGTCAGGATGCTGATTCTACAGCTATAGCTATTA
CAGAGGGTATTGAGTTAGCCCTCCATCAAGATAATCGTTTTAAATCTGAACCAGAAAATCTAGGGCCAGATCTAGAAAAA
GTGGAGTTAATTGGTTTGGCTGCTTCTGATGAAGCGATCGCCCATGCTCGAAAAATCTGTTCAGGAGTCATCTTTGCCAG
AGAACTTGTAGCAGCTCCTGCTAATTCCTGTACCCCAATAACTATGGCTGAAACTGCTCAGACCTTAGCTAAAGAGTTTG
GTCTAACTCTAGAAATTTTAGAAAAAGAAGATTGTGAAAAACTAGGAATGGGAGCTTTTCTTGGAGTTGCTCAAGGTTCT
GACTTGCCACCAAAATTCATTCATGTAACTTATAAACCAGAAGTTACTCCTCGTCGCAAGCTAGCAATAGTAGGAAAAGG
TTTAACTTTTGACTCTGGTGGGTTAAACTTAAAAGTCTCTGGTAGTGGCATTGAAATGATGAAAATTGATATGGGTGGTG
CAGGTACAACTTTTGGTACTATTAAGGCGATCGCTCAGTTAAAACCAGATGTAGAAGTTCATTTTATCAGTGCTGTAACT
GAAAATATGGTTAGTGGTCACGCCATACATCCCGGTGACTTTCTGACTGCTTCCAATGGTAAAATTATTGAAGTTAATAA
TACAGATGCAGAGGGACGTTTGACTTTGGCAGATGCATTAGTCTTTGCTGAAAAGTTGGGAGTAGATGCAATTATAGATT
TAGCGACTCTCACAGGTGCTTGTGTTGTGGCATTAGGTAATGATATTGCTGGTCTGTGGAGCCCTAATGATAATTTAGCT
GCAGAAATAACAGCAGCAGCAGAAAAAGCTGGAGAGAAAATGTGGCGGATGCCTTTGGAGGAGAAATATTTCGAGGGTTT
GAAAGCTATGCATGCTGATATGAAGAATACCGGTCCTCGCCCTGGTGGTGCTATTACTGCAGCTTTATTTTTGAAGCAAT
TTGTTAAAAATACGCCTTGGGCACATTTAGATATTGCCGGTCCGGTTTGGGTAGATACAGAAAATGGTTACAATAATCAA
GGTGCAACTGGTTATGGTGTTCGGACTCTAGTGAATTGGATTTTGAGTTAG

Upstream 100 bases:

>100_bases
ATGCCTCAAGCCATTCTACTGTAGATGAAAGGCGCAAAGCAAATATATTAGCAAGACAGATTAAGATAATCTACTTATAA
ACACTTAAGAAAAAATCAAC

Downstream 100 bases:

>100_bases
TGGGAATTAGACAAAACAGTAGCAGAAAATATACTCAAGTATAGACAAGTAAAAGTTTTGACGTCAAAAACATATAAATC
CTTAATAAGTATGGGTTTTA

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 496; Mature: 496

Protein sequence:

>496_residues
MEIKVGNIPQLKWAGDALAIGLFEDAIKLTEDAIELTEEMAELDEMLSGTLSELIKETEFKGKANSSVSTRVGIKTSIRK
IIVVGLGKLEKFKLDSLRQAAATCGRLAKKERCKTLGISLPMCQDADSTAIAITEGIELALHQDNRFKSEPENLGPDLEK
VELIGLAASDEAIAHARKICSGVIFARELVAAPANSCTPITMAETAQTLAKEFGLTLEILEKEDCEKLGMGAFLGVAQGS
DLPPKFIHVTYKPEVTPRRKLAIVGKGLTFDSGGLNLKVSGSGIEMMKIDMGGAGTTFGTIKAIAQLKPDVEVHFISAVT
ENMVSGHAIHPGDFLTASNGKIIEVNNTDAEGRLTLADALVFAEKLGVDAIIDLATLTGACVVALGNDIAGLWSPNDNLA
AEITAAAEKAGEKMWRMPLEEKYFEGLKAMHADMKNTGPRPGGAITAALFLKQFVKNTPWAHLDIAGPVWVDTENGYNNQ
GATGYGVRTLVNWILS

Sequences:

>Translated_496_residues
MEIKVGNIPQLKWAGDALAIGLFEDAIKLTEDAIELTEEMAELDEMLSGTLSELIKETEFKGKANSSVSTRVGIKTSIRK
IIVVGLGKLEKFKLDSLRQAAATCGRLAKKERCKTLGISLPMCQDADSTAIAITEGIELALHQDNRFKSEPENLGPDLEK
VELIGLAASDEAIAHARKICSGVIFARELVAAPANSCTPITMAETAQTLAKEFGLTLEILEKEDCEKLGMGAFLGVAQGS
DLPPKFIHVTYKPEVTPRRKLAIVGKGLTFDSGGLNLKVSGSGIEMMKIDMGGAGTTFGTIKAIAQLKPDVEVHFISAVT
ENMVSGHAIHPGDFLTASNGKIIEVNNTDAEGRLTLADALVFAEKLGVDAIIDLATLTGACVVALGNDIAGLWSPNDNLA
AEITAAAEKAGEKMWRMPLEEKYFEGLKAMHADMKNTGPRPGGAITAALFLKQFVKNTPWAHLDIAGPVWVDTENGYNNQ
GATGYGVRTLVNWILS
>Mature_496_residues
MEIKVGNIPQLKWAGDALAIGLFEDAIKLTEDAIELTEEMAELDEMLSGTLSELIKETEFKGKANSSVSTRVGIKTSIRK
IIVVGLGKLEKFKLDSLRQAAATCGRLAKKERCKTLGISLPMCQDADSTAIAITEGIELALHQDNRFKSEPENLGPDLEK
VELIGLAASDEAIAHARKICSGVIFARELVAAPANSCTPITMAETAQTLAKEFGLTLEILEKEDCEKLGMGAFLGVAQGS
DLPPKFIHVTYKPEVTPRRKLAIVGKGLTFDSGGLNLKVSGSGIEMMKIDMGGAGTTFGTIKAIAQLKPDVEVHFISAVT
ENMVSGHAIHPGDFLTASNGKIIEVNNTDAEGRLTLADALVFAEKLGVDAIIDLATLTGACVVALGNDIAGLWSPNDNLA
AEITAAAEKAGEKMWRMPLEEKYFEGLKAMHADMKNTGPRPGGAITAALFLKQFVKNTPWAHLDIAGPVWVDTENGYNNQ
GATGYGVRTLVNWILS

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=480, Percent_Identity=36.0416666666667, Blast_Score=236, Evalue=4e-62,
Organism=Homo sapiens, GI47155554, Length=321, Percent_Identity=34.8909657320872, Blast_Score=144, Evalue=2e-34,
Organism=Escherichia coli, GI1790710, Length=508, Percent_Identity=33.0708661417323, Blast_Score=251, Evalue=5e-68,
Organism=Escherichia coli, GI87082123, Length=326, Percent_Identity=37.7300613496933, Blast_Score=183, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17556903, Length=303, Percent_Identity=33.993399339934, Blast_Score=132, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17565172, Length=311, Percent_Identity=26.0450160771704, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI21355725, Length=316, Percent_Identity=32.9113924050633, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24661038, Length=313, Percent_Identity=32.2683706070287, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI20129969, Length=494, Percent_Identity=28.1376518218623, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI20129963, Length=446, Percent_Identity=28.9237668161435, Blast_Score=155, Evalue=8e-38,
Organism=Drosophila melanogaster, GI21355645, Length=499, Percent_Identity=27.2545090180361, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24662223, Length=499, Percent_Identity=27.2545090180361, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI161077148, Length=443, Percent_Identity=28.4424379232506, Blast_Score=151, Evalue=1e-36,
Organism=Drosophila melanogaster, GI20130057, Length=443, Percent_Identity=28.4424379232506, Blast_Score=151, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24662227, Length=466, Percent_Identity=27.8969957081545, Blast_Score=149, Evalue=5e-36,
Organism=Drosophila melanogaster, GI19922386, Length=462, Percent_Identity=28.1385281385281, Blast_Score=145, Evalue=7e-35,
Organism=Drosophila melanogaster, GI21357381, Length=377, Percent_Identity=29.973474801061, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI221379063, Length=377, Percent_Identity=29.973474801061, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI221379062, Length=377, Percent_Identity=29.973474801061, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24646701, Length=252, Percent_Identity=26.984126984127, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24646703, Length=252, Percent_Identity=26.984126984127, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI21358201, Length=252, Percent_Identity=26.984126984127, Blast_Score=83, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_TRIEI (Q11A96)

Other databases:

- EMBL:   CP000393
- RefSeq:   YP_720051.1
- ProteinModelPortal:   Q11A96
- SMR:   Q11A96
- STRING:   Q11A96
- MEROPS:   M17.002
- GeneID:   4242452
- GenomeReviews:   CP000393_GR
- KEGG:   ter:Tery_0069
- NMPDR:   fig|203124.1.peg.3690
- eggNOG:   COG0260
- HOGENOM:   HBG742580
- OMA:   ELHKPCE
- PhylomeDB:   Q11A96
- ProtClustDB:   PRK00913
- BioCyc:   TERY203124:TERY_0069-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 52945; Mature: 52945

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 278-278 ACT_SITE 353-353

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIKVGNIPQLKWAGDALAIGLFEDAIKLTEDAIELTEEMAELDEMLSGTLSELIKETEF
CEEECCCCCCEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KGKANSSVSTRVGIKTSIRKIIVVGLGKLEKFKLDSLRQAAATCGRLAKKERCKTLGISL
CCCCCCCCEEECCHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PMCQDADSTAIAITEGIELALHQDNRFKSEPENLGPDLEKVELIGLAASDEAIAHARKIC
CCCCCCCCCEEEEECCEEEEEECCCCCCCCCHHCCCCHHHEEEEEEECCCHHHHHHHHHH
SGVIFARELVAAPANSCTPITMAETAQTLAKEFGLTLEILEKEDCEKLGMGAFLGVAQGS
HHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHCCEEEEECHHHHHHHCCCCEEEECCCC
DLPPKFIHVTYKPEVTPRRKLAIVGKGLTFDSGGLNLKVSGSGIEMMKIDMGGAGTTFGT
CCCCCEEEEEECCCCCCCCEEEEEECCEEECCCCEEEEECCCCEEEEEEECCCCCCHHHH
IKAIAQLKPDVEVHFISAVTENMVSGHAIHPGDFLTASNGKIIEVNNTDAEGRLTLADAL
HHHHHHCCCCCEEEEHHHHHHHHHCCCCCCCCCEEECCCCEEEEECCCCCCCEEEHHHHH
VFAEKLGVDAIIDLATLTGACVVALGNDIAGLWSPNDNLAAEITAAAEKAGEKMWRMPLE
HHHHHCCHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHH
EKYFEGLKAMHADMKNTGPRPGGAITAALFLKQFVKNTPWAHLDIAGPVWVDTENGYNNQ
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCEEEECCCCCCCC
GATGYGVRTLVNWILS
CCCCCCHHHHHHHHCC
>Mature Secondary Structure
MEIKVGNIPQLKWAGDALAIGLFEDAIKLTEDAIELTEEMAELDEMLSGTLSELIKETEF
CEEECCCCCCEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KGKANSSVSTRVGIKTSIRKIIVVGLGKLEKFKLDSLRQAAATCGRLAKKERCKTLGISL
CCCCCCCCEEECCHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PMCQDADSTAIAITEGIELALHQDNRFKSEPENLGPDLEKVELIGLAASDEAIAHARKIC
CCCCCCCCCEEEEECCEEEEEECCCCCCCCCHHCCCCHHHEEEEEEECCCHHHHHHHHHH
SGVIFARELVAAPANSCTPITMAETAQTLAKEFGLTLEILEKEDCEKLGMGAFLGVAQGS
HHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHCCEEEEECHHHHHHHCCCCEEEECCCC
DLPPKFIHVTYKPEVTPRRKLAIVGKGLTFDSGGLNLKVSGSGIEMMKIDMGGAGTTFGT
CCCCCEEEEEECCCCCCCCEEEEEECCEEECCCCEEEEECCCCEEEEEEECCCCCCHHHH
IKAIAQLKPDVEVHFISAVTENMVSGHAIHPGDFLTASNGKIIEVNNTDAEGRLTLADAL
HHHHHHCCCCCEEEEHHHHHHHHHCCCCCCCCCEEECCCCEEEEECCCCCCCEEEHHHHH
VFAEKLGVDAIIDLATLTGACVVALGNDIAGLWSPNDNLAAEITAAAEKAGEKMWRMPLE
HHHHHCCHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHH
EKYFEGLKAMHADMKNTGPRPGGAITAALFLKQFVKNTPWAHLDIAGPVWVDTENGYNNQ
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCEEEECCCCCCCC
GATGYGVRTLVNWILS
CCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA