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The map label for this gene is ilvD

Identifier: 113473955

GI number: 113473955

Start: 28954

End: 30639

Strand: Direct

Name: ilvD

Synonym: Tery_0019

Alternate gene names: 113473955

Gene position: 28954-30639 (Clockwise)

Preceding gene: 113473949

Following gene: 113473957

Centisome position: 0.37

GC content: 39.98

Gene sequence:

>1686_bases
ATGCCAGAGAATTTGAGAAGTCAATTAGTCACCAAAGGAGTACAACGCGCTCCCAACCGAGCTATGCTGAGAGCTGTGGG
TTTTGAAGATTCAGACTTTACCAAACCAATTATTGGGGTTGCCAATGCCCATAGCACTATTACTCCCTGCAACATGGGTA
TTAATGATTTGGCCATGAGAGCTGTAAGTGGAGTGAAAGAAGCTGGAGGAATGCCGCAGATATTTGGAACTATTACTATT
AGCGATGGAATTTCTATGGGTACTGAGGGGATGAAATATTCTCTGGTTTCTAGAGACGTTATTGCTGATTCCATCGAAAC
AGTTTGTAATGGCCAAACAATGGATGGAGTTCTAGCTATTGGTGGATGCGATAAAAATATGCCAGGAGCAATGATAGCGA
TCGCTAGGATGAATATTCCTGCTATCTTCGTATACGGTGGTACTATTAAACCAGGCAACTACAACGGTAAAGACCTAACA
GTTGTAAGTGCTTTTGAAGCAGTGGGAGAATATAGTGCTGGAAAAATTGACGAAACAGAATTAACAGAAGTTGAACGTAG
AGCTTGCCCTGGTGCTGGTTCCTGTGGAGGAATGTTTACTGCCAATACTATGTCTTCAGCTTTTGAAGCAATGGGTATGA
GTCTCATGTATTCATCAACAATGGCTGCAGAAGATGCAGAAAAAGCAGATAGCACAGAAAAATCAGCTCATGTTTTAGTA
GAAGCTATTCGCAAACAAATTTTACCTAGTCAAATTATTACCCGTAAAGCTATCGAAAATGCAATTTCAGTAATTATGGC
TGTAGGGGGTTCCACTAATGCAGTACTACACCTATTAGCAATTGCTTATGCTGCAAATGTGAAGTTATCTTTAGATGATT
TTGAAATAATTAGGGCCAGAGTACCTGTATTATGTGATTTGAAACCTAGTGGTAAATACGTTACAACAAATTTGCATCAA
GCGGGTGGAATTCCTTTAGTAATGAAAATGCTTTTAGAACATGATTTACTCCACCCAGATGCTTTAACCATAACAGGTAA
GACTATTGGAGAGCAATTAACAAATATACCTTCTGAACCACCTTCTAATCAAGACGTGATTCGCCCTTGGAATAATCCTA
TGTATGCTCAAGGACACTTGGCTATTTTAAAAGGAAATTTGGCGACAGAGGGAGCAGTTGCTAAAATTACAGGAGTGAAG
AACCCAGAAATAACAGGACTAGCAAGAGTATTTGATTCGGAAGAAGCTTGTTTAGAAGCAATATTAGCAGGGAAAATTCA
AGCAGGGAATATTATTGTAGTTCGCTATGAAGGTCCAAAAGGTGGACCAGGTATGCGAGAAATGTTAGCACCAACTTCGG
CTATTATTGGTGCTGGTTTGGGGGATAAAGTGGGATTAATTACTGATGGTAGGTTTTCTGGTGGTACTTATGGTATGGTG
GTTGGTCATGTAGCTCCAGAAGCTGCAGTAGGTGGCACGATCGCTCTAGTTAAGGAAGGAGATATGATTACTATTGATGC
TCATAAGCGTTTACTACAGTTAAATATTTCTGATGAGGAATTAGAAAAGCGTCGTCAAGTATGGAAACCACGAAAACCCC
AATATACTAGAGGTGTATTAGCTAAATATGCTAAGTTAGTTTCTTCTAGCAGTGTTGGAGCAGTAACTGACGCTGGATTA
GGTTGA

Upstream 100 bases:

>100_bases
ACTATTCAGAAATGGTATTAGCACTACTTATCTTAAGTCTTAGTATCTTTTGTCCCTTATTCTGAGAAAATTAAATACAT
AACACCATATAAAAAATACT

Downstream 100 bases:

>100_bases
AATTTAGTTAATAATTATTAACTTTTGGTTTGATCGTAATACCATATAGTTAAATACCATAGAATCCATTTTGTATCTTT
ATTTAAGCGAAAATTAGCTT

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 561; Mature: 560

Protein sequence:

>561_residues
MPENLRSQLVTKGVQRAPNRAMLRAVGFEDSDFTKPIIGVANAHSTITPCNMGINDLAMRAVSGVKEAGGMPQIFGTITI
SDGISMGTEGMKYSLVSRDVIADSIETVCNGQTMDGVLAIGGCDKNMPGAMIAIARMNIPAIFVYGGTIKPGNYNGKDLT
VVSAFEAVGEYSAGKIDETELTEVERRACPGAGSCGGMFTANTMSSAFEAMGMSLMYSSTMAAEDAEKADSTEKSAHVLV
EAIRKQILPSQIITRKAIENAISVIMAVGGSTNAVLHLLAIAYAANVKLSLDDFEIIRARVPVLCDLKPSGKYVTTNLHQ
AGGIPLVMKMLLEHDLLHPDALTITGKTIGEQLTNIPSEPPSNQDVIRPWNNPMYAQGHLAILKGNLATEGAVAKITGVK
NPEITGLARVFDSEEACLEAILAGKIQAGNIIVVRYEGPKGGPGMREMLAPTSAIIGAGLGDKVGLITDGRFSGGTYGMV
VGHVAPEAAVGGTIALVKEGDMITIDAHKRLLQLNISDEELEKRRQVWKPRKPQYTRGVLAKYAKLVSSSSVGAVTDAGL
G

Sequences:

>Translated_561_residues
MPENLRSQLVTKGVQRAPNRAMLRAVGFEDSDFTKPIIGVANAHSTITPCNMGINDLAMRAVSGVKEAGGMPQIFGTITI
SDGISMGTEGMKYSLVSRDVIADSIETVCNGQTMDGVLAIGGCDKNMPGAMIAIARMNIPAIFVYGGTIKPGNYNGKDLT
VVSAFEAVGEYSAGKIDETELTEVERRACPGAGSCGGMFTANTMSSAFEAMGMSLMYSSTMAAEDAEKADSTEKSAHVLV
EAIRKQILPSQIITRKAIENAISVIMAVGGSTNAVLHLLAIAYAANVKLSLDDFEIIRARVPVLCDLKPSGKYVTTNLHQ
AGGIPLVMKMLLEHDLLHPDALTITGKTIGEQLTNIPSEPPSNQDVIRPWNNPMYAQGHLAILKGNLATEGAVAKITGVK
NPEITGLARVFDSEEACLEAILAGKIQAGNIIVVRYEGPKGGPGMREMLAPTSAIIGAGLGDKVGLITDGRFSGGTYGMV
VGHVAPEAAVGGTIALVKEGDMITIDAHKRLLQLNISDEELEKRRQVWKPRKPQYTRGVLAKYAKLVSSSSVGAVTDAGL
G
>Mature_560_residues
PENLRSQLVTKGVQRAPNRAMLRAVGFEDSDFTKPIIGVANAHSTITPCNMGINDLAMRAVSGVKEAGGMPQIFGTITIS
DGISMGTEGMKYSLVSRDVIADSIETVCNGQTMDGVLAIGGCDKNMPGAMIAIARMNIPAIFVYGGTIKPGNYNGKDLTV
VSAFEAVGEYSAGKIDETELTEVERRACPGAGSCGGMFTANTMSSAFEAMGMSLMYSSTMAAEDAEKADSTEKSAHVLVE
AIRKQILPSQIITRKAIENAISVIMAVGGSTNAVLHLLAIAYAANVKLSLDDFEIIRARVPVLCDLKPSGKYVTTNLHQA
GGIPLVMKMLLEHDLLHPDALTITGKTIGEQLTNIPSEPPSNQDVIRPWNNPMYAQGHLAILKGNLATEGAVAKITGVKN
PEITGLARVFDSEEACLEAILAGKIQAGNIIVVRYEGPKGGPGMREMLAPTSAIIGAGLGDKVGLITDGRFSGGTYGMVV
GHVAPEAAVGGTIALVKEGDMITIDAHKRLLQLNISDEELEKRRQVWKPRKPQYTRGVLAKYAKLVSSSSVGAVTDAGLG

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=611, Percent_Identity=37.9705400981997, Blast_Score=395, Evalue=1e-111,
Organism=Escherichia coli, GI1788157, Length=480, Percent_Identity=31.6666666666667, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI2367371, Length=520, Percent_Identity=32.8846153846154, Blast_Score=195, Evalue=8e-51,
Organism=Escherichia coli, GI1786464, Length=496, Percent_Identity=34.2741935483871, Blast_Score=194, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6322476, Length=563, Percent_Identity=48.1349911190053, Blast_Score=528, Evalue=1e-151,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_TRIEI (Q11AD1)

Other databases:

- EMBL:   CP000393
- RefSeq:   YP_720016.1
- ProteinModelPortal:   Q11AD1
- SMR:   Q11AD1
- STRING:   Q11AD1
- GeneID:   4241826
- GenomeReviews:   CP000393_GR
- KEGG:   ter:Tery_0019
- NMPDR:   fig|203124.1.peg.5419
- eggNOG:   COG0129
- HOGENOM:   HBG671001
- OMA:   NMPGAMI
- PhylomeDB:   Q11AD1
- ProtClustDB:   PRK00911
- BioCyc:   TERY203124:TERY_0019-MONOMER
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 59126; Mature: 58995

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPENLRSQLVTKGVQRAPNRAMLRAVGFEDSDFTKPIIGVANAHSTITPCNMGINDLAMR
CCHHHHHHHHHHHHHHCCCHHHHEEECCCCCCCCCCCEEECCCCCCCCCCCCCHHHHHHH
AVSGVKEAGGMPQIFGTITISDGISMGTEGMKYSLVSRDVIADSIETVCNGQTMDGVLAI
HHHHHHHHCCCCEEEEEEEEECCCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCCCCEEEE
GGCDKNMPGAMIAIARMNIPAIFVYGGTIKPGNYNGKDLTVVSAFEAVGEYSAGKIDETE
ECCCCCCCCCEEEEEECCCCEEEEECCEECCCCCCCCEEEEEHHHHHHCCCCCCCCCHHH
LTEVERRACPGAGSCGGMFTANTMSSAFEAMGMSLMYSSTMAAEDAEKADSTEKSAHVLV
HHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCHHHHHHHH
EAIRKQILPSQIITRKAIENAISVIMAVGGSTNAVLHLLAIAYAANVKLSLDDFEIIRAR
HHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEECCHHHHHHHC
VPVLCDLKPSGKYVTTNLHQAGGIPLVMKMLLEHDLLHPDALTITGKTIGEQLTNIPSEP
CCEEEECCCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHCCCCCC
PSNQDVIRPWNNPMYAQGHLAILKGNLATEGAVAKITGVKNPEITGLARVFDSEEACLEA
CCCCCCCCCCCCCEEECCEEEEEECCCCCCCCEEEEECCCCCCHHHHHHHHCCHHHHHHH
ILAGKIQAGNIIVVRYEGPKGGPGMREMLAPTSAIIGAGLGDKVGLITDGRFSGGTYGMV
HHHCCEECCCEEEEEECCCCCCCCHHHHHCCHHHHHCCCCCCCEEEEECCCCCCCEEEEE
VGHVAPEAAVGGTIALVKEGDMITIDAHKRLLQLNISDEELEKRRQVWKPRKPQYTRGVL
EECCCCCHHCCCEEEEEECCCEEEEECCCEEEEECCCHHHHHHHHHHCCCCCCCHHHHHH
AKYAKLVSSSSVGAVTDAGLG
HHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
PENLRSQLVTKGVQRAPNRAMLRAVGFEDSDFTKPIIGVANAHSTITPCNMGINDLAMR
CHHHHHHHHHHHHHHCCCHHHHEEECCCCCCCCCCCEEECCCCCCCCCCCCCHHHHHHH
AVSGVKEAGGMPQIFGTITISDGISMGTEGMKYSLVSRDVIADSIETVCNGQTMDGVLAI
HHHHHHHHCCCCEEEEEEEEECCCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCCCCEEEE
GGCDKNMPGAMIAIARMNIPAIFVYGGTIKPGNYNGKDLTVVSAFEAVGEYSAGKIDETE
ECCCCCCCCCEEEEEECCCCEEEEECCEECCCCCCCCEEEEEHHHHHHCCCCCCCCCHHH
LTEVERRACPGAGSCGGMFTANTMSSAFEAMGMSLMYSSTMAAEDAEKADSTEKSAHVLV
HHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCHHHHHHHH
EAIRKQILPSQIITRKAIENAISVIMAVGGSTNAVLHLLAIAYAANVKLSLDDFEIIRAR
HHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEECCHHHHHHHC
VPVLCDLKPSGKYVTTNLHQAGGIPLVMKMLLEHDLLHPDALTITGKTIGEQLTNIPSEP
CCEEEECCCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHCCCCCC
PSNQDVIRPWNNPMYAQGHLAILKGNLATEGAVAKITGVKNPEITGLARVFDSEEACLEA
CCCCCCCCCCCCCEEECCEEEEEECCCCCCCCEEEEECCCCCCHHHHHHHHCCHHHHHHH
ILAGKIQAGNIIVVRYEGPKGGPGMREMLAPTSAIIGAGLGDKVGLITDGRFSGGTYGMV
HHHCCEECCCEEEEEECCCCCCCCHHHHHCCHHHHHCCCCCCCEEEEECCCCCCCEEEEE
VGHVAPEAAVGGTIALVKEGDMITIDAHKRLLQLNISDEELEKRRQVWKPRKPQYTRGVL
EECCCCCHHCCCEEEEEECCCEEEEECCCEEEEECCCHHHHHHHHHHCCCCCCCHHHHHH
AKYAKLVSSSSVGAVTDAGLG
HHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA