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The map label for this gene is fumC [H]

Identifier: 110835610

GI number: 110835610

Start: 3112833

End: 3114221

Strand: Reverse

Name: fumC [H]

Synonym: ABO_2749

Alternate gene names: 110835610

Gene position: 3114221-3112833 (Counterclockwise)

Preceding gene: 110835611

Following gene: 110835609

Centisome position: 99.81

GC content: 54.5

Gene sequence:

>1389_bases
ATGTCCACGGATCACTCTGATACTCGCATCGAAACGGACTCCTTGGGAGAGATAGCGGTTCCAAGTAGAGCTCGCTGGGG
GGCACAGACACAGCGGGCGGTGGATAACTTTCCTATTAGCGGCCGCACGCTTCCGCCACGGTTTATTCAGGCGGTGGTGC
ACATTAAGCGTTGTGCGGCTGAAGCAAACCGGGAGCTGGGAGAATTGCCTTCCAATAAAGCAGTGGCCATTGTTGGGGCC
TGTAATGACTTGTTGGCGGGTCACCATGGCGATCAGTTTCCTGTTGATATCTTTCAAACGGGTTCCGGCACTAGCACCAA
TATGAACGTTAATGAGGTGATTGCTCATCTGTGCGAAGAAGCGGGGGCTTCGATTCATCCCAATGATGATGTGAATTTGG
GACAGAGCAGTAACGACACTATTCCCACCGCCATCCATGTGTCTGCGGCGTTAGCCGTGACCGAACACCTGATTCCTGCG
CTGGAGCAGCTGATCGTCGAGCTGGGACTGCGCGCTCGGGAGCATCGGGAGACGGTGAAAACCGGGCGCACCCACCTTAT
GGATGCTATGCCAGTGACGGTCGAGCAGGAACTGCAAACCTGGGCGATGCAGTTGCAGGATGCTTGCGGGCGTGTGGCCG
GTGCGCGCGACGCCTTGTTGGCCGTACCCCAAGGGGGGACGGCCGTGGGGAGTGGCATCAACGCGCATCCAGCGTTCGGT
GAGACCTTTGCCAGCAAGCTAGCAGATGAAACTGGCCTGGCATTTCGGGCCTTACCGCACCCCTTTGTAGCGCAGAGCGC
GCTGGATGGTCCGTTGGCATTATCGGCAGCGCTGCGTGGTATTGCTGTGGTGTTGATGAAGATCAGTAACGATTTGCGCT
GGATGAATTCCGGGCCTACTCATGGGCTTGGTGAGATTCAATTACCGGCTACTCAGCCGGGTTCGTCGATTATGCCTGGC
AAAGTGAACCCGGTTATTTGTGAGTCTGCCACTATGGTGGCAACTCAGGTTATGGGTTTGGATCAGGCCAATGCTATTGC
CGCCCAGAGCGGCAATTTCCAGCTCAATGTGATGTTACCGCTGGTGGCCAGTAACTTGTTGGATATGACAGAGTGGTTAG
GCAATAGCTGCACTAATCTGGCTGAGCGAGCGATTAAAGGGATGACTTTCAATGAAGCTCGATTGGCTGAAGGGGTGGGT
AAGAACCCTATTTTAGTCACGGCCCTGAACCCTGTGATTGGTTATGAAAAAGCAGCGAAAATTGCTAAAGAAGCGTTTGC
TAGCGGCAGGCCGGTACTGGAGGTAGCCGAAGAACAGTCTGGTCTATCTAGGCAGAAATTAGAGCAGCTGCTGGATCCAA
AGGACCTGACGCATCCTTTAAAAGGATGA

Upstream 100 bases:

>100_bases
CCGAAACGGTATATGTGTTGATTGCACTTCTAATGAATCTGGCTTGTTGCCGTGCCATCATAAGACCGAACGAGTTTTTA
ATGTTGGCAGGAGGCAGACC

Downstream 100 bases:

>100_bases
TTGCGTTTATCCCTGGGTACATTACTACTTGCAGAACATAATCATTGGAAGTGATTCCTTGAAGTGAGCGTTCGGCGGGG
TGTCTACCTGGGTGGGATTT

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C 1 [H]

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MSTDHSDTRIETDSLGEIAVPSRARWGAQTQRAVDNFPISGRTLPPRFIQAVVHIKRCAAEANRELGELPSNKAVAIVGA
CNDLLAGHHGDQFPVDIFQTGSGTSTNMNVNEVIAHLCEEAGASIHPNDDVNLGQSSNDTIPTAIHVSAALAVTEHLIPA
LEQLIVELGLRAREHRETVKTGRTHLMDAMPVTVEQELQTWAMQLQDACGRVAGARDALLAVPQGGTAVGSGINAHPAFG
ETFASKLADETGLAFRALPHPFVAQSALDGPLALSAALRGIAVVLMKISNDLRWMNSGPTHGLGEIQLPATQPGSSIMPG
KVNPVICESATMVATQVMGLDQANAIAAQSGNFQLNVMLPLVASNLLDMTEWLGNSCTNLAERAIKGMTFNEARLAEGVG
KNPILVTALNPVIGYEKAAKIAKEAFASGRPVLEVAEEQSGLSRQKLEQLLDPKDLTHPLKG

Sequences:

>Translated_462_residues
MSTDHSDTRIETDSLGEIAVPSRARWGAQTQRAVDNFPISGRTLPPRFIQAVVHIKRCAAEANRELGELPSNKAVAIVGA
CNDLLAGHHGDQFPVDIFQTGSGTSTNMNVNEVIAHLCEEAGASIHPNDDVNLGQSSNDTIPTAIHVSAALAVTEHLIPA
LEQLIVELGLRAREHRETVKTGRTHLMDAMPVTVEQELQTWAMQLQDACGRVAGARDALLAVPQGGTAVGSGINAHPAFG
ETFASKLADETGLAFRALPHPFVAQSALDGPLALSAALRGIAVVLMKISNDLRWMNSGPTHGLGEIQLPATQPGSSIMPG
KVNPVICESATMVATQVMGLDQANAIAAQSGNFQLNVMLPLVASNLLDMTEWLGNSCTNLAERAIKGMTFNEARLAEGVG
KNPILVTALNPVIGYEKAAKIAKEAFASGRPVLEVAEEQSGLSRQKLEQLLDPKDLTHPLKG
>Mature_461_residues
STDHSDTRIETDSLGEIAVPSRARWGAQTQRAVDNFPISGRTLPPRFIQAVVHIKRCAAEANRELGELPSNKAVAIVGAC
NDLLAGHHGDQFPVDIFQTGSGTSTNMNVNEVIAHLCEEAGASIHPNDDVNLGQSSNDTIPTAIHVSAALAVTEHLIPAL
EQLIVELGLRAREHRETVKTGRTHLMDAMPVTVEQELQTWAMQLQDACGRVAGARDALLAVPQGGTAVGSGINAHPAFGE
TFASKLADETGLAFRALPHPFVAQSALDGPLALSAALRGIAVVLMKISNDLRWMNSGPTHGLGEIQLPATQPGSSIMPGK
VNPVICESATMVATQVMGLDQANAIAAQSGNFQLNVMLPLVASNLLDMTEWLGNSCTNLAERAIKGMTFNEARLAEGVGK
NPILVTALNPVIGYEKAAKIAKEAFASGRPVLEVAEEQSGLSRQKLEQLLDPKDLTHPLKG

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=460, Percent_Identity=44.1304347826087, Blast_Score=356, Evalue=3e-98,
Organism=Escherichia coli, GI1787896, Length=460, Percent_Identity=42.6086956521739, Blast_Score=361, Evalue=1e-101,
Organism=Escherichia coli, GI87082375, Length=465, Percent_Identity=37.8494623655914, Blast_Score=290, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI17553882, Length=460, Percent_Identity=41.5217391304348, Blast_Score=345, Evalue=2e-95,
Organism=Caenorhabditis elegans, GI32565146, Length=327, Percent_Identity=41.2844036697248, Blast_Score=263, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6324993, Length=463, Percent_Identity=40.6047516198704, Blast_Score=344, Evalue=2e-95,
Organism=Drosophila melanogaster, GI24640179, Length=464, Percent_Identity=43.75, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24640177, Length=464, Percent_Identity=43.75, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI78710009, Length=462, Percent_Identity=41.7748917748918, Blast_Score=354, Evalue=9e-98,
Organism=Drosophila melanogaster, GI24662684, Length=469, Percent_Identity=41.36460554371, Blast_Score=345, Evalue=5e-95,
Organism=Drosophila melanogaster, GI24583245, Length=464, Percent_Identity=37.9310344827586, Blast_Score=313, Evalue=2e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 48912; Mature: 48781

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTDHSDTRIETDSLGEIAVPSRARWGAQTQRAVDNFPISGRTLPPRFIQAVVHIKRCAA
CCCCCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
EANRELGELPSNKAVAIVGACNDLLAGHHGDQFPVDIFQTGSGTSTNMNVNEVIAHLCEE
HHHHHHHCCCCCCEEEEEECCHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHH
AGASIHPNDDVNLGQSSNDTIPTAIHVSAALAVTEHLIPALEQLIVELGLRAREHRETVK
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
TGRTHLMDAMPVTVEQELQTWAMQLQDACGRVAGARDALLAVPQGGTAVGSGINAHPAFG
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHCCCCCCCCCHH
ETFASKLADETGLAFRALPHPFVAQSALDGPLALSAALRGIAVVLMKISNDLRWMNSGPT
HHHHHHHHHHCCCEEECCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEECCCCCC
HGLGEIQLPATQPGSSIMPGKVNPVICESATMVATQVMGLDQANAIAAQSGNFQLNVMLP
CCCCCEECCCCCCCCCCCCCCCCCEEECCHHHHHHHHHCCCCCCHHEECCCCEEEEEEHH
LVASNLLDMTEWLGNSCTNLAERAIKGMTFNEARLAEGVGKNPILVTALNPVIGYEKAAK
HHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHCCCCCCEEEEECCHHHHHHHHHH
IAKEAFASGRPVLEVAEEQSGLSRQKLEQLLDPKDLTHPLKG
HHHHHHHCCCCHHHHHHHHCCCCHHHHHHHCCCHHCCCCCCC
>Mature Secondary Structure 
STDHSDTRIETDSLGEIAVPSRARWGAQTQRAVDNFPISGRTLPPRFIQAVVHIKRCAA
CCCCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
EANRELGELPSNKAVAIVGACNDLLAGHHGDQFPVDIFQTGSGTSTNMNVNEVIAHLCEE
HHHHHHHCCCCCCEEEEEECCHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHH
AGASIHPNDDVNLGQSSNDTIPTAIHVSAALAVTEHLIPALEQLIVELGLRAREHRETVK
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
TGRTHLMDAMPVTVEQELQTWAMQLQDACGRVAGARDALLAVPQGGTAVGSGINAHPAFG
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHCCCCCCCCCHH
ETFASKLADETGLAFRALPHPFVAQSALDGPLALSAALRGIAVVLMKISNDLRWMNSGPT
HHHHHHHHHHCCCEEECCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEECCCCCC
HGLGEIQLPATQPGSSIMPGKVNPVICESATMVATQVMGLDQANAIAAQSGNFQLNVMLP
CCCCCEECCCCCCCCCCCCCCCCCEEECCHHHHHHHHHCCCCCCHHEECCCCEEEEEEHH
LVASNLLDMTEWLGNSCTNLAERAIKGMTFNEARLAEGVGKNPILVTALNPVIGYEKAAK
HHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHCCCCCCEEEEECCHHHHHHHHHH
IAKEAFASGRPVLEVAEEQSGLSRQKLEQLLDPKDLTHPLKG
HHHHHHHCCCCHHHHHHHHCCCCHHHHHHHCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8806672; 10984043 [H]