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The map label for this gene is aceA [C]

Identifier: 110835602

GI number: 110835602

Start: 3100671

End: 3102269

Strand: Reverse

Name: aceA [C]

Synonym: ABO_2741

Alternate gene names: 110835602

Gene position: 3102269-3100671 (Counterclockwise)

Preceding gene: 110835606

Following gene: 110835598

Centisome position: 99.43

GC content: 53.22

Gene sequence:

>1599_bases
ATGTCATACACCAAAGACATCGAAGCACTCGGCTCCGTGGTTGGTGCGCAAAGCACCTGGAAAGATATCAACCCGGAATC
TGCGGTTCGCATGCGTCTGCAAAACCGTTTCAACACGCATCTGGACATCGCCAAGTACAACGCCAAGATCATGCGTGAAG
ACATGGCGGCCTATGACGCTGACACTTCCAAGTACACCCAGTCCCTGGGTTGCTGGCACGGTTTTGTTGGTCAGCAAAAA
ATGATCTCCATCAAAAAGCACTTCGGTAGCACTAAAGGTCGTTACCTGTACTTGTCTGGCTGGATGGTTGCTGCACTGCG
TTCTGAGTTTGGTCCGCTGCCTGACCAATCCATGCACGAGAAGACTGTCGTCGCTGACCTGATCCGTGAACTGTACACCT
TCTTGAAGCAGGCTGACGCTTGGGAACTGAATCACCTGTTCCGTGCGCTGGACGATGCCAAAGAAGCTGGCGACGAAGCC
AAGCAGAAAGAAATCATCGATCAGATCGACAACTTCGAAACTCACGTTGTTCCGATCATTGCCGACATCGATGCTGGTTT
CGGTAACCCGGAAGCCACCTACCTGATGGCCAAGCAACTGATCGAAGCCGGTGCTTGCTGTATCCAGATCGAAAACCAGG
TGTCTGACGAGAAGCAGTGTGGCCACCAAGACGGTAAAGTAACCGTTCCTCACGCTGACTTCCTGGCCAAGATCAACGCT
GTACGTTACGCGTTCCTGGAGCTGGGTATCGACGACGGTGTAATCGTTGCCCGTACTGACTCCCTAGGTGCTGGCCTGAC
CAAGCAAATCGCAGTAACCAACGAGCCGGGCGACTTGGGTGACCAGTACAACGCCTTCTTGGACGGTGACGTGATCGAAT
CCGCTGCCGACATCAACAACGGCGACGTTGTGATCAAGTCCAATGGCAAGCTGCTCAAGCCGAAGCGTTTGGCTTCTGGC
CTGTTCCAGTTTAAAGCCGGCTCAGGTATCGACCGTGTTGTTCTGGACTGTATCACCAGCCTGCAGAACGGCGCTGACCT
GTTGTGGATTGAGACTGAGAAGCCTCACGTTGGCCAGATTGCAGAAATGGTTAACCGCATCCGCGAAGTGGTGCCGGACG
CCAAGCTGGTTTACAACAACAGCCCGTCCTTCAACTGGACCCTGAACTTCCGTCAGCAGGTATTTGATGCTTGGGAGAAA
GAAGGTAAAGACGTGTCCGCTTACGATCGCGACCGTCTGATGAGCGCTGATTACGACAGCACTGAGCTTGCTCAGCTGGC
TGACGAGTGGACCAAGAACTTCCAGCGTGATGCGTCCCGTGAAGCAGGTATCTTCCACCACCTGATTACTCTGCCGACTT
ACCACACTGTTGCTCTGTCTACCGATAACCTGGCTAAAGGCTACTTCGGTGACGAAGGCATGTTGGCTTATGTTGCAGGC
GTTCAGCGTAAAGAAATCCGTCAGGGCATCGCTACTGTGAAGCACCAGGACATGGCCGGTTCTAATATCGGTGATGACCA
TAAAGAGTACTTCTCCGGCGAAGCTGCACTGAAAGCTGGCGGTAAAGACAACACCATGGGTCAGTTCGAGAACACCTAA

Upstream 100 bases:

>100_bases
GCACTAGAATGCGCGACATCGGTAGATCGGCATGGAATGTCATGAACAGGGTTTTCACTCTCCGGCATCGATAAACTAAT
TTCATATTCAGAGGTTCACC

Downstream 100 bases:

>100_bases
TTCTCGATAGATTCAAGGTAAGTCTTTAAGAGGCGGCCTCCGTAAGGGGGCCGCTTTTTTTGTGCTGAAAAAAAACGTCT
TCCACCACAGTAAAATGCGG

Product: isocitrate lyase

Products: NA

Alternate protein names: ICL; Isocitrase; Isocitratase [H]

Number of amino acids: Translated: 532; Mature: 531

Protein sequence:

>532_residues
MSYTKDIEALGSVVGAQSTWKDINPESAVRMRLQNRFNTHLDIAKYNAKIMREDMAAYDADTSKYTQSLGCWHGFVGQQK
MISIKKHFGSTKGRYLYLSGWMVAALRSEFGPLPDQSMHEKTVVADLIRELYTFLKQADAWELNHLFRALDDAKEAGDEA
KQKEIIDQIDNFETHVVPIIADIDAGFGNPEATYLMAKQLIEAGACCIQIENQVSDEKQCGHQDGKVTVPHADFLAKINA
VRYAFLELGIDDGVIVARTDSLGAGLTKQIAVTNEPGDLGDQYNAFLDGDVIESAADINNGDVVIKSNGKLLKPKRLASG
LFQFKAGSGIDRVVLDCITSLQNGADLLWIETEKPHVGQIAEMVNRIREVVPDAKLVYNNSPSFNWTLNFRQQVFDAWEK
EGKDVSAYDRDRLMSADYDSTELAQLADEWTKNFQRDASREAGIFHHLITLPTYHTVALSTDNLAKGYFGDEGMLAYVAG
VQRKEIRQGIATVKHQDMAGSNIGDDHKEYFSGEAALKAGGKDNTMGQFENT

Sequences:

>Translated_532_residues
MSYTKDIEALGSVVGAQSTWKDINPESAVRMRLQNRFNTHLDIAKYNAKIMREDMAAYDADTSKYTQSLGCWHGFVGQQK
MISIKKHFGSTKGRYLYLSGWMVAALRSEFGPLPDQSMHEKTVVADLIRELYTFLKQADAWELNHLFRALDDAKEAGDEA
KQKEIIDQIDNFETHVVPIIADIDAGFGNPEATYLMAKQLIEAGACCIQIENQVSDEKQCGHQDGKVTVPHADFLAKINA
VRYAFLELGIDDGVIVARTDSLGAGLTKQIAVTNEPGDLGDQYNAFLDGDVIESAADINNGDVVIKSNGKLLKPKRLASG
LFQFKAGSGIDRVVLDCITSLQNGADLLWIETEKPHVGQIAEMVNRIREVVPDAKLVYNNSPSFNWTLNFRQQVFDAWEK
EGKDVSAYDRDRLMSADYDSTELAQLADEWTKNFQRDASREAGIFHHLITLPTYHTVALSTDNLAKGYFGDEGMLAYVAG
VQRKEIRQGIATVKHQDMAGSNIGDDHKEYFSGEAALKAGGKDNTMGQFENT
>Mature_531_residues
SYTKDIEALGSVVGAQSTWKDINPESAVRMRLQNRFNTHLDIAKYNAKIMREDMAAYDADTSKYTQSLGCWHGFVGQQKM
ISIKKHFGSTKGRYLYLSGWMVAALRSEFGPLPDQSMHEKTVVADLIRELYTFLKQADAWELNHLFRALDDAKEAGDEAK
QKEIIDQIDNFETHVVPIIADIDAGFGNPEATYLMAKQLIEAGACCIQIENQVSDEKQCGHQDGKVTVPHADFLAKINAV
RYAFLELGIDDGVIVARTDSLGAGLTKQIAVTNEPGDLGDQYNAFLDGDVIESAADINNGDVVIKSNGKLLKPKRLASGL
FQFKAGSGIDRVVLDCITSLQNGADLLWIETEKPHVGQIAEMVNRIREVVPDAKLVYNNSPSFNWTLNFRQQVFDAWEKE
GKDVSAYDRDRLMSADYDSTELAQLADEWTKNFQRDASREAGIFHHLITLPTYHTVALSTDNLAKGYFGDEGMLAYVAGV
QRKEIRQGIATVKHQDMAGSNIGDDHKEYFSGEAALKAGGKDNTMGQFENT

Specific function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway [H]

COG id: COG2224

COG function: function code C; Isocitrate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family [H]

Homologues:

Organism=Escherichia coli, GI1790445, Length=496, Percent_Identity=26.4112903225806, Blast_Score=121, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17561814, Length=435, Percent_Identity=27.816091954023, Blast_Score=131, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI71982926, Length=435, Percent_Identity=27.816091954023, Blast_Score=131, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6320908, Length=505, Percent_Identity=26.1386138613861, Blast_Score=110, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6325263, Length=390, Percent_Identity=25.1282051282051, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006254
- InterPro:   IPR000918
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.1 [H]

Molecular weight: Translated: 59057; Mature: 58926

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYTKDIEALGSVVGAQSTWKDINPESAVRMRLQNRFNTHLDIAKYNAKIMREDMAAYDA
CCCCHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHCC
DTSKYTQSLGCWHGFVGQQKMISIKKHFGSTKGRYLYLSGWMVAALRSEFGPLPDQSMHE
CHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHCCCCCCCHHHH
KTVVADLIRELYTFLKQADAWELNHLFRALDDAKEAGDEAKQKEIIDQIDNFETHVVPII
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEEE
ADIDAGFGNPEATYLMAKQLIEAGACCIQIENQVSDEKQCGHQDGKVTVPHADFLAKINA
EECCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHCCCCCCEEECCCHHHHHHHHH
VRYAFLELGIDDGVIVARTDSLGAGLTKQIAVTNEPGDLGDQYNAFLDGDVIESAADINN
HHHHHHHCCCCCCEEEEECCCCCCCCEEEEEEECCCCCCCCHHHHHCCCHHHHHHHCCCC
GDVVIKSNGKLLKPKRLASGLFQFKAGSGIDRVVLDCITSLQNGADLLWIETEKPHVGQI
CCEEEECCCCEECHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHH
AEMVNRIREVVPDAKLVYNNSPSFNWTLNFRQQVFDAWEKEGKDVSAYDRDRLMSADYDS
HHHHHHHHHHCCCCEEEECCCCCEEEEECHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCH
TELAQLADEWTKNFQRDASREAGIFHHLITLPTYHTVALSTDNLAKGYFGDEGMLAYVAG
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHC
VQRKEIRQGIATVKHQDMAGSNIGDDHKEYFSGEAALKAGGKDNTMGQFENT
CHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCHHEECCCCCCCCCCCCCC
>Mature Secondary Structure 
SYTKDIEALGSVVGAQSTWKDINPESAVRMRLQNRFNTHLDIAKYNAKIMREDMAAYDA
CCCHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHCC
DTSKYTQSLGCWHGFVGQQKMISIKKHFGSTKGRYLYLSGWMVAALRSEFGPLPDQSMHE
CHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHCCCCCCCHHHH
KTVVADLIRELYTFLKQADAWELNHLFRALDDAKEAGDEAKQKEIIDQIDNFETHVVPII
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEEE
ADIDAGFGNPEATYLMAKQLIEAGACCIQIENQVSDEKQCGHQDGKVTVPHADFLAKINA
EECCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHCCCCCCEEECCCHHHHHHHHH
VRYAFLELGIDDGVIVARTDSLGAGLTKQIAVTNEPGDLGDQYNAFLDGDVIESAADINN
HHHHHHHCCCCCCEEEEECCCCCCCCEEEEEEECCCCCCCCHHHHHCCCHHHHHHHCCCC
GDVVIKSNGKLLKPKRLASGLFQFKAGSGIDRVVLDCITSLQNGADLLWIETEKPHVGQI
CCEEEECCCCEECHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHH
AEMVNRIREVVPDAKLVYNNSPSFNWTLNFRQQVFDAWEKEGKDVSAYDRDRLMSADYDS
HHHHHHHHHHCCCCEEEECCCCCEEEEECHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCH
TELAQLADEWTKNFQRDASREAGIFHHLITLPTYHTVALSTDNLAKGYFGDEGMLAYVAG
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHC
VQRKEIRQGIATVKHQDMAGSNIGDDHKEYFSGEAALKAGGKDNTMGQFENT
CHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCHHEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]