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The map label for this gene is cvrA [H]

Identifier: 110835599

GI number: 110835599

Start: 3095020

End: 3096720

Strand: Direct

Name: cvrA [H]

Synonym: ABO_2738

Alternate gene names: 110835599

Gene position: 3095020-3096720 (Clockwise)

Preceding gene: 110835571

Following gene: 110835600

Centisome position: 99.19

GC content: 57.55

Gene sequence:

>1701_bases
TTGGAATCATTGAATATCTTTCTGCTGATCGGCACCGGTCTGATGTTCACCGGCCTGCTACTGGGTTCTCTGAGCGCTCG
CTTCGGGGTGCCGTCCCTGCTCATCTTTCTAGTGGTGGGCATGGTGGCCGGGGAAGACGGCCTAGGCGGCATCGAGTTTG
ATGATTTCTCCACCGCTTATGTGATTGGCAATATCGCGTTGGCGGTGATTCTGCTCGATGGCGGCCTACGCACGCGATTA
AGCACCTTCAAATTGGGCCTACGCCCCGCCCTTAGCCTGGCTACTTTAGGGGTGGCCATCTCTGCCGCCCTGGTGGGCGC
TTTTACTACTTGGTTAATCGGGGTGGACTGGCGGGTGGGTCTGCTGCTGGGCGGTATTATCGGCTCCACCGATGCGGCGG
CCGTTTTCAGTGTTATCAAAGGCGCTGGCGTCACCCTGAATGAACGTGTGGCAAGTACCCTGGAGATCGAATCCGGTCTC
AACGACCCCATGGCCATCTTTATTACCCTGATGCTGGTAGGCATGTTGGTGGACCCGGATGCCCAGTGGGGCGCGGGGAT
GCTGGTCACTCTGATCCAACAGTTTGGTTTGGGCATCCTGCTGGGCTTGTTGCTGGGGGCCGTGATCAGCGAAGTGTTGC
TGCGGGTGCGTAGCAACGAAGGGCTACATGCTTTACTGCTGTGCAGCGGTGGCGCCATGGTGTTTGCCATTACCAATTTG
GTAGGCGGCTCCGGTTTTCTGGCGGTATACCTGACCGGCTTGGTAGCCGGTAATCGCCGGGGCGGCACCGGTGACAATGT
GCTCAAAGCCATGGACTCCATGGCCTGGCTGGCCCAGTCCGGCATGTTTCTGATCTTGGGTCTGCTGGTGACGCCGTCGC
GACTCATCGAAAACCTTCCCTATGCCCTCGCCGTGGCAGCCTTTTTGATGTTGCTAGCCCGCCCGCTATCCGTATGGATT
AGTCTGCTACCCTTCCGTTTTACTTGGCGCGAAGAAACCTTTATTGCCTGGACCGGGTTACGTGGTGCCGTGCCCATTGT
ACTGGCCGTTTTCCCGCTACTGGCCGGCGTGGAACAAACCTATCTGCTATTTGATATTACCCTCGTGGTGGTGCTGATTT
CCCTGCTTGGGCAAGGCGCAAGCCTGCGCTTTGTCGCCCGCAAACTGAAAGTCTCGGTGCCGCGCACCACCGAGCCGAAA
CAAACCGTGGCCCTGGCCGCCCCTCGCGATCGCTACTTGATGCAGTTTGAAGTGGAAGACGGCGCTAAGGCCGTAGGCAA
GAGCTTGGGGGAACTGGGCGAAAACGAGCGCACCCCGTTGATTTTGTATCGCAACACGCGGGTGCTCAGCCTCAGTGATG
ACCCCAAAATTGAAGCCGGTGACTTGATTGCCTGGCTCGCACCGCTATCACACAAATCCGGCCTGTCCGACCTATGCCAT
AAATTAAGCAGTGATGAGAAACGTTATTACGGCGACTTCAGCGTGCTGGGCAAAACCCCGGTAGCGCAATTGATTGCGGT
GTATGGGGTACAAGCCCCTCCACCACTCTGGCAAGGACTGACCGTGGCCGAGATCTTCACCAAACAAGTGGGAAAACAAA
CCGTAGTGGGTGATACGGTGCGTGTCAGCGGCCTGCGGCTAAGAGCAAGGTCTGTTGAAAACGGCACGGTCGTCATGGCC
GGGCTGAAACTTCCCGGATAA

Upstream 100 bases:

>100_bases
GGGTGGCGAAAAGAGTTTTGAGCTTGGCCTGAATCGCACCGCCGGTTCCGTGTAAGCTATTGTACTCTATAACTCTGTTC
TCACTTAACTAGGAACGCAT

Downstream 100 bases:

>100_bases
GGCCGGCGCAAAGCACATGCAAAGTATGCTGTTATTGAGCCAATGTGCCGGCCTCCAAGCATAAAGCGCTGGTAAGAAGT
TCGGGTAGAAGACCACTATA

Product: sodium/hydrogen exchanger family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 566; Mature: 566

Protein sequence:

>566_residues
MESLNIFLLIGTGLMFTGLLLGSLSARFGVPSLLIFLVVGMVAGEDGLGGIEFDDFSTAYVIGNIALAVILLDGGLRTRL
STFKLGLRPALSLATLGVAISAALVGAFTTWLIGVDWRVGLLLGGIIGSTDAAAVFSVIKGAGVTLNERVASTLEIESGL
NDPMAIFITLMLVGMLVDPDAQWGAGMLVTLIQQFGLGILLGLLLGAVISEVLLRVRSNEGLHALLLCSGGAMVFAITNL
VGGSGFLAVYLTGLVAGNRRGGTGDNVLKAMDSMAWLAQSGMFLILGLLVTPSRLIENLPYALAVAAFLMLLARPLSVWI
SLLPFRFTWREETFIAWTGLRGAVPIVLAVFPLLAGVEQTYLLFDITLVVVLISLLGQGASLRFVARKLKVSVPRTTEPK
QTVALAAPRDRYLMQFEVEDGAKAVGKSLGELGENERTPLILYRNTRVLSLSDDPKIEAGDLIAWLAPLSHKSGLSDLCH
KLSSDEKRYYGDFSVLGKTPVAQLIAVYGVQAPPPLWQGLTVAEIFTKQVGKQTVVGDTVRVSGLRLRARSVENGTVVMA
GLKLPG

Sequences:

>Translated_566_residues
MESLNIFLLIGTGLMFTGLLLGSLSARFGVPSLLIFLVVGMVAGEDGLGGIEFDDFSTAYVIGNIALAVILLDGGLRTRL
STFKLGLRPALSLATLGVAISAALVGAFTTWLIGVDWRVGLLLGGIIGSTDAAAVFSVIKGAGVTLNERVASTLEIESGL
NDPMAIFITLMLVGMLVDPDAQWGAGMLVTLIQQFGLGILLGLLLGAVISEVLLRVRSNEGLHALLLCSGGAMVFAITNL
VGGSGFLAVYLTGLVAGNRRGGTGDNVLKAMDSMAWLAQSGMFLILGLLVTPSRLIENLPYALAVAAFLMLLARPLSVWI
SLLPFRFTWREETFIAWTGLRGAVPIVLAVFPLLAGVEQTYLLFDITLVVVLISLLGQGASLRFVARKLKVSVPRTTEPK
QTVALAAPRDRYLMQFEVEDGAKAVGKSLGELGENERTPLILYRNTRVLSLSDDPKIEAGDLIAWLAPLSHKSGLSDLCH
KLSSDEKRYYGDFSVLGKTPVAQLIAVYGVQAPPPLWQGLTVAEIFTKQVGKQTVVGDTVRVSGLRLRARSVENGTVVMA
GLKLPG
>Mature_566_residues
MESLNIFLLIGTGLMFTGLLLGSLSARFGVPSLLIFLVVGMVAGEDGLGGIEFDDFSTAYVIGNIALAVILLDGGLRTRL
STFKLGLRPALSLATLGVAISAALVGAFTTWLIGVDWRVGLLLGGIIGSTDAAAVFSVIKGAGVTLNERVASTLEIESGL
NDPMAIFITLMLVGMLVDPDAQWGAGMLVTLIQQFGLGILLGLLLGAVISEVLLRVRSNEGLHALLLCSGGAMVFAITNL
VGGSGFLAVYLTGLVAGNRRGGTGDNVLKAMDSMAWLAQSGMFLILGLLVTPSRLIENLPYALAVAAFLMLLARPLSVWI
SLLPFRFTWREETFIAWTGLRGAVPIVLAVFPLLAGVEQTYLLFDITLVVVLISLLGQGASLRFVARKLKVSVPRTTEPK
QTVALAAPRDRYLMQFEVEDGAKAVGKSLGELGENERTPLILYRNTRVLSLSDDPKIEAGDLIAWLAPLSHKSGLSDLCH
KLSSDEKRYYGDFSVLGKTPVAQLIAVYGVQAPPPLWQGLTVAEIFTKQVGKQTVVGDTVRVSGLRLRARSVENGTVVMA
GLKLPG

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG3263

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI87081854, Length=546, Percent_Identity=42.8571428571429, Blast_Score=367, Evalue=1e-102,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 60042; Mature: 60042

Theoretical pI: Translated: 8.18; Mature: 8.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESLNIFLLIGTGLMFTGLLLGSLSARFGVPSLLIFLVVGMVAGEDGLGGIEFDDFSTAY
CCCCEEEEEECHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHH
VIGNIALAVILLDGGLRTRLSTFKLGLRPALSLATLGVAISAALVGAFTTWLIGVDWRVG
HHHHHHHEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
LLLGGIIGSTDAAAVFSVIKGAGVTLNERVASTLEIESGLNDPMAIFITLMLVGMLVDPD
HHHHHHHCCCHHHHHHHHHHCCCCEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
AQWGAGMLVTLIQQFGLGILLGLLLGAVISEVLLRVRSNEGLHALLLCSGGAMVFAITNL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEHHHH
VGGSGFLAVYLTGLVAGNRRGGTGDNVLKAMDSMAWLAQSGMFLILGLLVTPSRLIENLP
CCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCHHHHHHHCC
YALAVAAFLMLLARPLSVWISLLPFRFTWREETFIAWTGLRGAVPIVLAVFPLLAGVEQT
HHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCEEEEEECCCCHHHHHHHHHHHHHCCCHH
YLLFDITLVVVLISLLGQGASLRFVARKLKVSVPRTTEPKQTVALAAPRDRYLMQFEVED
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEEEECC
GAKAVGKSLGELGENERTPLILYRNTRVLSLSDDPKIEAGDLIAWLAPLSHKSGLSDLCH
CHHHHHHHHHHCCCCCCCCEEEEECCEEEEECCCCCCCCCCHHHHHHCCCCCCCHHHHHH
KLSSDEKRYYGDFSVLGKTPVAQLIAVYGVQAPPPLWQGLTVAEIFTKQVGKQTVVGDTV
HHCCCCHHHCCCHHCCCCCHHHHHHHHHCCCCCCCHHCCCHHHHHHHHHHCCCCCCCCCE
RVSGLRLRARSVENGTVVMAGLKLPG
EECCEEEEEEECCCCEEEEEECCCCC
>Mature Secondary Structure
MESLNIFLLIGTGLMFTGLLLGSLSARFGVPSLLIFLVVGMVAGEDGLGGIEFDDFSTAY
CCCCEEEEEECHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHH
VIGNIALAVILLDGGLRTRLSTFKLGLRPALSLATLGVAISAALVGAFTTWLIGVDWRVG
HHHHHHHEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
LLLGGIIGSTDAAAVFSVIKGAGVTLNERVASTLEIESGLNDPMAIFITLMLVGMLVDPD
HHHHHHHCCCHHHHHHHHHHCCCCEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
AQWGAGMLVTLIQQFGLGILLGLLLGAVISEVLLRVRSNEGLHALLLCSGGAMVFAITNL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEHHHH
VGGSGFLAVYLTGLVAGNRRGGTGDNVLKAMDSMAWLAQSGMFLILGLLVTPSRLIENLP
CCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCHHHHHHHCC
YALAVAAFLMLLARPLSVWISLLPFRFTWREETFIAWTGLRGAVPIVLAVFPLLAGVEQT
HHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCEEEEEECCCCHHHHHHHHHHHHHCCCHH
YLLFDITLVVVLISLLGQGASLRFVARKLKVSVPRTTEPKQTVALAAPRDRYLMQFEVED
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEEEECC
GAKAVGKSLGELGENERTPLILYRNTRVLSLSDDPKIEAGDLIAWLAPLSHKSGLSDLCH
CHHHHHHHHHHCCCCCCCCEEEEECCEEEEECCCCCCCCCCHHHHHHCCCCCCCHHHHHH
KLSSDEKRYYGDFSVLGKTPVAQLIAVYGVQAPPPLWQGLTVAEIFTKQVGKQTVVGDTV
HHCCCCHHHCCCHHCCCCCHHHHHHHHHCCCCCCCHHCCCHHHHHHHHHHCCCCCCCCCE
RVSGLRLRARSVENGTVVMAGLKLPG
EECCEEEEEEECCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]