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The map label for this gene is proC [H]

Identifier: 110835529

GI number: 110835529

Start: 3016291

End: 3017100

Strand: Reverse

Name: proC [H]

Synonym: ABO_2668

Alternate gene names: 110835529

Gene position: 3017100-3016291 (Counterclockwise)

Preceding gene: 110835530

Following gene: 110835528

Centisome position: 96.7

GC content: 61.73

Gene sequence:

>810_bases
ATGGCACAACAACTAATCGGATTTATCGGCGCCGGCAACATGGCAACCAGCCTGGCCGGAGGCATGGTGGCGAAAGGAAT
TCGCCCGGCCCGTATCTGGATGAGCGACCCCTCTAAAGACCGGTTGGACGAAGTCGCCCAGCTGCAACGGGTGCATGTGA
GTACCGAAAACCGTGATGTGGCGGGGCGGGTCGACGTGCTGGTGCTGGCGGTGAAGCCACAGATGATGGAGCAGGTGTGT
ACCGACCTGCGTGACCTGATCGCGGAGCGTCAGCCCCTGGTGATCTCCATTGCCGCCGGTGTGACCGTGGGCAACCTGCG
TCGCTGGCTGGGTAGTACTCCGATTGTGCGCTGCATGCCCAATACGCCGTCGCTGGTACAGGCCGGCGCCACTGGCCTGT
ATGCCGCCGATGATGTGAGCGATGAGCAAAAAGCCATGGCCAAGGAAATTCTTGGTTCCGTGGGTATCGCGTTCTGGTTT
GACGAAGAAAAAGAACTGGATGCGGTCACCGCCGTTTCTGGCTCCGGTCCGGCGTACTTTTTCCTGCTGATGGAATCGCT
GATCGAAGCGGCCAAGGCCCAGGGGCTGGATGCGGGCACTGCTCGGCAGATGGTGCTGCAAACGGCCTGGGGCGCAGCCC
AACTGGCGATTACCAGTGAAGTGGGCCCGGATGTGCTGCGCCAGCAAGTCACCAGCCCCGGTGGCACTACCGCCGCAGCA
TTGGGTGTGTTTGAGGAAGCCGGTTTTCGCGAACAGGTGCAAGCCGCCGTTGCTGCCGCGCGTGAGCGGTCGGAAGAGCT
GGCAGGATAA

Upstream 100 bases:

>100_bases
ATCCGGTGGCTATTGAAGAAGGTGCTACCGTGATCCGGCTGGGCACCGCCCTGTTCGGCCCGCGCCCGCCCAAGGCTTGA
TAACAAAGGACTGCGCAGTT

Downstream 100 bases:

>100_bases
AGCAGCAACACGTGGCAAGCAGCAAGATGCGGGGATGATTAGAAGCTTTTGAGATGCGGTGCCCACGCAATTAGGCTTGA
GCGTGGGTACGGTCTATTTT

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 269; Mature: 268

Protein sequence:

>269_residues
MAQQLIGFIGAGNMATSLAGGMVAKGIRPARIWMSDPSKDRLDEVAQLQRVHVSTENRDVAGRVDVLVLAVKPQMMEQVC
TDLRDLIAERQPLVISIAAGVTVGNLRRWLGSTPIVRCMPNTPSLVQAGATGLYAADDVSDEQKAMAKEILGSVGIAFWF
DEEKELDAVTAVSGSGPAYFFLLMESLIEAAKAQGLDAGTARQMVLQTAWGAAQLAITSEVGPDVLRQQVTSPGGTTAAA
LGVFEEAGFREQVQAAVAAARERSEELAG

Sequences:

>Translated_269_residues
MAQQLIGFIGAGNMATSLAGGMVAKGIRPARIWMSDPSKDRLDEVAQLQRVHVSTENRDVAGRVDVLVLAVKPQMMEQVC
TDLRDLIAERQPLVISIAAGVTVGNLRRWLGSTPIVRCMPNTPSLVQAGATGLYAADDVSDEQKAMAKEILGSVGIAFWF
DEEKELDAVTAVSGSGPAYFFLLMESLIEAAKAQGLDAGTARQMVLQTAWGAAQLAITSEVGPDVLRQQVTSPGGTTAAA
LGVFEEAGFREQVQAAVAAARERSEELAG
>Mature_268_residues
AQQLIGFIGAGNMATSLAGGMVAKGIRPARIWMSDPSKDRLDEVAQLQRVHVSTENRDVAGRVDVLVLAVKPQMMEQVCT
DLRDLIAERQPLVISIAAGVTVGNLRRWLGSTPIVRCMPNTPSLVQAGATGLYAADDVSDEQKAMAKEILGSVGIAFWFD
EEKELDAVTAVSGSGPAYFFLLMESLIEAAKAQGLDAGTARQMVLQTAWGAAQLAITSEVGPDVLRQQVTSPGGTTAAAL
GVFEEAGFREQVQAAVAAARERSEELAG

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797095, Length=269, Percent_Identity=37.546468401487, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI24797097, Length=269, Percent_Identity=37.546468401487, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI21361454, Length=268, Percent_Identity=35.8208955223881, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI198041662, Length=265, Percent_Identity=29.4339622641509, Blast_Score=114, Evalue=1e-25,
Organism=Escherichia coli, GI1786585, Length=268, Percent_Identity=36.5671641791045, Blast_Score=158, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17569021, Length=263, Percent_Identity=34.6007604562738, Blast_Score=140, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI17540664, Length=279, Percent_Identity=33.3333333333333, Blast_Score=123, Evalue=9e-29,
Organism=Saccharomyces cerevisiae, GI6320861, Length=216, Percent_Identity=32.8703703703704, Blast_Score=113, Evalue=3e-26,
Organism=Drosophila melanogaster, GI21358587, Length=268, Percent_Identity=35.4477611940299, Blast_Score=145, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24648116, Length=272, Percent_Identity=31.6176470588235, Blast_Score=117, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24647700, Length=171, Percent_Identity=36.2573099415205, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 28426; Mature: 28295

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQQLIGFIGAGNMATSLAGGMVAKGIRPARIWMSDPSKDRLDEVAQLQRVHVSTENRDV
CHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCC
AGRVDVLVLAVKPQMMEQVCTDLRDLIAERQPLVISIAAGVTVGNLRRWLGSTPIVRCMP
CCCEEEEEEEECHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCEEEECC
NTPSLVQAGATGLYAADDVSDEQKAMAKEILGSVGIAFWFDEEKELDAVTAVSGSGPAYF
CCCHHHHHCCCCCEECCCCCHHHHHHHHHHHHHCCEEEEECCCHHHHHHEEECCCCHHHH
FLLMESLIEAAKAQGLDAGTARQMVLQTAWGAAQLAITSEVGPDVLRQQVTSPGGTTAAA
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHEEEEECCCCHHHHHHHHCCCCCCHHHH
LGVFEEAGFREQVQAAVAAARERSEELAG
HHHHHHCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AQQLIGFIGAGNMATSLAGGMVAKGIRPARIWMSDPSKDRLDEVAQLQRVHVSTENRDV
HHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCC
AGRVDVLVLAVKPQMMEQVCTDLRDLIAERQPLVISIAAGVTVGNLRRWLGSTPIVRCMP
CCCEEEEEEEECHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCEEEECC
NTPSLVQAGATGLYAADDVSDEQKAMAKEILGSVGIAFWFDEEKELDAVTAVSGSGPAYF
CCCHHHHHCCCCCEECCCCCHHHHHHHHHHHHHCCEEEEECCCHHHHHHEEECCCCHHHH
FLLMESLIEAAKAQGLDAGTARQMVLQTAWGAAQLAITSEVGPDVLRQQVTSPGGTTAAA
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHEEEEECCCCHHHHHHHHCCCCCCHHHH
LGVFEEAGFREQVQAAVAAARERSEELAG
HHHHHHCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2107123; 10984043; 1676385 [H]