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The map label for this gene is hisB

Identifier: 110835142

GI number: 110835142

Start: 2600236

End: 2600850

Strand: Reverse

Name: hisB

Synonym: ABO_2281

Alternate gene names: 110835142

Gene position: 2600850-2600236 (Counterclockwise)

Preceding gene: 110835144

Following gene: 110835141

Centisome position: 83.36

GC content: 55.28

Gene sequence:

>615_bases
ATGAGCAAGCGAAGCGCTACCGTAGAGCGCAACACCCTGGAAACCCAGATTCAAGCCACTATCAATTTGGATGGTACCGG
GCAGTGCACGCTGGATACGGGTCTGCCGTTCCTTGAGCACATGCTGGATCAGGTGGCCCGTCATGGCCTGGTTGATTTGG
ATATCAAAGCCAAGGGTGATCTGCACATCGATGCCCACCACACGGTGGAAGATATCGGTATCACCCTTGGGCAGGCCTTC
GCCAAGGCTGTCGGTGATAAAAAAGGCGTTCGCCGTTACGGCCATGCCTATGTGCCGCTGGATGAAGCGCTGTCACGGGT
GGTGCTGGATCTGTCTGGCCGGCCTGGGCTGGAGATGTTTGTGGAATTTACGCGAGGCAGCATTGGCGGCTTTGATGTGG
ATCTGTTCTATGAATTTTTCCAGGGCTTCGTGAACCACGCCATGATTACCCTGCATATTGATAACCTTCGCGGTAAAAAC
GCGCATCACCAGGCCGAGACCGTCTTTAAGGCGTTTGGCCGTGCACTGCGTATGGCCGTAGAGCCTGATCCTCGTATGGA
TGGTATTACGCCCTCCACGAAGGGCACCCTGAGCGAAAGTGGCGATAGCCAGTAA

Upstream 100 bases:

>100_bases
TAAGGGTGTGGGCTTCTACGCTGATCGGCATCTGTCCTCTCCGCTGGTTAGGTCCTGTTGGGGTGCGTATAATAGCCGGT
CCAATGCCTGGGAGGTATAG

Downstream 100 bases:

>100_bases
GCAGCCCAGTAGCAATTACAAGGACAGCCCCGAGTATGAGCGAAGTCGTTGCCGTTATTGATTACGGAATGGGTAACCTG
CACTCCGCAGGTAAGGCGCT

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 204; Mature: 203

Protein sequence:

>204_residues
MSKRSATVERNTLETQIQATINLDGTGQCTLDTGLPFLEHMLDQVARHGLVDLDIKAKGDLHIDAHHTVEDIGITLGQAF
AKAVGDKKGVRRYGHAYVPLDEALSRVVLDLSGRPGLEMFVEFTRGSIGGFDVDLFYEFFQGFVNHAMITLHIDNLRGKN
AHHQAETVFKAFGRALRMAVEPDPRMDGITPSTKGTLSESGDSQ

Sequences:

>Translated_204_residues
MSKRSATVERNTLETQIQATINLDGTGQCTLDTGLPFLEHMLDQVARHGLVDLDIKAKGDLHIDAHHTVEDIGITLGQAF
AKAVGDKKGVRRYGHAYVPLDEALSRVVLDLSGRPGLEMFVEFTRGSIGGFDVDLFYEFFQGFVNHAMITLHIDNLRGKN
AHHQAETVFKAFGRALRMAVEPDPRMDGITPSTKGTLSESGDSQ
>Mature_203_residues
SKRSATVERNTLETQIQATINLDGTGQCTLDTGLPFLEHMLDQVARHGLVDLDIKAKGDLHIDAHHTVEDIGITLGQAFA
KAVGDKKGVRRYGHAYVPLDEALSRVVLDLSGRPGLEMFVEFTRGSIGGFDVDLFYEFFQGFVNHAMITLHIDNLRGKNA
HHQAETVFKAFGRALRMAVEPDPRMDGITPSTKGTLSESGDSQ

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=195, Percent_Identity=47.6923076923077, Blast_Score=174, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6324776, Length=221, Percent_Identity=41.6289592760181, Blast_Score=165, Evalue=5e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_ALCBS (Q0VM69)

Other databases:

- EMBL:   AM286690
- RefSeq:   YP_694001.1
- ProteinModelPortal:   Q0VM69
- SMR:   Q0VM69
- STRING:   Q0VM69
- GeneID:   4212198
- GenomeReviews:   AM286690_GR
- KEGG:   abo:ABO_2281
- NMPDR:   fig|393595.12.peg.2283
- eggNOG:   COG0131
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- PhylomeDB:   Q0VM69
- BioCyc:   ABOR393595:ABO_2281-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 22390; Mature: 22258

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKRSATVERNTLETQIQATINLDGTGQCTLDTGLPFLEHMLDQVARHGLVDLDIKAKGD
CCCCCCCHHHHHHHEEEEEEEEECCCCCEEECCCCHHHHHHHHHHHHCCCEEEEEECCCC
LHIDAHHTVEDIGITLGQAFAKAVGDKKGVRRYGHAYVPLDEALSRVVLDLSGRPGLEMF
EEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHH
VEFTRGSIGGFDVDLFYEFFQGFVNHAMITLHIDNLRGKNAHHQAETVFKAFGRALRMAV
HHHHCCCCCCCHHHHHHHHHHHHHHCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHC
EPDPRMDGITPSTKGTLSESGDSQ
CCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SKRSATVERNTLETQIQATINLDGTGQCTLDTGLPFLEHMLDQVARHGLVDLDIKAKGD
CCCCCCHHHHHHHEEEEEEEEECCCCCEEECCCCHHHHHHHHHHHHCCCEEEEEECCCC
LHIDAHHTVEDIGITLGQAFAKAVGDKKGVRRYGHAYVPLDEALSRVVLDLSGRPGLEMF
EEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHH
VEFTRGSIGGFDVDLFYEFFQGFVNHAMITLHIDNLRGKNAHHQAETVFKAFGRALRMAV
HHHHCCCCCCCHHHHHHHHHHHHHHCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHC
EPDPRMDGITPSTKGTLSESGDSQ
CCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA