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The map label for this gene is dtD

Identifier: 110835117

GI number: 110835117

Start: 2576084

End: 2576521

Strand: Reverse

Name: dtD

Synonym: ABO_2256

Alternate gene names: 110835117

Gene position: 2576521-2576084 (Counterclockwise)

Preceding gene: 110835119

Following gene: 110835116

Centisome position: 82.58

GC content: 48.86

Gene sequence:

>438_bases
GTGAAAGTATTAATGCAGCGAGTTAGTGAAGCCCATGTGGATGTGAGCGGTAGAACCGTGGGGGCGATTGATAATGGTTT
GTTATTGTTCATTGGTATAGAAAAGCACGATGACACCGCTTTAGTGGACAGGATGGTTGAACGCATCATTGGCTATAGAG
TTTTTGCGGACGAGCGAGGGAAAATGAATTGGGATGTGCGCGATGCGGGTGGGGCGTTACTGGCTATTTCTCAGTTTACT
CTCGTTGCGGATACTCGAAAGGGGCGTAGGCCGAGTTTTAGTAGTGCGGCAGATCCCGTTTTGGCAAGGCCATTATACGA
GCACTGTGTAGCACAATTGAAGGCTCATGGTCTGCCTGTGGCCACAGGGGTTTTTGCCGCTGAGATGCAGGTTTCTTTGG
TTAATGATGGCCCTGTTACCTTTATGCTTGAGATGTGA

Upstream 100 bases:

>100_bases
AGCTTAATTGGGTTGACAGGGGTGGACACTCTTCCATGGATCCGGGGGTGGCGCAGGCTCTGGTTAACGCGGTAACCCGA
CTGGATCGGAGGGCGAAGCA

Downstream 100 bases:

>100_bases
TTTATTATGGATCCGCTTGTTGCAAAGCCGTCTCCCTTGTTTATGATGAATTGAGTTGCCTCAAAATGGTAACGGGGAAC
GCGTTGTCGGCATAGTGTCG

Product: D-tyrosyl-tRNA(Tyr) deacylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 145; Mature: 145

Protein sequence:

>145_residues
MKVLMQRVSEAHVDVSGRTVGAIDNGLLLFIGIEKHDDTALVDRMVERIIGYRVFADERGKMNWDVRDAGGALLAISQFT
LVADTRKGRRPSFSSAADPVLARPLYEHCVAQLKAHGLPVATGVFAAEMQVSLVNDGPVTFMLEM

Sequences:

>Translated_145_residues
MKVLMQRVSEAHVDVSGRTVGAIDNGLLLFIGIEKHDDTALVDRMVERIIGYRVFADERGKMNWDVRDAGGALLAISQFT
LVADTRKGRRPSFSSAADPVLARPLYEHCVAQLKAHGLPVATGVFAAEMQVSLVNDGPVTFMLEM
>Mature_145_residues
MKVLMQRVSEAHVDVSGRTVGAIDNGLLLFIGIEKHDDTALVDRMVERIIGYRVFADERGKMNWDVRDAGGALLAISQFT
LVADTRKGRRPSFSSAADPVLARPLYEHCVAQLKAHGLPVATGVFAAEMQVSLVNDGPVTFMLEM

Specific function: Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine

COG id: COG1490

COG function: function code J; D-Tyr-tRNAtyr deacylase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DTD family

Homologues:

Organism=Homo sapiens, GI30795227, Length=148, Percent_Identity=39.1891891891892, Blast_Score=92, Evalue=2e-19,
Organism=Escherichia coli, GI1790320, Length=145, Percent_Identity=51.7241379310345, Blast_Score=159, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI115533292, Length=147, Percent_Identity=34.6938775510204, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6319982, Length=147, Percent_Identity=36.734693877551, Blast_Score=108, Evalue=3e-25,
Organism=Drosophila melanogaster, GI281361569, Length=146, Percent_Identity=35.6164383561644, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DTD_ALCBS (Q0VM94)

Other databases:

- EMBL:   AM286690
- RefSeq:   YP_693976.1
- ProteinModelPortal:   Q0VM94
- SMR:   Q0VM94
- STRING:   Q0VM94
- GeneID:   4211414
- GenomeReviews:   AM286690_GR
- KEGG:   abo:ABO_2256
- NMPDR:   fig|393595.12.peg.2257
- eggNOG:   COG1490
- HOGENOM:   HBG286048
- OMA:   MKAVIQR
- PhylomeDB:   Q0VM94
- ProtClustDB:   PRK05273
- BioCyc:   ABOR393595:ABO_2256-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00518
- InterPro:   IPR003732
- Gene3D:   G3DSA:3.50.80.10
- PANTHER:   PTHR10472
- TIGRFAMs:   TIGR00256

Pfam domain/function: PF02580 Tyr_Deacylase; SSF69500 DTyrtRNA_deacyls

EC number: NA

Molecular weight: Translated: 15840; Mature: 15840

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: ACT_SITE 80-80

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLMQRVSEAHVDVSGRTVGAIDNGLLLFIGIEKHDDTALVDRMVERIIGYRVFADERG
CHHHHHHHHHHCCCCCCCEEEEECCCEEEEEEECCCCCHHHHHHHHHHHHCEEEEECCCC
KMNWDVRDAGGALLAISQFTLVADTRKGRRPSFSSAADPVLARPLYEHCVAQLKAHGLPV
CCCCCEECCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
ATGVFAAEMQVSLVNDGPVTFMLEM
HHHHEEEEEEEEEECCCCEEEEEEC
>Mature Secondary Structure
MKVLMQRVSEAHVDVSGRTVGAIDNGLLLFIGIEKHDDTALVDRMVERIIGYRVFADERG
CHHHHHHHHHHCCCCCCCEEEEECCCEEEEEEECCCCCHHHHHHHHHHHHCEEEEECCCC
KMNWDVRDAGGALLAISQFTLVADTRKGRRPSFSSAADPVLARPLYEHCVAQLKAHGLPV
CCCCCEECCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
ATGVFAAEMQVSLVNDGPVTFMLEM
HHHHEEEEEEEEEECCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA