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The map label for this gene is pip [H]

Identifier: 110835119

GI number: 110835119

Start: 2576518

End: 2577441

Strand: Reverse

Name: pip [H]

Synonym: ABO_2257

Alternate gene names: 110835119

Gene position: 2577441-2576518 (Counterclockwise)

Preceding gene: 110835120

Following gene: 110835117

Centisome position: 82.61

GC content: 55.74

Gene sequence:

>924_bases
ATGGCGTTATTCCCTTATTTGGATGCTAACCGGCAGTTTTATCTTCCCGTAGGCGAGGGGCATCAACTGTATGTGGAGGA
AAGCGGCAATCCACAGGGCAGCCCGGTTGTCGTGCTGCATGGTGGGCCTGGTGGCGGTTGCTCCCCAGCGTTGCGGCGTT
TTTTTGATCCGCAAAAATTTCGCATGATTCTGTTTGATCAGCGTGGTTCCGGTCAAAGCCGGCCGCTGGGTTCTATCGAT
AATAATACCTTGAGCCATTTGCTATTGGATCTCGAAAAGATTCGCCAAGCGTTACATATTGAGCGTTGGATGGTGTTTGG
TGGCTCCTGGGGAGCAACACTGGCACTTGCGTATTTGGCGGCGTTCCCGCAGTACATTACGGCAATGGTGCTGCGGGGTA
TTTTTCTTTGTCGAGAGCGGGACTTAGACTGGCTCTACACTAGCAAAGGTGCTGCGCGTTTGTTCCCGGAAGCCTGGCAA
GCGCTGGAGCAGCAAGCGCCTCCCGGCAGTGGCCATTTGCTTGAACGTTATTATCAGGGACTACAGGGGGATGATGCGCA
TCGCTATGCGCGGGCATGGTGTAACTGGGAATCGACACTAGCCCTGATGCCCACCCAGCCGCCTGGGGCGGGTAGTGATG
GCGAGCTGTGCATGGCGAGGCAAGAAACCCATTATTTTCTTGCCGGCGGTTTTATTGAGCGCCCCTTGTTAGAGGTCTGT
GCAGGGAGCCAGGTGCCGGTGGAAATTGTGCATGGGCGCAGGGATTTCGTCTGTCCGCCGGAGCAAGCACTAGCATTGCA
TCAAGTGTTGCCCAATAGCGAGCTTAATTGGGTTGACAGGGGTGGACACTCTTCCATGGATCCGGGGGTGGCGCAGGCTC
TGGTTAACGCGGTAACCCGACTGGATCGGAGGGCGAAGCAGTGA

Upstream 100 bases:

>100_bases
GGCCTGCTCTGGTAGAGCGTTGTCACAGGCGGCCAGCAGACCTTGCAGCAGTACTAGCAACAGGTATGCTAAACCCCTTC
TTTTTCTCAGAACTTCCATC

Downstream 100 bases:

>100_bases
AAGTATTAATGCAGCGAGTTAGTGAAGCCCATGTGGATGTGAGCGGTAGAACCGTGGGGGCGATTGATAATGGTTTGTTA
TTGTTCATTGGTATAGAAAA

Product: proline iminopeptidase (PIP)

Products: NA

Alternate protein names: PIP; Prolyl aminopeptidase; PAP [H]

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MALFPYLDANRQFYLPVGEGHQLYVEESGNPQGSPVVVLHGGPGGGCSPALRRFFDPQKFRMILFDQRGSGQSRPLGSID
NNTLSHLLLDLEKIRQALHIERWMVFGGSWGATLALAYLAAFPQYITAMVLRGIFLCRERDLDWLYTSKGAARLFPEAWQ
ALEQQAPPGSGHLLERYYQGLQGDDAHRYARAWCNWESTLALMPTQPPGAGSDGELCMARQETHYFLAGGFIERPLLEVC
AGSQVPVEIVHGRRDFVCPPEQALALHQVLPNSELNWVDRGGHSSMDPGVAQALVNAVTRLDRRAKQ

Sequences:

>Translated_307_residues
MALFPYLDANRQFYLPVGEGHQLYVEESGNPQGSPVVVLHGGPGGGCSPALRRFFDPQKFRMILFDQRGSGQSRPLGSID
NNTLSHLLLDLEKIRQALHIERWMVFGGSWGATLALAYLAAFPQYITAMVLRGIFLCRERDLDWLYTSKGAARLFPEAWQ
ALEQQAPPGSGHLLERYYQGLQGDDAHRYARAWCNWESTLALMPTQPPGAGSDGELCMARQETHYFLAGGFIERPLLEVC
AGSQVPVEIVHGRRDFVCPPEQALALHQVLPNSELNWVDRGGHSSMDPGVAQALVNAVTRLDRRAKQ
>Mature_306_residues
ALFPYLDANRQFYLPVGEGHQLYVEESGNPQGSPVVVLHGGPGGGCSPALRRFFDPQKFRMILFDQRGSGQSRPLGSIDN
NTLSHLLLDLEKIRQALHIERWMVFGGSWGATLALAYLAAFPQYITAMVLRGIFLCRERDLDWLYTSKGAARLFPEAWQA
LEQQAPPGSGHLLERYYQGLQGDDAHRYARAWCNWESTLALMPTQPPGAGSDGELCMARQETHYFLAGGFIERPLLEVCA
GSQVPVEIVHGRRDFVCPPEQALALHQVLPNSELNWVDRGGHSSMDPGVAQALVNAVTRLDRRAKQ

Specific function: Specifically catalyzes the removal of N-terminal proline residues from peptides [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S33 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR005944
- InterPro:   IPR002410 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.4.11.5 [H]

Molecular weight: Translated: 34124; Mature: 33993

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALFPYLDANRQFYLPVGEGHQLYVEESGNPQGSPVVVLHGGPGGGCSPALRRFFDPQKF
CCCCCEECCCCEEEEEECCCCEEEEECCCCCCCCCEEEEECCCCCCCCHHHHHHCCCCCE
RMILFDQRGSGQSRPLGSIDNNTLSHLLLDLEKIRQALHIERWMVFGGSWGATLALAYLA
EEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHH
AFPQYITAMVLRGIFLCRERDLDWLYTSKGAARLFPEAWQALEQQAPPGSGHLLERYYQG
HHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHCCHHHHHHHHHCCCCCCCHHHHHHHCC
LQGDDAHRYARAWCNWESTLALMPTQPPGAGSDGELCMARQETHYFLAGGFIERPLLEVC
CCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCEEEEECCCEEEEECCHHHHHHHHHH
AGSQVPVEIVHGRRDFVCPPEQALALHQVLPNSELNWVDRGGHSSMDPGVAQALVNAVTR
CCCCCCEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCEECCCCCCCCHHHHHHHHHHHHH
LDRRAKQ
HHHHHCC
>Mature Secondary Structure 
ALFPYLDANRQFYLPVGEGHQLYVEESGNPQGSPVVVLHGGPGGGCSPALRRFFDPQKF
CCCCEECCCCEEEEEECCCCEEEEECCCCCCCCCEEEEECCCCCCCCHHHHHHCCCCCE
RMILFDQRGSGQSRPLGSIDNNTLSHLLLDLEKIRQALHIERWMVFGGSWGATLALAYLA
EEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHH
AFPQYITAMVLRGIFLCRERDLDWLYTSKGAARLFPEAWQALEQQAPPGSGHLLERYYQG
HHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHCCHHHHHHHHHCCCCCCCHHHHHHHCC
LQGDDAHRYARAWCNWESTLALMPTQPPGAGSDGELCMARQETHYFLAGGFIERPLLEVC
CCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCEEEEECCCEEEEECCHHHHHHHHHH
AGSQVPVEIVHGRRDFVCPPEQALALHQVLPNSELNWVDRGGHSSMDPGVAQALVNAVTR
CCCCCCEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCEECCCCCCCCHHHHHHHHHHHHH
LDRRAKQ
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]