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The map label for this gene is bioF

Identifier: 110835080

GI number: 110835080

Start: 2531966

End: 2533126

Strand: Reverse

Name: bioF

Synonym: ABO_2219

Alternate gene names: 110835080

Gene position: 2533126-2531966 (Counterclockwise)

Preceding gene: 110835081

Following gene: 110835079

Centisome position: 81.19

GC content: 60.29

Gene sequence:

>1161_bases
GTGGGCTTTGATCTGGCCACCGATCTGGCTGCACGCCGCCGCCAGCACCGTTACCGGCAAGCGCGTATCATGGATGGCCC
CAGTGGCCGCCATGCGTTGCTGGGTGGGCGCCAGTATCTGAATTTCTGCAGCAATGATTATCTTGGTTTGGCCAATGACC
CGGCTGTGGTGGCGGCCTTTCAACAAGGCGCTGCGGATTGGGGGGTGGGCAGTGGCGCCTCGCATTTAGTGTGTGGTCAT
CAACGTCCCCACCAACAGCTGGAGGAAGCGCTGGCGGCCCATACCGGTCGTCAGCGTGCCTTGTTGTTCTCCACCGGTTA
CATGGCCAACCTGGGCGTTATGACCGCCTTGCTGAGCAAGGGGGATGCGGTGTTCCAAGACCGTCTTAATCATGCCTCGC
TGCTGGATGGCGGTTTACTCAGTGGTGCCCGTTTTCGACGGTTTCCCCATAATGATGGGCAGGCGCTGGCTAGCCAATTG
GCCCGCAGTGAGGCGCGCCGGAAATTGGTGGTGGTCGACGGGGTGTTCAGTATGGATGGCGACGAGGCGCCACTGGTGGA
CTATGCCGAGGCCTGCGAAGGCCATGATGCCTGGTTGATGGTGGATGATGCCCACGGCATCGGCGTGCTGGACGCTCAGG
GCCGTGGCAGTGTCTTCACTCAGGGCGTCAACGAACGGGTGCCGGTGCTGATGGGAACCCTAGGTAAAGGATTGGGTACG
GCGGGTGCTTTTGTGGCCGGTAGCGATGAATTAATCGAAACATTGATCCAGTTCGCCCGCACTTTTATCTATACCACGGC
CATGCCTGCCGCCGTGGCCAGCGCCACCCTGGTTAGCCTGAGAAAATCCCGAGAGGAGAATTGGCGTCGGGATACGTTGG
CAGAGTTGATCGCCCGTTTCCGCCAGGGTGCCCGTGCGTTGGGCTACACCCTGATGCCATCGCAAACGCCTATCCAGCCT
TTGCTGATTGGCAGTGATGTGGATGCCACGGCGCTCAGTGAGGCACTTCGCGAAAAAGGGTTTCTCATTACCGCGATCCG
CCCGCCCACGGTGCGGGAAGGTGAAGCGCGCTTGCGAGTGACGTTATCTGCCGCCCATGAGGTTGAGGATGTGGATGCGT
TGCTGGCGGCGCTGGCGCAATGCCAAACCCAAGACGTTTAA

Upstream 100 bases:

>100_bases
TGGGCTCTTCTACAATGCCATGGACAGCAAACGCACGGCCAAGCACGTGCTCGACAAGGACACCGGGCGCCCCACCGCTA
CCGAACACTGAGGTCTGCCC

Downstream 100 bases:

>100_bases
ATCACAGACTTTTTACCACCGAGATCGTTGTTTCTTCTGTGGCAAAAAAAGGAAGATGAATGCCCAGGTTGATCCCTTTT
CATAACACTTATCGGGCCAC

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase

Number of amino acids: Translated: 386; Mature: 385

Protein sequence:

>386_residues
MGFDLATDLAARRRQHRYRQARIMDGPSGRHALLGGRQYLNFCSNDYLGLANDPAVVAAFQQGAADWGVGSGASHLVCGH
QRPHQQLEEALAAHTGRQRALLFSTGYMANLGVMTALLSKGDAVFQDRLNHASLLDGGLLSGARFRRFPHNDGQALASQL
ARSEARRKLVVVDGVFSMDGDEAPLVDYAEACEGHDAWLMVDDAHGIGVLDAQGRGSVFTQGVNERVPVLMGTLGKGLGT
AGAFVAGSDELIETLIQFARTFIYTTAMPAAVASATLVSLRKSREENWRRDTLAELIARFRQGARALGYTLMPSQTPIQP
LLIGSDVDATALSEALREKGFLITAIRPPTVREGEARLRVTLSAAHEVEDVDALLAALAQCQTQDV

Sequences:

>Translated_386_residues
MGFDLATDLAARRRQHRYRQARIMDGPSGRHALLGGRQYLNFCSNDYLGLANDPAVVAAFQQGAADWGVGSGASHLVCGH
QRPHQQLEEALAAHTGRQRALLFSTGYMANLGVMTALLSKGDAVFQDRLNHASLLDGGLLSGARFRRFPHNDGQALASQL
ARSEARRKLVVVDGVFSMDGDEAPLVDYAEACEGHDAWLMVDDAHGIGVLDAQGRGSVFTQGVNERVPVLMGTLGKGLGT
AGAFVAGSDELIETLIQFARTFIYTTAMPAAVASATLVSLRKSREENWRRDTLAELIARFRQGARALGYTLMPSQTPIQP
LLIGSDVDATALSEALREKGFLITAIRPPTVREGEARLRVTLSAAHEVEDVDALLAALAQCQTQDV
>Mature_385_residues
GFDLATDLAARRRQHRYRQARIMDGPSGRHALLGGRQYLNFCSNDYLGLANDPAVVAAFQQGAADWGVGSGASHLVCGHQ
RPHQQLEEALAAHTGRQRALLFSTGYMANLGVMTALLSKGDAVFQDRLNHASLLDGGLLSGARFRRFPHNDGQALASQLA
RSEARRKLVVVDGVFSMDGDEAPLVDYAEACEGHDAWLMVDDAHGIGVLDAQGRGSVFTQGVNERVPVLMGTLGKGLGTA
GAFVAGSDELIETLIQFARTFIYTTAMPAAVASATLVSLRKSREENWRRDTLAELIARFRQGARALGYTLMPSQTPIQPL
LIGSDVDATALSEALREKGFLITAIRPPTVREGEARLRVTLSAAHEVEDVDALLAALAQCQTQDV

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily

Homologues:

Organism=Homo sapiens, GI7657118, Length=380, Percent_Identity=33.6842105263158, Blast_Score=215, Evalue=4e-56,
Organism=Homo sapiens, GI284448556, Length=343, Percent_Identity=35.2769679300292, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI83977442, Length=387, Percent_Identity=30.749354005168, Blast_Score=169, Evalue=6e-42,
Organism=Homo sapiens, GI83977440, Length=387, Percent_Identity=30.749354005168, Blast_Score=168, Evalue=6e-42,
Organism=Homo sapiens, GI83977444, Length=387, Percent_Identity=30.749354005168, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI4758668, Length=363, Percent_Identity=28.9256198347107, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI4502025, Length=353, Percent_Identity=30.5949008498584, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI40316939, Length=353, Percent_Identity=30.5949008498584, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI119220554, Length=363, Percent_Identity=28.6501377410468, Blast_Score=145, Evalue=5e-35,
Organism=Homo sapiens, GI5454084, Length=268, Percent_Identity=24.6268656716418, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1786993, Length=353, Percent_Identity=49.8583569405099, Blast_Score=306, Evalue=1e-84,
Organism=Escherichia coli, GI1790046, Length=387, Percent_Identity=35.4005167958656, Blast_Score=229, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI71994529, Length=382, Percent_Identity=32.4607329842932, Blast_Score=216, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI32566772, Length=362, Percent_Identity=28.1767955801105, Blast_Score=147, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI17560914, Length=361, Percent_Identity=27.4238227146814, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17560912, Length=361, Percent_Identity=27.4238227146814, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI71982617, Length=297, Percent_Identity=24.5791245791246, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI71982625, Length=295, Percent_Identity=24.7457627118644, Blast_Score=91, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6320438, Length=364, Percent_Identity=30.7692307692308, Blast_Score=162, Evalue=9e-41,
Organism=Saccharomyces cerevisiae, GI6320267, Length=361, Percent_Identity=29.0858725761773, Blast_Score=142, Evalue=9e-35,
Organism=Saccharomyces cerevisiae, GI6323954, Length=269, Percent_Identity=26.0223048327138, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24662918, Length=379, Percent_Identity=34.5646437994723, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI17137420, Length=386, Percent_Identity=29.0155440414508, Blast_Score=161, Evalue=7e-40,
Organism=Drosophila melanogaster, GI17136286, Length=361, Percent_Identity=27.9778393351801, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24653280, Length=284, Percent_Identity=22.887323943662, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24653276, Length=284, Percent_Identity=22.887323943662, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24653278, Length=284, Percent_Identity=22.887323943662, Blast_Score=85, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BIOF_ALCBS (Q0VMD1)

Other databases:

- EMBL:   AM286690
- RefSeq:   YP_693939.1
- ProteinModelPortal:   Q0VMD1
- STRING:   Q0VMD1
- GeneID:   4212137
- GenomeReviews:   AM286690_GR
- KEGG:   abo:ABO_2219
- NMPDR:   fig|393595.12.peg.2218
- eggNOG:   COG0156
- HOGENOM:   HBG649839
- OMA:   ATVMAMS
- PhylomeDB:   Q0VMD1
- BioCyc:   ABOR393595:ABO_2219-MONOMER
- HAMAP:   MF_01693
- InterPro:   IPR022834
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR00858

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.3.1.47

Molecular weight: Translated: 41516; Mature: 41384

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: BINDING 19-19 BINDING 131-131 BINDING 177-177 BINDING 350-350

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGFDLATDLAARRRQHRYRQARIMDGPSGRHALLGGRQYLNFCSNDYLGLANDPAVVAAF
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHCCHHHHHHHCCCCCCCCCCCHHHHHH
QQGAADWGVGSGASHLVCGHQRPHQQLEEALAAHTGRQRALLFSTGYMANLGVMTALLSK
HHCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHC
GDAVFQDRLNHASLLDGGLLSGARFRRFPHNDGQALASQLARSEARRKLVVVDGVFSMDG
CCHHHHHHCCHHHHHCCCHHCCHHHHCCCCCCHHHHHHHHHHHHHHCEEEEEECEEECCC
DEAPLVDYAEACEGHDAWLMVDDAHGIGVLDAQGRGSVFTQGVNERVPVLMGTLGKGLGT
CCCCCHHHHHHCCCCCCEEEEECCCCCEEEECCCCCCHHHCCCCCCCHHHHHHHCCCCCC
AGAFVAGSDELIETLIQFARTFIYTTAMPAAVASATLVSLRKSREENWRRDTLAELIARF
CCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RQGARALGYTLMPSQTPIQPLLIGSDVDATALSEALREKGFLITAIRPPTVREGEARLRV
HHCHHHHCEEECCCCCCCCEEEECCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEE
TLSAAHEVEDVDALLAALAQCQTQDV
EEEHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
GFDLATDLAARRRQHRYRQARIMDGPSGRHALLGGRQYLNFCSNDYLGLANDPAVVAAF
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHCCHHHHHHHCCCCCCCCCCCHHHHHH
QQGAADWGVGSGASHLVCGHQRPHQQLEEALAAHTGRQRALLFSTGYMANLGVMTALLSK
HHCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHC
GDAVFQDRLNHASLLDGGLLSGARFRRFPHNDGQALASQLARSEARRKLVVVDGVFSMDG
CCHHHHHHCCHHHHHCCCHHCCHHHHCCCCCCHHHHHHHHHHHHHHCEEEEEECEEECCC
DEAPLVDYAEACEGHDAWLMVDDAHGIGVLDAQGRGSVFTQGVNERVPVLMGTLGKGLGT
CCCCCHHHHHHCCCCCCEEEEECCCCCEEEECCCCCCHHHCCCCCCCHHHHHHHCCCCCC
AGAFVAGSDELIETLIQFARTFIYTTAMPAAVASATLVSLRKSREENWRRDTLAELIARF
CCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RQGARALGYTLMPSQTPIQPLLIGSDVDATALSEALREKGFLITAIRPPTVREGEARLRV
HHCHHHHCEEECCCCCCCCEEEECCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEE
TLSAAHEVEDVDALLAALAQCQTQDV
EEEHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA