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The map label for this gene is ribD [H]

Identifier: 110835035

GI number: 110835035

Start: 2483014

End: 2484147

Strand: Reverse

Name: ribD [H]

Synonym: ABO_2174

Alternate gene names: 110835035

Gene position: 2484147-2483014 (Counterclockwise)

Preceding gene: 110835036

Following gene: 110835034

Centisome position: 79.62

GC content: 62.35

Gene sequence:

>1134_bases
ATGAGTTTTTCGGCTGCCGACCACCAGTACATGGCTCGAGCGTTGCAGTTGGCACGTCGTGGGCTGTATACCACGGACCC
TAATCCGCGGGTAGGGTGCGTGTTGGTGCGTGATGGCGCGGTGGTTGGTGAGGGTTTTCATGCCCGCGCCGGGACTCCCC
ACGCCGAGCGTCATGCACTGGCACAAGCCGGTGAGCGGGCGCGGGGCGCTACTGCCTATGTGACCCTGGAGCCCTGCTCT
CACACTGGGCGCACCGGCCCCTGTGCTGATGCGCTAATCGATGCCGGCGTCACGCGGGTGGTGGCTGCCATGGAAGATCC
GAATCCGCTGGTGGCGGGGCAGGGTTTGCAGCGCTTGGCGGATGCGGGAATCGCCACTGCAGTCGGTTTGCTGGAAGCGG
AGGCCCGAGCCCTGAATCCGGGTTTTGTTTCCCGCATGACCCGTCAGCGTCCCTATATCCGTATCAAGATTGCCGCCAGC
GTGGACGGGCGCACCGCCATGGCCAATGGCGAATCCCAGTGGATTACCGGCCCAGCCGCCCGCGAAGACGTGCAGCGTCT
ACGCGCGCGCAGCTCTGCGGTGATAACCGGTGTGGGTACGGTGCTGGCGGATCGACCCTCTTATACAGTGAGGCCTAGAC
AGTGGCGCTTGGCCGAATACCGCCAGCATGCGGCTGACGACGATTGGGTGCGACAGCCTCTGCGGGTGATTCTAGATCGC
ACCCTACGCACGCCGCCGGATGTGCCGGTGGTCAGCGCCTTAGGGCATTGTTTGTTGGTGGCAGGGGAACAACACCCAGG
ACGCCAGAATGCGCTGGAGTCCGCCGGTGCGGAAGTAATGCTCTTGCCCGCCTCCGGTTCCGGGATCGACTTGCAGCAGT
TGTTAATCGAATTGAACCGGCGCGAATGTAACGAAGTGCTGGTAGAATGTGGCGCCACACTGGCCGGTGCCTTTGTTCGC
GAGGGTTTGTTCGACGAAATTCTTGTGTATATGGCGCCAACTCTGCTGGGTTCGTCCGCCCGGCCGTTATTGGGGTTGCC
GCAACTGGCCAGCATGAGTGAGAAAGTGGCGCTGAAATGGCAGGATGTGCGCCAAGTTGGTGATGATCTGCGTCTGACGC
TGGTTTCGGCCTGA

Upstream 100 bases:

>100_bases
ATCGCAGTTTTCAGGATATTTCCGAGTTTTCCGCTGAAGTGGATCGCCTGAAAAAGGCGGGCGGCAAACCCGGTGACAAG
CTGGGTGAGCCAAAAGAATC

Downstream 100 bases:

>100_bases
TCAACGACCCTCCTTTTTCCGCCCGAATTCAAGAGGTTTCCATGTTTACCGGCATTATCGAATCCATGGGCAAGGTGGCC
GCGATGACCCCAAAAGGGGG

Product: (S)-2-hydroxy-fatty-acid dehydrogenase

Products: NA

Alternate protein names: Diaminohydroxyphosphoribosylaminopyrimidine deaminase; DRAP deaminase; Riboflavin-specific deaminase; 5-amino-6-(5-phosphoribosylamino)uracil reductase; HTP reductase [H]

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MSFSAADHQYMARALQLARRGLYTTDPNPRVGCVLVRDGAVVGEGFHARAGTPHAERHALAQAGERARGATAYVTLEPCS
HTGRTGPCADALIDAGVTRVVAAMEDPNPLVAGQGLQRLADAGIATAVGLLEAEARALNPGFVSRMTRQRPYIRIKIAAS
VDGRTAMANGESQWITGPAAREDVQRLRARSSAVITGVGTVLADRPSYTVRPRQWRLAEYRQHAADDDWVRQPLRVILDR
TLRTPPDVPVVSALGHCLLVAGEQHPGRQNALESAGAEVMLLPASGSGIDLQQLLIELNRRECNEVLVECGATLAGAFVR
EGLFDEILVYMAPTLLGSSARPLLGLPQLASMSEKVALKWQDVRQVGDDLRLTLVSA

Sequences:

>Translated_377_residues
MSFSAADHQYMARALQLARRGLYTTDPNPRVGCVLVRDGAVVGEGFHARAGTPHAERHALAQAGERARGATAYVTLEPCS
HTGRTGPCADALIDAGVTRVVAAMEDPNPLVAGQGLQRLADAGIATAVGLLEAEARALNPGFVSRMTRQRPYIRIKIAAS
VDGRTAMANGESQWITGPAAREDVQRLRARSSAVITGVGTVLADRPSYTVRPRQWRLAEYRQHAADDDWVRQPLRVILDR
TLRTPPDVPVVSALGHCLLVAGEQHPGRQNALESAGAEVMLLPASGSGIDLQQLLIELNRRECNEVLVECGATLAGAFVR
EGLFDEILVYMAPTLLGSSARPLLGLPQLASMSEKVALKWQDVRQVGDDLRLTLVSA
>Mature_376_residues
SFSAADHQYMARALQLARRGLYTTDPNPRVGCVLVRDGAVVGEGFHARAGTPHAERHALAQAGERARGATAYVTLEPCSH
TGRTGPCADALIDAGVTRVVAAMEDPNPLVAGQGLQRLADAGIATAVGLLEAEARALNPGFVSRMTRQRPYIRIKIAASV
DGRTAMANGESQWITGPAAREDVQRLRARSSAVITGVGTVLADRPSYTVRPRQWRLAEYRQHAADDDWVRQPLRVILDRT
LRTPPDVPVVSALGHCLLVAGEQHPGRQNALESAGAEVMLLPASGSGIDLQQLLIELNRRECNEVLVECGATLAGAFVRE
GLFDEILVYMAPTLLGSSARPLLGLPQLASMSEKVALKWQDVRQVGDDLRLTLVSA

Specific function: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate [H]

COG id: COG0117

COG function: function code H; Pyrimidine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the HTP reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786616, Length=372, Percent_Identity=52.4193548387097, Blast_Score=364, Evalue=1e-102,
Organism=Escherichia coli, GI145693172, Length=176, Percent_Identity=36.9318181818182, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193
- InterPro:   IPR004794
- InterPro:   IPR011549
- InterPro:   IPR002734 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1; PF01872 RibD_C [H]

EC number: =3.5.4.26; =1.1.1.193 [H]

Molecular weight: Translated: 40448; Mature: 40317

Theoretical pI: Translated: 7.87; Mature: 7.87

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFSAADHQYMARALQLARRGLYTTDPNPRVGCVLVRDGAVVGEGFHARAGTPHAERHAL
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCEEECCCCCCCCCCCHHHHHHH
AQAGERARGATAYVTLEPCSHTGRTGPCADALIDAGVTRVVAAMEDPNPLVAGQGLQRLA
HHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
DAGIATAVGLLEAEARALNPGFVSRMTRQRPYIRIKIAASVDGRTAMANGESQWITGPAA
HHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEEEEEECCCCCEEECCCCCCEEECCHH
REDVQRLRARSSAVITGVGTVLADRPSYTVRPRQWRLAEYRQHAADDDWVRQPLRVILDR
HHHHHHHHHHCCEEEEEHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHH
TLRTPPDVPVVSALGHCLLVAGEQHPGRQNALESAGAEVMLLPASGSGIDLQQLLIELNR
HHCCCCCCHHHHHHCCEEEEECCCCCCHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHH
RECNEVLVECGATLAGAFVREGLFDEILVYMAPTLLGSSARPLLGLPQLASMSEKVALKW
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCHHHHHHHH
QDVRQVGDDLRLTLVSA
HHHHHCCCCEEEEEECC
>Mature Secondary Structure 
SFSAADHQYMARALQLARRGLYTTDPNPRVGCVLVRDGAVVGEGFHARAGTPHAERHAL
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCEEECCCCCCCCCCCHHHHHHH
AQAGERARGATAYVTLEPCSHTGRTGPCADALIDAGVTRVVAAMEDPNPLVAGQGLQRLA
HHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
DAGIATAVGLLEAEARALNPGFVSRMTRQRPYIRIKIAASVDGRTAMANGESQWITGPAA
HHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEEEEEECCCCCEEECCCCCCEEECCHH
REDVQRLRARSSAVITGVGTVLADRPSYTVRPRQWRLAEYRQHAADDDWVRQPLRVILDR
HHHHHHHHHHCCEEEEEHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHH
TLRTPPDVPVVSALGHCLLVAGEQHPGRQNALESAGAEVMLLPASGSGIDLQQLLIELNR
HHCCCCCCHHHHHHCCEEEEECCCCCCHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHH
RECNEVLVECGATLAGAFVREGLFDEILVYMAPTLLGSSARPLLGLPQLASMSEKVALKW
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCHHHHHHHH
QDVRQVGDDLRLTLVSA
HHHHHCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1406588; 9278503; 9068650 [H]