Click here to switch to the map view.

The map label for this gene is folB [H]

Identifier: 110834918

GI number: 110834918

Start: 2344762

End: 2345178

Strand: Reverse

Name: folB [H]

Synonym: ABO_2057

Alternate gene names: 110834918

Gene position: 2345178-2344762 (Counterclockwise)

Preceding gene: 110834920

Following gene: 110834917

Centisome position: 75.16

GC content: 51.8

Gene sequence:

>417_bases
ATGGGATTCATCCAGTGCGCTAGCGTCGATGAATGCCACGGCAAGAGAGCCAGTATGGATATTGTTTATATCAATGATTT
GAAAGTGGATACGGTAATCGGCATTTTCGATTGGGAGCGTCGCATCCGCCAGACCGTGAGTCTGGATCTGGAAATGGCGG
CAGATATTTGCAAAGGAGCGGCCTCGGATCACATTGATGATGCATTGGATTACAAAGCCATTGGCAAGCGGTTGATCACC
TTTATTGAAGGCAGTGAATTTCAGTTGGTGGAAACTCTGGCGGAGAATGTGGCGCAGCTGGTGTTGAATGAGTTCAGTGT
GCCGTGGCTAAAATTGCGACTCAGCAAGCCGGGCGCTTTGCGCGGCGCCCGTGATGTGGGGGTGATCATTGAGCGGGGTG
TGCGTCCCAATGCCTGA

Upstream 100 bases:

>100_bases
GCTGAGGCAGCGAAATTGGCACCCAAGTAGTGCTTTGGGGCCATTGTACACAGCATCCCATTGCTGCCTGAGCTGCAAGC
GTAACATCTGATTACCTGAA

Downstream 100 bases:

>100_bases
CGTGTCTCAGGCTCAGGTATTTCTAAGCCTGGGCTCCAATATCGACCGTGAGCACAATATTAGCTCTGGGTTAGATGCCC
TAAAGCGGGCATTTTCCCCC

Product: dihydroneopterin aldolase

Products: NA

Alternate protein names: DHNA [H]

Number of amino acids: Translated: 138; Mature: 137

Protein sequence:

>138_residues
MGFIQCASVDECHGKRASMDIVYINDLKVDTVIGIFDWERRIRQTVSLDLEMAADICKGAASDHIDDALDYKAIGKRLIT
FIEGSEFQLVETLAENVAQLVLNEFSVPWLKLRLSKPGALRGARDVGVIIERGVRPNA

Sequences:

>Translated_138_residues
MGFIQCASVDECHGKRASMDIVYINDLKVDTVIGIFDWERRIRQTVSLDLEMAADICKGAASDHIDDALDYKAIGKRLIT
FIEGSEFQLVETLAENVAQLVLNEFSVPWLKLRLSKPGALRGARDVGVIIERGVRPNA
>Mature_137_residues
GFIQCASVDECHGKRASMDIVYINDLKVDTVIGIFDWERRIRQTVSLDLEMAADICKGAASDHIDDALDYKAIGKRLITF
IEGSEFQLVETLAENVAQLVLNEFSVPWLKLRLSKPGALRGARDVGVIIERGVRPNA

Specific function: Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. Can use L-threo-dihydroneopterin and D-erythro-dihydroneopterin as substrates for the formation of 6-hydroxymethyldihydropterin, but it can also catalyze the epimeriza

COG id: COG1539

COG function: function code H; Dihydroneopterin aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHNA family [H]

Homologues:

Organism=Escherichia coli, GI87082204, Length=115, Percent_Identity=50.4347826086956, Blast_Score=120, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006156
- InterPro:   IPR006157 [H]

Pfam domain/function: PF02152 FolB [H]

EC number: =4.1.2.25 [H]

Molecular weight: Translated: 15333; Mature: 15202

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGFIQCASVDECHGKRASMDIVYINDLKVDTVIGIFDWERRIRQTVSLDLEMAADICKGA
CCCEECCCCHHHCCCCCCEEEEEECCCCEEHEEEHHHHHHHHHHHHCCHHHHHHHHHCCC
ASDHIDDALDYKAIGKRLITFIEGSEFQLVETLAENVAQLVLNEFSVPWLKLRLSKPGAL
CCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCC
RGARDVGVIIERGVRPNA
CCCCHHHHHHCCCCCCCC
>Mature Secondary Structure 
GFIQCASVDECHGKRASMDIVYINDLKVDTVIGIFDWERRIRQTVSLDLEMAADICKGA
CCEECCCCHHHCCCCCCEEEEEECCCCEEHEEEHHHHHHHHHHHHCCHHHHHHHHHCCC
ASDHIDDALDYKAIGKRLITFIEGSEFQLVETLAENVAQLVLNEFSVPWLKLRLSKPGAL
CCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCC
RGARDVGVIIERGVRPNA
CCCCHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]