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The map label for this gene is strD [H]

Identifier: 110834904

GI number: 110834904

Start: 2330790

End: 2331455

Strand: Reverse

Name: strD [H]

Synonym: ABO_2043

Alternate gene names: 110834904

Gene position: 2331455-2330790 (Counterclockwise)

Preceding gene: 110834905

Following gene: 110834903

Centisome position: 74.72

GC content: 59.16

Gene sequence:

>666_bases
GTGAAGGCCATGATCCTGGCCGCCGGCTACGGCAAGCGCATGCGCCCGCTCACCGACCACACCCCCAAGCCGCTATTGCG
GGCGGGGGGCAAGGCGTTGATCGAATATCATATTGAAGCGTTGCGCGATGCCGGCATTGAATCCTTAGTGATTAATACCG
GTTGGTTGGGCGAGAAGCTGGTGGCCTTCCTGGGAGAGGGTACTCGCTACGGCATTCCCCTTGTTTACTCCCATGAAGGT
ACACCGCTGGAAACCGCTGGGGGCATCAAGCGAGCGCTGCCGTTGCTGGGCGATCAGCCGTTTGTGCTGATTAACGGAGA
TATTTGGACCGATTTTGACCTGACTCGGCTAGTGGATAATCGCCCGGACCCGGTGCATCTGGTGCTGGTGAATAACCCGG
AACATCACCCGAAAGGGGATTTTCATCTGACAGACACGAGCCGCTTGCGCGATAATGCCGAGCCTAAGCTCACCTATGCC
GGTATTGGCCGTTTTGACCCTGCTATTTTTGCGCAGTTAGCGGACGGTGAAGCGAAGCTGGCGCCGGTGTTGCGTGCGGC
CATGGCCGACGATGCGGCCAGCGGCGAGCATCATGCAGGGCAGTGGTGGGATATCGGCACCCCGGAACGTCTCGCCGAAC
TGGATCGATTGCTCAGCGGCACATGA

Upstream 100 bases:

>100_bases
GCGATGTGCCGCGTTTCTTTGCTTACTTGCGCACGGTTATCGCCCGGCGCCCGGAGCTTTGCGATCTACAGTGGGTTCTC
GATCAGATCGAGGACAACCA

Downstream 100 bases:

>100_bases
TCCAGTGCTGAAATTGATTGTTTTGTGAGATCGGTGCAATCACCGCTCCACAGTGACGCTGTCACAACACATGCATTTTA
AGGAATTGTCATGCCCAAGC

Product: nucleotidyltransferase family protein

Products: NA

Alternate protein names: Sugar-nucleotidylation enzyme; dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MKAMILAAGYGKRMRPLTDHTPKPLLRAGGKALIEYHIEALRDAGIESLVINTGWLGEKLVAFLGEGTRYGIPLVYSHEG
TPLETAGGIKRALPLLGDQPFVLINGDIWTDFDLTRLVDNRPDPVHLVLVNNPEHHPKGDFHLTDTSRLRDNAEPKLTYA
GIGRFDPAIFAQLADGEAKLAPVLRAAMADDAASGEHHAGQWWDIGTPERLAELDRLLSGT

Sequences:

>Translated_221_residues
MKAMILAAGYGKRMRPLTDHTPKPLLRAGGKALIEYHIEALRDAGIESLVINTGWLGEKLVAFLGEGTRYGIPLVYSHEG
TPLETAGGIKRALPLLGDQPFVLINGDIWTDFDLTRLVDNRPDPVHLVLVNNPEHHPKGDFHLTDTSRLRDNAEPKLTYA
GIGRFDPAIFAQLADGEAKLAPVLRAAMADDAASGEHHAGQWWDIGTPERLAELDRLLSGT
>Mature_221_residues
MKAMILAAGYGKRMRPLTDHTPKPLLRAGGKALIEYHIEALRDAGIESLVINTGWLGEKLVAFLGEGTRYGIPLVYSHEG
TPLETAGGIKRALPLLGDQPFVLINGDIWTDFDLTRLVDNRPDPVHLVLVNNPEHHPKGDFHLTDTSRLRDNAEPKLTYA
GIGRFDPAIFAQLADGEAKLAPVLRAAMADDAASGEHHAGQWWDIGTPERLAELDRLLSGT

Specific function: Involved in the biosynthesis of the streptose moiety of streptomycin. Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=230, Percent_Identity=30, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI11761619, Length=230, Percent_Identity=30, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI133931050, Length=226, Percent_Identity=29.646017699115, Blast_Score=90, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6320148, Length=122, Percent_Identity=37.7049180327869, Blast_Score=84, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21355443, Length=224, Percent_Identity=29.4642857142857, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24644084, Length=224, Percent_Identity=29.4642857142857, Blast_Score=97, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005908
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 24135; Mature: 24135

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAMILAAGYGKRMRPLTDHTPKPLLRAGGKALIEYHIEALRDAGIESLVINTGWLGEKL
CCEEEEECCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHH
VAFLGEGTRYGIPLVYSHEGTPLETAGGIKRALPLLGDQPFVLINGDIWTDFDLTRLVDN
HHHHCCCCCCCCEEEECCCCCCCHHCCCHHHHHHHCCCCCEEEEECCEECCCHHHHHHCC
RPDPVHLVLVNNPEHHPKGDFHLTDTSRLRDNAEPKLTYAGIGRFDPAIFAQLADGEAKL
CCCCEEEEEECCCCCCCCCCEEECCHHHHCCCCCCEEEEECCCCCCHHHHHHHCCCCHHH
APVLRAAMADDAASGEHHAGQWWDIGTPERLAELDRLLSGT
HHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MKAMILAAGYGKRMRPLTDHTPKPLLRAGGKALIEYHIEALRDAGIESLVINTGWLGEKL
CCEEEEECCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHH
VAFLGEGTRYGIPLVYSHEGTPLETAGGIKRALPLLGDQPFVLINGDIWTDFDLTRLVDN
HHHHCCCCCCCCEEEECCCCCCCHHCCCHHHHHHHCCCCCEEEEECCEECCCHHHHHHCC
RPDPVHLVLVNNPEHHPKGDFHLTDTSRLRDNAEPKLTYAGIGRFDPAIFAQLADGEAKL
CCCCEEEEEECCCCCCCCCCEEECCHHHHCCCCCCEEEEECCCCCCHHHHHHHCCCCHHH
APVLRAAMADDAASGEHHAGQWWDIGTPERLAELDRLLSGT
HHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3118332 [H]