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The map label for this gene is trpE [H]

Identifier: 110834888

GI number: 110834888

Start: 2315386

End: 2316876

Strand: Reverse

Name: trpE [H]

Synonym: ABO_2027

Alternate gene names: 110834888

Gene position: 2316876-2315386 (Counterclockwise)

Preceding gene: 110834892

Following gene: 110834887

Centisome position: 74.26

GC content: 59.36

Gene sequence:

>1491_bases
ATGTCACCACAAGAACTGGATCGTTTTGCCCAGCAGGGCTATACCCGGGTGCCCGTGGTTCGCGAAGTATTGGCGGATTT
GGATACGCCGCTGTCGGCCTATCGTAAGCTGGCGTCTGGCCCCTACACCTACCTGTTTGAATCGGTGCAGGGGGGCGAAC
GGTGGGGCCGGTATTCCATTATTGGCCTGCCGGCCACAGAGGTGGTGCGGATTACTGGCCAGCAGGTGCAGGTCGATGGC
CCAGAGGGGCGTCAGCATTACGAAGCGGCTGACCCTATTAGCTGGGTGGAAGAGTATCGAAAAGCCTATCGTAGCCCAGA
CTTGGAGGGCTTGCCCCGTTTTAATGGCGGCCTGGTGGGGTATTTCGGTTATGACAGCGTGCGGTATTTCGAGCCACGTT
TGGGGCCTGCACCTGGCGAGGATGTGCTGGGGGTTCCGGATATCCTGCTGATGCGGTCCGAGGAGGTGGTGGTCTTCGAT
AACCTGCGCGGGGCGCTGTTCCTGGTGGTGCATGTGGACCCGAAAGAAGACGGGGTACTGATGCGCGCCGAGCAGCGGCT
AGAGGCGTTGGAAAGCCAGCTGCGCGCTCCCTTGTCGGAGCCGGCACATACCGTTTACGGCGAGCCTGTGGACGAAAACG
ATTTCCACCATGAATTTCCGCAAGACGCTTTCAAGGCGGGTGTGGAAACCATCCGCGAGTACATCCTGGCGGGGGACGTG
ATGCAGGTGGTGCCGTCCCAGCGCATGAGTTGTCCGTTTCAGGCGCCGGCGCTGGATTTGTATCGTGCCCTGCGTTACCT
GAATCCGTCGCCTTACATGTTCTATCTGGATCTGGACGATTTTCATATCGCCGGCTCTTCGCCGGAAATTCTGGCTCGCG
CTGAGCAGGGGCGAACGACGGTGCGGCCACTGGCGGGCACGCGCAAACGCGGTGCCAATGAAGCGGAAGATTTGGCGCTG
GAAAAAGACTTGCTGGCGGACCCGAAGGAAATTGCCGAGCACCTGATGCTGATTGATTTGGGGCGCAACGATATTGGCCG
TGTTTCTAAGGCGGGCAAGGTGGAGGTTTCCGACCAGATGGTCGTGGAGCGTTATTCCCACGTGATGCATATTGTGTCCA
ATGTGGACGGCGAGCTACGCGAAGATTTGGGGCCGCTGGATGTGCTGCGTGCCACCTTCCCGGCGGGCACCCTGAGCGGT
GCGCCGAAGATCCGCGCTATGGAAATCATTGACGAACTGGAGCCCACCAAGCGCGGCGTCTACGGGGGCGCAGTGGGGTA
TATCGGTTTTAACGGCGATATGGACACGGCTATCGCTATCCGTACTGCAGTGATCAAGGATCAACGCCTGTACGTGCAGG
CTGGGGCAGGGATTGTGGCCGACTCCGTGCCGCAGTCTGAATGGGACGAGACCATGAATAAAGCCCGGGCAGTATTCCGA
GCGGTAAACATGGCATTGGGTGGTCTCAACCTGGCAGACGGAGGACAGTAA

Upstream 100 bases:

>100_bases
TCTGTACTGACACGTCTTTTGATTATTTTTCCTCTACAATTATTGCTCTAGATCGCGGTCCGCCTAAGTGCTGGGCCGTA
GCGAAATGCTAAGGACAATT

Downstream 100 bases:

>100_bases
TAATGCGCGTGCTGATGATCGATAATTACGACAGTTTTACCTACAACCTGGTGCAGTACCTACAGGAGCTGGGTGCTGAG
GTGCTGGTGCACCGCAACGA

Product: anthranilate synthase, component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 496; Mature: 495

Protein sequence:

>496_residues
MSPQELDRFAQQGYTRVPVVREVLADLDTPLSAYRKLASGPYTYLFESVQGGERWGRYSIIGLPATEVVRITGQQVQVDG
PEGRQHYEAADPISWVEEYRKAYRSPDLEGLPRFNGGLVGYFGYDSVRYFEPRLGPAPGEDVLGVPDILLMRSEEVVVFD
NLRGALFLVVHVDPKEDGVLMRAEQRLEALESQLRAPLSEPAHTVYGEPVDENDFHHEFPQDAFKAGVETIREYILAGDV
MQVVPSQRMSCPFQAPALDLYRALRYLNPSPYMFYLDLDDFHIAGSSPEILARAEQGRTTVRPLAGTRKRGANEAEDLAL
EKDLLADPKEIAEHLMLIDLGRNDIGRVSKAGKVEVSDQMVVERYSHVMHIVSNVDGELREDLGPLDVLRATFPAGTLSG
APKIRAMEIIDELEPTKRGVYGGAVGYIGFNGDMDTAIAIRTAVIKDQRLYVQAGAGIVADSVPQSEWDETMNKARAVFR
AVNMALGGLNLADGGQ

Sequences:

>Translated_496_residues
MSPQELDRFAQQGYTRVPVVREVLADLDTPLSAYRKLASGPYTYLFESVQGGERWGRYSIIGLPATEVVRITGQQVQVDG
PEGRQHYEAADPISWVEEYRKAYRSPDLEGLPRFNGGLVGYFGYDSVRYFEPRLGPAPGEDVLGVPDILLMRSEEVVVFD
NLRGALFLVVHVDPKEDGVLMRAEQRLEALESQLRAPLSEPAHTVYGEPVDENDFHHEFPQDAFKAGVETIREYILAGDV
MQVVPSQRMSCPFQAPALDLYRALRYLNPSPYMFYLDLDDFHIAGSSPEILARAEQGRTTVRPLAGTRKRGANEAEDLAL
EKDLLADPKEIAEHLMLIDLGRNDIGRVSKAGKVEVSDQMVVERYSHVMHIVSNVDGELREDLGPLDVLRATFPAGTLSG
APKIRAMEIIDELEPTKRGVYGGAVGYIGFNGDMDTAIAIRTAVIKDQRLYVQAGAGIVADSVPQSEWDETMNKARAVFR
AVNMALGGLNLADGGQ
>Mature_495_residues
SPQELDRFAQQGYTRVPVVREVLADLDTPLSAYRKLASGPYTYLFESVQGGERWGRYSIIGLPATEVVRITGQQVQVDGP
EGRQHYEAADPISWVEEYRKAYRSPDLEGLPRFNGGLVGYFGYDSVRYFEPRLGPAPGEDVLGVPDILLMRSEEVVVFDN
LRGALFLVVHVDPKEDGVLMRAEQRLEALESQLRAPLSEPAHTVYGEPVDENDFHHEFPQDAFKAGVETIREYILAGDVM
QVVPSQRMSCPFQAPALDLYRALRYLNPSPYMFYLDLDDFHIAGSSPEILARAEQGRTTVRPLAGTRKRGANEAEDLALE
KDLLADPKEIAEHLMLIDLGRNDIGRVSKAGKVEVSDQMVVERYSHVMHIVSNVDGELREDLGPLDVLRATFPAGTLSGA
PKIRAMEIIDELEPTKRGVYGGAVGYIGFNGDMDTAIAIRTAVIKDQRLYVQAGAGIVADSVPQSEWDETMNKARAVFRA
VNMALGGLNLADGGQ

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=383, Percent_Identity=42.5587467362924, Blast_Score=258, Evalue=9e-70,
Organism=Escherichia coli, GI1788114, Length=470, Percent_Identity=31.9148936170213, Blast_Score=228, Evalue=5e-61,
Organism=Escherichia coli, GI1786809, Length=205, Percent_Identity=31.7073170731707, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI87082077, Length=264, Percent_Identity=28.030303030303, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6320935, Length=471, Percent_Identity=39.2781316348195, Blast_Score=309, Evalue=8e-85,
Organism=Saccharomyces cerevisiae, GI6324361, Length=401, Percent_Identity=25.6857855361596, Blast_Score=103, Evalue=5e-23,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 54866; Mature: 54735

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPQELDRFAQQGYTRVPVVREVLADLDTPLSAYRKLASGPYTYLFESVQGGERWGRYSI
CCHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCCEEE
IGLPATEVVRITGQQVQVDGPEGRQHYEAADPISWVEEYRKAYRSPDLEGLPRFNGGLVG
EECCHHHEEEECCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEE
YFGYDSVRYFEPRLGPAPGEDVLGVPDILLMRSEEVVVFDNLRGALFLVVHVDPKEDGVL
EECCCCEEEECCCCCCCCCCCCCCCCCEEEECCCCEEEEECCCCEEEEEEEECCCCCCEE
MRAEQRLEALESQLRAPLSEPAHTVYGEPVDENDFHHEFPQDAFKAGVETIREYILAGDV
HHHHHHHHHHHHHHCCCCCCCCHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
MQVVPSQRMSCPFQAPALDLYRALRYLNPSPYMFYLDLDDFHIAGSSPEILARAEQGRTT
HHHCCHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCEEECCCCHHHHHHHHCCCCE
VRPLAGTRKRGANEAEDLALEKDLLADPKEIAEHLMLIDLGRNDIGRVSKAGKVEVSDQM
ECCCCCCHHCCCCHHHHHHHHHHHCCCHHHHHHHHEEEECCCCCHHHCCCCCCEECHHHH
VVERYSHVMHIVSNVDGELREDLGPLDVLRATFPAGTLSGAPKIRAMEIIDELEPTKRGV
HHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCHHHCCC
YGGAVGYIGFNGDMDTAIAIRTAVIKDQRLYVQAGAGIVADSVPQSEWDETMNKARAVFR
CCCEEEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCEECCCCCHHHHHHHHHHHHHHH
AVNMALGGLNLADGGQ
HHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SPQELDRFAQQGYTRVPVVREVLADLDTPLSAYRKLASGPYTYLFESVQGGERWGRYSI
CHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCCEEE
IGLPATEVVRITGQQVQVDGPEGRQHYEAADPISWVEEYRKAYRSPDLEGLPRFNGGLVG
EECCHHHEEEECCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEE
YFGYDSVRYFEPRLGPAPGEDVLGVPDILLMRSEEVVVFDNLRGALFLVVHVDPKEDGVL
EECCCCEEEECCCCCCCCCCCCCCCCCEEEECCCCEEEEECCCCEEEEEEEECCCCCCEE
MRAEQRLEALESQLRAPLSEPAHTVYGEPVDENDFHHEFPQDAFKAGVETIREYILAGDV
HHHHHHHHHHHHHHCCCCCCCCHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
MQVVPSQRMSCPFQAPALDLYRALRYLNPSPYMFYLDLDDFHIAGSSPEILARAEQGRTT
HHHCCHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCEEECCCCHHHHHHHHCCCCE
VRPLAGTRKRGANEAEDLALEKDLLADPKEIAEHLMLIDLGRNDIGRVSKAGKVEVSDQM
ECCCCCCHHCCCCHHHHHHHHHHHCCCHHHHHHHHEEEECCCCCHHHCCCCCCEECHHHH
VVERYSHVMHIVSNVDGELREDLGPLDVLRATFPAGTLSGAPKIRAMEIIDELEPTKRGV
HHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCHHHCCC
YGGAVGYIGFNGDMDTAIAIRTAVIKDQRLYVQAGAGIVADSVPQSEWDETMNKARAVFR
CCCEEEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCEECCCCCHHHHHHHHHHHHHHH
AVNMALGGLNLADGGQ
HHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2404959 [H]