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The map label for this gene is idsA

Identifier: 110834767

GI number: 110834767

Start: 2183099

End: 2184010

Strand: Direct

Name: idsA

Synonym: ABO_1906

Alternate gene names: 110834767

Gene position: 2183099-2184010 (Clockwise)

Preceding gene: 110834766

Following gene: 110834768

Centisome position: 69.97

GC content: 55.59

Gene sequence:

>912_bases
ATGAGTGAGAGAACCCACTGGCGCGACTATCTCGCCCTCACTAAACCCGGCGTGGTCATGCTGCTTATGGTCACCGCGGT
GGCGGGCATGTTTCTAGCCACCGAACCGGCAGGCATGGTGCCATTAGCCACTTTCATCCCTGCCTTTGTGGGGCTGTCGC
TGGCCATGATGGCCTCCGCCGCGATCAACCAAATTATGGATCAGAAAATTGACGCCATTATGAAGCGCACCGAAAAGCGC
CCTCTGGTTGCCGGAAAGCTGACCCCCAAAGCCGCCATCACCTTTGCGGTGCTGCTAGCAACCGCCTCAATGATTATGCT
GTACTTTCTGGTGAACCCGCTAACGGCGTGGTTGACCTTGTTCGGCTTTGTCGGCTATGCCTTTATTTACACCCTGTATC
TCAAACGCGCTACACCGCAAAACATCGTGATTGGGGGTATCGCGGGCGCCATCCCGCCGCTACTGGGCTGGACCGCCGTC
ACCGGTGAAGCACACCCCTACGCTTGGCTGCTAGTGCTCATCATCTTCGTTTGGACCCCACCACACTTCTGGGCGCTGGC
CATCCATCGCCGCGATGAATATGCCAAGGCCGATATACCCATGTTACCGGTGACCCATGGCATCCCGTTTACCCGTGAAT
CGGTGCTCTACTACACCATCTTGCTGTTTATCTGCACGCTGCTGCCTTACCTCACCGGCATGAGCGACCTGATTTATTTG
CTCAGCGCGTTGATCCTCGGCTTGGTATTTCTCTATCACGCAGTACGCCTGCGTTTTTCTGAAGACCCGAAACTTCCAAT
GAAAACCTTCGGTTATTCAATTACTTATTTGTTCGCTCTGTTTACCGCCCTGCTGGTAGACCACTACCTGCCCGTGACGC
CCGCCAATGTCGCGTCCTGGCTTGGCGCATGA

Upstream 100 bases:

>100_bases
TGGCAGTGCTACTGTTAGCTAGTCTGGTCTTATTTATCCGTGCCATAAACGTAAAATGCGGCAAACGCGAACCAAAGTCA
CAACAAAAAGGAGCCCCGTC

Downstream 100 bases:

>100_bases
GGCACACATAAGCCAAGGTGCCGGAGCCCAGAGGAGGCACCGGCGCCCTGCCGCGCTATACTCTTCCCCATAGAATACCA
ACTAGGGGAAAACAACATGG

Product: prenyltransferase family protein

Products: heme O; pyrophosphate [C]

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MSERTHWRDYLALTKPGVVMLLMVTAVAGMFLATEPAGMVPLATFIPAFVGLSLAMMASAAINQIMDQKIDAIMKRTEKR
PLVAGKLTPKAAITFAVLLATASMIMLYFLVNPLTAWLTLFGFVGYAFIYTLYLKRATPQNIVIGGIAGAIPPLLGWTAV
TGEAHPYAWLLVLIIFVWTPPHFWALAIHRRDEYAKADIPMLPVTHGIPFTRESVLYYTILLFICTLLPYLTGMSDLIYL
LSALILGLVFLYHAVRLRFSEDPKLPMKTFGYSITYLFALFTALLVDHYLPVTPANVASWLGA

Sequences:

>Translated_303_residues
MSERTHWRDYLALTKPGVVMLLMVTAVAGMFLATEPAGMVPLATFIPAFVGLSLAMMASAAINQIMDQKIDAIMKRTEKR
PLVAGKLTPKAAITFAVLLATASMIMLYFLVNPLTAWLTLFGFVGYAFIYTLYLKRATPQNIVIGGIAGAIPPLLGWTAV
TGEAHPYAWLLVLIIFVWTPPHFWALAIHRRDEYAKADIPMLPVTHGIPFTRESVLYYTILLFICTLLPYLTGMSDLIYL
LSALILGLVFLYHAVRLRFSEDPKLPMKTFGYSITYLFALFTALLVDHYLPVTPANVASWLGA
>Mature_302_residues
SERTHWRDYLALTKPGVVMLLMVTAVAGMFLATEPAGMVPLATFIPAFVGLSLAMMASAAINQIMDQKIDAIMKRTEKRP
LVAGKLTPKAAITFAVLLATASMIMLYFLVNPLTAWLTLFGFVGYAFIYTLYLKRATPQNIVIGGIAGAIPPLLGWTAVT
GEAHPYAWLLVLIIFVWTPPHFWALAIHRRDEYAKADIPMLPVTHGIPFTRESVLYYTILLFICTLLPYLTGMSDLIYLL
SALILGLVFLYHAVRLRFSEDPKLPMKTFGYSITYLFALFTALLVDHYLPVTPANVASWLGA

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=194, Percent_Identity=39.1752577319588, Blast_Score=124, Evalue=1e-28,
Organism=Escherichia coli, GI1786631, Length=285, Percent_Identity=36.140350877193, Blast_Score=182, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI71998235, Length=281, Percent_Identity=32.3843416370107, Blast_Score=131, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6325085, Length=275, Percent_Identity=32, Blast_Score=128, Evalue=1e-30,
Organism=Drosophila melanogaster, GI19921064, Length=280, Percent_Identity=33.9285714285714, Blast_Score=130, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CYOE_ALCBS (Q0VN94)

Other databases:

- EMBL:   AM286690
- RefSeq:   YP_693626.1
- STRING:   Q0VN94
- GeneID:   4211346
- GenomeReviews:   AM286690_GR
- KEGG:   abo:ABO_1906
- NMPDR:   fig|393595.12.peg.1909
- eggNOG:   COG0109
- HOGENOM:   HBG656003
- OMA:   SYYQLTK
- PhylomeDB:   Q0VN94
- BioCyc:   ABOR393595:ABO_1906-MONOMER
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.- [C]

Molecular weight: Translated: 33608; Mature: 33477

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: PS00943 UBIA; PS01319 RBFA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x13061294)-; HASH(0x133a02d8)-; HASH(0x12c4dd54)-; HASH(0x13858b88)-; HASH(0x13b3939c)-; HASH(0x1363d868)-; HASH(0x133ccb68)-; HASH(0x13119dc4)-; HASH(0x11cef370)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSERTHWRDYLALTKPGVVMLLMVTAVAGMFLATEPAGMVPLATFIPAFVGLSLAMMASA
CCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
AINQIMDQKIDAIMKRTEKRPLVAGKLTPKAAITFAVLLATASMIMLYFLVNPLTAWLTL
HHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FGFVGYAFIYTLYLKRATPQNIVIGGIAGAIPPLLGWTAVTGEAHPYAWLLVLIIFVWTP
HHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHCCHHCCCCCCHHHHHHHHHHHHHCC
PHFWALAIHRRDEYAKADIPMLPVTHGIPFTRESVLYYTILLFICTLLPYLTGMSDLIYL
CHHHHHHHHHCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
LSALILGLVFLYHAVRLRFSEDPKLPMKTFGYSITYLFALFTALLVDHYLPVTPANVASW
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
LGA
HCH
>Mature Secondary Structure 
SERTHWRDYLALTKPGVVMLLMVTAVAGMFLATEPAGMVPLATFIPAFVGLSLAMMASA
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
AINQIMDQKIDAIMKRTEKRPLVAGKLTPKAAITFAVLLATASMIMLYFLVNPLTAWLTL
HHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FGFVGYAFIYTLYLKRATPQNIVIGGIAGAIPPLLGWTAVTGEAHPYAWLLVLIIFVWTP
HHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHCCHHCCCCCCHHHHHHHHHHHHHCC
PHFWALAIHRRDEYAKADIPMLPVTHGIPFTRESVLYYTILLFICTLLPYLTGMSDLIYL
CHHHHHHHHHCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
LSALILGLVFLYHAVRLRFSEDPKLPMKTFGYSITYLFALFTALLVDHYLPVTPANVASW
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
LGA
HCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: protoheme; farnesyl-PP [C]

Specific reaction: protoheme + farnesyl-PP = heme O + pyrophosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA