Click here to switch to the map view.

The map label for this gene is mtaD [H]

Identifier: 110834613

GI number: 110834613

Start: 1998270

End: 1999601

Strand: Direct

Name: mtaD [H]

Synonym: ABO_1752

Alternate gene names: 110834613

Gene position: 1998270-1999601 (Clockwise)

Preceding gene: 110834600

Following gene: 110834614

Centisome position: 64.04

GC content: 59.16

Gene sequence:

>1332_bases
ATGAGCGACAATCAGGCTGACCTGATCGTCCACGCCCGCTGGATTGCCCCTGTGGCCCCGCAGGAAGCGGTGCTGGAGAA
CCATGCCGTGGTGGTCAAAGACGGTCGCATTGCCGACCTGCTCCCCAGCGCCCTGGCTAACGTAAAGTGGCAAAGCGAAG
AGCAACAGCACCTGGGTGATCACCTGCTAATCCCAGGCTTGGTCAATGCCCATACCCACGCGGCCATGAACTTGCTACGC
GGCATCGCCGATGACCTGCCGCTAATGACTTGGCTGGAAAAACATATCTGGCCCGCCGAAGGCCGCTTTGTCAGTGAAAC
CTTTGTCTACGACGGTACCCGGCTCGCCGCAGCAGAAATGATCCGTTCCGGCACCACTTGCTTTGCCGATATGTATTTCT
TCCCCGCCAATGCCGCCCGCGCCACGGTTGAAGCCGGCCTGCGCGCCAGCCTGTTCTGCCCGCTGCTGGACTTCCCCACC
CCTATGGGCTCCGGGCCGGAGGAGTATTTGCGCTTGGCCACCGACGCCATGGATGAATGGCAACATGAGCCGCGCATCCA
GATCGGCTTTGGCCCCCATGCCCCCTATACGGTGTCCGATGGACCTCTGCAGAAAGTACTCACCCTCGCCGAAGAGTTGG
ACGTACCAATAATGATGCACGTGCACGAAACAGCCGGGGAGATCCAGATGGAGGTGCGCAACACTGGCGAGCGCCCCCTG
ACCCGGCTGCATAATCTGGGCTTGCTATCACCGCGCCTGCTGGCCGTTCACATGACCCAACTCACCGATGAAGAAATCGC
TTTGGTGGCACAAACCGGCACCCACGTTGTGCATTGCCCGGAATCCAACCTGAAACTGGCCAGTGGCTTCGCGCCGGTTG
AGAAACTACGCAAAGCCAATATTAACGTAGCGCTAGGCACCGACGGGGCCGCCAGCAATAATGATCTGGACATGCTGGGT
GAAGCCCGCACCGCCGCTTTTTTAACCAAGGGCGTCAGCCTGCAGGCGGATGCGCAACCGGCCATGGAAACACTGAAAAT
GGCCACCCTGAATGGCGCCAAAGCATTGGGTCGAGATAACGAAATCGGCTCGTTGGAAATGGGTAAACAGGCGGATATGG
TGGCTGTGGATTTGAACCGACTGGAGACCCAGCCGGTCTATGACCCAGTGGCCCAATTGATTTACGCTGCCACCCGCGAC
CAGATCACCCACACATGGGTGGGCGGGCGCTGCCTGATGGATAACCGCCAGCTAACCACACTCAACGAAGCCCTGATCCT
CAAGAATGCCAAGCAGTGGCAAGAAAAAATCGCCGGAGCCGACCGTGACTGA

Upstream 100 bases:

>100_bases
AGTTTACCGTCACGCAGTCAGGGCAAGATCCACCGCGACACGCTATACTGCGGCGCACAATTCGGGGGTTACTGCCCCCA
GTTCGAGCAAGGAGTTATGC

Downstream 100 bases:

>100_bases
ACAGCAAACCCACACCCCGAACGTAGACGCCGGCGAAATCGCCAAGTTCAACGCCCTGGCTGAGCAGTGGTGGGACCCCA
ATTCCCAATTCCGCCCGCTG

Product: N-ethylammeline chlorohydrolase

Products: NA

Alternate protein names: MTA/SAH deaminase [H]

Number of amino acids: Translated: 443; Mature: 442

Protein sequence:

>443_residues
MSDNQADLIVHARWIAPVAPQEAVLENHAVVVKDGRIADLLPSALANVKWQSEEQQHLGDHLLIPGLVNAHTHAAMNLLR
GIADDLPLMTWLEKHIWPAEGRFVSETFVYDGTRLAAAEMIRSGTTCFADMYFFPANAARATVEAGLRASLFCPLLDFPT
PMGSGPEEYLRLATDAMDEWQHEPRIQIGFGPHAPYTVSDGPLQKVLTLAEELDVPIMMHVHETAGEIQMEVRNTGERPL
TRLHNLGLLSPRLLAVHMTQLTDEEIALVAQTGTHVVHCPESNLKLASGFAPVEKLRKANINVALGTDGAASNNDLDMLG
EARTAAFLTKGVSLQADAQPAMETLKMATLNGAKALGRDNEIGSLEMGKQADMVAVDLNRLETQPVYDPVAQLIYAATRD
QITHTWVGGRCLMDNRQLTTLNEALILKNAKQWQEKIAGADRD

Sequences:

>Translated_443_residues
MSDNQADLIVHARWIAPVAPQEAVLENHAVVVKDGRIADLLPSALANVKWQSEEQQHLGDHLLIPGLVNAHTHAAMNLLR
GIADDLPLMTWLEKHIWPAEGRFVSETFVYDGTRLAAAEMIRSGTTCFADMYFFPANAARATVEAGLRASLFCPLLDFPT
PMGSGPEEYLRLATDAMDEWQHEPRIQIGFGPHAPYTVSDGPLQKVLTLAEELDVPIMMHVHETAGEIQMEVRNTGERPL
TRLHNLGLLSPRLLAVHMTQLTDEEIALVAQTGTHVVHCPESNLKLASGFAPVEKLRKANINVALGTDGAASNNDLDMLG
EARTAAFLTKGVSLQADAQPAMETLKMATLNGAKALGRDNEIGSLEMGKQADMVAVDLNRLETQPVYDPVAQLIYAATRD
QITHTWVGGRCLMDNRQLTTLNEALILKNAKQWQEKIAGADRD
>Mature_442_residues
SDNQADLIVHARWIAPVAPQEAVLENHAVVVKDGRIADLLPSALANVKWQSEEQQHLGDHLLIPGLVNAHTHAAMNLLRG
IADDLPLMTWLEKHIWPAEGRFVSETFVYDGTRLAAAEMIRSGTTCFADMYFFPANAARATVEAGLRASLFCPLLDFPTP
MGSGPEEYLRLATDAMDEWQHEPRIQIGFGPHAPYTVSDGPLQKVLTLAEELDVPIMMHVHETAGEIQMEVRNTGERPLT
RLHNLGLLSPRLLAVHMTQLTDEEIALVAQTGTHVVHCPESNLKLASGFAPVEKLRKANINVALGTDGAASNNDLDMLGE
ARTAAFLTKGVSLQADAQPAMETLKMATLNGAKALGRDNEIGSLEMGKQADMVAVDLNRLETQPVYDPVAQLIYAATRDQ
ITHTWVGGRCLMDNRQLTTLNEALILKNAKQWQEKIAGADRD

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=395, Percent_Identity=27.5949367088608, Blast_Score=132, Evalue=6e-31,
Organism=Escherichia coli, GI1789249, Length=392, Percent_Identity=25.765306122449, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI87082177, Length=435, Percent_Identity=25.5172413793103, Blast_Score=93, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17540282, Length=390, Percent_Identity=24.8717948717949, Blast_Score=101, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6319963, Length=336, Percent_Identity=25, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24643849, Length=398, Percent_Identity=29.1457286432161, Blast_Score=129, Evalue=5e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.28 [H]

Molecular weight: Translated: 48495; Mature: 48364

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDNQADLIVHARWIAPVAPQEAVLENHAVVVKDGRIADLLPSALANVKWQSEEQQHLGD
CCCCCCEEEEEEEECCCCCCHHHHHCCCEEEEECCCHHHHHHHHHHCCCCCCCHHHHCCC
HLLIPGLVNAHTHAAMNLLRGIADDLPLMTWLEKHIWPAEGRFVSETFVYDGTRLAAAEM
EEECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHH
IRSGTTCFADMYFFPANAARATVEAGLRASLFCPLLDFPTPMGSGPEEYLRLATDAMDEW
HHCCCCEEEEEEEECCCHHHHHHHHCCCHHHCCHHHCCCCCCCCCHHHHHHHHHHHHHHH
QHEPRIQIGFGPHAPYTVSDGPLQKVLTLAEELDVPIMMHVHETAGEIQMEVRNTGERPL
CCCCEEEEECCCCCCEECCCCHHHHHHHHHHHCCCCEEEEEECCCCCEEEEECCCCCHHH
TRLHNLGLLSPRLLAVHMTQLTDEEIALVAQTGTHVVHCPESNLKLASGFAPVEKLRKAN
HHHHHCCCCCHHHHHHHHHHCCCCCEEEEEECCCEEEECCCCCCEECCCCHHHHHHHHCC
INVALGTDGAASNNDLDMLGEARTAAFLTKGVSLQADAQPAMETLKMATLNGAKALGRDN
CEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHCCCHHHCCCCC
EIGSLEMGKQADMVAVDLNRLETQPVYDPVAQLIYAATRDQITHTWVGGRCLMDNRQLTT
CCCCCCCCCCCCEEEEEHHHCCCCCHHHHHHHHHHHHHHCCEEEEEECCEEEECCCCCHH
LNEALILKNAKQWQEKIAGADRD
HHHHHHHHCHHHHHHHHCCCCCC
>Mature Secondary Structure 
SDNQADLIVHARWIAPVAPQEAVLENHAVVVKDGRIADLLPSALANVKWQSEEQQHLGD
CCCCCEEEEEEEECCCCCCHHHHHCCCEEEEECCCHHHHHHHHHHCCCCCCCHHHHCCC
HLLIPGLVNAHTHAAMNLLRGIADDLPLMTWLEKHIWPAEGRFVSETFVYDGTRLAAAEM
EEECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHH
IRSGTTCFADMYFFPANAARATVEAGLRASLFCPLLDFPTPMGSGPEEYLRLATDAMDEW
HHCCCCEEEEEEEECCCHHHHHHHHCCCHHHCCHHHCCCCCCCCCHHHHHHHHHHHHHHH
QHEPRIQIGFGPHAPYTVSDGPLQKVLTLAEELDVPIMMHVHETAGEIQMEVRNTGERPL
CCCCEEEEECCCCCCEECCCCHHHHHHHHHHHCCCCEEEEEECCCCCEEEEECCCCCHHH
TRLHNLGLLSPRLLAVHMTQLTDEEIALVAQTGTHVVHCPESNLKLASGFAPVEKLRKAN
HHHHHCCCCCHHHHHHHHHHCCCCCEEEEEECCCEEEECCCCCCEECCCCHHHHHHHHCC
INVALGTDGAASNNDLDMLGEARTAAFLTKGVSLQADAQPAMETLKMATLNGAKALGRDN
CEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHCCCHHHCCCCC
EIGSLEMGKQADMVAVDLNRLETQPVYDPVAQLIYAATRDQITHTWVGGRCLMDNRQLTT
CCCCCCCCCCCCEEEEEHHHCCCCCHHHHHHHHHHHHHHCCEEEEEECCEEEECCCCCHH
LNEALILKNAKQWQEKIAGADRD
HHHHHHHHCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA