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The map label for this gene is fadH [C]

Identifier: 110834565

GI number: 110834565

Start: 1940064

End: 1941317

Strand: Direct

Name: fadH [C]

Synonym: ABO_1704

Alternate gene names: 110834565

Gene position: 1940064-1941317 (Clockwise)

Preceding gene: 110834563

Following gene: 110834567

Centisome position: 62.18

GC content: 55.74

Gene sequence:

>1254_bases
GTGAGCCACGCTGATACCCTGAGCCAGACTCTGACACTACCCTGCGGCGTTACCCTACCCAACCGCTTCGGTAAATCCGC
CATGAGCGAAGCACTGGGCACTATCGATAATCATGTTACTCCGAAGCTGGAACGTCTCTATGCCCGTTGGGCAAAGGGCG
GCACCGGCCTGAATATTACCGGAAACATCATGATTGATCGCCGCCATACCGGTGAGCCAAACAATGTGGTGGTGGAAGAT
GAGCGTGACATGCCACTACTAAAGCGTTGGGCAGAGGCAGGCAAATCTCAGGGCGGCGCTATCTGGGTGCAACTGAATCA
TCCCGGCAAGCAAATCCCTCGTATGCTGGCCAGCGGCGATACCCTCTCTCCTTCTGCCGTACCCTTTGGCAAGGAACTGA
AAAGTGCCTTTAAAACTCCCCGCGCGCTGACTGAAGAAGAAATTCAAGACATCATCCAACGTTTTGCCCGCACCGCCAGC
ATCTGTAAGAAAGCCGGTTTCACCGGCGTACAAATTCACGGTGCCCATGGTTATTTGGTAAGCCAATTCCTGTCCGGCCA
CCATAACCGTCGCACAGACCAATGGGGCGGCTCATTGGAAAATCGCATGCGCTTCCCACTGGAAATCTATCGCGCTATTC
GTAAGGAGGTGGGTGAGGGCTACCCGGTAAGCATCAAGCTCAACTCCGCCGATTTTCAGCGCGGGGGCTTCAGCGAAGAA
GAATCCATGACCGTAGCCAAAACCCTCGCGGATGAAGGCCTAGACCTGCTGGAAATTTCCGGCGGCAACTACGAAAACCC
GGTCATGGCAGGCGCCAAAGGCGTGCGCGAAAGCACCGTCAACCGGGAAGCCTACTTCCTCGATTACGCCAATGAAATTC
GCAAGCGGGTTTCCGTTCCGCTGATGGTTACCGGAGGCTTCCGCTCGGCCAAAGCCATGGCCGAAGCCGTAAATAGTGGC
GCGACCGACGTCATCGGCATTGCTCGTCCTCTAGCCGTTGAACCCGACCTACCCAACGCCATTCAAGCTGGCCGAGAAGG
TGTTGTCAGCCGCGTCACCCCGCGTAAAACCGGCATTAAAGCCATTGATGAAATGGCCATGATGGAAGTGTCCTGGTATA
CCCGTCAGCTACACCGCATGGGTGCCGGCAAAGAGCCCAAACCAAACGAAAGCGTATTACTCGCCCTGTTCAAGGTTATC
GCAACCATGGGCGTTGGCAGTTTCAAGACCCGCCGGTTACGGGCCAACATCTGA

Upstream 100 bases:

>100_bases
GTTTGACGATTATAAAACTAGCTTATAGTTTGACCACCATCAAACTATACCGTTGCGGCAAACCTTGCCGTCACAGTTAG
TCACCACCGGAGAAAACACT

Downstream 100 bases:

>100_bases
ACGGACAGCTGCAAGAAAATGATGCGCATGGATGGCGCACATTTTTTATCAATCGCTGACATAAAAAGCCCCGAATATCG
GGGCTTTTTATGTTCCTGTT

Product: NADH:flavin oxidoreductase/NADH oxidase

Products: trans-transtetradehydroacyl-CoA; NADPH [C]

Alternate protein names: NA

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MSHADTLSQTLTLPCGVTLPNRFGKSAMSEALGTIDNHVTPKLERLYARWAKGGTGLNITGNIMIDRRHTGEPNNVVVED
ERDMPLLKRWAEAGKSQGGAIWVQLNHPGKQIPRMLASGDTLSPSAVPFGKELKSAFKTPRALTEEEIQDIIQRFARTAS
ICKKAGFTGVQIHGAHGYLVSQFLSGHHNRRTDQWGGSLENRMRFPLEIYRAIRKEVGEGYPVSIKLNSADFQRGGFSEE
ESMTVAKTLADEGLDLLEISGGNYENPVMAGAKGVRESTVNREAYFLDYANEIRKRVSVPLMVTGGFRSAKAMAEAVNSG
ATDVIGIARPLAVEPDLPNAIQAGREGVVSRVTPRKTGIKAIDEMAMMEVSWYTRQLHRMGAGKEPKPNESVLLALFKVI
ATMGVGSFKTRRLRANI

Sequences:

>Translated_417_residues
MSHADTLSQTLTLPCGVTLPNRFGKSAMSEALGTIDNHVTPKLERLYARWAKGGTGLNITGNIMIDRRHTGEPNNVVVED
ERDMPLLKRWAEAGKSQGGAIWVQLNHPGKQIPRMLASGDTLSPSAVPFGKELKSAFKTPRALTEEEIQDIIQRFARTAS
ICKKAGFTGVQIHGAHGYLVSQFLSGHHNRRTDQWGGSLENRMRFPLEIYRAIRKEVGEGYPVSIKLNSADFQRGGFSEE
ESMTVAKTLADEGLDLLEISGGNYENPVMAGAKGVRESTVNREAYFLDYANEIRKRVSVPLMVTGGFRSAKAMAEAVNSG
ATDVIGIARPLAVEPDLPNAIQAGREGVVSRVTPRKTGIKAIDEMAMMEVSWYTRQLHRMGAGKEPKPNESVLLALFKVI
ATMGVGSFKTRRLRANI
>Mature_416_residues
SHADTLSQTLTLPCGVTLPNRFGKSAMSEALGTIDNHVTPKLERLYARWAKGGTGLNITGNIMIDRRHTGEPNNVVVEDE
RDMPLLKRWAEAGKSQGGAIWVQLNHPGKQIPRMLASGDTLSPSAVPFGKELKSAFKTPRALTEEEIQDIIQRFARTASI
CKKAGFTGVQIHGAHGYLVSQFLSGHHNRRTDQWGGSLENRMRFPLEIYRAIRKEVGEGYPVSIKLNSADFQRGGFSEEE
SMTVAKTLADEGLDLLEISGGNYENPVMAGAKGVRESTVNREAYFLDYANEIRKRVSVPLMVTGGFRSAKAMAEAVNSGA
TDVIGIARPLAVEPDLPNAIQAGREGVVSRVTPRKTGIKAIDEMAMMEVSWYTRQLHRMGAGKEPKPNESVLLALFKVIA
TMGVGSFKTRRLRANI

Specific function: Reduces a range of alternative electron acceptors [H]

COG id: COG1902

COG function: function code C; NADH:flavin oxidoreductases, Old Yellow Enzyme family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1789463, Length=334, Percent_Identity=29.3413173652695, Blast_Score=141, Evalue=7e-35,
Organism=Escherichia coli, GI1787939, Length=318, Percent_Identity=27.6729559748428, Blast_Score=97, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17559802, Length=356, Percent_Identity=40.7303370786517, Blast_Score=241, Evalue=6e-64,
Organism=Caenorhabditis elegans, GI17565138, Length=411, Percent_Identity=35.5231143552311, Blast_Score=239, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI17540738, Length=370, Percent_Identity=36.7567567567568, Blast_Score=218, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI17564188, Length=368, Percent_Identity=35.054347826087, Blast_Score=218, Evalue=6e-57,
Organism=Caenorhabditis elegans, GI72001454, Length=360, Percent_Identity=36.9444444444444, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI17559804, Length=356, Percent_Identity=34.2696629213483, Blast_Score=212, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI17566914, Length=353, Percent_Identity=34.5609065155807, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17566916, Length=360, Percent_Identity=33.8888888888889, Blast_Score=172, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6321973, Length=85, Percent_Identity=42.3529411764706, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6325086, Length=126, Percent_Identity=36.5079365079365, Blast_Score=78, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013027
- InterPro:   IPR016040
- InterPro:   IPR001155
- InterPro:   IPR001327
- InterPro:   IPR000103 [H]

Pfam domain/function: PF00724 Oxidored_FMN; PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: 1.3.1.34 [C]

Molecular weight: Translated: 45672; Mature: 45541

Theoretical pI: Translated: 10.03; Mature: 10.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHADTLSQTLTLPCGVTLPNRFGKSAMSEALGTIDNHVTPKLERLYARWAKGGTGLNIT
CCCHHHHHHHEECCCCCCCCHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEE
GNIMIDRRHTGEPNNVVVEDERDMPLLKRWAEAGKSQGGAIWVQLNHPGKQIPRMLASGD
EEEEEEECCCCCCCCEEEECCCCCHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHCCC
TLSPSAVPFGKELKSAFKTPRALTEEEIQDIIQRFARTASICKKAGFTGVQIHGAHGYLV
CCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHH
SQFLSGHHNRRTDQWGGSLENRMRFPLEIYRAIRKEVGEGYPVSIKLNSADFQRGGFSEE
HHHHCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCH
ESMTVAKTLADEGLDLLEISGGNYENPVMAGAKGVRESTVNREAYFLDYANEIRKRVSVP
HHHHHHHHHHHCCCCEEEECCCCCCCCHHHCCCHHHHHHCCCHHEEHHHHHHHHHHCCCC
LMVTGGFRSAKAMAEAVNSGATDVIGIARPLAVEPDLPNAIQAGREGVVSRVTPRKTGIK
EEEECCCHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHH
AIDEMAMMEVSWYTRQLHRMGAGKEPKPNESVLLALFKVIATMGVGSFKTRRLRANI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCCC
>Mature Secondary Structure 
SHADTLSQTLTLPCGVTLPNRFGKSAMSEALGTIDNHVTPKLERLYARWAKGGTGLNIT
CCHHHHHHHEECCCCCCCCHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEE
GNIMIDRRHTGEPNNVVVEDERDMPLLKRWAEAGKSQGGAIWVQLNHPGKQIPRMLASGD
EEEEEEECCCCCCCCEEEECCCCCHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHCCC
TLSPSAVPFGKELKSAFKTPRALTEEEIQDIIQRFARTASICKKAGFTGVQIHGAHGYLV
CCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHH
SQFLSGHHNRRTDQWGGSLENRMRFPLEIYRAIRKEVGEGYPVSIKLNSADFQRGGFSEE
HHHHCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCH
ESMTVAKTLADEGLDLLEISGGNYENPVMAGAKGVRESTVNREAYFLDYANEIRKRVSVP
HHHHHHHHHHHCCCCEEEECCCCCCCCHHHCCCHHHHHHCCCHHEEHHHHHHHHHHCCCC
LMVTGGFRSAKAMAEAVNSGATDVIGIARPLAVEPDLPNAIQAGREGVVSRVTPRKTGIK
EEEECCCHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHH
AIDEMAMMEVSWYTRQLHRMGAGKEPKPNESVLLALFKVIATMGVGSFKTRRLRANI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: FAD. [C]

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: transDidehydroacyl-CoA; NADP+ [C]

Specific reaction: transDidehydroacyl-CoA + NADP+ =trans-transtetradehydroacyl-CoA + NADPH [C]

General reaction: Redox reaction [C]

Inhibitor: Iodoacetic acid; N-Ethyl maleimide [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8357835 [H]