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The map label for this gene is pyrC [H]

Identifier: 110834544

GI number: 110834544

Start: 1918222

End: 1919544

Strand: Direct

Name: pyrC [H]

Synonym: ABO_1683

Alternate gene names: 110834544

Gene position: 1918222-1919544 (Clockwise)

Preceding gene: 110834543

Following gene: 110834548

Centisome position: 61.48

GC content: 56.16

Gene sequence:

>1323_bases
ATGAACTGTGAAAACAGCTCTAGCCTATTAATCAAAGGTGCCACGGTCCTGTTGCCTGGTGGCCCTGAAGAAACCGATGT
GGCCTGTCGTGATGGCCGCATTGTGGCTATTGGCGAGCCCTTTCAGGCAGACACGATCTTCGAGGCCCGCGGCTTACACC
TCTTACCTGGCGCCGTGGATTCCCAAGTCCATTTCCGCGAACCGGGCATGACACACAAGGAAACGCTGGAAGCTGGCACA
CGCGGTGCCATTCTCGGCGGCATCACTAGTGTCTTCGAGATGCCTAACACTCAGCCTTTAACGCTCTACGCGGAAGATTT
GCAGGCCAAAATTGCCATTGCAGAACGGGATGCCTGGTGCAATTACGCCTTTTATATCGGCGGGTCCGCCGCCAATGCCG
AGCAGCTGGAAGAACTGGAATGTTTACCCGCCTGCAGCGGTGTAAAAATTTTTATGGGCAGTTCATTTGGCGATTTGCTC
GCCGATAGCGATGACGTGTTACGCAATATACTCCGCCATGGTCGCCGGCGAGTGGCGGTTCATGCTGAAGACGAAGCCCG
CTTACTGTCTCGCCGACACCTTGCTGAAGAAGCAGCAAACCCTGTAGCCCACCCCGTTTGGCGCGATGAAAACAGCGCCC
TGTTAGCCACTCAGCGCATTGTCGCACTGGCAGCAGAAGCTGGCCGCCCCCTACATGTGCTGCACATATCTACCGCCGAG
GAGATGGCGTTCTTGCAACATCACAAGTCCAGCGTGTCGGTAGAGGTGCTGCCCCAACATCTCACTCTATCGGCACCGGA
GTGCTACGAACGGCTCGGCACGCTGGCACAGATGAATCCTCCGATCCGCGATCAACGCCACCAAGATGCGCTCTGGAAAG
CGGTACAAAACGGTATCGTGGATGTCATCGGCAGCGACCACGCCCCCCATACTCGAGAAGAAAAACAGCGACCCTATCCG
AATTCACCCAGCGGCATGACCGGAACCCAAACACTGCTACCCTTGATGCTCAATCATGTTAACCAGGGACGACTCAGCCT
CCCGCGATTAGTGGATATGGTATGCGCAGGACCTGCGCGGCTGTTCGGCATGGCTGGCAAAGGGCGAATTGCGGTGGGGT
ACGATGCTGATTTGACCTTAGTAGACATGCAACGTAAACAAGCGGTGGATGACCGCAAACTGGCCTCACCTTCAGGCTGG
AGCGCCTACGATGGCATGATGCTGCAAGGCTGGCCTTCGGCCACGATTATTGCAGGGCAAATTGTCATGCTCGACGAGCA
GGTCATCGGCAGCCCAGCAGGAAAACCGCTCAGGTTTCTATAA

Upstream 100 bases:

>100_bases
CTCAGCCTCATTCCCCGTGTGAGCCAAGACATCACCGCGTTTTCAGAAAGTGTATCCGATACCAATCAGCAACTCGTTCA
GGGCTATAAAAGGATTCAAA

Downstream 100 bases:

>100_bases
CGGGCACAGCCAGTTAAAAATACCCCTCAAAAACAACACTCACGTGGATGATGAAAAGGATTTCGCGTTCTCTGGAGTTT
GGCGCCAAGCGGCCCGCGGT

Product: dihydroorotase

Products: NA

Alternate protein names: Allantoin-utilizing enzyme [H]

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MNCENSSSLLIKGATVLLPGGPEETDVACRDGRIVAIGEPFQADTIFEARGLHLLPGAVDSQVHFREPGMTHKETLEAGT
RGAILGGITSVFEMPNTQPLTLYAEDLQAKIAIAERDAWCNYAFYIGGSAANAEQLEELECLPACSGVKIFMGSSFGDLL
ADSDDVLRNILRHGRRRVAVHAEDEARLLSRRHLAEEAANPVAHPVWRDENSALLATQRIVALAAEAGRPLHVLHISTAE
EMAFLQHHKSSVSVEVLPQHLTLSAPECYERLGTLAQMNPPIRDQRHQDALWKAVQNGIVDVIGSDHAPHTREEKQRPYP
NSPSGMTGTQTLLPLMLNHVNQGRLSLPRLVDMVCAGPARLFGMAGKGRIAVGYDADLTLVDMQRKQAVDDRKLASPSGW
SAYDGMMLQGWPSATIIAGQIVMLDEQVIGSPAGKPLRFL

Sequences:

>Translated_440_residues
MNCENSSSLLIKGATVLLPGGPEETDVACRDGRIVAIGEPFQADTIFEARGLHLLPGAVDSQVHFREPGMTHKETLEAGT
RGAILGGITSVFEMPNTQPLTLYAEDLQAKIAIAERDAWCNYAFYIGGSAANAEQLEELECLPACSGVKIFMGSSFGDLL
ADSDDVLRNILRHGRRRVAVHAEDEARLLSRRHLAEEAANPVAHPVWRDENSALLATQRIVALAAEAGRPLHVLHISTAE
EMAFLQHHKSSVSVEVLPQHLTLSAPECYERLGTLAQMNPPIRDQRHQDALWKAVQNGIVDVIGSDHAPHTREEKQRPYP
NSPSGMTGTQTLLPLMLNHVNQGRLSLPRLVDMVCAGPARLFGMAGKGRIAVGYDADLTLVDMQRKQAVDDRKLASPSGW
SAYDGMMLQGWPSATIIAGQIVMLDEQVIGSPAGKPLRFL
>Mature_440_residues
MNCENSSSLLIKGATVLLPGGPEETDVACRDGRIVAIGEPFQADTIFEARGLHLLPGAVDSQVHFREPGMTHKETLEAGT
RGAILGGITSVFEMPNTQPLTLYAEDLQAKIAIAERDAWCNYAFYIGGSAANAEQLEELECLPACSGVKIFMGSSFGDLL
ADSDDVLRNILRHGRRRVAVHAEDEARLLSRRHLAEEAANPVAHPVWRDENSALLATQRIVALAAEAGRPLHVLHISTAE
EMAFLQHHKSSVSVEVLPQHLTLSAPECYERLGTLAQMNPPIRDQRHQDALWKAVQNGIVDVIGSDHAPHTREEKQRPYP
NSPSGMTGTQTLLPLMLNHVNQGRLSLPRLVDMVCAGPARLFGMAGKGRIAVGYDADLTLVDMQRKQAVDDRKLASPSGW
SAYDGMMLQGWPSATIIAGQIVMLDEQVIGSPAGKPLRFL

Specific function: Catalyzes the conversion of allantoin (5- ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Allantoinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=426, Percent_Identity=28.4037558685446, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI4503051, Length=447, Percent_Identity=25.503355704698, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI4503375, Length=443, Percent_Identity=24.3792325056433, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI19923821, Length=444, Percent_Identity=24.5495495495495, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI62422571, Length=447, Percent_Identity=25.503355704698, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI4503379, Length=444, Percent_Identity=25.2252252252252, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI4503377, Length=445, Percent_Identity=26.2921348314607, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI190194363, Length=454, Percent_Identity=26.6519823788546, Blast_Score=100, Evalue=3e-21,
Organism=Escherichia coli, GI1786722, Length=456, Percent_Identity=31.5789473684211, Blast_Score=182, Evalue=5e-47,
Organism=Escherichia coli, GI87082175, Length=457, Percent_Identity=27.1334792122538, Blast_Score=146, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI193204318, Length=430, Percent_Identity=27.4418604651163, Blast_Score=159, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17539558, Length=448, Percent_Identity=24.7767857142857, Blast_Score=107, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI71989490, Length=446, Percent_Identity=24.4394618834081, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI86575075, Length=453, Percent_Identity=22.2958057395143, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6322218, Length=419, Percent_Identity=27.6849642004773, Blast_Score=144, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24642586, Length=424, Percent_Identity=30.4245283018868, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI18859883, Length=429, Percent_Identity=28.6713286713287, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI221377917, Length=445, Percent_Identity=27.6404494382022, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI17137462, Length=441, Percent_Identity=26.984126984127, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24644287, Length=304, Percent_Identity=28.9473684210526, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017593
- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.5 [H]

Molecular weight: Translated: 47823; Mature: 47823

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNCENSSSLLIKGATVLLPGGPEETDVACRDGRIVAIGEPFQADTIFEARGLHLLPGAVD
CCCCCCCCEEEECEEEEECCCCCCCCEEECCCEEEEECCCCCCCCEECCCCCEECCCCCC
SQVHFREPGMTHKETLEAGTRGAILGGITSVFEMPNTQPLTLYAEDLQAKIAIAERDAWC
CCEEECCCCCCHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEEECCCCE
NYAFYIGGSAANAEQLEELECLPACSGVKIFMGSSFGDLLADSDDVLRNILRHGRRRVAV
EEEEEECCCCCCHHHHHHHHHCCCCCCCEEEECCCHHHHHCCCHHHHHHHHHCCCEEEEE
HAEDEARLLSRRHLAEEAANPVAHPVWRDENSALLATQRIVALAAEAGRPLHVLHISTAE
ECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEHHHHHHHHHHHHCCCCEEEEEECCHH
EMAFLQHHKSSVSVEVLPQHLTLSAPECYERLGTLAQMNPPIRDQRHQDALWKAVQNGIV
HHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCE
DVIGSDHAPHTREEKQRPYPNSPSGMTGTQTLLPLMLNHVNQGRLSLPRLVDMVCAGPAR
EEECCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHH
LFGMAGKGRIAVGYDADLTLVDMQRKQAVDDRKLASPSGWSAYDGMMLQGWPSATIIAGQ
HHCCCCCCEEEEECCCCEEEEECHHHHCCCHHHCCCCCCCCHHCCEEEECCCCCEEEEEE
IVMLDEQVIGSPAGKPLRFL
EEEECHHHHCCCCCCCCCCC
>Mature Secondary Structure
MNCENSSSLLIKGATVLLPGGPEETDVACRDGRIVAIGEPFQADTIFEARGLHLLPGAVD
CCCCCCCCEEEECEEEEECCCCCCCCEEECCCEEEEECCCCCCCCEECCCCCEECCCCCC
SQVHFREPGMTHKETLEAGTRGAILGGITSVFEMPNTQPLTLYAEDLQAKIAIAERDAWC
CCEEECCCCCCHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEEECCCCE
NYAFYIGGSAANAEQLEELECLPACSGVKIFMGSSFGDLLADSDDVLRNILRHGRRRVAV
EEEEEECCCCCCHHHHHHHHHCCCCCCCEEEECCCHHHHHCCCHHHHHHHHHCCCEEEEE
HAEDEARLLSRRHLAEEAANPVAHPVWRDENSALLATQRIVALAAEAGRPLHVLHISTAE
ECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEHHHHHHHHHHHHCCCCEEEEEECCHH
EMAFLQHHKSSVSVEVLPQHLTLSAPECYERLGTLAQMNPPIRDQRHQDALWKAVQNGIV
HHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCE
DVIGSDHAPHTREEKQRPYPNSPSGMTGTQTLLPLMLNHVNQGRLSLPRLVDMVCAGPAR
EEECCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHH
LFGMAGKGRIAVGYDADLTLVDMQRKQAVDDRKLASPSGWSAYDGMMLQGWPSATIIAGQ
HHCCCCCCEEEEECCCCEEEEECHHHHCCCHHHCCCCCCCCHHCCEEEECCCCCEEEEEE
IVMLDEQVIGSPAGKPLRFL
EEEECHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA