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The map label for this gene is purM

Identifier: 110834434

GI number: 110834434

Start: 1796855

End: 1797898

Strand: Direct

Name: purM

Synonym: ABO_1573

Alternate gene names: 110834434

Gene position: 1796855-1797898 (Clockwise)

Preceding gene: 110834430

Following gene: 110834435

Centisome position: 57.59

GC content: 58.62

Gene sequence:

>1044_bases
ATGACCGAACAGAAACGGCCACTGACGTACCGTGACGCAGGCGTCGACATCGACGCCGGTAACGAGCTGGTTAAACGCAT
CGCCCCTGTTGCCAAGCGGACCCGTCGCCCGGAAGTCCTCGGCGGTCTTGGTGGTTTCGGCGCCTTGTGCGAGCTACCCA
CCAAGTACAAAAACCCCGTTCTGGTTGCTGGCACCGATGGCGTCGGCACCAAACTGCGACTGGCCATCGATCACAATCGC
CACGAGAAAGTCGGCGTCGACCTAGTCGCCATGTGCGTCAATGACCTCATCGTAGGCGGAGCAGAACCCCTGTTCTTCCT
GGATTACTACGCCACCGGCAAACTGGATGTAGAGATTGCCACCAGCGTAGTAACCGGTATTGGCGAGGGCTGCGAGCTGG
CAGGCTGTGCCTTGATCGGCGGCGAAACCGCGGAAATGCCCGGCATGTATGAAGGCGAGGACTATGACTTGGCGGGCTTC
TGTGTCGGCGTGGTGGAAAAGGATGGCGTGCTGGATGGCAGCAAGGTAGAAGCCGGCGACAAGCTGATTGGTCTTGGCGC
CTCTGGCCCTCATTCCAACGGCTACTCTCTGATTCGTCGGATCATGGCTCAGGCTGAAACTGACATCGATCTGGACGGCA
AGCCACTGATTGAACACCTGCTCGAACCCACCCGAATTTACGTTAAATCCTTGCTCAAACTGATTGAGCAAGTACCGGTC
CATGCCATGGCTCACATTACCGGCGGCGGCCTGCCAGAAAACCTCCCCCGAGTTCTGCCGGACAACACCCGTGCTGTAAT
CGACACTAAAAGCTGGGAGTTCCCCGCAGTGTTCCAGTGGCTTCAGCAGGAAGGGCAAGTGCCCGCCTTCGAAATGTACC
GGACCTTTAACTGCGGCGTGGGCATGGTTATTGCGGTACCAGCCAGCCACGTTGATGACGCTCTCGCCCTGCTGGAAGCA
GAAGGTGAAAGCGCCTTCTTGATCGGTGAAATTCAGGCAGGCGACGGCCAGCCCGACGTCGTTCTGGACGGGCTGTCAGC
GTGA

Upstream 100 bases:

>100_bases
TGATGAAAACGTGCTTTACCCACCCAAGCTGCAAAGCAGAGGTTCCCCAGTAGGCTGACCGGTTGCTAGAATACGCGCCT
TCACCAATCCGGAGCTCCCC

Downstream 100 bases:

>100_bases
CTCACCGGCTAGCGGTATTGATTAGCGGCTCAGGCACCAACCTGCAAGCAATCATGGATGCCCGTGAACACGGCAGTCTC
GATGTCGAGATTGCCGTGGT

Product: phosphoribosylformylglycinamidine cyclo-ligase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MTEQKRPLTYRDAGVDIDAGNELVKRIAPVAKRTRRPEVLGGLGGFGALCELPTKYKNPVLVAGTDGVGTKLRLAIDHNR
HEKVGVDLVAMCVNDLIVGGAEPLFFLDYYATGKLDVEIATSVVTGIGEGCELAGCALIGGETAEMPGMYEGEDYDLAGF
CVGVVEKDGVLDGSKVEAGDKLIGLGASGPHSNGYSLIRRIMAQAETDIDLDGKPLIEHLLEPTRIYVKSLLKLIEQVPV
HAMAHITGGGLPENLPRVLPDNTRAVIDTKSWEFPAVFQWLQQEGQVPAFEMYRTFNCGVGMVIAVPASHVDDALALLEA
EGESAFLIGEIQAGDGQPDVVLDGLSA

Sequences:

>Translated_347_residues
MTEQKRPLTYRDAGVDIDAGNELVKRIAPVAKRTRRPEVLGGLGGFGALCELPTKYKNPVLVAGTDGVGTKLRLAIDHNR
HEKVGVDLVAMCVNDLIVGGAEPLFFLDYYATGKLDVEIATSVVTGIGEGCELAGCALIGGETAEMPGMYEGEDYDLAGF
CVGVVEKDGVLDGSKVEAGDKLIGLGASGPHSNGYSLIRRIMAQAETDIDLDGKPLIEHLLEPTRIYVKSLLKLIEQVPV
HAMAHITGGGLPENLPRVLPDNTRAVIDTKSWEFPAVFQWLQQEGQVPAFEMYRTFNCGVGMVIAVPASHVDDALALLEA
EGESAFLIGEIQAGDGQPDVVLDGLSA
>Mature_346_residues
TEQKRPLTYRDAGVDIDAGNELVKRIAPVAKRTRRPEVLGGLGGFGALCELPTKYKNPVLVAGTDGVGTKLRLAIDHNRH
EKVGVDLVAMCVNDLIVGGAEPLFFLDYYATGKLDVEIATSVVTGIGEGCELAGCALIGGETAEMPGMYEGEDYDLAGFC
VGVVEKDGVLDGSKVEAGDKLIGLGASGPHSNGYSLIRRIMAQAETDIDLDGKPLIEHLLEPTRIYVKSLLKLIEQVPVH
AMAHITGGGLPENLPRVLPDNTRAVIDTKSWEFPAVFQWLQQEGQVPAFEMYRTFNCGVGMVIAVPASHVDDALALLEAE
GESAFLIGEIQAGDGQPDVVLDGLSA

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=352, Percent_Identity=49.4318181818182, Blast_Score=331, Evalue=6e-91,
Organism=Homo sapiens, GI209869995, Length=352, Percent_Identity=49.4318181818182, Blast_Score=331, Evalue=6e-91,
Organism=Homo sapiens, GI209869993, Length=352, Percent_Identity=49.4318181818182, Blast_Score=331, Evalue=6e-91,
Organism=Escherichia coli, GI1788845, Length=346, Percent_Identity=69.0751445086705, Blast_Score=493, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI17567511, Length=336, Percent_Identity=42.5595238095238, Blast_Score=247, Evalue=8e-66,
Organism=Saccharomyces cerevisiae, GI6321203, Length=340, Percent_Identity=47.6470588235294, Blast_Score=306, Evalue=4e-84,
Organism=Drosophila melanogaster, GI24582400, Length=292, Percent_Identity=43.4931506849315, Blast_Score=243, Evalue=1e-64,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_ALCBS (Q0VP77)

Other databases:

- EMBL:   AM286690
- RefSeq:   YP_693293.1
- ProteinModelPortal:   Q0VP77
- SMR:   Q0VP77
- STRING:   Q0VP77
- GeneID:   4211149
- GenomeReviews:   AM286690_GR
- KEGG:   abo:ABO_1573
- NMPDR:   fig|393595.12.peg.1578
- eggNOG:   COG0150
- HOGENOM:   HBG531222
- OMA:   HYDLAGF
- PhylomeDB:   Q0VP77
- BioCyc:   ABOR393595:ABO_1573-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00741_B
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 36922; Mature: 36791

Theoretical pI: Translated: 4.39; Mature: 4.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEQKRPLTYRDAGVDIDAGNELVKRIAPVAKRTRRPEVLGGLGGFGALCELPTKYKNPV
CCCCCCCCEEECCCCEECCCHHHHHHHHHHHHHCCCCHHHHCCCCHHHHHCCCCCCCCCE
LVAGTDGVGTKLRLAIDHNRHEKVGVDLVAMCVNDLIVGGAEPLFFLDYYATGKLDVEIA
EEEECCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCEEEHHHH
TSVVTGIGEGCELAGCALIGGETAEMPGMYEGEDYDLAGFCVGVVEKDGVLDGSKVEAGD
HHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCC
KLIGLGASGPHSNGYSLIRRIMAQAETDIDLDGKPLIEHLLEPTRIYVKSLLKLIEQVPV
EEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHCCH
HAMAHITGGGLPENLPRVLPDNTRAVIDTKSWEFPAVFQWLQQEGQVPAFEMYRTFNCGV
HHEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHHCCCC
GMVIAVPASHVDDALALLEAEGESAFLIGEIQAGDGQPDVVLDGLSA
CEEEEECCHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCEEECCCCC
>Mature Secondary Structure 
TEQKRPLTYRDAGVDIDAGNELVKRIAPVAKRTRRPEVLGGLGGFGALCELPTKYKNPV
CCCCCCCEEECCCCEECCCHHHHHHHHHHHHHCCCCHHHHCCCCHHHHHCCCCCCCCCE
LVAGTDGVGTKLRLAIDHNRHEKVGVDLVAMCVNDLIVGGAEPLFFLDYYATGKLDVEIA
EEEECCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCEEEHHHH
TSVVTGIGEGCELAGCALIGGETAEMPGMYEGEDYDLAGFCVGVVEKDGVLDGSKVEAGD
HHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCC
KLIGLGASGPHSNGYSLIRRIMAQAETDIDLDGKPLIEHLLEPTRIYVKSLLKLIEQVPV
EEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHCCH
HAMAHITGGGLPENLPRVLPDNTRAVIDTKSWEFPAVFQWLQQEGQVPAFEMYRTFNCGV
HHEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHHCCCC
GMVIAVPASHVDDALALLEAEGESAFLIGEIQAGDGQPDVVLDGLSA
CEEEEECCHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA