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The map label for this gene is pmpM [H]

Identifier: 110834415

GI number: 110834415

Start: 1776184

End: 1777566

Strand: Direct

Name: pmpM [H]

Synonym: ABO_1554

Alternate gene names: 110834415

Gene position: 1776184-1777566 (Clockwise)

Preceding gene: 110834413

Following gene: 110834416

Centisome position: 56.93

GC content: 59.8

Gene sequence:

>1383_bases
ATGTTATCCCGCCGTCAAGAGCTTGCCGCCCAACTCACCCTCGCATTGCCAATTCTGGGTGGGCAACTGGCACAAACGGC
CAACGGCTTTGTGGACACCATGATGGCCGGCCGTGTTGGCGCCAATGATTTGGCGGCGGTGGCCGTGGGCGCCAGCATTT
GGGTGCCCCTGTTCCTGTTCATGACCGGCGTACTGATGAGCGCCACCCCAATACTGTCGCGCCATCTCGGCGGCAAAGCT
TATCACCGCATTAACCCCCTCGCCCAGCAGGGCCTCTGGTTGGCTCTTGTGCTAGGGGTTCTTTGCGCACTTATTCTACG
CAGCATTGCTCCGTTATTGGTATGGATGGACGTGGATCCGGCGATCCGACCCATGGTCAGCGGCTACCTGGATGCGCTTA
GCTGGGGCATGCCTGGCGCCGCCATTATGCTGGCGTTGCGCAGTTATACCGAGGCCATGAACCATACCCGGCCGGTGCTG
CTAATCAGCGTAATCGGCCTAATGATCAACATCCCTAGTAACTATGTGCTGATCTACGGAAAACTGGGCTTCCCAGCCAT
GGGGGGAGTCGGCTGCGGTTGGGCCACCTCACTGGTAATGTGGTCCATGGCAATAATGATGATGGTCTATACCCATCGCC
ACCCGGTGTATCAGCATGCACCATTGAATCTGCGACAGCGGCATTTCGAGCGCGCCAATCTAGCCTACATGCTGCGGCTG
GGCTTACCCGTAGGCCTGTCAATTTTCTTTGAGGTAAGTATCTTTGCGGTCATTGCCCTTCTCATCGGCAGCCTGGGGGC
CCAGGTCGTCGCCAGCCACCAGATCGCGCTCAACTTCACCTCCCTGATTTTTATGGTGCCGCTGAGTTTCGCCCTGGCCG
CCACCGTTCGGGTGGGTCACGCCCGAGGACGCAGCGATCAAAACGGTATTCGCGTGGCCGTGCAGGTGGCCATGGCAATC
ACCCTGGTGGTGGGCATCACCGCCGCCTCCAGTCTGGTGCTGGCCCGGCACTGGATTCCCCGTATTTATACCGACAACGG
CTCGGTGATTGCACTCGCCAGCTACCTGTTGTTGTTCGCGGCCCTGTACCAGATCTCGGATGCATTGCAGGTTTGCGCCA
ACGGGTGCCTGCGCGGTTTCGAAGATACCGGCTGGCCCATGGTAATGACATTGCTGGCCTACTGGGGCATCGGCCTGCCC
ATCGGGTACGGCCTGGCATTAACTGATTGGTGGGTCGAGCCCATGGGCCCTGCCGGATTCTGGATCGGTCTGGTAGCGGG
CTTGACCAGTGCCGCCGTCTTCCTTGGCTGGCGCTTGCGTTGGCGGCTCAAGCAACCGCTATCAGAGCCGGAAGTGTCAG
CCTCTACCCCCTTCGCGTCCTGA

Upstream 100 bases:

>100_bases
TGCAAGGCAGTTTGCGGTATGGTAGCCGCCGTCTTGCGAACCTGATTCTGTTCTATTTCGTTCACCACACCCGTTCCGCT
TACAACAGTGGCACCTGCCT

Downstream 100 bases:

>100_bases
TCGAAAAGTTCGCTGTTCTTACAGTCTTTACACTCGAATGTCGCTGCGGCGCCACATTTACATTTCCTTTGCAGTTTGTT
TGTAGATAATAACAATTCTC

Product: MATE efflux family protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: H(+)/drug antiporter; Multidrug-efflux transporter [H]

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MLSRRQELAAQLTLALPILGGQLAQTANGFVDTMMAGRVGANDLAAVAVGASIWVPLFLFMTGVLMSATPILSRHLGGKA
YHRINPLAQQGLWLALVLGVLCALILRSIAPLLVWMDVDPAIRPMVSGYLDALSWGMPGAAIMLALRSYTEAMNHTRPVL
LISVIGLMINIPSNYVLIYGKLGFPAMGGVGCGWATSLVMWSMAIMMMVYTHRHPVYQHAPLNLRQRHFERANLAYMLRL
GLPVGLSIFFEVSIFAVIALLIGSLGAQVVASHQIALNFTSLIFMVPLSFALAATVRVGHARGRSDQNGIRVAVQVAMAI
TLVVGITAASSLVLARHWIPRIYTDNGSVIALASYLLLFAALYQISDALQVCANGCLRGFEDTGWPMVMTLLAYWGIGLP
IGYGLALTDWWVEPMGPAGFWIGLVAGLTSAAVFLGWRLRWRLKQPLSEPEVSASTPFAS

Sequences:

>Translated_460_residues
MLSRRQELAAQLTLALPILGGQLAQTANGFVDTMMAGRVGANDLAAVAVGASIWVPLFLFMTGVLMSATPILSRHLGGKA
YHRINPLAQQGLWLALVLGVLCALILRSIAPLLVWMDVDPAIRPMVSGYLDALSWGMPGAAIMLALRSYTEAMNHTRPVL
LISVIGLMINIPSNYVLIYGKLGFPAMGGVGCGWATSLVMWSMAIMMMVYTHRHPVYQHAPLNLRQRHFERANLAYMLRL
GLPVGLSIFFEVSIFAVIALLIGSLGAQVVASHQIALNFTSLIFMVPLSFALAATVRVGHARGRSDQNGIRVAVQVAMAI
TLVVGITAASSLVLARHWIPRIYTDNGSVIALASYLLLFAALYQISDALQVCANGCLRGFEDTGWPMVMTLLAYWGIGLP
IGYGLALTDWWVEPMGPAGFWIGLVAGLTSAAVFLGWRLRWRLKQPLSEPEVSASTPFAS
>Mature_460_residues
MLSRRQELAAQLTLALPILGGQLAQTANGFVDTMMAGRVGANDLAAVAVGASIWVPLFLFMTGVLMSATPILSRHLGGKA
YHRINPLAQQGLWLALVLGVLCALILRSIAPLLVWMDVDPAIRPMVSGYLDALSWGMPGAAIMLALRSYTEAMNHTRPVL
LISVIGLMINIPSNYVLIYGKLGFPAMGGVGCGWATSLVMWSMAIMMMVYTHRHPVYQHAPLNLRQRHFERANLAYMLRL
GLPVGLSIFFEVSIFAVIALLIGSLGAQVVASHQIALNFTSLIFMVPLSFALAATVRVGHARGRSDQNGIRVAVQVAMAI
TLVVGITAASSLVLARHWIPRIYTDNGSVIALASYLLLFAALYQISDALQVCANGCLRGFEDTGWPMVMTLLAYWGIGLP
IGYGLALTDWWVEPMGPAGFWIGLVAGLTSAAVFLGWRLRWRLKQPLSEPEVSASTPFAS

Specific function: Multidrug efflux pump that functions as an H(+)/drug antiporter. Confers resistance to benzalkonium chloride, fluoroquinolones, ethidium bromide, acriflavine and tetraphenylphosphonium chloride [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI22907060, Length=466, Percent_Identity=24.4635193133047, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI153792564, Length=454, Percent_Identity=22.6872246696035, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI38261960, Length=363, Percent_Identity=23.4159779614325, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI48994890, Length=436, Percent_Identity=44.0366972477064, Blast_Score=341, Evalue=7e-95,
Organism=Escherichia coli, GI226510954, Length=464, Percent_Identity=22.8448275862069, Blast_Score=85, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6320545, Length=451, Percent_Identity=21.0643015521064, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6321821, Length=380, Percent_Identity=19.4736842105263, Blast_Score=67, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49666; Mature: 49666

Theoretical pI: Translated: 9.75; Mature: 9.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSRRQELAAQLTLALPILGGQLAQTANGFVDTMMAGRVGANDLAAVAVGASIWVPLFLF
CCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
MTGVLMSATPILSRHLGGKAYHRINPLAQQGLWLALVLGVLCALILRSIAPLLVWMDVDP
HHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCH
AIRPMVSGYLDALSWGMPGAAIMLALRSYTEAMNHTRPVLLISVIGLMINIPSNYVLIYG
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEE
KLGFPAMGGVGCGWATSLVMWSMAIMMMVYTHRHPVYQHAPLNLRQRHFERANLAYMLRL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHH
GLPVGLSIFFEVSIFAVIALLIGSLGAQVVASHQIALNFTSLIFMVPLSFALAATVRVGH
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARGRSDQNGIRVAVQVAMAITLVVGITAASSLVLARHWIPRIYTDNGSVIALASYLLLFA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHH
ALYQISDALQVCANGCLRGFEDTGWPMVMTLLAYWGIGLPIGYGLALTDWWVEPMGPAGF
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCHHH
WIGLVAGLTSAAVFLGWRLRWRLKQPLSEPEVSASTPFAS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLSRRQELAAQLTLALPILGGQLAQTANGFVDTMMAGRVGANDLAAVAVGASIWVPLFLF
CCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
MTGVLMSATPILSRHLGGKAYHRINPLAQQGLWLALVLGVLCALILRSIAPLLVWMDVDP
HHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCH
AIRPMVSGYLDALSWGMPGAAIMLALRSYTEAMNHTRPVLLISVIGLMINIPSNYVLIYG
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEE
KLGFPAMGGVGCGWATSLVMWSMAIMMMVYTHRHPVYQHAPLNLRQRHFERANLAYMLRL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHH
GLPVGLSIFFEVSIFAVIALLIGSLGAQVVASHQIALNFTSLIFMVPLSFALAATVRVGH
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARGRSDQNGIRVAVQVAMAITLVVGITAASSLVLARHWIPRIYTDNGSVIALASYLLLFA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHH
ALYQISDALQVCANGCLRGFEDTGWPMVMTLLAYWGIGLPIGYGLALTDWWVEPMGPAGF
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCHHH
WIGLVAGLTSAAVFLGWRLRWRLKQPLSEPEVSASTPFAS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]