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The map label for this gene is phoQ [H]

Identifier: 110834227

GI number: 110834227

Start: 1554530

End: 1555864

Strand: Direct

Name: phoQ [H]

Synonym: ABO_1366

Alternate gene names: 110834227

Gene position: 1554530-1555864 (Clockwise)

Preceding gene: 110834226

Following gene: 110834229

Centisome position: 49.82

GC content: 56.1

Gene sequence:

>1335_bases
ATGCTCCTGATTCTGCTGCTTCCGGCCGGCATTGGTCTGATGGCACTGGCTTGGATCATCCATGGGGCCTTGCTGGAGAG
GATGACCATGGACTTAGTAGAACGCCGCTTGAAAGATGAGGTAGCTTTTCTGGAACACCAGATCCGCCAATCCGGTGGCC
AGATTGATACACTCCAGACCGGCGACTATTTTCAGGAAGTGCTCCTCCACGCCTTCGCCATCGCCATCGCTTCTCCGTCT
GGGCAGTCCATCTCACCGGAGACCTGGACTCCGATTCTGAGGCCGTTGCTCACCTCCGGGCAGGAGGGAGCCGTGAGAGC
CAGGGATGCTGAGGTACCAGCTGCGCCTTCCCAAATGCTTGGGTATCGCCGTGCCTTCACGGTCGACGGAAACCCCTTCG
TGATCATTGTTGCCGAGGATATGGAGGCGCTTCATCGGAGCCAGGCCAAACTCCATATCTGGACTGCCGTCGTCTCGGTT
TTACTGGTCATTCTGATGATCGGGAGCATATGGCTGGGAATCACTCTGGCCCTGCGGTCAATAGCGGGCCTTCAGATGAA
CCTGAAAAAACTTCAGTCAGGCGAGCTCTCCCGTATTAACGCAGACGGCCCGGAGGAGTTCCAGCCCCTCGTCCGGCAAC
TCAATCGACTGCTGGATTCACTGGATGACCGGCTGGAACGCTCCCGTGACGCACTTGCCAACCTTTCCCACAGCGTGAAA
ACCCCCATAGCGGCTGTCAGACAGATCCTGGAAGACACCAGTCGCCCGCTCGATGAGAAGCTGAGATGGGAAATGGCGGC
GCGCCTCGACGACATAGATGCTCAGCTTGAGGCCGAAATGCGGCGAAGCCGGTTTGCGGGTCCACAGGTCGGCCAAAGTG
TATGTCCGATCAAACAGGCCCGGGATCTGCTGTGGATGCTTGGCCGCCTCTACCCCGATAAATCTTTTGAATTGTCAACG
GATCTGCCTGAAAACCATCGCTGGCCTGTCGAGGAGCATGATCTGAACGAAATCCTTGGCAACTTGCTGGATAACGCAGG
CAAATGGTCATCCCGCTGGGTGGAGCTCACGCTGAGTGAAGATCAAGAGCAGTTAAAAATTATCATCAGCGACGACGGAG
CGGGCGTATCAGAAACAGCCCACTCACAATTGGGCAAGCGAGGATTGAGGCTGGACGAGCAAACACCCGGTCATGGATTG
GGGCTGGCTATTGTCCACGCAATAGTTGAGCGTTATCAGGGACAGGTTCATTACACGTCCAGTAAGGTAGGAGGCCTTAC
TGCAGTTGTTGTAATCCCTGGTTCTGATCGATTCGGCGACCGGTCAGACAACTGA

Upstream 100 bases:

>100_bases
CGGCTCAGGAAGCTGGTGGGACCGGACACCATCAAGACCCGACGTGGTCAGGGGTACCTGTTCGATGCCGATAGCCGCTA
GACCTCGCTCAGTCAGGGGG

Downstream 100 bases:

>100_bases
CACCTTCACCCTCCATTCTCTATGCTTCAAGTCAAATTCATCAATAGTTGGGATGATGATTTGGAGTCTCGTCCAGCCTG
TTCAATCTCGACCGCTCTAT

Product: PhoQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MLLILLLPAGIGLMALAWIIHGALLERMTMDLVERRLKDEVAFLEHQIRQSGGQIDTLQTGDYFQEVLLHAFAIAIASPS
GQSISPETWTPILRPLLTSGQEGAVRARDAEVPAAPSQMLGYRRAFTVDGNPFVIIVAEDMEALHRSQAKLHIWTAVVSV
LLVILMIGSIWLGITLALRSIAGLQMNLKKLQSGELSRINADGPEEFQPLVRQLNRLLDSLDDRLERSRDALANLSHSVK
TPIAAVRQILEDTSRPLDEKLRWEMAARLDDIDAQLEAEMRRSRFAGPQVGQSVCPIKQARDLLWMLGRLYPDKSFELST
DLPENHRWPVEEHDLNEILGNLLDNAGKWSSRWVELTLSEDQEQLKIIISDDGAGVSETAHSQLGKRGLRLDEQTPGHGL
GLAIVHAIVERYQGQVHYTSSKVGGLTAVVVIPGSDRFGDRSDN

Sequences:

>Translated_444_residues
MLLILLLPAGIGLMALAWIIHGALLERMTMDLVERRLKDEVAFLEHQIRQSGGQIDTLQTGDYFQEVLLHAFAIAIASPS
GQSISPETWTPILRPLLTSGQEGAVRARDAEVPAAPSQMLGYRRAFTVDGNPFVIIVAEDMEALHRSQAKLHIWTAVVSV
LLVILMIGSIWLGITLALRSIAGLQMNLKKLQSGELSRINADGPEEFQPLVRQLNRLLDSLDDRLERSRDALANLSHSVK
TPIAAVRQILEDTSRPLDEKLRWEMAARLDDIDAQLEAEMRRSRFAGPQVGQSVCPIKQARDLLWMLGRLYPDKSFELST
DLPENHRWPVEEHDLNEILGNLLDNAGKWSSRWVELTLSEDQEQLKIIISDDGAGVSETAHSQLGKRGLRLDEQTPGHGL
GLAIVHAIVERYQGQVHYTSSKVGGLTAVVVIPGSDRFGDRSDN
>Mature_444_residues
MLLILLLPAGIGLMALAWIIHGALLERMTMDLVERRLKDEVAFLEHQIRQSGGQIDTLQTGDYFQEVLLHAFAIAIASPS
GQSISPETWTPILRPLLTSGQEGAVRARDAEVPAAPSQMLGYRRAFTVDGNPFVIIVAEDMEALHRSQAKLHIWTAVVSV
LLVILMIGSIWLGITLALRSIAGLQMNLKKLQSGELSRINADGPEEFQPLVRQLNRLLDSLDDRLERSRDALANLSHSVK
TPIAAVRQILEDTSRPLDEKLRWEMAARLDDIDAQLEAEMRRSRFAGPQVGQSVCPIKQARDLLWMLGRLYPDKSFELST
DLPENHRWPVEEHDLNEILGNLLDNAGKWSSRWVELTLSEDQEQLKIIISDDGAGVSETAHSQLGKRGLRLDEQTPGHGL
GLAIVHAIVERYQGQVHYTSSKVGGLTAVVVIPGSDRFGDRSDN

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=295, Percent_Identity=29.8305084745763, Blast_Score=131, Evalue=7e-32,
Organism=Escherichia coli, GI1787894, Length=253, Percent_Identity=25.6916996047431, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790346, Length=248, Percent_Identity=27.0161290322581, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1788393, Length=345, Percent_Identity=22.8985507246377, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1790861, Length=346, Percent_Identity=24.5664739884393, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1789808, Length=282, Percent_Identity=23.4042553191489, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49281; Mature: 49281

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLILLLPAGIGLMALAWIIHGALLERMTMDLVERRLKDEVAFLEHQIRQSGGQIDTLQT
CEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCC
GDYFQEVLLHAFAIAIASPSGQSISPETWTPILRPLLTSGQEGAVRARDAEVPAAPSQML
CHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCEECCCCCCCCCHHHHH
GYRRAFTVDGNPFVIIVAEDMEALHRSQAKLHIWTAVVSVLLVILMIGSIWLGITLALRS
CCCCEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAGLQMNLKKLQSGELSRINADGPEEFQPLVRQLNRLLDSLDDRLERSRDALANLSHSVK
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TPIAAVRQILEDTSRPLDEKLRWEMAARLDDIDAQLEAEMRRSRFAGPQVGQSVCPIKQA
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
RDLLWMLGRLYPDKSFELSTDLPENHRWPVEEHDLNEILGNLLDNAGKWSSRWVELTLSE
HHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEECC
DQEQLKIIISDDGAGVSETAHSQLGKRGLRLDEQTPGHGLGLAIVHAIVERYQGQVHYTS
CCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEC
SKVGGLTAVVVIPGSDRFGDRSDN
CCCCCEEEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MLLILLLPAGIGLMALAWIIHGALLERMTMDLVERRLKDEVAFLEHQIRQSGGQIDTLQT
CEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCC
GDYFQEVLLHAFAIAIASPSGQSISPETWTPILRPLLTSGQEGAVRARDAEVPAAPSQML
CHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCEECCCCCCCCCHHHHH
GYRRAFTVDGNPFVIIVAEDMEALHRSQAKLHIWTAVVSVLLVILMIGSIWLGITLALRS
CCCCEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAGLQMNLKKLQSGELSRINADGPEEFQPLVRQLNRLLDSLDDRLERSRDALANLSHSVK
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TPIAAVRQILEDTSRPLDEKLRWEMAARLDDIDAQLEAEMRRSRFAGPQVGQSVCPIKQA
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
RDLLWMLGRLYPDKSFELSTDLPENHRWPVEEHDLNEILGNLLDNAGKWSSRWVELTLSE
HHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEECC
DQEQLKIIISDDGAGVSETAHSQLGKRGLRLDEQTPGHGLGLAIVHAIVERYQGQVHYTS
CCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEC
SKVGGLTAVVVIPGSDRFGDRSDN
CCCCCEEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA