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The map label for this gene is phoP [H]

Identifier: 110834226

GI number: 110834226

Start: 1553842

End: 1554510

Strand: Direct

Name: phoP [H]

Synonym: ABO_1365

Alternate gene names: 110834226

Gene position: 1553842-1554510 (Clockwise)

Preceding gene: 110834216

Following gene: 110834227

Centisome position: 49.8

GC content: 58.89

Gene sequence:

>669_bases
ATGAGATTACTTCTGGTGGAAGATGACTACCTGCTGACAAATGGGCTAAGCGCCCAACTGGAAAAGGCCGGTTTCAGCGT
GGATACCGCCCGTACAGCGCGGGAAGCCCGGCACCTCGGGCAGCAGGAAAGTTACCGCGCCGGTATTCTTGACCTGGGCC
TGCCCGACGGCAACGGCCTGGACGTACTGAAACAGTGGCGGACGCATAAGGTCAGTTTCCCGGTGTTGATCCTGACCGCC
AGGGGAGACTGGCAGGACAAGGTCAATGGCTTGAAGGCCGGCGCCGATGATTACCTCGCGAAGCCTTTCCAGACCGAAGA
GCTGATTGCCCGACTTCACGCCATCGTCCGGCGAAGCGAAGGCAGAATAATGGATACCCTGACAGCGGGCCGGTTCGAGC
TGGACGAAAATCGCCAGACGTTAAGGGCCGGTGACGAGACCGAACATAGCCTGACCGGTACGGAGTTCCGTTTGCTCCGA
TGTCTGATGAGTCGTCCCGGGCAGGTTTTCTCGAAAGAACAGCTTCTCGACCAGCTATACAGCATCGACGACATACCCAG
CGAGAACGTGATCGAAGCGTATGTGCGGCGGCTCAGGAAGCTGGTGGGACCGGACACCATCAAGACCCGACGTGGTCAGG
GGTACCTGTTCGATGCCGATAGCCGCTAG

Upstream 100 bases:

>100_bases
TCCAGGCTGAAAATCGGAATTATTTTTTGTTCTGGCACAATTCAGCTTGGGCAGCGACACTGACGGACTCTGATGCTCAA
TTTAGAAAGGCAGTTCAGGA

Downstream 100 bases:

>100_bases
ACCTCGCTCAGTCAGGGGGATGCTCCTGATTCTGCTGCTTCCGGCCGGCATTGGTCTGATGGCACTGGCTTGGATCATCC
ATGGGGCCTTGCTGGAGAGG

Product: DNA-binding heavy metal response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 222; Mature: 222

Protein sequence:

>222_residues
MRLLLVEDDYLLTNGLSAQLEKAGFSVDTARTAREARHLGQQESYRAGILDLGLPDGNGLDVLKQWRTHKVSFPVLILTA
RGDWQDKVNGLKAGADDYLAKPFQTEELIARLHAIVRRSEGRIMDTLTAGRFELDENRQTLRAGDETEHSLTGTEFRLLR
CLMSRPGQVFSKEQLLDQLYSIDDIPSENVIEAYVRRLRKLVGPDTIKTRRGQGYLFDADSR

Sequences:

>Translated_222_residues
MRLLLVEDDYLLTNGLSAQLEKAGFSVDTARTAREARHLGQQESYRAGILDLGLPDGNGLDVLKQWRTHKVSFPVLILTA
RGDWQDKVNGLKAGADDYLAKPFQTEELIARLHAIVRRSEGRIMDTLTAGRFELDENRQTLRAGDETEHSLTGTEFRLLR
CLMSRPGQVFSKEQLLDQLYSIDDIPSENVIEAYVRRLRKLVGPDTIKTRRGQGYLFDADSR
>Mature_222_residues
MRLLLVEDDYLLTNGLSAQLEKAGFSVDTARTAREARHLGQQESYRAGILDLGLPDGNGLDVLKQWRTHKVSFPVLILTA
RGDWQDKVNGLKAGADDYLAKPFQTEELIARLHAIVRRSEGRIMDTLTAGRFELDENRQTLRAGDETEHSLTGTEFRLLR
CLMSRPGQVFSKEQLLDQLYSIDDIPSENVIEAYVRRLRKLVGPDTIKTRRGQGYLFDADSR

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=41.4414414414414, Blast_Score=174, Evalue=4e-45,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=41.8181818181818, Blast_Score=158, Evalue=3e-40,
Organism=Escherichia coli, GI1789402, Length=215, Percent_Identity=40.9302325581395, Blast_Score=154, Evalue=4e-39,
Organism=Escherichia coli, GI1786784, Length=229, Percent_Identity=34.4978165938865, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI1786599, Length=223, Percent_Identity=33.6322869955157, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1789809, Length=231, Percent_Identity=31.6017316017316, Blast_Score=118, Evalue=2e-28,
Organism=Escherichia coli, GI1790860, Length=218, Percent_Identity=33.4862385321101, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI87082012, Length=223, Percent_Identity=34.0807174887892, Blast_Score=117, Evalue=6e-28,
Organism=Escherichia coli, GI2367329, Length=234, Percent_Identity=37.6068376068376, Blast_Score=110, Evalue=5e-26,
Organism=Escherichia coli, GI1786911, Length=225, Percent_Identity=35.1111111111111, Blast_Score=107, Evalue=6e-25,
Organism=Escherichia coli, GI1790863, Length=231, Percent_Identity=29.4372294372294, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=29.2576419213974, Blast_Score=100, Evalue=6e-23,
Organism=Escherichia coli, GI1788394, Length=237, Percent_Identity=31.2236286919831, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI1788550, Length=118, Percent_Identity=32.2033898305085, Blast_Score=69, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25145; Mature: 25145

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLLVEDDYLLTNGLSAQLEKAGFSVDTARTAREARHLGQQESYRAGILDLGLPDGNGL
CEEEEECCCEEEECCCHHHHHHCCCCCHHHHHHHHHHHCCCCHHHCCCEEEECCCCCCCH
DVLKQWRTHKVSFPVLILTARGDWQDKVNGLKAGADDYLAKPFQTEELIARLHAIVRRSE
HHHHHHHHCCCCCCEEEEEECCCCHHHHHHHCCCCHHHHCCCCCHHHHHHHHHHHHHHCC
GRIMDTLTAGRFELDENRQTLRAGDETEHSLTGTEFRLLRCLMSRPGQVFSKEQLLDQLY
CCEEEHHCCCCEEECCCHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHH
SIDDIPSENVIEAYVRRLRKLVGPDTIKTRRGQGYLFDADSR
CCCCCCCHHHHHHHHHHHHHHHCCCCCEECCCCEEEEECCCC
>Mature Secondary Structure
MRLLLVEDDYLLTNGLSAQLEKAGFSVDTARTAREARHLGQQESYRAGILDLGLPDGNGL
CEEEEECCCEEEECCCHHHHHHCCCCCHHHHHHHHHHHCCCCHHHCCCEEEECCCCCCCH
DVLKQWRTHKVSFPVLILTARGDWQDKVNGLKAGADDYLAKPFQTEELIARLHAIVRRSE
HHHHHHHHCCCCCCEEEEEECCCCHHHHHHHCCCCHHHHCCCCCHHHHHHHHHHHHHHCC
GRIMDTLTAGRFELDENRQTLRAGDETEHSLTGTEFRLLRCLMSRPGQVFSKEQLLDQLY
CCEEEHHCCCCEEECCCHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHH
SIDDIPSENVIEAYVRRLRKLVGPDTIKTRRGQGYLFDADSR
CCCCCCCHHHHHHHHHHHHHHHCCCCCEECCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA