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The map label for this gene is mscS [H]

Identifier: 110834186

GI number: 110834186

Start: 1505251

End: 1506069

Strand: Direct

Name: mscS [H]

Synonym: ABO_1325

Alternate gene names: 110834186

Gene position: 1505251-1506069 (Clockwise)

Preceding gene: 110834184

Following gene: 110834187

Centisome position: 48.24

GC content: 48.84

Gene sequence:

>819_bases
ATGGATCAATATCTGTCGCAACTAGAAACCTTTGCCAATGAAAACTTGGTGCCCTATGCCTGGAGCATTGCCGCCGCACT
GGTAATTTTCATTGTTGGTAGCTGGGTGGTTGCTCGGCTAAGTCACTGGGTGCAAAAACTACTAAACAAACGAATGGATG
AAACGGTCGCCACCTTCTTAGGGCGCATTGTTCATATCTTGTTATTTGTTTTCGTTGTTATTGCGTCTTTAGATCAGCTT
GGCATTGAAACGACCTCGCTAGTTGCCATTTTGGGTGCTGCCGGCTTGGCTGTTGGCTTGGCATTGAAAGACTCTCTGGG
TAACTTTGCTGCCGGCGTGATGCTTATCCTGTTCAAGCCGTTCCGCGTGGGCCATTACGTTGAAGCAGGGGGAACTTCTG
GTACCGTTAAAGAAATCCGCATTTTCGCAACCATCATGAACAGCCCGGACAATAAAGTACTTACTGTCCCTAACGGCGCA
ATCATGTCCGGTAATATCGTCAATTACTCCGAAAAACCGACCCGCCGTGTGGATATGGTCTTCGGTGTTGCCTACGATGC
TGATCTTTCTGTGGTGAAAAAGGTGCTTGAAGAGATTCTTGCTGCGGATGAGCGTGTTCTGAAGGATCCAGCCCCAACTA
TTGTGGTAGGTGAGCTGGCGGATAGCTCAGTTAATTTCCTATGCCGCCCCTGGGTAAATAGCGCGGATTACTGGCCAGTT
CTGTGGGACACCACAGAAGCGGCGAAACTTCGCTTTGACGAAGCAGGGATTGGCATTCCGTTCCCACAGATGGACGTACA
TCTAGACAAAAATGACTAA

Upstream 100 bases:

>100_bases
GATGAAATCTTTGTAAAAACCTGTATGCCAGCAGCTTTCGCACTTGGGGTTGCTGTAGGAATGGGCATAATTGCGCATCA
CTGGATGAGGAGTACGCTTA

Downstream 100 bases:

>100_bases
GGAGTTATTCATGCGCAGTAAGACAATCGCTGCCATGCTGCTAACCGCCGGACTTCCGGCGGTTTCTGTAGCTGCGCAAG
ACGCAGCTGCCGATAAGGGT

Product: small-conductance mechanosensitive channel

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
MDQYLSQLETFANENLVPYAWSIAAALVIFIVGSWVVARLSHWVQKLLNKRMDETVATFLGRIVHILLFVFVVIASLDQL
GIETTSLVAILGAAGLAVGLALKDSLGNFAAGVMLILFKPFRVGHYVEAGGTSGTVKEIRIFATIMNSPDNKVLTVPNGA
IMSGNIVNYSEKPTRRVDMVFGVAYDADLSVVKKVLEEILAADERVLKDPAPTIVVGELADSSVNFLCRPWVNSADYWPV
LWDTTEAAKLRFDEAGIGIPFPQMDVHLDKND

Sequences:

>Translated_272_residues
MDQYLSQLETFANENLVPYAWSIAAALVIFIVGSWVVARLSHWVQKLLNKRMDETVATFLGRIVHILLFVFVVIASLDQL
GIETTSLVAILGAAGLAVGLALKDSLGNFAAGVMLILFKPFRVGHYVEAGGTSGTVKEIRIFATIMNSPDNKVLTVPNGA
IMSGNIVNYSEKPTRRVDMVFGVAYDADLSVVKKVLEEILAADERVLKDPAPTIVVGELADSSVNFLCRPWVNSADYWPV
LWDTTEAAKLRFDEAGIGIPFPQMDVHLDKND
>Mature_272_residues
MDQYLSQLETFANENLVPYAWSIAAALVIFIVGSWVVARLSHWVQKLLNKRMDETVATFLGRIVHILLFVFVVIASLDQL
GIETTSLVAILGAAGLAVGLALKDSLGNFAAGVMLILFKPFRVGHYVEAGGTSGTVKEIRIFATIMNSPDNKVLTVPNGA
IMSGNIVNYSEKPTRRVDMVFGVAYDADLSVVKKVLEEILAADERVLKDPAPTIVVGELADSSVNFLCRPWVNSADYWPV
LWDTTEAAKLRFDEAGIGIPFPQMDVHLDKND

Specific function: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1789291, Length=256, Percent_Identity=47.265625, Blast_Score=258, Evalue=4e-70,
Organism=Escherichia coli, GI1786670, Length=211, Percent_Identity=29.3838862559242, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI1787591, Length=255, Percent_Identity=25.4901960784314, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI2367355, Length=251, Percent_Identity=25.4980079681275, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685
- InterPro:   IPR006686
- InterPro:   IPR011014
- InterPro:   IPR008910 [H]

Pfam domain/function: PF00924 MS_channel; PF05552 TM_helix [H]

EC number: NA

Molecular weight: Translated: 29752; Mature: 29752

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQYLSQLETFANENLVPYAWSIAAALVIFIVGSWVVARLSHWVQKLLNKRMDETVATFL
CCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GRIVHILLFVFVVIASLDQLGIETTSLVAILGAAGLAVGLALKDSLGNFAAGVMLILFKP
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
FRVGHYVEAGGTSGTVKEIRIFATIMNSPDNKVLTVPNGAIMSGNIVNYSEKPTRRVDMV
HHCCCEEECCCCCCCHHHHHHHHHHHCCCCCCEEECCCCCEEECCEECCCCCCCHHHHHE
FGVAYDADLSVVKKVLEEILAADERVLKDPAPTIVVGELADSSVNFLCRPWVNSADYWPV
EEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEECCCCCCCCCCE
LWDTTEAAKLRFDEAGIGIPFPQMDVHLDKND
EECCCHHHHEEECCCCCCCCCCCCEEEECCCC
>Mature Secondary Structure
MDQYLSQLETFANENLVPYAWSIAAALVIFIVGSWVVARLSHWVQKLLNKRMDETVATFL
CCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GRIVHILLFVFVVIASLDQLGIETTSLVAILGAAGLAVGLALKDSLGNFAAGVMLILFKP
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
FRVGHYVEAGGTSGTVKEIRIFATIMNSPDNKVLTVPNGAIMSGNIVNYSEKPTRRVDMV
HHCCCEEECCCCCCCHHHHHHHHHHHCCCCCCEEECCCCCEEECCEECCCCCCCHHHHHE
FGVAYDADLSVVKKVLEEILAADERVLKDPAPTIVVGELADSSVNFLCRPWVNSADYWPV
EEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEECCCCCCCCCCE
LWDTTEAAKLRFDEAGIGIPFPQMDVHLDKND
EECCCHHHHEEECCCCCCCCCCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12542086 [H]