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The map label for this gene is icdA [H]

Identifier: 110834143

GI number: 110834143

Start: 1456565

End: 1457827

Strand: Direct

Name: icdA [H]

Synonym: ABO_1282

Alternate gene names: 110834143

Gene position: 1456565-1457827 (Clockwise)

Preceding gene: 110834142

Following gene: 110834145

Centisome position: 46.68

GC content: 51.86

Gene sequence:

>1263_bases
ATGGGATACCAAAAGATTACGGTTCCGGCAGACGGTGACAAAATCACGGTTAACGCGGACCTGTCCCTGAATGTTCCCAA
TCATCCGATCATTCCTTATATCGAAGGTGATGGTATTGGTGTTGATATTTCACCCGTAATGATCAAGGTGGTTAACGCCG
CAATTGAAAAAGCTTACGGGACAAAGCGTGGCATTACGTGGATGGAAGTTTATGCCGGGGAAAAAGCCACGGTGGTATAC
GGGCCAGATGTTTGGCTACCCGAAGAAACGCTGGAAGCTCTTAGAGAGTTCGCTGTGGGAATCAAAGGGCCGTTGACCAC
CCCAGTGGGCGGCGGCATTCGCTCTCTCAATGTATCCCTGCGTCAGGAGTTGGATCTTTACACTTGTATGCGCCCGGTGC
GCTATTTTGAAGGCGTTCCTAGCCCGGTGACCCACCCCGAGCTCACTGACATGATTATCTTCCGTGAGAACTCTGAAGAT
ATCTACGCAGGGATTGAATGGGCAGCGGATAGCCCGGAAGCGACTAAATTAATCCGTTTTTTACGCGAAGAGATGGGCGT
TACCCAAATCCGTTTTCCGGAAGGCTGCGGTATTGGTATCAAGCCAGTATCCCGCGAGGGGACCCAGCGCTTGGTGCGCA
AGGCGATTCAGTACGCTATTGATAATGATAAAGATTCCGTCACCTTGGTGCACAAAGGCAACATCATGAAGTATACGGAG
GGGGCCTTTAAGGATTGGGGCTACCAGCTTGCCGGTGAACGGTTTGGCGCGCAATTGCTTGACGGTGGCCCCTGGATGAC
CATGAAGAATCCGCGTACTGGCAAGGAAATCATCATTAAAGATGTAATTGCAGATGCCTTCCTGCAACAGATATTGATGC
GCCCGGCGGATTACAGCGTAATCGCAACGCTGAACCTGAACGGCGATTACATTTCTGATGCTCTGGCGGCGGAAGTCGGT
GGAATCGGTATTGCGCCGGGTGCCAACATCGGTGGCTCCGTGTCCCTGTTCGAGGCCACTCATGGCACCGCGCCCAAATA
CACGGGTCAAGATAAGGTGAACCCGGGCTCGCTCATTCTATCTGCGGAAATGATGTTGCGTCACATGGGCTGGAATGATG
CAGCTGACCTAATTATTAATGGTGTGGAAGGGGCAATTGCCGCCAAGACAGTAACCTATGACTTTGAGCGGTTGATGCCG
GATGCAACATTGTTACGGTGTTCAGAGTTTGGGGATGCGGTGATTGAACATATGGGCGCCTGA

Upstream 100 bases:

>100_bases
CAGCGCGGTTGTGTCTATTGGCGTCTGCCTTCATCCTTTGGGGCAATGAGATACTCGAAAGAAGCGCCTTATTTCGTTTT
ATGCAGAGGGAGAAGTATAG

Downstream 100 bases:

>100_bases
GGCGCCCATATGCATTAATACGAATTCACCCAGCCTGCAGCGCAGCGTCAGGAAGGCGTCGTCTGATCTTCAGTGGCCCC
TTCCTCATTGCTGGCCTCTT

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MGYQKITVPADGDKITVNADLSLNVPNHPIIPYIEGDGIGVDISPVMIKVVNAAIEKAYGTKRGITWMEVYAGEKATVVY
GPDVWLPEETLEALREFAVGIKGPLTTPVGGGIRSLNVSLRQELDLYTCMRPVRYFEGVPSPVTHPELTDMIIFRENSED
IYAGIEWAADSPEATKLIRFLREEMGVTQIRFPEGCGIGIKPVSREGTQRLVRKAIQYAIDNDKDSVTLVHKGNIMKYTE
GAFKDWGYQLAGERFGAQLLDGGPWMTMKNPRTGKEIIIKDVIADAFLQQILMRPADYSVIATLNLNGDYISDALAAEVG
GIGIAPGANIGGSVSLFEATHGTAPKYTGQDKVNPGSLILSAEMMLRHMGWNDAADLIINGVEGAIAAKTVTYDFERLMP
DATLLRCSEFGDAVIEHMGA

Sequences:

>Translated_420_residues
MGYQKITVPADGDKITVNADLSLNVPNHPIIPYIEGDGIGVDISPVMIKVVNAAIEKAYGTKRGITWMEVYAGEKATVVY
GPDVWLPEETLEALREFAVGIKGPLTTPVGGGIRSLNVSLRQELDLYTCMRPVRYFEGVPSPVTHPELTDMIIFRENSED
IYAGIEWAADSPEATKLIRFLREEMGVTQIRFPEGCGIGIKPVSREGTQRLVRKAIQYAIDNDKDSVTLVHKGNIMKYTE
GAFKDWGYQLAGERFGAQLLDGGPWMTMKNPRTGKEIIIKDVIADAFLQQILMRPADYSVIATLNLNGDYISDALAAEVG
GIGIAPGANIGGSVSLFEATHGTAPKYTGQDKVNPGSLILSAEMMLRHMGWNDAADLIINGVEGAIAAKTVTYDFERLMP
DATLLRCSEFGDAVIEHMGA
>Mature_419_residues
GYQKITVPADGDKITVNADLSLNVPNHPIIPYIEGDGIGVDISPVMIKVVNAAIEKAYGTKRGITWMEVYAGEKATVVYG
PDVWLPEETLEALREFAVGIKGPLTTPVGGGIRSLNVSLRQELDLYTCMRPVRYFEGVPSPVTHPELTDMIIFRENSEDI
YAGIEWAADSPEATKLIRFLREEMGVTQIRFPEGCGIGIKPVSREGTQRLVRKAIQYAIDNDKDSVTLVHKGNIMKYTEG
AFKDWGYQLAGERFGAQLLDGGPWMTMKNPRTGKEIIIKDVIADAFLQQILMRPADYSVIATLNLNGDYISDALAAEVGG
IGIAPGANIGGSVSLFEATHGTAPKYTGQDKVNPGSLILSAEMMLRHMGWNDAADLIINGVEGAIAAKTVTYDFERLMPD
ATLLRCSEFGDAVIEHMGA

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=392, Percent_Identity=31.6326530612245, Blast_Score=179, Evalue=6e-45,
Organism=Homo sapiens, GI28178816, Length=352, Percent_Identity=25.2840909090909, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI28178821, Length=352, Percent_Identity=25.2840909090909, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI28178838, Length=366, Percent_Identity=25.9562841530055, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI4758582, Length=355, Percent_Identity=26.4788732394366, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI28178819, Length=181, Percent_Identity=29.2817679558011, Blast_Score=79, Evalue=8e-15,
Organism=Escherichia coli, GI1787381, Length=414, Percent_Identity=77.2946859903382, Blast_Score=679, Evalue=0.0,
Organism=Escherichia coli, GI1788101, Length=380, Percent_Identity=28.6842105263158, Blast_Score=106, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71986051, Length=364, Percent_Identity=34.8901098901099, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI25144293, Length=305, Percent_Identity=28.1967213114754, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17505779, Length=301, Percent_Identity=27.5747508305648, Blast_Score=101, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17550882, Length=365, Percent_Identity=25.2054794520548, Blast_Score=90, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6324709, Length=393, Percent_Identity=32.0610687022901, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6322097, Length=370, Percent_Identity=27.8378378378378, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6324291, Length=310, Percent_Identity=28.7096774193548, Blast_Score=119, Evalue=7e-28,
Organism=Saccharomyces cerevisiae, GI6319830, Length=361, Percent_Identity=24.0997229916898, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24643270, Length=391, Percent_Identity=33.7595907928389, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24643268, Length=391, Percent_Identity=34.2710997442455, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24661184, Length=389, Percent_Identity=31.6195372750643, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI161078635, Length=298, Percent_Identity=25.503355704698, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI161078637, Length=298, Percent_Identity=25.503355704698, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI161078633, Length=298, Percent_Identity=25.503355704698, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24650122, Length=298, Percent_Identity=25.503355704698, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI161078639, Length=303, Percent_Identity=25.0825082508251, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI20130355, Length=389, Percent_Identity=24.6786632390745, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI281362242, Length=325, Percent_Identity=26.4615384615385, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24648872, Length=325, Percent_Identity=26.4615384615385, Blast_Score=82, Evalue=1e-15,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 45711; Mature: 45580

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGYQKITVPADGDKITVNADLSLNVPNHPIIPYIEGDGIGVDISPVMIKVVNAAIEKAYG
CCCEEEEECCCCCEEEEEEEEEEECCCCCEEEEECCCCCCEEHHHHHHHHHHHHHHHHCC
TKRGITWMEVYAGEKATVVYGPDVWLPEETLEALREFAVGIKGPLTTPVGGGIRSLNVSL
CCCCCEEEEEECCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEHHH
RQELDLYTCMRPVRYFEGVPSPVTHPELTDMIIFRENSEDIYAGIEWAADSPEATKLIRF
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCHHHHHHHHH
LREEMGVTQIRFPEGCGIGIKPVSREGTQRLVRKAIQYAIDNDKDSVTLVHKGNIMKYTE
HHHHCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEECC
GAFKDWGYQLAGERFGAQLLDGGPWMTMKNPRTGKEIIIKDVIADAFLQQILMRPADYSV
CCHHHCCHHHHHHHHCCHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEE
IATLNLNGDYISDALAAEVGGIGIAPGANIGGSVSLFEATHGTAPKYTGQDKVNPGSLIL
EEEEECCCCHHHHHHHHHHCCEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEE
SAEMMLRHMGWNDAADLIINGVEGAIAAKTVTYDFERLMPDATLLRCSEFGDAVIEHMGA
EHHHHHHHCCCCCCHHHEEECCCCCEEEEEEEEEHHHHCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GYQKITVPADGDKITVNADLSLNVPNHPIIPYIEGDGIGVDISPVMIKVVNAAIEKAYG
CCEEEEECCCCCEEEEEEEEEEECCCCCEEEEECCCCCCEEHHHHHHHHHHHHHHHHCC
TKRGITWMEVYAGEKATVVYGPDVWLPEETLEALREFAVGIKGPLTTPVGGGIRSLNVSL
CCCCCEEEEEECCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEHHH
RQELDLYTCMRPVRYFEGVPSPVTHPELTDMIIFRENSEDIYAGIEWAADSPEATKLIRF
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCHHHHHHHHH
LREEMGVTQIRFPEGCGIGIKPVSREGTQRLVRKAIQYAIDNDKDSVTLVHKGNIMKYTE
HHHHCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEECC
GAFKDWGYQLAGERFGAQLLDGGPWMTMKNPRTGKEIIIKDVIADAFLQQILMRPADYSV
CCHHHCCHHHHHHHHCCHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEE
IATLNLNGDYISDALAAEVGGIGIAPGANIGGSVSLFEATHGTAPKYTGQDKVNPGSLIL
EEEEECCCCHHHHHHHHHHCCEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEE
SAEMMLRHMGWNDAADLIINGVEGAIAAKTVTYDFERLMPDATLLRCSEFGDAVIEHMGA
EHHHHHHHCCCCCCHHHEEECCCCCEEEEEEEEEHHHHCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3112144; 8905232; 9278503; 9352899; 9298646; 2204109; 2682654; 10623532 [H]