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The map label for this gene is icd [H]

Identifier: 110834142

GI number: 110834142

Start: 1453952

End: 1456174

Strand: Direct

Name: icd [H]

Synonym: ABO_1281

Alternate gene names: 110834142

Gene position: 1453952-1456174 (Clockwise)

Preceding gene: 110834140

Following gene: 110834143

Centisome position: 46.6

GC content: 48.85

Gene sequence:

>2223_bases
ATGACCACGCCTAAAATTATTTATACCATGACCGATGAGGCGCCAGCGCTGGCGACCTATTCCTTTTTGCCCATTATCGA
GAAATTCACTTCTATCGCTGGTATTGAAGTAGAAAGCAGTGATATCTCCCTCGCAACGCGCATTTTAGCCAGTTTCCCTG
AATATTTGTCAGAACAGCAGAAGGTAAAGGATACACTATCTGAACTGAGTGACCTGACCCAGGATCCTGAGGCCAACATT
ATCAAGCTGCCAAATATCAGCGCCTCCATTCCACAGCTTAGAGAAGCTATCGCTGAATTGAACGAGCATGGCTACGCGGT
GCCGGAATATCCTGATGAGCCTCAAAATGAGAAAGAGAAAGATATTCAGGCTAGGTACACCAAAATTCTGGGTTCCGCAG
TAAACCCTGTACTTCGTGAAGGCAATTCTGACCGTCGCGCGCCGATTGCGGTAAAAAATTACGCTCGAAAGAACCCGCAT
AGCATGGGGTATTGGAGTCCTGCTTCACGCACCCATGTTGCACATATGCGCGGGGGCGATTTCTTTTCCCATGAGACCTC
GTGCACTATCGACAAGGCCTGCAAGGTACGCATTGAATTTGAGGATTCAAACGGTAATATCACCGTGAAGAAGCCGGATT
TGGCGCTCCTCGATGGCGAAGTCATTGATGCCATGTATATGAGCAAAAAAGCACTCTGTGCTTTTTTTGACGAGCAAATC
GAAGACGCGAAGAACACGGGGATGTTGTTTTCCCTGCACGTGAAAGCGACCATGATGAAGGTGTCACACCCTATCGTGTT
TGGTCATGCTGTGCGTTGTTTCTACCGGGAGTTGTTCGAGAAACACGGTGAGATTCTCGAGAAAATCGGCGCCAACCCTA
ATAATGGCCTGAGCAACATCTATCAGAAAATTGAAGAGTTGCCGATTTCCCAGCGTTTGGAAATTGAATCCACAATTCGG
GCCTGCTATTTGCACCGTCCGGAGTTGGCCATGGTTGATTCAGACCGAGGTATTTCTAATCTTCACGTTCCTTCAGACGT
TATTGTGGATGCCTCTATGCCGGCGATGATTCGCCAGGGCGGCAAAATGTACGGTGCTGATGGCAAGCTGAAAGATACCA
AAGCGGTGATCCCTGAAAGTACCTACGCGACTATTTATCAAGAAGTAATTAATTTCTGCAAAACCCACGGCGCCTTTGAT
CCGGTTACCTGTGGCTCCGTGCCTAATGTTGGTTTGATGGCGCAGAAAGCAGAAGAGTACGGCTCTCACGATAAAACGTT
CGAAGCCACCGCAGACGGCTCCATGCGTATCGTTCGAGAGGACGGTGAGGTGTTGCTAACCCATAAAGTGGAACAGGGTG
ATATCTGGCGTATGTGCCAGGCAAAAGACCTGCCAATTCGGGACTGGGTCAAGCTAGCGGTGGTACGTGCACGGCTGAGC
AATACCCCGGCCATTTTCTGGTTGGATAAAGAACGGGCCCATGATGCACAGCTGATTCTGAAGGTTAAGGAATACCTGAA
AGACCACGATACCGAGGGTCTTGATATCCGGATCATGTCTCCGGTACAGGCTATCCGCTATACCATGGAGCGAATGATCC
GTGGCAAGGATACCATTTCAGTAACAGGTAACGTGCTACGTGACTATTTGACGGACTTGTTCCCCATTCTGGAGCTGGGG
ACCAGTGCCAAGATGTTGTCCATTGTGCCGTTAATGGCGGGGGGCGGCCTCTATGAAACCGGAGCCGGCGGTTCCGCTCC
CAAGCATGTACAGCAATTCTTGGAAGAAAATCACCTGCGTTGGGATTCACTGGGTGAATTTCTTGCCCTGTCGGTATCTA
TTCAAGAGCTCGGCGAAAAATATGGCAACAAAAAAGCCAAGGTGATTGCTGCGGCTCTGGATAAAGCTAATGAGCAGTAT
CTTGAGCAGAACAAGTCACCCTCACGTAAAGTTGGCCAGCCGGATAATCGGGTAAGTCATTTTTATGTGGCCATGTACTG
GGCTCAGGCCTTAGCGGCTCAAGACGATGATGCTGAGTTGAAAGAAAAATTCACAGAAATCGCCTCTTCCCTTAGCCAGA
ACGAAGAGAAAATCGTTAAAGAAATGGTAGCAGTACAAGGTTCTCCTATTGATATCGGCGGGTACTATAACCCTGATTTC
AATAAAGCCTCGCAAGCCATGCGTCCCAGCGGGACCTTTAACCAGATTCTCGAAAAGCTGTAA

Upstream 100 bases:

>100_bases
GGAGGGAACACTGTTGTTTCCTGCCCGCTGATCTGACGGTCAAAAGCCGACTGAAATCAGGCGGAAAGCTCTACCAATAC
AATTGGGACCTTGTAAATCT

Downstream 100 bases:

>100_bases
GGTAAAGCAAGACAGGTCGGCCTGGATCAAACAGGTCGGCTTGTGGCCCGGTGGTAATGCAGAGTAAGCCGACAGCCTGG
GGATGAATCTGGCGCTACGG

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 740; Mature: 739

Protein sequence:

>740_residues
MTTPKIIYTMTDEAPALATYSFLPIIEKFTSIAGIEVESSDISLATRILASFPEYLSEQQKVKDTLSELSDLTQDPEANI
IKLPNISASIPQLREAIAELNEHGYAVPEYPDEPQNEKEKDIQARYTKILGSAVNPVLREGNSDRRAPIAVKNYARKNPH
SMGYWSPASRTHVAHMRGGDFFSHETSCTIDKACKVRIEFEDSNGNITVKKPDLALLDGEVIDAMYMSKKALCAFFDEQI
EDAKNTGMLFSLHVKATMMKVSHPIVFGHAVRCFYRELFEKHGEILEKIGANPNNGLSNIYQKIEELPISQRLEIESTIR
ACYLHRPELAMVDSDRGISNLHVPSDVIVDASMPAMIRQGGKMYGADGKLKDTKAVIPESTYATIYQEVINFCKTHGAFD
PVTCGSVPNVGLMAQKAEEYGSHDKTFEATADGSMRIVREDGEVLLTHKVEQGDIWRMCQAKDLPIRDWVKLAVVRARLS
NTPAIFWLDKERAHDAQLILKVKEYLKDHDTEGLDIRIMSPVQAIRYTMERMIRGKDTISVTGNVLRDYLTDLFPILELG
TSAKMLSIVPLMAGGGLYETGAGGSAPKHVQQFLEENHLRWDSLGEFLALSVSIQELGEKYGNKKAKVIAAALDKANEQY
LEQNKSPSRKVGQPDNRVSHFYVAMYWAQALAAQDDDAELKEKFTEIASSLSQNEEKIVKEMVAVQGSPIDIGGYYNPDF
NKASQAMRPSGTFNQILEKL

Sequences:

>Translated_740_residues
MTTPKIIYTMTDEAPALATYSFLPIIEKFTSIAGIEVESSDISLATRILASFPEYLSEQQKVKDTLSELSDLTQDPEANI
IKLPNISASIPQLREAIAELNEHGYAVPEYPDEPQNEKEKDIQARYTKILGSAVNPVLREGNSDRRAPIAVKNYARKNPH
SMGYWSPASRTHVAHMRGGDFFSHETSCTIDKACKVRIEFEDSNGNITVKKPDLALLDGEVIDAMYMSKKALCAFFDEQI
EDAKNTGMLFSLHVKATMMKVSHPIVFGHAVRCFYRELFEKHGEILEKIGANPNNGLSNIYQKIEELPISQRLEIESTIR
ACYLHRPELAMVDSDRGISNLHVPSDVIVDASMPAMIRQGGKMYGADGKLKDTKAVIPESTYATIYQEVINFCKTHGAFD
PVTCGSVPNVGLMAQKAEEYGSHDKTFEATADGSMRIVREDGEVLLTHKVEQGDIWRMCQAKDLPIRDWVKLAVVRARLS
NTPAIFWLDKERAHDAQLILKVKEYLKDHDTEGLDIRIMSPVQAIRYTMERMIRGKDTISVTGNVLRDYLTDLFPILELG
TSAKMLSIVPLMAGGGLYETGAGGSAPKHVQQFLEENHLRWDSLGEFLALSVSIQELGEKYGNKKAKVIAAALDKANEQY
LEQNKSPSRKVGQPDNRVSHFYVAMYWAQALAAQDDDAELKEKFTEIASSLSQNEEKIVKEMVAVQGSPIDIGGYYNPDF
NKASQAMRPSGTFNQILEKL
>Mature_739_residues
TTPKIIYTMTDEAPALATYSFLPIIEKFTSIAGIEVESSDISLATRILASFPEYLSEQQKVKDTLSELSDLTQDPEANII
KLPNISASIPQLREAIAELNEHGYAVPEYPDEPQNEKEKDIQARYTKILGSAVNPVLREGNSDRRAPIAVKNYARKNPHS
MGYWSPASRTHVAHMRGGDFFSHETSCTIDKACKVRIEFEDSNGNITVKKPDLALLDGEVIDAMYMSKKALCAFFDEQIE
DAKNTGMLFSLHVKATMMKVSHPIVFGHAVRCFYRELFEKHGEILEKIGANPNNGLSNIYQKIEELPISQRLEIESTIRA
CYLHRPELAMVDSDRGISNLHVPSDVIVDASMPAMIRQGGKMYGADGKLKDTKAVIPESTYATIYQEVINFCKTHGAFDP
VTCGSVPNVGLMAQKAEEYGSHDKTFEATADGSMRIVREDGEVLLTHKVEQGDIWRMCQAKDLPIRDWVKLAVVRARLSN
TPAIFWLDKERAHDAQLILKVKEYLKDHDTEGLDIRIMSPVQAIRYTMERMIRGKDTISVTGNVLRDYLTDLFPILELGT
SAKMLSIVPLMAGGGLYETGAGGSAPKHVQQFLEENHLRWDSLGEFLALSVSIQELGEKYGNKKAKVIAAALDKANEQYL
EQNKSPSRKVGQPDNRVSHFYVAMYWAQALAAQDDDAELKEKFTEIASSLSQNEEKIVKEMVAVQGSPIDIGGYYNPDFN
KASQAMRPSGTFNQILEKL

Specific function: Unknown

COG id: COG2838

COG function: function code C; Monomeric isocitrate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monomeric-type IDH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001804
- InterPro:   IPR004436 [H]

Pfam domain/function: PF03971 IDH [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 82599; Mature: 82468

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPKIIYTMTDEAPALATYSFLPIIEKFTSIAGIEVESSDISLATRILASFPEYLSEQQ
CCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHHHHH
KVKDTLSELSDLTQDPEANIIKLPNISASIPQLREAIAELNEHGYAVPEYPDEPQNEKEK
HHHHHHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHH
DIQARYTKILGSAVNPVLREGNSDRRAPIAVKNYARKNPHSMGYWSPASRTHVAHMRGGD
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCEEEEECCCC
FFSHETSCTIDKACKVRIEFEDSNGNITVKKPDLALLDGEVIDAMYMSKKALCAFFDEQI
CCCCCCCCEECCEEEEEEEEECCCCEEEEECCCEEEECHHHHHHHHHHHHHHHHHHHHHH
EDAKNTGMLFSLHVKATMMKVSHPIVFGHAVRCFYRELFEKHGEILEKIGANPNNGLSNI
HHHCCCCEEEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
YQKIEELPISQRLEIESTIRACYLHRPELAMVDSDRGISNLHVPSDVIVDASMPAMIRQG
HHHHHHCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCEEECCCCCHHHHCC
GKMYGADGKLKDTKAVIPESTYATIYQEVINFCKTHGAFDPVTCGSVPNVGLMAQKAEEY
CCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHH
GSHDKTFEATADGSMRIVREDGEVLLTHKVEQGDIWRMCQAKDLPIRDWVKLAVVRARLS
CCCCCCEEECCCCCEEEEECCCCEEEEEECCCCCHHHHHCCCCCCHHHHHHHHHHHHHHC
NTPAIFWLDKERAHDAQLILKVKEYLKDHDTEGLDIRIMSPVQAIRYTMERMIRGKDTIS
CCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHCCCCCEE
VTGNVLRDYLTDLFPILELGTSAKMLSIVPLMAGGGLYETGAGGSAPKHVQQFLEENHLR
ECHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHCCCC
WDSLGEFLALSVSIQELGEKYGNKKAKVIAAALDKANEQYLEQNKSPSRKVGQPDNRVSH
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHH
FYVAMYWAQALAAQDDDAELKEKFTEIASSLSQNEEKIVKEMVAVQGSPIDIGGYYNPDF
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEECCCCCCCH
NKASQAMRPSGTFNQILEKL
HHHHHHCCCCCCHHHHHHHC
>Mature Secondary Structure 
TTPKIIYTMTDEAPALATYSFLPIIEKFTSIAGIEVESSDISLATRILASFPEYLSEQQ
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHHHHH
KVKDTLSELSDLTQDPEANIIKLPNISASIPQLREAIAELNEHGYAVPEYPDEPQNEKEK
HHHHHHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHH
DIQARYTKILGSAVNPVLREGNSDRRAPIAVKNYARKNPHSMGYWSPASRTHVAHMRGGD
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCEEEEECCCC
FFSHETSCTIDKACKVRIEFEDSNGNITVKKPDLALLDGEVIDAMYMSKKALCAFFDEQI
CCCCCCCCEECCEEEEEEEEECCCCEEEEECCCEEEECHHHHHHHHHHHHHHHHHHHHHH
EDAKNTGMLFSLHVKATMMKVSHPIVFGHAVRCFYRELFEKHGEILEKIGANPNNGLSNI
HHHCCCCEEEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
YQKIEELPISQRLEIESTIRACYLHRPELAMVDSDRGISNLHVPSDVIVDASMPAMIRQG
HHHHHHCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCEEECCCCCHHHHCC
GKMYGADGKLKDTKAVIPESTYATIYQEVINFCKTHGAFDPVTCGSVPNVGLMAQKAEEY
CCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHH
GSHDKTFEATADGSMRIVREDGEVLLTHKVEQGDIWRMCQAKDLPIRDWVKLAVVRARLS
CCCCCCEEECCCCCEEEEECCCCEEEEEECCCCCHHHHHCCCCCCHHHHHHHHHHHHHHC
NTPAIFWLDKERAHDAQLILKVKEYLKDHDTEGLDIRIMSPVQAIRYTMERMIRGKDTIS
CCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHCCCCCEE
VTGNVLRDYLTDLFPILELGTSAKMLSIVPLMAGGGLYETGAGGSAPKHVQQFLEENHLR
ECHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHCCCC
WDSLGEFLALSVSIQELGEKYGNKKAKVIAAALDKANEQYLEQNKSPSRKVGQPDNRVSH
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHH
FYVAMYWAQALAAQDDDAELKEKFTEIASSLSQNEEKIVKEMVAVQGSPIDIGGYYNPDF
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEECCCCCCCH
NKASQAMRPSGTFNQILEKL
HHHHHHCCCCCCHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12005040; 4149369; 12467571 [H]