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The map label for this gene is yhaE [H]

Identifier: 110834093

GI number: 110834093

Start: 1403539

End: 1404465

Strand: Direct

Name: yhaE [H]

Synonym: ABO_1232

Alternate gene names: 110834093

Gene position: 1403539-1404465 (Clockwise)

Preceding gene: 110834092

Following gene: 110834094

Centisome position: 44.98

GC content: 57.71

Gene sequence:

>927_bases
ATGCGTAATATCTGTTTCCTCGGCATCGGTTTGATGGGCGAGCCTATGGTGGCACGGCTGTTGGATGCCGGTTTCTCTTT
GACTCTCTGGAATCGCACTGTTGAAAAGGCGCAGCCGTTTAGCGGACGGGCGCGTATTGCCAGCAGCCCAGCCGAGGCGG
TGGCTGAGGCTGATGTGGTCATTACCATGCTTGAAAATGGCACCGCAGTCGAGCAGGTGCTGTACCAGAGTAATGCCATT
GCCCGTTTATCTCCGGGGGCCTTGGTTATCGATATGAGCTCCGTCGAGCCCGCTACTGCCCGGCGTCATGGGGCGCGGGT
AGCAGAGCTGGGCGGATGTTATCTGGATGCGCCAGTGTCTGGCGGCACCCGTGGTGCACAAGCCGGTACGTTGTCGATCA
TGGCGGGGGGCAATGATCAAGACTTTGATGAGGCAACCGCGGTGTTTCAGGCCATGGGCCGCGCCACGCTTATTGGCCCT
GTGGGTAGCGGGCAGCTGGCCAAGTTAGCTAATCAGACGATTGTCGGCATCACCATTGGCGCTGTGTCAGAGGCTTTGCT
ATTGGCTGCAAAAGGCGGCGCCCGGCCAGAAAAGGTTCGCGAAGCGCTACTCGGTGGCTTTGCCGGAAGTAAGATTTTAG
AGCAGCATGGCGAGCGTATGTTGGCACGGAATTTTGAGCCCGGTGCTCCGGCGCGAATTCAGCTCAAGGATCTGGGTATG
ATCCTGGATGAAGCTCGCACGGAGGGATTGACGCTGCCCTTGAGCCAGCGCGTGTTCGAGCAATATCGTGCGCTGCTGGC
CAGTGGTCATGGCGAAGTTGACCACAGTGGTCTGTTGCTGGAACTAGAAAGGCTAAATGGCGTGCAGCTCAACCCCGATG
CCGCTGATCACTTTAGTCCAACTGACTTGGATAAGGAGACGCACTAA

Upstream 100 bases:

>100_bases
AGGCGACGCAACACACTTACGTCTACGTCTGGCGGTCGAATTCCTACAGTCATTGACGTGGATCGCGTAGACTTTTCGCT
CAACCAGCTCTGGAAGTATT

Downstream 100 bases:

>100_bases
TGCCACGGTTCGCTGCCAACCTGTCCATGTTGTTCACCGAATTACCCTTTCCTGAGCGCTTTGCCGCCGCTGCAGACGCC
GGTTTTAAAGGCGTCGAATA

Product: 2-hydroxy-3-oxopropionate reductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MRNICFLGIGLMGEPMVARLLDAGFSLTLWNRTVEKAQPFSGRARIASSPAEAVAEADVVITMLENGTAVEQVLYQSNAI
ARLSPGALVIDMSSVEPATARRHGARVAELGGCYLDAPVSGGTRGAQAGTLSIMAGGNDQDFDEATAVFQAMGRATLIGP
VGSGQLAKLANQTIVGITIGAVSEALLLAAKGGARPEKVREALLGGFAGSKILEQHGERMLARNFEPGAPARIQLKDLGM
ILDEARTEGLTLPLSQRVFEQYRALLASGHGEVDHSGLLLELERLNGVQLNPDAADHFSPTDLDKETH

Sequences:

>Translated_308_residues
MRNICFLGIGLMGEPMVARLLDAGFSLTLWNRTVEKAQPFSGRARIASSPAEAVAEADVVITMLENGTAVEQVLYQSNAI
ARLSPGALVIDMSSVEPATARRHGARVAELGGCYLDAPVSGGTRGAQAGTLSIMAGGNDQDFDEATAVFQAMGRATLIGP
VGSGQLAKLANQTIVGITIGAVSEALLLAAKGGARPEKVREALLGGFAGSKILEQHGERMLARNFEPGAPARIQLKDLGM
ILDEARTEGLTLPLSQRVFEQYRALLASGHGEVDHSGLLLELERLNGVQLNPDAADHFSPTDLDKETH
>Mature_308_residues
MRNICFLGIGLMGEPMVARLLDAGFSLTLWNRTVEKAQPFSGRARIASSPAEAVAEADVVITMLENGTAVEQVLYQSNAI
ARLSPGALVIDMSSVEPATARRHGARVAELGGCYLDAPVSGGTRGAQAGTLSIMAGGNDQDFDEATAVFQAMGRATLIGP
VGSGQLAKLANQTIVGITIGAVSEALLLAAKGGARPEKVREALLGGFAGSKILEQHGERMLARNFEPGAPARIQLKDLGM
ILDEARTEGLTLPLSQRVFEQYRALLASGHGEVDHSGLLLELERLNGVQLNPDAADHFSPTDLDKETH

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=294, Percent_Identity=28.2312925170068, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI40556376, Length=281, Percent_Identity=29.8932384341637, Blast_Score=123, Evalue=2e-28,
Organism=Escherichia coli, GI1786719, Length=280, Percent_Identity=42.1428571428571, Blast_Score=209, Evalue=2e-55,
Organism=Escherichia coli, GI145693186, Length=292, Percent_Identity=40.7534246575342, Blast_Score=198, Evalue=4e-52,
Organism=Escherichia coli, GI1790315, Length=284, Percent_Identity=31.6901408450704, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI1789092, Length=284, Percent_Identity=26.7605633802817, Blast_Score=85, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17557316, Length=188, Percent_Identity=35.1063829787234, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI28574115, Length=279, Percent_Identity=26.5232974910394, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24655230, Length=296, Percent_Identity=28.3783783783784, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI19922568, Length=296, Percent_Identity=28.3783783783784, Blast_Score=110, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 32403; Mature: 32403

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNICFLGIGLMGEPMVARLLDAGFSLTLWNRTVEKAQPFSGRARIASSPAEAVAEADVV
CCCEEEEECCCCCCHHHHHHHHCCCEEEEEHHHHHHCCCCCCCCEECCCHHHHHHHCCEE
ITMLENGTAVEQVLYQSNAIARLSPGALVIDMSSVEPATARRHGARVAELGGCYLDAPVS
EEEECCCHHHHHHHHHCCCEEEECCCEEEEEECCCCCHHHHHHCCCCHHHCCEEEECCCC
GGTRGAQAGTLSIMAGGNDQDFDEATAVFQAMGRATLIGPVGSGQLAKLANQTIVGITIG
CCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCEEEEECCCCCHHHHHHCCEEEEEEHH
AVSEALLLAAKGGARPEKVREALLGGFAGSKILEQHGERMLARNFEPGAPARIQLKDLGM
HHHHHHHEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHH
ILDEARTEGLTLPLSQRVFEQYRALLASGHGEVDHSGLLLELERLNGVQLNPDAADHFSP
HHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCEEECCCCCCCCCC
TDLDKETH
CCCCCCCC
>Mature Secondary Structure
MRNICFLGIGLMGEPMVARLLDAGFSLTLWNRTVEKAQPFSGRARIASSPAEAVAEADVV
CCCEEEEECCCCCCHHHHHHHHCCCEEEEEHHHHHHCCCCCCCCEECCCHHHHHHHCCEE
ITMLENGTAVEQVLYQSNAIARLSPGALVIDMSSVEPATARRHGARVAELGGCYLDAPVS
EEEECCCHHHHHHHHHCCCEEEECCCEEEEEECCCCCHHHHHHCCCCHHHCCEEEECCCC
GGTRGAQAGTLSIMAGGNDQDFDEATAVFQAMGRATLIGPVGSGQLAKLANQTIVGITIG
CCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCEEEEECCCCCHHHHHHCCEEEEEEHH
AVSEALLLAAKGGARPEKVREALLGGFAGSKILEQHGERMLARNFEPGAPARIQLKDLGM
HHHHHHHEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHH
ILDEARTEGLTLPLSQRVFEQYRALLASGHGEVDHSGLLLELERLNGVQLNPDAADHFSP
HHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCEEECCCCCCCCCC
TDLDKETH
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10601204; 9278503 [H]