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The map label for this gene is hyi [H]

Identifier: 110834094

GI number: 110834094

Start: 1404465

End: 1405253

Strand: Direct

Name: hyi [H]

Synonym: ABO_1233

Alternate gene names: 110834094

Gene position: 1404465-1405253 (Clockwise)

Preceding gene: 110834093

Following gene: 110834095

Centisome position: 45.01

GC content: 53.74

Gene sequence:

>789_bases
ATGCCACGGTTCGCTGCCAACCTGTCCATGTTGTTCACCGAATTACCCTTTCCTGAGCGCTTTGCCGCCGCTGCAGACGC
CGGTTTTAAAGGCGTCGAATACCTGTTTCCCTATGATTGGCCTGCACAGCAACTGGCCCAATGGCTGGCGGACAATGGCC
TGACCCAGGTGCTGTTTAATTTGCCGGCCGGAGATTGGCAGGCGGGGGAGCGGGGGATTGCGTGCCTGCCGGACCGAATA
GCCGCATTTCGCGAAGACGTTTTTATGGCCATGGAGTATGCCCAGGCGCTGGATTGCCAGCAGGTGAACTGTTTGGCGGG
TCTAAAACCCGATGAACTATCCTCGGAGGTAGCCTTTACAACGTTGGTAGAGAATCTGCGTTTTGCCGCGGATCTATTCG
ACGCTCAGGGGCTGACTTTGACGCTGGAAGCGATAAACTCTCGAGTAGATATGCCAGGTTTTTTGGTGGATACCTCCGCC
ACGGCCATGGCGGTCATAGAGGCGGTTGGTCGTGAGAATATTCGTTTGCAGTATGATCTCTACCATATGCAGATCATGGA
AGGGGACCTGTGTCGTTCCCTTTCTCAACTTTGCCCCCATATAGGACATATTCAGTTTGCCGATAATCCTGGGCGTAATG
AGCCCGGTAGCGGCGAAATTCATTTTGATACCGTGTTTGCCCACATCGATTCCTTGGACTATGCAGGATGGGTAAGTGCG
GAGTATCGACCGTTGACAGATACGGCAACCAGCCTGGGCTGGTTTAACGCAACAAAACAGGAGCCGTGA

Upstream 100 bases:

>100_bases
GTGGTCTGTTGCTGGAACTAGAAAGGCTAAATGGCGTGCAGCTCAACCCCGATGCCGCTGATCACTTTAGTCCAACTGAC
TTGGATAAGGAGACGCACTA

Downstream 100 bases:

>100_bases
TGCAATTCAATTGGGGTGGGAAGATCATCCTTGGCCTGCTCGGCATGCTTGTGGGTGGGCCCGTTGGCCTGGGCATAGGC
TTGCTGATTGGACATATGCT

Product: hydroxypyruvate isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 262; Mature: 261

Protein sequence:

>262_residues
MPRFAANLSMLFTELPFPERFAAAADAGFKGVEYLFPYDWPAQQLAQWLADNGLTQVLFNLPAGDWQAGERGIACLPDRI
AAFREDVFMAMEYAQALDCQQVNCLAGLKPDELSSEVAFTTLVENLRFAADLFDAQGLTLTLEAINSRVDMPGFLVDTSA
TAMAVIEAVGRENIRLQYDLYHMQIMEGDLCRSLSQLCPHIGHIQFADNPGRNEPGSGEIHFDTVFAHIDSLDYAGWVSA
EYRPLTDTATSLGWFNATKQEP

Sequences:

>Translated_262_residues
MPRFAANLSMLFTELPFPERFAAAADAGFKGVEYLFPYDWPAQQLAQWLADNGLTQVLFNLPAGDWQAGERGIACLPDRI
AAFREDVFMAMEYAQALDCQQVNCLAGLKPDELSSEVAFTTLVENLRFAADLFDAQGLTLTLEAINSRVDMPGFLVDTSA
TAMAVIEAVGRENIRLQYDLYHMQIMEGDLCRSLSQLCPHIGHIQFADNPGRNEPGSGEIHFDTVFAHIDSLDYAGWVSA
EYRPLTDTATSLGWFNATKQEP
>Mature_261_residues
PRFAANLSMLFTELPFPERFAAAADAGFKGVEYLFPYDWPAQQLAQWLADNGLTQVLFNLPAGDWQAGERGIACLPDRIA
AFREDVFMAMEYAQALDCQQVNCLAGLKPDELSSEVAFTTLVENLRFAADLFDAQGLTLTLEAINSRVDMPGFLVDTSAT
AMAVIEAVGRENIRLQYDLYHMQIMEGDLCRSLSQLCPHIGHIQFADNPGRNEPGSGEIHFDTVFAHIDSLDYAGWVSAE
YRPLTDTATSLGWFNATKQEP

Specific function: Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) [H]

COG id: COG3622

COG function: function code G; Hydroxypyruvate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hyi family [H]

Homologues:

Organism=Homo sapiens, GI300068962, Length=261, Percent_Identity=40.2298850574713, Blast_Score=190, Evalue=1e-48,
Organism=Homo sapiens, GI300068964, Length=243, Percent_Identity=40.3292181069959, Blast_Score=174, Evalue=7e-44,
Organism=Escherichia coli, GI1786718, Length=256, Percent_Identity=50, Blast_Score=265, Evalue=3e-72,
Organism=Escherichia coli, GI1789095, Length=259, Percent_Identity=42.0849420849421, Blast_Score=216, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17552022, Length=254, Percent_Identity=37.7952755905512, Blast_Score=167, Evalue=7e-42,
Organism=Drosophila melanogaster, GI17530883, Length=258, Percent_Identity=31.3953488372093, Blast_Score=131, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017643
- InterPro:   IPR013022
- InterPro:   IPR012307 [H]

Pfam domain/function: PF01261 AP_endonuc_2 [H]

EC number: =5.3.1.22 [H]

Molecular weight: Translated: 29041; Mature: 28910

Theoretical pI: Translated: 4.10; Mature: 4.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRFAANLSMLFTELPFPERFAAAADAGFKGVEYLFPYDWPAQQLAQWLADNGLTQVLFN
CCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHCCCHHHHHEE
LPAGDWQAGERGIACLPDRIAAFREDVFMAMEYAQALDCQQVNCLAGLKPDELSSEVAFT
CCCCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHHHH
TLVENLRFAADLFDAQGLTLTLEAINSRVDMPGFLVDTSATAMAVIEAVGRENIRLQYDL
HHHHHHHHHHHHHCCCCCEEEEEHHHCCCCCCCEEEECCHHHHHHHHHHCCCCEEEEEEE
YHMQIMEGDLCRSLSQLCPHIGHIQFADNPGRNEPGSGEIHFDTVFAHIDSLDYAGWVSA
EEEEECCCHHHHHHHHHCHHCCCEEECCCCCCCCCCCCEEEHHHHHHHHHCCCCCCCCCC
EYRPLTDTATSLGWFNATKQEP
CCCCCCHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
PRFAANLSMLFTELPFPERFAAAADAGFKGVEYLFPYDWPAQQLAQWLADNGLTQVLFN
CCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHCCCHHHHHEE
LPAGDWQAGERGIACLPDRIAAFREDVFMAMEYAQALDCQQVNCLAGLKPDELSSEVAFT
CCCCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHHHH
TLVENLRFAADLFDAQGLTLTLEAINSRVDMPGFLVDTSATAMAVIEAVGRENIRLQYDL
HHHHHHHHHHHHHCCCCCEEEEEHHHCCCCCCCEEEECCHHHHHHHHHHCCCCEEEEEEE
YHMQIMEGDLCRSLSQLCPHIGHIQFADNPGRNEPGSGEIHFDTVFAHIDSLDYAGWVSA
EEEEECCCHHHHHHHHHCHHCCCEEECCCCCCCCCCCCEEEHHHHHHHHHCCCCCCCCCC
EYRPLTDTATSLGWFNATKQEP
CCCCCCHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8440684; 10561547; 9278503 [H]